Strain Name:
C57BL/6J-MtgxR0117Btlr/Mmmh
Stock Number:
038403-MU
Citation ID:
RRID:MMRRC_038403-MU
Other Names:
R0117 (G1), C57BL/6J-MtgxR0117Btlr
Major Collection:

Gene Information

Nfat5
Name: nuclear factor of activated T cells 5
Synonyms: nfatz, TonEBP, B130038B15Rik, OREBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 54446
HGNC: HGNC:7774
Homologene: 4811
Lmf1
Name: lipase maturation factor 1
Synonyms: 2400010G15Rik, Tmem112
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 76483
Homologene: 23384
Htr2a
Name: 5-hydroxytryptamine (serotonin) receptor 2A
Synonyms: 5-HT2A receptor, Htr-2, Htr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 15558
VEGA: 14
HGNC: HGNC:5293
Homologene: 68073
Rapgef2
Name: Rap guanine nucleotide exchange factor (GEF) 2
Synonyms: 5830453M24Rik, Pdzgef1, RA-GEF-1, CNRasGEF, nRapGEP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76089
Homologene: 35477
Btaf1
Name: B-TFIID TATA-box binding protein associated factor 1
Synonyms: E430027O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107182
Homologene: 31978
Pcnt
Name: pericentrin (kendrin)
Synonyms: Pcnt2, m239Asp, m275Asp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18541
VEGA: 10
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: D7H15F32S1, D15F32S1h, D7H15F37S1, rjs, jdf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Rabgap1
Name: RAB GTPase activating protein 1
Synonyms: Gapcena
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227800
Homologene: 49301
Phldb1
Name: pleckstrin homology like domain, family B, member 1
Synonyms: LL5A, D330037A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 102693
Homologene: 15903
Mcm9
Name: minichromosome maintenance 9 homologous recombination repair factor
Synonyms: 9030408O17Rik, Mcmdc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71567
VEGA: 10
Homologene: 13546
Angptl4
Name: angiopoietin-like 4
Synonyms: FIAF, BK89, HFARP, NG27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 57875
Homologene: 10755
Mpp3
Name: membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
Synonyms: Dlgh3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13384
HGNC: HGNC:7221
Homologene: 31065
Eps15
Name: epidermal growth factor receptor pathway substrate 15
Synonyms: 2410112D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13858
HGNC: HGNC:3419
Homologene: 128359
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: LR11, mSorLA, 2900010L19Rik, Sorla
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20660
Homologene: 2336
Def8
Name: differentially expressed in FDCP 8
Synonyms: D8Ertd713e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 23854
Homologene: 14279
Casp8ap2
Name: caspase 8 associated protein 2
Synonyms: D4Ertd659e, FLASH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 26885
HGNC: HGNC:1510
Homologene: 8066
Tvp23b
Name: trans-golgi network vesicle protein 23B
Synonyms: 1810036I24Rik, Fam18b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67510
Homologene: 128511
Cep76
Name: centrosomal protein 76
Synonyms: 6230425F05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225659
VEGA: 18
Homologene: 11774
Cep192
Name: centrosomal protein 192
Synonyms: D430014P18Rik, 4631422C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 70799
VEGA: 18
Homologene: 73526
Dach1
Name: dachshund family transcription factor 1
Synonyms: Dac, E130112M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 13134
HGNC: HGNC:2663
Homologene: 7288
Fig4
Name: FIG4 phosphoinositide 5-phosphatase
Synonyms: A530089I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103199
VEGA: 10
Homologene: 6713
Tgm5
Name: transglutaminase 5
Synonyms: 2310007C07Rik, TGx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74176
Homologene: 20899
Fmnl3
Name: formin-like 3
Synonyms: 2700073B04Rik, Wbp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22379
Homologene: 69101
Pkdrej
Name: polycystin (PKD) family receptor for egg jelly
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18766
VEGA: 15
HGNC: HGNC:9015
Homologene: 4427
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 229003
Homologene: 14118
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: A530024P18Rik, 2310008C07Rik, 2310003D02Rik, mXin beta, myomaxin, Cmya3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241431
Homologene: 19388
Dscam
Name: DS cell adhesion molecule
Synonyms: 4932410A21Rik, Down syndrome cell adhesion molecule
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13508
HGNC: HGNC:3039
Homologene: 74393
Impg2
Name: interphotoreceptor matrix proteoglycan 2
Synonyms: PG10.2, IPM200, Spacrcan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224224
Homologene: 9439
Serpina1c
Name: serine (or cysteine) peptidase inhibitor, clade A, member 1C
Synonyms: PI6, PI3, Spi1-3, Spi1-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20702
HGNC: HGNC:8941
Homologene: 20103
Bbs10
Name: Bardet-Biedl syndrome 10 (human)
Synonyms: 1300007O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71769
VEGA: 10
Homologene: 49781
Zc3h15
Name: zinc finger CCCH-type containing 15
Synonyms: FM22, Ierepo4, 1810012H02Rik, 1700006A17Rik, 2610312B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 69082
Homologene: 10216
Olfr1098
Name: olfactory receptor 1098
Synonyms: GA_x6K02T2Q125-48410458-48409511, MOR206-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258842
Homologene: 37005
Ninl
Name: ninein-like
Synonyms: LOC381388, LOC381387, 4930519N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 78177
Homologene: 57024
Gm20431
Name: predicted gene 20431
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Tubb1
Name: tubulin, beta 1 class VI
Synonyms: 2810484G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 545486
Homologene: 69474
Mgarp
Name: mitochondria localized glutamic acid rich protein
Synonyms: Osap, 4930583H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67749
Homologene: 49858
Postn
Name: periostin, osteoblast specific factor
Synonyms: OSF-2, Periostin, Osf2, peri, A630052E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 50706
Homologene: 4730
Kcna2
Name: potassium voltage-gated channel, shaker-related subfamily, member 2
Synonyms: Kv1.2, Kca1-2, Mk-2, Akr6a4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 16490
HGNC: HGNC:6220
Homologene: 21034
CK137956
Name: cDNA sequence CK137956
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 635169
Homologene: 57187
Plch2
Name: phospholipase C, eta 2
Synonyms: PLCeta2, A930027K05Rik, Plcl4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269615
Homologene: 85172
Rbak
Name: RB-associated KRAB zinc finger
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 57782
Homologene: 23287
Cyp2b23
Name: cytochrome P450, family 2, subfamily b, polypeptide 23
Synonyms: EG243881
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243881
Homologene: 117483
Psmc4
Name: proteasome (prosome, macropain) 26S subunit, ATPase, 4
Synonyms: MIP224, CIP21, CAR interacting protein 21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 23996
HGNC: HGNC:9551
Homologene: 4744
Lmntd2
Name: lamin tail domain containing 2
Synonyms: 1600016N20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72000
Homologene: 104159
Olfr862
Name: olfactory receptor 862
Synonyms: GA_x6K02T2PVTD-13624132-13623212, MOR146-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258555
Homologene: 115540
Olfr27
Name: olfactory receptor 27
Synonyms: MTPCR56, MOR171-6, GA_x6K02T2PVTD-32841223-32842158
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258826
VEGA: 9
Homologene: 110610
Gsta5
Name: glutathione S-transferase alpha 5
Synonyms: Gm10639
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 100042314
Homologene: 74378
Plxnb1
Name: plexin B1
Synonyms: 2900002G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235611
HGNC: HGNC:9103
Homologene: 130508
Pld2
Name: phospholipase D2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18806
HGNC: HGNC:9068
Homologene: 55672
Prl8a8
Name: prolactin family 8, subfamily a, member 81
Synonyms: PLP-Cgamma, 1600032B14Rik, Prlpc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 74188
Homologene: 137338
Gmpr
Name: guanosine monophosphate reductase
Synonyms: 2310004P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66355
HGNC: HGNC:4376
Homologene: 5009
Stmnd1
Name: stathmin domain containing 1
Synonyms: LOC380842, Gm1574
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 380842
VEGA: 13
Homologene: 54416
Sntb1
Name: syntrophin, basic 1
Synonyms: beta1-Syntrophin, 59-1 DAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20649
Homologene: 9618
Cyp4f13
Name: cytochrome P450, family 4, subfamily f, polypeptide 13
Synonyms: P450 CYP4F13, leukotriene B4 omega hydroxylase, 0610030I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 170716
HGNC: HGNC:2646
Homologene: 73902
Pde6c
Name: phosphodiesterase 6C, cGMP specific, cone, alpha prime
Synonyms: cpfl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 110855
VEGA: 19
HGNC: HGNC:8787
Homologene: 4521
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 2 at 37,561,885 bp
  • C to T, chromosome 2 at 67,517,120 bp
  • T to C, chromosome 2 at 83,658,083 bp
  • T to A, chromosome 2 at 86,922,870 bp
  • C to T, chromosome 2 at 121,075,102 bp
  • G to A, chromosome 2 at 150,937,673 bp
  • A to G, chromosome 2 at 167,644,758 bp
  • T to C, chromosome 2 at 174,457,784 bp
  • C to A, chromosome 2 at 181,232,759 bp
  • G to T, chromosome 3 at 51,396,712 bp
  • C to T, chromosome 3 at 54,383,481 bp
  • A to G, chromosome 3 at 79,079,177 bp
  • A to G, chromosome 3 at 107,105,354 bp
  • A to G, chromosome 4 at 32,640,817 bp
  • T to A, chromosome 4 at 109,382,819 bp
  • T to A, chromosome 4 at 127,946,792 bp
  • T to A, chromosome 4 at 154,985,358 bp
  • G to T, chromosome 5 at 143,173,632 bp
  • A to T, chromosome 7 at 26,673,114 bp
  • A to T, chromosome 7 at 28,042,740 bp
  • C to A, chromosome 7 at 56,213,611 bp
  • G to A, chromosome 7 at 141,210,123 bp
  • C to T, chromosome 8 at 107,339,075 bp
  • G to A, chromosome 8 at 123,456,495 bp
  • T to C, chromosome 9 at 19,884,299 bp
  • T to A, chromosome 9 at 39,144,850 bp
  • A to G, chromosome 9 at 42,033,577 bp
  • T to C, chromosome 9 at 44,711,706 bp
  • C to T, chromosome 9 at 78,304,418 bp
  • A to G, chromosome 9 at 109,105,218 bp
  • G to A, chromosome 10 at 41,230,041 bp
  • A to G, chromosome 10 at 53,537,736 bp
  • A to T, chromosome 10 at 76,408,727 bp
  • T to A, chromosome 10 at 111,299,333 bp
  • T to C, chromosome 11 at 62,879,604 bp
  • G to A, chromosome 11 at 70,557,388 bp
  • G to A, chromosome 11 at 102,000,573 bp
  • T to G, chromosome 12 at 103,895,012 bp
  • T to A, chromosome 13 at 27,508,490 bp
  • T to A, chromosome 13 at 45,517,084 bp
  • C to A, chromosome 13 at 46,285,486 bp
  • G to A, chromosome 14 at 74,645,093 bp
  • C to T, chromosome 14 at 98,168,748 bp
  • A to G, chromosome 15 at 55,906,353 bp
  • T to A, chromosome 15 at 85,816,099 bp
  • G to C, chromosome 15 at 99,322,738 bp
  • A to G, chromosome 16 at 56,261,642 bp
  • T to C, chromosome 16 at 96,673,678 bp
  • G to T, chromosome 17 at 25,655,991 bp
  • G to T, chromosome 17 at 32,930,606 bp
  • A to T, chromosome 17 at 33,780,802 bp
  • T to C, chromosome 18 at 67,626,674 bp
  • T to C, chromosome 18 at 67,850,737 bp
  • A to G, chromosome 19 at 36,969,968 bp
  • A to G, chromosome 19 at 38,151,531 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0117 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038403-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.