Strain Name:
C57BL/6J-MtgxR0037Btlr/Mmmh
Stock Number:
038331-MU
Citation ID:
RRID:MMRRC_038331-MU
Other Names:
R0037 (G1), C57BL/6J-MtgxR0037Btlr
Major Collection:

Gene Information

Myo10
Name: myosin X
Synonyms: myosin-X, D15Ertd600e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 17909
HGNC: HGNC:7593
Homologene: 36328
Ppp1r16b
Name: protein phosphatase 1, regulatory subunit 16B
Synonyms: C130078N17Rik, Wdt4, ANKRD4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228852
Homologene: 9194
Inpp5d
Name: inositol polyphosphate-5-phosphatase D
Synonyms: SHIP, SHIP1, SHIP-1, Src homology 2 domain-containing inositol-5-phosphatase, s-SHIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 16331
HGNC: HGNC:6079
Homologene: 4046
Utp20
Name: UTP20 small subunit processome component
Synonyms: DRIM, 3830408P06Rik, mDRIM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 70683
VEGA: 10
Homologene: 38373
Foxp1
Name: forkhead box P1
Synonyms: 3110052D19Rik, 4932443N09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 108655
HGNC: HGNC:3823
Homologene: 13092
Phf3
Name: PHD finger protein 3
Synonyms: 2310061N19Rik, AU020177
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 213109
HGNC: HGNC:8921
Homologene: 9040
Enox1
Name: ecto-NOX disulfide-thiol exchanger 1
Synonyms: D230005D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 239188
VEGA: 14
Homologene: 56793
Urb2
Name: URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 382038
Homologene: 8859
Swap70
Name: SWA-70 protein
Synonyms: 70kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20947
Homologene: 7557
Ralgapb
Name: Ral GTPase activating protein, beta subunit (non-catalytic)
Synonyms: B230339M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228850
Homologene: 10666
Trim24
Name: tripartite motif-containing 24
Synonyms: Tif1a, D430004I05Rik, A130082H20Rik, TIF1alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 21848
Homologene: 20830
Camsap2
Name: calmodulin regulated spectrin-associated protein family, member 2
Synonyms: 4930541M15Rik, Camsap1l1, 1600013L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 67886
Homologene: 18927
Son
Name: Son DNA binding protein
Synonyms: 2900011L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 20658
Homologene: 10551
Melk
Name: maternal embryonic leucine zipper kinase
Synonyms: MPK38
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 17279
Homologene: 32111
Insig2
Name: insulin induced gene 2
Synonyms: 2900053I11Rik, C730043J18Rik, Insig-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 72999
Homologene: 9400
Pfas
Name: phosphoribosylformylglycinamidine synthase (FGAR amidotransferase)
Synonyms: Sofa, 4432409B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237823
HGNC: HGNC:8863
Homologene: 5970
Aars
Name: alanyl-tRNA synthetase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234734
HGNC: HGNC:20
Homologene: 1213
Dag1
Name: dystroglycan 1
Synonyms: D9Wsu13e, beta-dystroglycan, alpha-dystroglycan, dystrophin associated glycoprotein 1, DG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 13138
HGNC: HGNC:2666
Homologene: 3234
Amph
Name: amphiphysin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218038
HGNC: HGNC:471
Homologene: 121585
Fut8
Name: fucosyltransferase 8
Synonyms: alpha (1,6) fucosyltransferase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 53618
VEGA: 12
HGNC: HGNC:4019
Homologene: 9650
Zfp473
Name: zinc finger protein 473
Synonyms: D030014N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 243963
Homologene: 18698
Uggt1
Name: UDP-glucose glycoprotein glucosyltransferase 1
Synonyms: 0910001L17Rik, A930007H10Rik, C820010P03Rik, Ugcgl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 320011
Homologene: 10586
Lemd3
Name: LEM domain containing 3
Synonyms: Man1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 380664
Homologene: 8633
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 94109
Homologene: 69536
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Tprgl
Name: transformation related protein 63 regulated like
Synonyms: 1200015A19Rik, mover
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 67808
Homologene: 12192
Ppfia4
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
Synonyms: Gm3812, Liprin-alpha4, 1110008G13Rik, LOC100042382
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 68507
HGNC: HGNC:9248
Homologene: 66200
Lrp4
Name: low density lipoprotein receptor-related protein 4
Synonyms: 6430526J12Rik, mdig, Megf7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228357
HGNC: HGNC:6696
Homologene: 17964
Slc20a1
Name: solute carrier family 20, member 1
Synonyms: Glvr1, PiT-1, Glvr-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20515
Homologene: 38049
Dclk1
Name: doublecortin-like kinase 1
Synonyms: CPG16, 2810480F11Rik, Dcamkl1, Click-I, 1700113D08Rik, Dcl, DCLK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 13175
HGNC: HGNC:2700
Homologene: 130530
Hs2st1
Name: heparan sulfate 2-O-sulfotransferase 1
Synonyms: Hs2st
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 23908
HGNC: HGNC:5193
Homologene: 8025
Cpt2
Name: carnitine palmitoyltransferase 2
Synonyms: CPT II, CPTII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 12896
HGNC: HGNC:2330
Homologene: 77
Fscn1
Name: fascin actin-bundling protein 1
Synonyms: fascin-1, Fan1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 14086
Homologene: 48164
Ankrd61
Name: ankyrin repeat domain 61
Synonyms: 4921520G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 66729
Homologene: 87028
Il5ra
Name: interleukin 5 receptor, alpha
Synonyms: IL-5 receptor alpha chain, Il5r, CD125, CDw125
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 16192
HGNC: HGNC:6017
Homologene: 473
Nlrp9b
Name: NLR family, pyrin domain containing 9B
Synonyms: Nalp9b, Nalp-delta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 243874
Homologene: 18530
Dusp26
Name: dual specificity phosphatase 26 (putative)
Synonyms: 2310043K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 66959
Homologene: 11421
Mast3
Name: microtubule associated serine/threonine kinase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 546071
Homologene: 66191
Nlrc5
Name: NLR family, CARD domain containing 5
Synonyms: AI451557
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 434341
Homologene: 88935
Ect2l
Name: epithelial cell transforming sequence 2 oncogene-like
Synonyms: Gm10331, C330021H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 100045792
Homologene: 46005
Exoc3
Name: exocyst complex component 3
Synonyms: Sec6l1, E430013E20Rik, 2810050O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 211446
VEGA: 13
Homologene: 38296
Ddhd1
Name: DDHD domain containing 1
Synonyms: 9630061G18Rik, 4921528E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 114874
Homologene: 35221
Gm5800
Name: predicted gene 5800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 545047
Homologene: 128452
Gm5475
Name: predicted gene 5475
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 432982
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 30,804,918 bp
  • A to T, chromosome 1 at 36,185,932 bp
  • A to G, chromosome 1 at 87,708,129 bp
  • A to T, chromosome 1 at 121,306,920 bp
  • A to T, chromosome 1 at 134,324,089 bp
  • C to T, chromosome 1 at 136,281,892 bp
  • A to G, chromosome 2 at 76,863,272 bp
  • A to G, chromosome 2 at 91,471,203 bp
  • T to C, chromosome 2 at 129,210,772 bp
  • T to C, chromosome 2 at 158,437,411 bp
  • T to A, chromosome 2 at 158,757,209 bp
  • A to G, chromosome 3 at 55,256,059 bp
  • T to A, chromosome 3 at 144,437,644 bp
  • T to C, chromosome 4 at 44,360,864 bp
  • A to G, chromosome 4 at 107,907,974 bp
  • C to A, chromosome 4 at 154,160,137 bp
  • A to G, chromosome 5 at 142,970,694 bp
  • T to C, chromosome 5 at 143,894,977 bp
  • A to T, chromosome 6 at 37,957,549 bp
  • T to A, chromosome 6 at 99,162,969 bp
  • T to A, chromosome 6 at 106,742,686 bp
  • T to A, chromosome 7 at 20,023,722 bp
  • T to A, chromosome 7 at 44,733,900 bp
  • T to A, chromosome 7 at 110,264,080 bp
  • T to A, chromosome 8 at 15,917,248 bp
  • G to A, chromosome 8 at 31,096,360 bp
  • C to T, chromosome 8 at 70,783,699 bp
  • G to A, chromosome 8 at 94,489,535 bp
  • G to A, chromosome 8 at 111,043,259 bp
  • T to A, chromosome 8 at 124,047,195 bp
  • G to T, chromosome 9 at 108,207,353 bp
  • A to G, chromosome 10 at 18,143,097 bp
  • T to C, chromosome 10 at 88,798,404 bp
  • A to C, chromosome 10 at 120,925,456 bp
  • A to G, chromosome 11 at 69,000,036 bp
  • T to C, chromosome 12 at 77,365,037 bp
  • A to T, chromosome 13 at 19,100,653 bp
  • T to C, chromosome 13 at 74,199,539 bp
  • A to G, chromosome 14 at 45,610,510 bp
  • T to C, chromosome 14 at 51,716,148 bp
  • T to C, chromosome 14 at 77,699,310 bp
  • C to T, chromosome 15 at 25,666,532 bp
  • T to A, chromosome 15 at 100,424,202 bp
  • C to A, chromosome 16 at 91,664,728 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0037 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038331-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.