Strain Name:
C57BL/6J-MtgxR8890Btlr/Mmmh
Stock Number:
068694-MU
Citation ID:
RRID:MMRRC_068694-MU
Other Names:
R8890 (G1)
Major Collection:

Strain Information

Nphs1
Name: nephrosis 1, nephrin
Synonyms: nephrin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54631
HGNC: HGNC:7908
Homologene: 20974
Adam23
Name: a disintegrin and metallopeptidase domain 23
Synonyms: MDC3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23792
HGNC: HGNC:202
Homologene: 2826
Nbea
Name: neurobeachin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Zfp532
Name: zinc finger protein 532
Synonyms: C530030I18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 328977
Homologene: 138627
Psmd1
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
Synonyms: P112, S1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70247
HGNC: HGNC:9554
Homologene: 2100
Kdm5a
Name: lysine demethylase 5A
Synonyms: Jarid1a, RBP2, Rbbp2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214899
HGNC: HGNC:9886
Homologene: 3419
Hat1
Name: histone aminotransferase 1
Synonyms: 2410071B14Rik, KAT1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 107435
HGNC: HGNC:4821
Homologene: 2701
Rif1
Name: replication timing regulatory factor 1
Synonyms: 5730435J01Rik, D2Ertd145e, 6530403D07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 51869
Homologene: 41231
Zbtb40
Name: zinc finger and BTB domain containing 40
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230848
Homologene: 8912
Cramp1
Name: cramped chromatin regulator 1
Synonyms: Cramp1l, Tce4, 5830477H08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57354
VEGA: 17
Homologene: 35373
Scfd1
Name: Sec1 family domain containing 1
Synonyms: RA410, STXBP1L2, 3110021P21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76983
VEGA: 12
Homologene: 5650
Ccser2
Name: coiled-coil serine rich 2
Synonyms: 1700012P13Rik, Gcap14, 2900054P12Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72972
Homologene: 10367
Gabbr1
Name: gamma-aminobutyric acid type B receptor subunit 1
Synonyms: GABAB1, GABAbR1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 54393
HGNC: HGNC:4070
Homologene: 1132
Iqsec3
Name: IQ motif and Sec7 domain 3
Synonyms: synarfGEF, BRAG3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243621
Homologene: 46091
Il17rc
Name: interleukin 17 receptor C
Synonyms: IL17-RL, Il17rl, 1110025H02Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171095
Homologene: 15894
Il31ra
Name: interleukin 31 receptor A
Synonyms: GLM-R, GPL
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218624
VEGA: 13
Homologene: 51395
Tmco1
Name: transmembrane and coiled-coil domains 1
Synonyms: 1190006A08Rik, ESTM39, 4930403O06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68944
Homologene: 10384
Piezo1
Name: piezo-type mechanosensitive ion channel component 1
Synonyms: Fam38a, Piezo1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234839
Homologene: 124356
Lrrc8c
Name: leucine rich repeat containing 8 family, member C
Synonyms: E430036I04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100604
Homologene: 12997
Mecom
Name: MDS1 and EVI1 complex locus
Synonyms: Evi-1, Jbo, ZNFPR1B1, D630039M04Rik, Prdm3, Mds1, Evi1, MDS1-EVI1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14013
HGNC: HGNC:3498
Homologene: 21086
C1ql3
Name: C1q-like 3
Synonyms: 1110065A22Rik, K100
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227580
Homologene: 17701
Astl
Name: astacin like metalloendopeptidase
Synonyms: Ovastacin, C87576, Sas1b
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 215095
Homologene: 128191
Myh15
Name: myosin, heavy chain 15
Synonyms: EG667772
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 667772
VEGA: 16
Homologene: 18929
Pcdh7
Name: protocadherin 7
Synonyms: BH-protocadherin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54216
HGNC: HGNC:8659
Homologene: 36101
Efcab6
Name: EF-hand calcium binding domain 6
Synonyms: 4932408N08Rik, 4931407K02Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 77627
Homologene: 11259
Hsh2d
Name: hematopoietic SH2 domain containing
Synonyms: Hsh2, ALX
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 209488
Homologene: 13142
Fhad1
Name: forkhead-associated phosphopeptide binding domain 1
Synonyms: 2900090M10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329977
Homologene: 77947
Nwd1
Name: NACHT and WD repeat domain containing 1
Synonyms: A230063L24Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319555
Homologene: 72261
Vmn2r115
Name: vomeronasal 2, receptor 115
Synonyms: V2Rp4, EG638102
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 638102
Homologene: 86604
Ctsq
Name: cathepsin Q
Synonyms: 1600010J02Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 104002
Homologene: 122226
Rpgrip1
Name: retinitis pigmentosa GTPase regulator interacting protein 1
Synonyms: 4930505G06Rik, nmf247, A930002K18Rik, 4930401L23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 77945
Homologene: 10679
Sult1e1
Name: sulfotransferase family 1E, member 1
Synonyms: Ste, EST
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20860
Homologene: 101388
Mmp1a
Name: matrix metallopeptidase 1a (interstitial collagenase)
Synonyms: Mcol-A
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83995
VEGA: 9
HGNC: HGNC:7155
Homologene: 20544
Spag17
Name: sperm associated antigen 17
Synonyms: PF6, 4931427F14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74362
Homologene: 52601
Cyp2j5
Name: cytochrome P450, family 2, subfamily j, polypeptide 5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13109
HGNC: HGNC:2634
Homologene: 116530
Klhdc7b
Name: kelch domain containing 7B
Synonyms: EG546648
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 546648
Homologene: 34707
Grid2
Name: glutamate receptor, ionotropic, delta 2
Synonyms: B230104L07Rik, GluRdelta2, tpr
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14804
HGNC: HGNC:4576
Homologene: 74399
Whamm
Name: WAS protein homolog associated with actin, golgi membranes and microtubules
Synonyms: Whdc1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434204
Homologene: 45851
Cox11
Name: cytochrome c oxidase assembly protein 11, copper chaperone
Synonyms: 2010004I09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69802
HGNC: HGNC:2261
Homologene: 3221
Scai
Name: suppressor of cancer cell invasion
Synonyms: A930041I02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320271
Homologene: 15523
Myom3
Name: myomesin family, member 3
Synonyms: 8430427K15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242702
Homologene: 19432
Hivep3
Name: human immunodeficiency virus type I enhancer binding protein 3
Synonyms: Shn3, E030045D18Rik, Krc, 2900056N03Rik, Schnurri-3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16656
Homologene: 7803
Or10ag60
Name: olfactory receptor family 10 subfamily AG member 60
Synonyms: MOR264-4, GA_x6K02T2Q125-49112575-49113519, Olfr1130
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258835
Homologene: 133705
Pheta2
Name: PH domain containing endocytic trafficking adaptor 2
Synonyms: Ses2, C920005C14Rik, Fam109b
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 338368
Homologene: 18578
Mindy4
Name: MINDY lysine 48 deubiquitinase 4
Synonyms: Fam188b, LOC384387, C330043M08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330323
Homologene: 49991
Or52r1
Name: olfactory receptor family 52 subfamily R member 1
Synonyms: MOR30-1, Olfr569, GA_x6K02T2PBJ9-5599295-5598351
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259092
Homologene: 17500
Ralb
Name: v-ral simian leukemia viral oncogene B
Synonyms: 5730472O18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 64143
HGNC: HGNC:9840
Homologene: 20632
Or10j5
Name: olfactory receptor family 10 subfamily J member 5
Synonyms: MOR267-13, Olfr16, MOR23, GA_x6K02T2R7CC-893157-892228
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18313
Homologene: 7460
Gabra1
Name: gamma-aminobutyric acid type A receptor subunit alpha 1
Synonyms: GABAA alpha 1, GABAAR alpha1, Gabra-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14394
HGNC: HGNC:4075
Homologene: 629
Rassf4
Name: Ras association (RalGDS/AF-6) domain family member 4
Synonyms: 3830411C14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 213391
Homologene: 12926
Glt28d2
Name: glycosyltransferase 28 domain containing 2
Synonyms: 4732486J07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 320302
Homologene: 44843
Mterf3
Name: mitochondrial transcription termination factor 3
Synonyms: 2410017I18Rik, Mterfd1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66410
Homologene: 9310
Mipep
Name: mitochondrial intermediate peptidase
Synonyms: 5730405E07Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 70478
VEGA: 14
HGNC: HGNC:7104
Homologene: 4337
4930567H17Rik
Name: RIKEN cDNA 4930567H17 gene
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 619303
Homologene: 134521
Or52ae9
Name: olfactory receptor family 52 subfamily AE member 9
Synonyms: Olfr629, GA_x6K02T2PBJ9-6466772-6465828, MOR26-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258818
Homologene: 105159
Eif3j2
Name: eukaryotic translation initiation factor 3, subunit J2
Synonyms: Gm9781
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 100042807
HGNC: HGNC:3270
Homologene: 37845
Tmem109
Name: transmembrane protein 109
Synonyms: mitsugumin23, MG23, 1110006I15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68539
Homologene: 11458
Zfp131
Name: zinc finger protein 131
Synonyms: Znf131, 2610109I01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72465
VEGA: 13
Homologene: 12464
Acrv1
Name: acrosomal vesicle protein 1
Synonyms: SP-10, Msa63
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11451
HGNC: HGNC:127
Homologene: 1219
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 63,585,365 bp
  • G to A, chromosome 1 at 86,085,192 bp
  • G to A, chromosome 1 at 119,483,516 bp
  • A to G, chromosome 1 at 167,316,245 bp
  • G to A, chromosome 1 at 172,957,478 bp
  • T to A, chromosome 2 at 13,010,373 bp
  • T to C, chromosome 2 at 39,150,388 bp
  • T to C, chromosome 2 at 52,098,863 bp
  • G to A, chromosome 2 at 71,438,793 bp
  • A to T, chromosome 2 at 87,608,068 bp
  • A to T, chromosome 2 at 127,356,559 bp
  • A to G, chromosome 3 at 29,952,733 bp
  • T to C, chromosome 3 at 56,019,363 bp
  • A to T, chromosome 3 at 85,872,052 bp
  • T to A, chromosome 3 at 100,004,678 bp
  • T to A, chromosome 4 at 96,634,318 bp
  • T to C, chromosome 4 at 120,096,460 bp
  • G to A, chromosome 4 at 135,814,254 bp
  • A to G, chromosome 4 at 136,998,586 bp
  • A to T, chromosome 4 at 141,929,591 bp
  • G to T, chromosome 4 at 143,964,924 bp
  • A to T, chromosome 5 at 57,719,375 bp
  • C to T, chromosome 5 at 87,579,860 bp
  • A to T, chromosome 5 at 105,607,088 bp
  • T to C, chromosome 6 at 55,278,238 bp
  • A to T, chromosome 6 at 63,256,939 bp
  • G to T, chromosome 6 at 113,479,070 bp
  • T to A, chromosome 6 at 116,640,344 bp
  • T to A, chromosome 6 at 120,389,663 bp
  • T to C, chromosome 6 at 121,412,556 bp
  • C to T, chromosome 7 at 30,462,655 bp
  • A to G, chromosome 7 at 81,593,892 bp
  • A to T, chromosome 7 at 102,887,492 bp
  • G to T, chromosome 7 at 103,740,468 bp
  • T to C, chromosome 8 at 72,197,846 bp
  • T to A, chromosome 8 at 72,711,856 bp
  • T to C, chromosome 8 at 122,489,591 bp
  • TG to TGG, chromosome 9 at 7,465,083 bp
  • A to T, chromosome 9 at 36,693,312 bp
  • T to A, chromosome 11 at 42,133,726 bp
  • A to C, chromosome 11 at 90,643,773 bp
  • A to G, chromosome 12 at 51,427,895 bp
  • T to A, chromosome 13 at 61,037,688 bp
  • C to T, chromosome 13 at 66,916,612 bp
  • T to C, chromosome 13 at 112,524,327 bp
  • A to T, chromosome 13 at 119,782,802 bp
  • T to G, chromosome 14 at 36,879,395 bp
  • G to A, chromosome 14 at 52,145,044 bp
  • G to T, chromosome 14 at 60,872,057 bp
  • G to T, chromosome 15 at 82,343,417 bp
  • A to G, chromosome 15 at 83,945,148 bp
  • A to G, chromosome 15 at 89,388,685 bp
  • C to A, chromosome 16 at 49,138,767 bp
  • A to G, chromosome 17 at 23,359,523 bp
  • C to T, chromosome 17 at 24,983,140 bp
  • T to C, chromosome 17 at 37,047,544 bp
  • A to G, chromosome 18 at 43,477,211 bp
  • C to T, chromosome 18 at 65,624,333 bp
  • T to C, chromosome 19 at 10,871,871 bp
  • G to A, chromosome X at 70,394,388 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8890 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068694-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.