Strain Name:
C57BL/6J-MtgxR8165Btlr/Mmmh
Stock Number:
067591-MU
Citation ID:
RRID:MMRRC_067591-MU
Other Names:
R8165 (G1)
Major Collection:

Strain Information

Kit
Name: KIT proto-oncogene receptor tyrosine kinase
Synonyms: SOW3, Dominant white spotting, c-KIT, Steel Factor Receptor, CD117, belly-spot, Tr-kit, Gsfsow3, Gsfsco5, SCO1, SCO5, Gsfsco1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16590
HGNC: HGNC:6342
Homologene: 187
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Areg
Name: amphiregulin
Synonyms: AR, Sdgf, Mcub
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11839
HGNC: HGNC:651
Homologene: 1252
Mad1l1
Name: MAD1 mitotic arrest deficient 1-like 1
Synonyms: Mad1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17120
HGNC: HGNC:6762
Homologene: 74500
Mga
Name: MAX gene associated
Synonyms: Mga, D030062C11Rik, C130042M01Rik, Mad5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 29808
Homologene: 49351
Bcar3
Name: breast cancer anti-estrogen resistance 3
Synonyms: AND-34
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 29815
HGNC: HGNC:973
Homologene: 31181
Zfp710
Name: zinc finger protein 710
Synonyms: 5430400N05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 209225
Homologene: 19625
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320528
VEGA: 9
Homologene: 41188
Brpf3
Name: bromodomain and PHD finger containing, 3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268936
Homologene: 16092
Ccdc91
Name: coiled-coil domain containing 91
Synonyms: 1700086G08Rik, 1810060J02Rik, p56
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67015
Homologene: 10131
Plk4
Name: polo like kinase 4
Synonyms: Stk18, Sak
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20873
Homologene: 7962
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: 1810014J18Rik, 9030205D12Rik, A330063D19Rik, AD013
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 109151
Homologene: 11844
Tbcd
Name: tubulin-specific chaperone d
Synonyms: 2310057L06Rik, A030005L14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108903
Homologene: 4368
Zgrf1
Name: zinc finger, GRF-type containing 1
Synonyms: 4930422G04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71643
Homologene: 34708
Tmem87a
Name: transmembrane protein 87A
Synonyms: A930025J12Rik, Elkin1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 211499
Homologene: 9165
Ndufb6
Name: NADH:ubiquinone oxidoreductase subunit B6
Synonyms: LOC230075
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230075
HGNC: HGNC:7701
Homologene: 1864
Lin54
Name: lin-54 DREAM MuvB core complex component
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231506
Homologene: 18212
Casz1
Name: castor zinc finger 1
Synonyms: D4Ertd432e, 2410019P08Rik, Cst, castor
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69743
Homologene: 9824
Gdpd5
Name: glycerophosphodiester phosphodiesterase domain containing 5
Synonyms: Gde2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233552
Homologene: 32741
Amph
Name: amphiphysin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218038
HGNC: HGNC:471
Homologene: 121585
Cops8
Name: COP9 signalosome subunit 8
Synonyms: Csn8, Sgn8, 9430009J09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108679
Homologene: 4882
Gp2
Name: glycoprotein 2 zymogen granule membrane
Synonyms: 2310037I18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67133
HGNC: HGNC:4441
Homologene: 133790
Cacna2d2
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 2
Synonyms: a2d2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56808
HGNC: HGNC:1400
Homologene: 4400
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Ush2a
Name: usherin
Synonyms: MUSH2A, LOC269160, Ush2a, A930037M10Rik, A930011D15Rik, LOC381317, Ushrn
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Kng2
Name: kininogen 2
Synonyms: Kininogen-II
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 385643
HGNC: HGNC:6383
Homologene: 88343
Arhgap29
Name: Rho GTPase activating protein 29
Synonyms: 6720461J18Rik, B130017I01Rik, C76601, Parg1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 214137
Homologene: 3539
Aox2
Name: aldehyde oxidase 2
Synonyms: Aox3l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213043
Homologene: 84622
Scn9a
Name: sodium channel, voltage-gated, type IX, alpha
Synonyms: PN1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20274
Homologene: 2237
Gpr179
Name: G protein-coupled receptor 179
Synonyms: 5330439C02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217143
Homologene: 34917
Spic
Name: Spi-C transcription factor (Spi-1/PU.1 related)
Synonyms: Spi-C, C76795, Prf
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20728
Homologene: 7953
Nek9
Name: NIMA (never in mitosis gene a)-related expressed kinase 9
Synonyms: C130021H08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217718
Homologene: 13222
Stkld1
Name: serine/threonine kinase-like domain containing 1
Synonyms: Gm711, LOC279029
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 279029
Homologene: 19586
Megf8
Name: multiple EGF-like-domains 8
Synonyms: b2b288Clo, b2b1702Clo, m687Ddg, Egfl4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269878
HGNC: HGNC:3233
Homologene: 15988
Mgat4b
Name: mannoside acetylglucosaminyltransferase 4, isoenzyme B
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103534
HGNC: HGNC:7048
Homologene: 8611
Idh3b
Name: isocitrate dehydrogenase 3 (NAD+) beta
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 170718
HGNC: HGNC:5385
Homologene: 5035
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330267
Homologene: 46582
Vrk2
Name: vaccinia related kinase 2
Synonyms: 2810003O05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69922
Homologene: 55966
Or1j11
Name: olfactory receptor family 1 subfamily E member 1
Synonyms: Olfr339, MOR136-3, GA_x6K02T2NLDC-33116096-33117025
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258951
Homologene: 133615
Tll2
Name: tolloid-like 2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 24087
VEGA: 19
Homologene: 56545
Plin4
Name: perilipin 4
Synonyms: S3-12
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57435
Homologene: 69311
Tbc1d31
Name: TBC1 domain family, member 31
Synonyms: LOC210544, Wdr67, D330013L20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 210544
Homologene: 17089
0610040J01Rik
Name: RIKEN cDNA 0610040J01 gene
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76261
Homologene: 49537
Nol4l
Name: nucleolar protein 4-like
Synonyms: LOC381396, 8430427H17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329540
Homologene: 129589
Vill
Name: villin-like
Synonyms: Villp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22351
Homologene: 22650
Sel1l2
Name: sel-1 suppressor of lin-12-like 2 (C. elegans)
Synonyms: LOC228684
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228684
Homologene: 16802
Neil3
Name: nei like 3 (E. coli)
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234258
Homologene: 10094
Terf2
Name: telomeric repeat binding factor 2
Synonyms: TRF2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21750
Homologene: 4133
Pp2d1
Name: protein phosphatase 2C-like domain containing 1
Synonyms: 4921523A10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 110332
VEGA: 17
Homologene: 16981
Btnl2
Name: butyrophilin-like 2
Synonyms: BTL-II, BTLN2, butyrophylin-like MHC class II associated, NG9
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 547431
HGNC: HGNC:1142
Homologene: 10482
Phf1
Name: PHD finger protein 1
Synonyms: PHF2, D17Ertd455e, Tctex3, Tctex-3, mPcl1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21652
VEGA: 17
HGNC: HGNC:8919
Homologene: 7567
Clrn3
Name: clarin 3
Synonyms: Tmem12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 212070
Homologene: 17544
Cnksr3
Name: Cnksr family member 3
Synonyms: Magi1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215748
Homologene: 18192
Dnase1l3
Name: deoxyribonuclease 1-like 3
Synonyms: DNasegamma
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13421
HGNC: HGNC:2959
Homologene: 3630
Cpa2
Name: carboxypeptidase A2, pancreatic
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232680
HGNC: HGNC:2297
Homologene: 37541
Pde2a
Name: phosphodiesterase 2A, cGMP-stimulated
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207728
HGNC: HGNC:8777
Homologene: 1952
Dnajc28
Name: DnaJ heat shock protein family (Hsp40) member C28
Synonyms: ORF28
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 246738
HGNC: HGNC:1297
Homologene: 9869
Med7
Name: mediator complex subunit 7
Synonyms: Crsp9, Crsp33, 1110063B05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66213
HGNC: HGNC:2378
Homologene: 3153
Taar7d
Name: trace amine-associated receptor 7D
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 435206
Homologene: 115653
Spmip10
Name: sperm microtubule inner protein 10
Synonyms: 1700065I17Rik, Tex43
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67343
Homologene: 77918
Nt5dc2
Name: 5'-nucleotidase domain containing 2
Synonyms: 2510015F01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 70021
VEGA: 14
Homologene: 11290
1110037F02Rik
Name:
Type: Gene
Species: Mouse
Chromosome: 4
Fam65a
Name:
Type: Gene
Species: Mouse
Chromosome: 8
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 58,308,929 bp
  • A to G, chromosome 1 at 90,612,007 bp
  • G to A, chromosome 1 at 150,646,658 bp
  • C to A, chromosome 1 at 188,451,755 bp
  • A to G, chromosome 2 at 26,946,656 bp
  • T to A, chromosome 2 at 36,421,703 bp
  • A to G, chromosome 2 at 66,540,530 bp
  • C to A, chromosome 2 at 119,947,238 bp
  • T to C, chromosome 2 at 120,370,478 bp
  • T to A, chromosome 2 at 130,280,500 bp
  • T to A, chromosome 2 at 140,262,706 bp
  • A to T, chromosome 2 at 153,420,553 bp
  • G to C, chromosome 3 at 40,813,574 bp
  • C to T, chromosome 3 at 121,988,573 bp
  • C to T, chromosome 3 at 122,511,156 bp
  • T to A, chromosome 3 at 127,563,383 bp
  • T to A, chromosome 4 at 11,542,128 bp
  • C to T, chromosome 4 at 40,270,665 bp
  • C to T, chromosome 4 at 148,944,431 bp
  • C to A, chromosome 5 at 63,897,946 bp
  • A to T, chromosome 5 at 75,620,880 bp
  • A to G, chromosome 5 at 91,143,633 bp
  • A to G, chromosome 5 at 100,454,499 bp
  • T to C, chromosome 5 at 140,315,058 bp
  • T to A, chromosome 6 at 12,468,963 bp
  • A to G, chromosome 6 at 30,564,346 bp
  • C to T, chromosome 6 at 147,631,588 bp
  • T to A, chromosome 7 at 25,353,873 bp
  • T to C, chromosome 7 at 80,086,027 bp
  • A to T, chromosome 7 at 99,456,482 bp
  • G to A, chromosome 7 at 101,500,448 bp
  • A to T, chromosome 7 at 119,450,152 bp
  • T to C, chromosome 7 at 135,528,404 bp
  • A to G, chromosome 8 at 53,589,094 bp
  • A to C, chromosome 8 at 91,041,141 bp
  • C to A, chromosome 8 at 105,620,888 bp
  • T to C, chromosome 8 at 107,083,024 bp
  • A to G, chromosome 9 at 67,858,790 bp
  • A to G, chromosome 9 at 107,525,454 bp
  • T to A, chromosome 9 at 119,066,753 bp
  • C to T, chromosome 10 at 7,154,467 bp
  • T to A, chromosome 10 at 24,027,597 bp
  • A to T, chromosome 10 at 88,677,566 bp
  • A to G, chromosome 11 at 26,535,575 bp
  • T to A, chromosome 11 at 46,441,246 bp
  • A to T, chromosome 11 at 50,210,974 bp
  • A to G, chromosome 11 at 97,351,538 bp
  • C to T, chromosome 11 at 121,493,885 bp
  • C to T, chromosome 12 at 85,303,643 bp
  • T to A, chromosome 13 at 13,698,360 bp
  • A to G, chromosome 13 at 19,094,837 bp
  • T to C, chromosome 14 at 7,994,299 bp
  • A to G, chromosome 14 at 31,138,929 bp
  • A to G, chromosome 15 at 57,960,949 bp
  • T to C, chromosome 16 at 22,987,496 bp
  • G to A, chromosome 16 at 91,616,907 bp
  • T to C, chromosome 17 at 26,937,070 bp
  • C to T, chromosome 17 at 28,806,274 bp
  • T to A, chromosome 17 at 34,368,708 bp
  • A to G, chromosome 17 at 53,515,229 bp
  • G to A, chromosome 17 at 56,107,019 bp
  • T to A, chromosome 18 at 56,589,475 bp
  • A to G, chromosome 19 at 41,088,874 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8165 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067591-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.