Strain Name:
C57BL/6J-MtgxR6835Btlr/Mmmh
Stock Number:
044944-MU
Citation ID:
RRID:MMRRC_044944-MU
Other Names:
R6835 (G1)
Major Collection:

Strain Information

Utrn
Name: utrophin
Synonyms: G-utrophin, DRP, Dmdl
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Rtel1
Name: regulator of telomere elongation helicase 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269400
Homologene: 13168
Crym
Name: crystallin, mu
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12971
HGNC: HGNC:2418
Homologene: 1424
Dtnb
Name: dystrobrevin, beta
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13528
HGNC: HGNC:3058
Homologene: 74875
Morc3
Name: microrchidia 3
Synonyms: Zcwcc3, D16Jhu32e, 1110051N18Rik, 1110051N18Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 338467
Homologene: 32257
Fmn2
Name: formin 2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 54418
Homologene: 137334
Fam133b
Name: family with sequence similarity 133, member B
Synonyms: 2900022K02Rik, 5830415L20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68152
Homologene: 85443
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: D630005A10Rik, apollon, A430032G04Rik, A430040A19Rik, Bruce
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12211
Homologene: 7248
Gpi1
Name: glucose-6-phosphate isomerase 1
Synonyms: Gpi-1s, Gpi-1t, Gpi-1, autocrine motility factor, AMF, NK, Gpi1-t, maturation factor, Org, neuroleukin, NK/GPI, Gpi-1r, MF, Gpi1-s, Gpi1-r
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14751
HGNC: HGNC:4458
Homologene: 145
Hunk
Name: hormonally upregulated Neu-associated kinase
Synonyms: Bstk1, Mak-v
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 26559
VEGA: 16
Homologene: 8742
Pikfyve
Name: phosphoinositide kinase, FYVE type zinc finger containing
Synonyms: Pip5k3, PipkIII, 5230400C17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18711
Homologene: 32115
Lmnb2
Name: lamin B2
Synonyms: lamin B3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16907
HGNC: HGNC:6638
Homologene: 7818
Icam1
Name: intercellular adhesion molecule 1
Synonyms: Ly-47, Icam-1, MALA-2, CD54
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15894
VEGA: 9
HGNC: HGNC:5344
Homologene: 168
Ino80d
Name: INO80 complex subunit D
Synonyms: A430093A21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227195
Homologene: 9819
Cttn
Name: cortactin
Synonyms: Ems1, 1110020L01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13043
HGNC: HGNC:3338
Homologene: 3834
Strip2
Name: striatin interacting protein 2
Synonyms: Fam40b, Myoscape, D330017J20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320609
Homologene: 66198
Myadm
Name: myeloid-associated differentiation marker
Synonyms: D7Wsu62e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 50918
HGNC: HGNC:7544
Homologene: 9668
Itpkc
Name: inositol 1,4,5-trisphosphate 3-kinase C
Synonyms: 9130023N17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233011
Homologene: 11868
Mns1
Name: meiosis-specific nuclear structural protein 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17427
Homologene: 40628
Tek
Name: TEK receptor tyrosine kinase
Synonyms: Tie2, tie-2, Cd202b, Hyk
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21687
Homologene: 397
Cfap46
Name: cilia and flagella associated protein 46
Synonyms: Ttc40, 9330101J02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 212124
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 4632412F08Rik, 5330435L01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237979
Homologene: 10406
Taf5
Name: TATA-box binding protein associated factor 5
Synonyms: 6330528C20Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226182
VEGA: 19
Homologene: 5064
Hfm1
Name: HFM1, ATP-dependent DNA helicase homolog
Synonyms: Mer3, LOC381663, Sec63d1, A330009G12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330149
Homologene: 87103
Gpr179
Name: G protein-coupled receptor 179
Synonyms: 5330439C02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217143
Homologene: 34917
Edem1
Name: ER degradation enhancer, mannosidase alpha-like 1
Synonyms: A130059K23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 192193
Homologene: 33836
Zfp747
Name: zinc finger protein 747
Synonyms: 6430604K15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269997
Homologene: 118005
Nt5dc1
Name: 5'-nucleotidase domain containing 1
Synonyms: 6030401B09Rik, Nt5c2l1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 319638
Homologene: 16281
Arhgef4
Name: Rho guanine nucleotide exchange factor 4
Synonyms: 9330140K16Rik, C230030N03Rik, Asef
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226970
HGNC: HGNC:684
Homologene: 49414
Zfp202
Name: zinc finger protein 202
Synonyms: C130037E22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 80902
Homologene: 68317
Actl11
Name: actin-like 11
Synonyms: 4921517D21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67722
Homologene: 69412
Or13c7
Name: olfactory receptor family 13 subfamily C member 7
Synonyms: mOR37a, GA_x6K02T2N78B-16092200-16091241, Olfr155, Olfr37a, OR37A, MOR262-14
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 29845
Homologene: 84331
Tmbim7
Name: transmembrane BAX inhibitor motif containing 7
Synonyms: Tmbim1b, Lfg5, 4930511M11Rik, 4930500J03Rik, 4930403J02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75010
Homologene: 81927
Hdac7
Name: histone deacetylase 7
Synonyms: 5830434K02Rik, Hdac7a
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 56233
Homologene: 9124
Rdh7
Name: retinol dehydrogenase 7
Synonyms: CRAD2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54150
Homologene: 137324
Hsp90b1
Name: heat shock protein 90, beta (Grp94), member 1
Synonyms: tumor rejection antigen (gp96) 1, Tra1, 90 kDa, GRP94, Targ2, ERp99, Tra-1, endoplasmin, gp96
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22027
Homologene: 2476
Irag1
Name: inositol 1,4,5-triphosphate receptor associated 1
Synonyms: Ris1, Mrvi1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17540
HGNC: HGNC:7237
Homologene: 4425
Krt75
Name: keratin 75
Synonyms: Krtcap1, 4732468K03Rik, K6hf, Krt2-6hf
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 109052
Homologene: 20983
Zfp112
Name: zinc finger protein 112
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57745
Homologene: 49338
Etfa
Name: electron transferring flavoprotein, alpha polypeptide
Synonyms: 2010200I21Rik, D9Ertd394e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110842
HGNC: HGNC:3481
Homologene: 100
Xbp1
Name: X-box binding protein 1
Synonyms: D11Ertd39e, TREB5, TREB-5, XBP-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22433
Homologene: 3722
Zbp1
Name: Z-DNA binding protein 1
Synonyms: mZaDLM, 2010010H03Rik, Dai
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 58203
Homologene: 10972
Or1e31
Name: olfactory receptor family 1 subfamily E member 31
Synonyms: MOR135-24, Olfr391, Olfr391-ps, MOR135-30_i, Olfr391-ps1, GA_x6K02T2P1NL-3951666-3950698
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258236
Pcdhgb1
Name: protocadherin gamma subfamily B, 1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93699
HGNC: HGNC:8708
Homologene: 81867
Pcdhga2
Name: protocadherin gamma subfamily A, 2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93710
HGNC: HGNC:8700
Homologene: 69262
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 34,806,493 bp
  • C to A, chromosome 1 at 63,074,326 bp
  • T to G, chromosome 1 at 65,258,843 bp
  • C to A, chromosome 1 at 174,699,669 bp
  • T to A, chromosome 2 at 173,213,911 bp
  • A to G, chromosome 2 at 181,355,953 bp
  • T to C, chromosome 4 at 43,854,912 bp
  • T to G, chromosome 4 at 94,853,434 bp
  • A to G, chromosome 5 at 3,554,732 bp
  • A to T, chromosome 5 at 3,661,943 bp
  • G to A, chromosome 5 at 106,878,815 bp
  • T to C, chromosome 6 at 29,941,917 bp
  • T to C, chromosome 6 at 108,854,399 bp
  • T to C, chromosome 7 at 3,297,676 bp
  • T to C, chromosome 7 at 24,125,806 bp
  • A to C, chromosome 7 at 27,227,815 bp
  • T to C, chromosome 7 at 34,227,138 bp
  • T to G, chromosome 7 at 110,921,334 bp
  • A to C, chromosome 7 at 120,186,645 bp
  • T to C, chromosome 7 at 127,374,047 bp
  • T to A, chromosome 7 at 139,652,498 bp
  • T to C, chromosome 7 at 144,456,497 bp
  • G to T, chromosome 9 at 21,027,125 bp
  • C to T, chromosome 9 at 40,210,235 bp
  • A to G, chromosome 9 at 55,495,819 bp
  • T to C, chromosome 9 at 72,452,744 bp
  • A to G, chromosome 9 at 107,930,562 bp
  • A to T, chromosome 10 at 12,727,764 bp
  • A to C, chromosome 10 at 34,310,379 bp
  • A to G, chromosome 10 at 80,909,960 bp
  • A to T, chromosome 10 at 86,694,085 bp
  • T to A, chromosome 10 at 127,884,739 bp
  • A to G, chromosome 11 at 5,521,809 bp
  • A to G, chromosome 11 at 73,799,235 bp
  • A to T, chromosome 11 at 97,347,467 bp
  • C to T, chromosome 11 at 113,830,048 bp
  • C to T, chromosome 12 at 3,632,841 bp
  • T to A, chromosome 15 at 97,802,747 bp
  • C to T, chromosome 15 at 101,571,037 bp
  • T to G, chromosome 16 at 90,472,524 bp
  • A to T, chromosome 16 at 93,847,421 bp
  • T to C, chromosome 17 at 74,642,504 bp
  • T to C, chromosome 18 at 37,670,789 bp
  • T to A, chromosome 18 at 37,680,500 bp
  • A to G, chromosome 19 at 47,077,337 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6835 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044944-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.