Strain Name:
C57BL/6J-MtgxR8473Btlr/Mmmh
Stock Number:
067917-MU
Citation ID:
RRID:MMRRC_067917-MU
Other Names:
R8473 (G1)
Major Collection:

Strain Information

Derl2
Name: Der1-like domain family, member 2
Synonyms: CGI-101, F-lana, Derlin-2, Flana
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 116891
Homologene: 9356
Ptpn12
Name: protein tyrosine phosphatase, non-receptor type 12
Synonyms: PTP-P19, PTP-PEST, P19-PTP
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19248
HGNC: HGNC:9645
Homologene: 37691
Exoc5
Name: exocyst complex component 5
Synonyms: Sec10l1, SEC10, PRO1912
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105504
Homologene: 38195
Scaper
Name: S phase cyclin A-associated protein in the ER
Synonyms: D530014O03Rik, Zfp291
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244891
VEGA: 9
Homologene: 32488
Stag1
Name: STAG1 cohesin complex component
Synonyms: Scc3, SA-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20842
Homologene: 21191
Rbbp6
Name: retinoblastoma binding protein 6, ubiquitin ligase
Synonyms: C030034J04Rik, 4933422O15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19647
HGNC: HGNC:9889
Homologene: 136812
Atg13
Name: autophagy related 13
Synonyms: 1110053A20Rik, D2Ertd391e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 51897
Homologene: 32229
Smc5
Name: structural maintenance of chromosomes 5
Synonyms: Smc5l1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226026
VEGA: 19
Homologene: 41009
Atp5f1a
Name: ATP synthase F1 subunit alpha
Synonyms: Atp5a1, D18Ertd206e, Atpm, Mom2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 11946
HGNC: HGNC:823
Homologene: 2985
Dpy19l2
Name: dpy-19 like 2
Synonyms: 4932443J21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320752
VEGA: 9
Homologene: 77569
Blnk
Name: B cell linker
Synonyms: Bca, SLP-65, Ly57, Ly-57, BLNK, BASH, BCA
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17060
Homologene: 32038
Hmcn1
Name: hemicentin 1
Synonyms: EG545370, LOC240793
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Tmx4
Name: thioredoxin-related transmembrane protein 4
Synonyms: D2Bwg1356e, 2810417D04Rik, 4930500L08Rik, Txndc13
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 52837
Homologene: 10901
Vmn1r59
Name: vomeronasal 1 receptor 59
Synonyms: V1rd10
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404284
Homologene: 41799
Lrrc37
Name: leucine rich repeat containing 37
Synonyms: Gm884, LOC380730
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380730
Homologene: 134511
Pik3r6
Name: phosphoinositide-3-kinase regulatory subunit 5
Synonyms: p87PIKAP, p84 Pikap
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104709
Homologene: 46215
Dgkb
Name: diacylglycerol kinase, beta
Synonyms: DGK-beta, C630029D13Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217480
VEGA: 12
HGNC: HGNC:2850
Homologene: 37875
Grm5
Name: glutamate receptor, metabotropic 5
Synonyms: mGluR5, Gprc1e, 6430542K11Rik, Glu5R
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108071
HGNC: HGNC:4597
Homologene: 37354
Acad12
Name: acyl-Coenzyme A dehydrogenase family, member 12
Synonyms: 9330129D05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 338350
Adamts15
Name: ADAM metallopeptidase with thrombospondin type 1 motif 15
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235130
VEGA: 9
Homologene: 8610
Il27ra
Name: interleukin 27 receptor, alpha
Synonyms: Tccr, WSX-1, IL-27R
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50931
Homologene: 3562
Kif19a
Name: kinesin family member 19A
Synonyms: N-8 kinesin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 286942
Homologene: 17709
Herc6
Name: hect domain and RLD 6
Synonyms: 2510038N07Rik, Herc5, CEB1, 4930427L17Rik, 1700121D12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67138
Homologene: 70768
Tdpoz3
Name: TD and POZ domain containing 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 399674
Homologene: 128308
Kcnh8
Name: potassium voltage-gated channel, subfamily H (eag-related), member 8
Synonyms: C130090D05Rik, Kv12.1, ELK1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 211468
Homologene: 14332
Gfm1
Name: G elongation factor, mitochondrial 1
Synonyms: D3Wsu133e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 28030
Homologene: 6449
Wdr20rt
Name: WD repeat domain 20, retrogene
Synonyms: Wdr20b, 4930427E19Rik, 4921538B03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70948
VEGA: 12
Fancg
Name: Fanconi anemia, complementation group G
Synonyms: Xrcc9
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 60534
HGNC: HGNC:3588
Homologene: 3402
Csf3
Name: colony stimulating factor 3 (granulocyte)
Synonyms: Csfg, G-CSF, MGI-IG
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12985
HGNC: HGNC:2438
Homologene: 7677
4930583I09Rik
Name: RIKEN cDNA 4930583I09 gene
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78057
VEGA: 17
Or8d4
Name: olfactory receptor family 8 subfamily D member 4
Synonyms: Olfr985, GA_x6K02T2PVTD-33825763-33824828, mOR171-4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258854
VEGA: 9
Homologene: 17416
Pcdhgb7
Name: protocadherin gamma subfamily B, 7
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93704
HGNC: HGNC:8714
Homologene: 75102
Tdpoz2
Name: TD and POZ domain containing 2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 399673
Homologene: 133956
Gm6882
Name: predicted gene 6882
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 628475
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 150,603,800 bp
  • G to A, chromosome 2 at 82,946,992 bp
  • A to T, chromosome 2 at 91,688,648 bp
  • T to C, chromosome 2 at 134,609,524 bp
  • T to C, chromosome 3 at 67,453,718 bp
  • T to C, chromosome 3 at 93,651,846 bp
  • T to A, chromosome 3 at 93,826,563 bp
  • A to G, chromosome 4 at 43,004,963 bp
  • T to C, chromosome 5 at 20,998,359 bp
  • T to C, chromosome 5 at 121,607,475 bp
  • T to A, chromosome 6 at 57,647,114 bp
  • A to T, chromosome 7 at 5,454,065 bp
  • A to T, chromosome 7 at 21,427,515 bp
  • T to A, chromosome 7 at 87,603,070 bp
  • T to C, chromosome 7 at 123,001,198 bp
  • A to G, chromosome 8 at 84,042,106 bp
  • C to A, chromosome 9 at 24,581,230 bp
  • T to A, chromosome 9 at 30,904,789 bp
  • T to C, chromosome 9 at 40,127,210 bp
  • T to C, chromosome 9 at 55,550,847 bp
  • T to A, chromosome 9 at 100,880,787 bp
  • A to G, chromosome 11 at 68,526,381 bp
  • A to G, chromosome 11 at 71,019,209 bp
  • T to C, chromosome 11 at 98,702,102 bp
  • T to C, chromosome 11 at 103,543,440 bp
  • T to G, chromosome 11 at 114,787,551 bp
  • A to G, chromosome 12 at 38,184,940 bp
  • A to G, chromosome 12 at 65,226,606 bp
  • T to C, chromosome 14 at 49,019,403 bp
  • A to T, chromosome 17 at 52,978,292 bp
  • T to C, chromosome 17 at 64,834,518 bp
  • T to A, chromosome 18 at 37,753,799 bp
  • T to C, chromosome 18 at 77,779,925 bp
  • A to T, chromosome 19 at 23,244,082 bp
  • T to C, chromosome 19 at 40,952,410 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8473 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
067917-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.