Strain Name:
C57BL/6J-MtgxR6943Btlr/Mmmh
Stock Number:
045057-MU
Citation ID:
RRID:MMRRC_045057-MU
Other Names:
R6943 (G1)
Major Collection:

Strain Information

Hlcs
Name: holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)
Synonyms: D16Jhu34, 410I21.SP6
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 110948
VEGA: 16
HGNC: HGNC:4976
Homologene: 37302
Itga8
Name: integrin alpha 8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241226
HGNC: HGNC:6144
Homologene: 37396
B4galt1
Name: UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
Synonyms: b1,4-Galactosyltransferase I, B-1,4-GalT1, beta 1,4-Galactosyltransferase I, Ggtb2, beta-1,4-GalT1, GalT, Ggtb
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14595
HGNC: HGNC:924
Homologene: 20378
Thbs3
Name: thrombospondin 3
Synonyms: Thbs-3, TSP3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 21827
Homologene: 5159
Epb41l5
Name: erythrocyte membrane protein band 4.1 like 5
Synonyms: 1700030C16Rik, Lulu1, NBL5, Epb4.1l5, E230025E14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226352
Homologene: 32492
Vangl1
Name: VANGL planar cell polarity 1
Synonyms: stbm, KITENIN, Lpp2, mStbm
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229658
Homologene: 44540
Gphn
Name: gephyrin
Synonyms: geph, 5730552E08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 268566
VEGA: 12
Homologene: 10820
Ccar1
Name: cell division cycle and apoptosis regulator 1
Synonyms: 2610511G16Rik, 9430036H15Rik, Carp1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67500
VEGA: 10
Homologene: 10086
Aspm
Name: abnormal spindle microtubule assembly
Synonyms: Sha1, MCPH5, D330028K02Rik, Aspm, Calmbp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12316
Homologene: 7650
Camsap2
Name: calmodulin regulated spectrin-associated protein family, member 2
Synonyms: Camsap1l1, 1600013L13Rik, 4930541M15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67886
Homologene: 18927
Nbr1
Name: NBR1, autophagy cargo receptor
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17966
HGNC: HGNC:6746
Homologene: 7438
Nedd1
Name: neural precursor cell expressed, developmentally down-regulated gene 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17997
VEGA: 10
HGNC: HGNC:7723
Homologene: 7439
Nol6
Name: nucleolar protein family 6 (RNA-associated)
Synonyms: Nrap
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230082
Homologene: 41505
Sgk1
Name: serum/glucocorticoid regulated kinase 1
Synonyms: Sgk
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20393
Homologene: 48364
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: enaptin165, nesprin-1, A330049M09Rik, C130039F11Rik, SYNE-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Ccdc80
Name: coiled-coil domain containing 80
Synonyms: Urb, DRO1, Ssg1, 2610001E17Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67896
Homologene: 12206
Ehmt2
Name: euchromatic histone lysine N-methyltransferase 2
Synonyms: G9a, NG36, Bat8, D17Ertd710e, KMT1C
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 110147
Homologene: 48460
Map3k1
Name: mitogen-activated protein kinase kinase kinase 1
Synonyms: MEKK1, Mekk
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26401
HGNC: HGNC:6848
Homologene: 8056
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: Coh1, 2310042E16Rik, 1810042B05Rik, C330002D13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: LOC381562, A930005E13Rik, D930005K06Rik, Zubr1, p600, 1810009A16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69116
Homologene: 10804
Zfp335
Name: zinc finger protein 335
Synonyms: 1810045J01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329559
Homologene: 11129
Arhgef1
Name: Rho guanine nucleotide exchange factor 1
Synonyms: Lbcl2, Lsc
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16801
HGNC: HGNC:681
Homologene: 3454
Tnc
Name: tenascin C
Synonyms: C130033P17Rik, TN, hexabrachion, Hxb, cytotactin, tenascin-C, TN-C
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21923
HGNC: HGNC:5318
Homologene: 55636
Glmp
Name: glycosylated lysosomal membrane protein
Synonyms: NCU-G1, 0610031J06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56700
Homologene: 10562
Nsun2
Name: NOL1/NOP2/Sun domain family member 2
Synonyms: Misu
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 28114
Homologene: 9817
Klrk1
Name: killer cell lectin-like receptor subfamily K, member 1
Synonyms: D6H12S2489E, NKG2-D, Nkg2d
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 27007
Homologene: 7209
Rbl1
Name: RB transcriptional corepressor like 1
Synonyms: retinoblastoma-like 1 (p107), p107
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19650
HGNC: HGNC:9893
Homologene: 2172
Zfp105
Name: zinc finger protein 105
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22646
Homologene: 2568
Cops6
Name: COP9 signalosome subunit 6
Synonyms: VIP/MOV34, Sgn3, COP9 complex S6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26893
Homologene: 4977
Nop9
Name: NOP9 nucleolar protein
Synonyms: 2610027L16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67842
Homologene: 41678
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: Dnahc5, Mdnah5, b2b1134Clo, b2b1154Clo, b2b1537Clo, b2b1565Clo, b2b3491Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Hivep2
Name: human immunodeficiency virus type I enhancer binding protein 2
Synonyms: Schnurri-2, MIBP1, Gm20114, Shn-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15273
HGNC: HGNC:4921
Homologene: 4900
Tgfbi
Name: transforming growth factor, beta induced
Synonyms: 68kDa, bIG-h3, Beta-ig
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21810
VEGA: 13
Homologene: 37294
Nfatc1
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
Synonyms: 2210017P03Rik, NF-ATc, NFATc, NFAT2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 18018
VEGA: 18
HGNC: HGNC:7775
Homologene: 32336
Stard9
Name: StAR related lipid transfer domain containing 9
Synonyms: Kif16a, E230025N21Rik, 4831403C07Rik, N-3 kinesin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668880
Homologene: 130712
Vmn1r204
Name: vomeronasal 1 receptor 204
Synonyms: Gm11301
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 632793
Homologene: 110880
Or8g34
Name: olfactory receptor family 8 subfamily G member 34
Synonyms: MOR171-42, MOR171-53, Olfr954, GA_x6K02T2PVTD-33158015-33158950
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258328
VEGA: 9
HGNC: HGNC:8484
Homologene: 71961
Unc13a
Name: unc-13 homolog A
Synonyms: Munc13-1, 2410078G03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382018
Homologene: 11279
Bsn
Name: bassoon
Synonyms: presynaptic cytomatrix protein
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12217
HGNC: HGNC:1117
Homologene: 31161
Tmem266
Name: transmembrane protein 266
Synonyms: AI118078
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244886
Homologene: 17551
Tmem241
Name: transmembrane protein 241
Synonyms: 6030446N20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 338363
Homologene: 87267
Notch4
Name: notch 4
Synonyms: Int-3, N4, Int3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18132
HGNC: HGNC:7884
Homologene: 3351
Plek2
Name: pleckstrin 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 27260
Homologene: 8447
Zfp11
Name: zinc finger protein 11
Synonyms: Zfp-11, Krox-6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22648
Homologene: 87241
Lrit1
Name: leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
Synonyms: Lrrc21
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239037
Homologene: 9215
Ces3b
Name: carboxylesterase 3B
Synonyms: Gm4738, ES31L
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13909
HGNC: HGNC:1865
Homologene: 84407
Or5m9b
Name: olfactory receptor family 5 subfamily M member 9B
Synonyms: MOR262-13, GA_x6K02T2Q125-47549689-47550621, Olfr1036, MOR245-25
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258245
Mark1
Name: MAP/microtubule affinity regulating kinase 1
Synonyms: B930025N23Rik, Emk3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226778
HGNC: HGNC:6896
Homologene: 49552
Fcgbp
Name: Fc fragment of IgG binding protein
Synonyms: A430096B05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 215384
Homologene: 68369
Vmn1r184
Name: vomeronasal 1 receptor, 184
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100312477
Homologene: 74353
Aacs
Name: acetoacetyl-CoA synthetase
Synonyms: 2210408B16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 78894
Homologene: 11322
Or1ad8
Name: olfactory receptor family 1 subfamily AD member 8
Synonyms: GA_x6K02T2QP88-4431129-4430206, MOR129-3, ID7, Olfr51
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18351
Homologene: 133578
Ngly1
Name: N-glycanase 1
Synonyms: 1110002C09Rik, PNGase, Png1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 59007
Homologene: 10117
Or10x4
Name: olfactory receptor family 10 subfamily X member 4
Synonyms: GA_x6K02T2P20D-20771141-20770212, GA_x6K02T2MFC0-1145-1312, Olfr248, MOR267-7, Olfr415
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258709
Foxd4
Name: forkhead box D4
Synonyms: FREAC5, Fkh2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14237
VEGA: 19
Homologene: 83248
Kmo
Name: kynurenine 3-monooxygenase
Synonyms: kynurenine 3-hydroxylase
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98256
HGNC: HGNC:6381
Homologene: 2729
Frmpd4
Name: FERM and PDZ domain containing 4
Synonyms: Preso1, Pdzk10, LOC237234, Pdzd10, PKAP1, Preso
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 333605
Homologene: 45843
H2-Q7
Name: histocompatibility 2, Q region locus 7
Synonyms: Qa-7, Ped, Qa7, H-2Q7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15018
Homologene: 128352
Gvin2
Name: GTPase, very large interferon inducible, family member 2
Synonyms: Gm4070
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042856
Homologene: 32708
Taf10
Name: TATA-box binding protein associated factor 10
Synonyms: Taf2h, 30kDa, TAFII30
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 24075
Homologene: 86923
Dusp29
Name: dual specificity phosphatase 29
Synonyms: Dupd1, EG435391
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 435391
VEGA: 14
Homologene: 51120
Echs1
Name: enoyl Coenzyme A hydratase, short chain, 1, mitochondrial
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 93747
HGNC: HGNC:3151
Homologene: 3018
Pcp4l1
Name: Purkinje cell protein 4-like 1
Synonyms: 1500036F01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66425
Homologene: 136091
Lyzl4
Name: lysozyme-like 4
Synonyms: 1810009N24Rik, LYC4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69032
Homologene: 23604
Lrrc3c
Name: leucine rich repeat containing 3C
Synonyms: LOC192852, Gm12
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192852
Homologene: 19077
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 119,609,129 bp
  • T to C, chromosome 1 at 136,304,449 bp
  • T to C, chromosome 1 at 139,480,542 bp
  • T to C, chromosome 1 at 171,174,453 bp
  • T to A, chromosome 1 at 174,391,841 bp
  • T to A, chromosome 1 at 175,658,375 bp
  • T to C, chromosome 1 at 184,898,787 bp
  • C to A, chromosome 2 at 12,155,371 bp
  • T to C, chromosome 2 at 86,074,920 bp
  • C to T, chromosome 2 at 120,702,196 bp
  • T to G, chromosome 2 at 157,188,286 bp
  • A to G, chromosome 2 at 164,894,875 bp
  • A to G, chromosome 3 at 88,326,610 bp
  • T to C, chromosome 3 at 89,224,864 bp
  • A to T, chromosome 3 at 102,165,781 bp
  • T to C, chromosome 4 at 40,812,860 bp
  • C to A, chromosome 4 at 41,118,962 bp
  • T to C, chromosome 4 at 63,982,745 bp
  • T to A, chromosome 4 at 139,437,131 bp
  • T to A, chromosome 5 at 125,506,298 bp
  • T to C, chromosome 5 at 129,658,088 bp
  • T to A, chromosome 5 at 138,163,528 bp
  • T to A, chromosome 6 at 129,621,240 bp
  • A to G, chromosome 7 at 24,923,731 bp
  • C to T, chromosome 7 at 26,267,138 bp
  • G to A, chromosome 7 at 28,092,052 bp
  • G to A, chromosome 7 at 105,744,176 bp
  • G to A, chromosome 7 at 105,901,980 bp
  • G to A, chromosome 7 at 140,108,094 bp
  • A to T, chromosome 8 at 71,652,377 bp
  • G to T, chromosome 8 at 105,093,078 bp
  • A to T, chromosome 9 at 39,461,863 bp
  • C to T, chromosome 9 at 55,377,567 bp
  • C to A, chromosome 9 at 108,107,817 bp
  • C to T, chromosome 9 at 121,582,981 bp
  • A to G, chromosome 9 at 122,925,238 bp
  • T to C, chromosome 10 at 5,083,940 bp
  • T to A, chromosome 10 at 14,128,314 bp
  • T to C, chromosome 10 at 21,882,694 bp
  • A to G, chromosome 10 at 62,746,936 bp
  • A to T, chromosome 10 at 92,711,306 bp
  • T to A, chromosome 11 at 51,007,326 bp
  • A to G, chromosome 11 at 98,599,249 bp
  • A to T, chromosome 11 at 101,577,951 bp
  • C to G, chromosome 12 at 78,492,181 bp
  • T to C, chromosome 12 at 78,889,309 bp
  • A to G, chromosome 13 at 11,566,948 bp
  • T to C, chromosome 13 at 22,556,304 bp
  • T to G, chromosome 13 at 56,637,176 bp
  • G to A, chromosome 13 at 69,630,033 bp
  • A to G, chromosome 13 at 111,772,712 bp
  • T to G, chromosome 14 at 16,283,467 bp
  • T to C, chromosome 14 at 21,677,067 bp
  • G to C, chromosome 14 at 37,060,095 bp
  • T to C, chromosome 14 at 55,752,813 bp
  • A to T, chromosome 15 at 28,235,720 bp
  • A to G, chromosome 15 at 35,448,689 bp
  • A to G, chromosome 16 at 45,095,082 bp
  • A to T, chromosome 16 at 94,141,402 bp
  • A to G, chromosome 17 at 34,583,603 bp
  • G to A, chromosome 17 at 34,911,430 bp
  • T to G, chromosome 17 at 35,439,584 bp
  • G to T, chromosome 18 at 12,047,584 bp
  • C to T, chromosome 18 at 80,635,555 bp
  • A to G, chromosome 19 at 24,899,876 bp
  • C to T, chromosome X at 167,604,583 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6943 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045057-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.