Strain Name:
C57BL/6J-MtgxR0178Btlr/Mmmh
Stock Number:
038446-MU
Citation ID:
RRID:MMRRC_038446-MU
Other Names:
R0178 (G1), C57BL/6J-MtgxR0178Btlr
Major Collection:

Gene Information

Rpl13a
Name: ribosomal protein L13A
Synonyms: tum-antigen, tum-transplantation antigen P198, Tstap198-7, 1810026N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22121
Homologene: 111053
Hlcs
Name: holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)
Synonyms: 410I21.SP6, D16Jhu34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 110948
VEGA: 16
HGNC: HGNC:4976
Homologene: 37302
Slc6a1
Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 1
Synonyms: XT-1, Gabt, Xtrp1, Gat1, Gabt1, GAT-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232333
Homologene: 2290
Cacna1g
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms: a1G, Cav3.1d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12291
HGNC: HGNC:1394
Homologene: 22544
Chrnb3
Name: cholinergic receptor, nicotinic, beta polypeptide 3
Synonyms: Acrb3, 5730417K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 108043
HGNC: HGNC:1963
Homologene: 36035
Ldb2
Name: LIM domain binding 2
Synonyms: CLIM1, Ldb3, CLP-36, CLIM-1b, CLIM-1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16826
HGNC: HGNC:6533
Homologene: 989
Tanc1
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Synonyms: 1200003E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66860
Homologene: 18946
Dnmt3b
Name: DNA methyltransferase 3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13436
HGNC: HGNC:2979
Homologene: 56000
Arfgap2
Name: ADP-ribosylation factor GTPase activating protein 2
Synonyms: 2310032E02Rik, Zfp289
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 77038
Homologene: 8735
Knl1
Name: kinetochore scaffold 1
Synonyms: 2310043D08Rik, 5730505K17Rik, Casc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76464
Homologene: 44890
Eef2
Name: eukaryotic translation elongation factor 2
Synonyms: Ef-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 13629
VEGA: 10
HGNC: HGNC:3214
Homologene: 134867
Abca1
Name: ATP-binding cassette, sub-family A (ABC1), member 1
Synonyms: ABC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11303
HGNC: HGNC:29
Homologene: 21130
Gdf10
Name: growth differentiation factor 10
Synonyms: Bmp3b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14560
VEGA: 14
HGNC: HGNC:4215
Homologene: 3640
Kcne1
Name: potassium voltage-gated channel, Isk-related subfamily, member 1
Synonyms: MinK, Isk, nmf190
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 16509
VEGA: 16
Homologene: 185
Amotl1
Name: angiomotin-like 1
Synonyms: 4932416D09Rik, JEAP, 2310067L22Rik, 2310010G08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75723
Homologene: 43977
Gm9847
Name: predicted pseudogene 9847
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 100043256
VEGA: 12
H13
Name: histocompatibility 13
Synonyms: H-13, 1200006O09Rik, 5031424B04Rik, 4930443L17Rik, Spp, Hm13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14950
Homologene: 7749
Zfp644
Name: zinc finger protein 644
Synonyms: 1110068L01Rik, BM-005, Zep-2, D5Ertd689e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 52397
Homologene: 12971
Vezf1
Name: vascular endothelial zinc finger 1
Synonyms: db1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22344
Homologene: 5175
Ubac1
Name: ubiquitin associated domain containing 1
Synonyms: 1110033G07Rik, Ubadc1, Kpc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 98766
Homologene: 9409
Grwd1
Name: glutamate-rich WD repeat containing 1
Synonyms: WDR28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101612
Homologene: 6644
Mtus1
Name: mitochondrial tumor suppressor 1
Synonyms: MD44, MTSG1, Atip1, B430305I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102103
Homologene: 100292
Zfc3h1
Name: zinc finger, C3H1-type containing
Synonyms: Psrc2, Ccdc131
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216345
Homologene: 17017
Colec12
Name: collectin sub-family member 12
Synonyms: SRCL, CL-P1, Scara4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 140792
VEGA: 18
Homologene: 34248
Cyp2r1
Name: cytochrome P450, family 2, subfamily r, polypeptide 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244209
Homologene: 75210
1700125H20Rik
Name: RIKEN cDNA 1700125H20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 73634
Homologene: 18763
Tmprss7
Name: transmembrane serine protease 7
Synonyms: LOC385645, B230219I23Rik, matriptase-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 208171
Homologene: 18178
Fer1l6
Name: fer-1-like 6 (C. elegans)
Synonyms: EG631797
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 631797
Homologene: 53396
Fhad1
Name: forkhead-associated (FHA) phosphopeptide binding domain 1
Synonyms: 2900090M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329977
Homologene: 77947
Gvin3
Name: GTPase, very large interferon inducible, family member 3
Synonyms: Gm1966
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434223
Homologene: 32708
9930021J03Rik
Name: RIKEN cDNA 9930021J03 gene
Synonyms: Gm9832
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 240613
Homologene: 19046
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Gbe1
Name: glucan (1,4-alpha-), branching enzyme 1
Synonyms: 2310045H19Rik, 2810426P10Rik, D16Ertd536e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74185
HGNC: HGNC:4180
Homologene: 129
Olfr205
Name: olfactory receptor 205
Synonyms: GA_x54KRFPKG5P-55543875-55542958, MOR182-11P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 257881
Homologene: 79469
Kcnma1
Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Synonyms: Slo, mSlo1, Slo1, MaxiK, BK channel alpha subunit, 5730414M22Rik, BKCa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16531
HGNC: HGNC:6284
Homologene: 1693
Ggt6
Name: gamma-glutamyltransferase 6
Synonyms: 9030405D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71522
Homologene: 51918
Lrrc6
Name: leucine rich repeat containing 6 (testis)
Synonyms: LRTP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 54562
Homologene: 34534
Sntb1
Name: syntrophin, basic 1
Synonyms: beta1-Syntrophin, 59-1 DAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20649
Homologene: 9618
Lrrc42
Name: leucine rich repeat containing 42
Synonyms: A930011F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 77809
Homologene: 12685
Fam118a
Name: family with sequence similarity 118, member A
Synonyms: C230014M12Rik, 3110048E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 73225
VEGA: 15
HGNC: HGNC:1313
Homologene: 9911
Cdh20
Name: cadherin 20
Synonyms: Cdh7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 23836
HGNC: HGNC:1760
Homologene: 8015
Rbm17
Name: RNA binding motif protein 17
Synonyms: 2700027J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76938
Homologene: 13162
Sh2d2a
Name: SH2 domain containing 2A
Synonyms: TSAd, Lck-associated adapter protein, Lad, RIBP, Rlk/Itk-binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 27371
Homologene: 2958
Clec2m
Name: C-type lectin domain family 2, member m
Synonyms: 4922502D21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 381816
Homologene: 77865
Capn5
Name: calpain 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12337
HGNC: HGNC:1482
Homologene: 31212
Olfr691
Name: olfactory receptor 691
Synonyms: GA_x6K02T2PBJ9-7966695-7965727, MOR31-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259063
Homologene: 17483
Slc27a1
Name: solute carrier family 27 (fatty acid transporter), member 1
Synonyms: FATP1, Fatp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 26457
Homologene: 8063
Krt40
Name: keratin 40
Synonyms: Ka36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 406221
Homologene: 46321
Asb2
Name: ankyrin repeat and SOCS box-containing 2
Synonyms: 1110008E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 65256
Homologene: 69202
Serpina6
Name: serine (or cysteine) peptidase inhibitor, clade A, member 6
Synonyms: Cbg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 12401
HGNC: HGNC:1540
Homologene: 20417
Prl2c5
Name: prolactin family 2, subfamily c, member 5
Synonyms: MRP-4, PLF-4, Mrpplf4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 107849
Homologene: 40763
4930596D02Rik
Name: RIKEN cDNA 4930596D02 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239036
Nrg3
Name: neuregulin 3
Synonyms: ska
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18183
HGNC: HGNC:7999
Homologene: 32051
Adcy6
Name: adenylate cyclase 6
Synonyms: AC6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 11512
VEGA: 15
HGNC: HGNC:237
Homologene: 22400
Cers5
Name: ceramide synthase 5
Synonyms: 2310081H14Rik, Trh4, CerS5, Lass5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71949
Homologene: 23634
Myot
Name: myotilin
Synonyms: 5530402I04Rik, Ttid
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 58916
Homologene: 4942
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 104,975,051 bp
  • G to A, chromosome 2 at 11,587,779 bp
  • A to T, chromosome 2 at 26,021,428 bp
  • A to T, chromosome 2 at 40,725,907 bp
  • T to A, chromosome 2 at 59,835,447 bp
  • C to T, chromosome 2 at 91,267,361 bp
  • T to A, chromosome 2 at 119,058,405 bp
  • A to G, chromosome 2 at 152,681,067 bp
  • A to G, chromosome 2 at 153,675,018 bp
  • A to T, chromosome 3 at 87,849,423 bp
  • T to C, chromosome 4 at 53,081,953 bp
  • A to G, chromosome 4 at 107,247,720 bp
  • A to C, chromosome 4 at 141,955,340 bp
  • A to T, chromosome 5 at 44,473,499 bp
  • C to T, chromosome 5 at 106,636,905 bp
  • T to G, chromosome 6 at 114,304,852 bp
  • T to C, chromosome 6 at 129,326,823 bp
  • A to T, chromosome 7 at 45,134,458 bp
  • T to C, chromosome 7 at 45,830,630 bp
  • A to G, chromosome 7 at 98,132,891 bp
  • G to A, chromosome 7 at 105,336,922 bp
  • A to T, chromosome 7 at 106,601,821 bp
  • T to C, chromosome 7 at 114,550,408 bp
  • T to A, chromosome 8 at 27,393,364 bp
  • G to T, chromosome 8 at 41,002,361 bp
  • T to C, chromosome 8 at 71,584,462 bp
  • G to A, chromosome 9 at 14,548,773 bp
  • G to A, chromosome 10 at 81,180,292 bp
  • T to C, chromosome 10 at 115,406,725 bp
  • A to G, chromosome 11 at 72,436,818 bp
  • A to G, chromosome 11 at 85,178,438 bp
  • A to T, chromosome 11 at 88,078,399 bp
  • G to A, chromosome 11 at 94,463,483 bp
  • T to C, chromosome 11 at 99,541,739 bp
  • T to C, chromosome 12 at 14,494,648 bp
  • G to A, chromosome 12 at 103,325,552 bp
  • A to G, chromosome 12 at 103,646,913 bp
  • A to T, chromosome 13 at 13,191,805 bp
  • C to T, chromosome 14 at 23,526,767 bp
  • A to G, chromosome 14 at 33,924,101 bp
  • T to G, chromosome 14 at 35,811,478 bp
  • A to T, chromosome 14 at 38,376,456 bp
  • T to C, chromosome 15 at 55,906,144 bp
  • T to A, chromosome 15 at 58,637,914 bp
  • A to C, chromosome 15 at 66,454,101 bp
  • T to C, chromosome 15 at 85,045,880 bp
  • G to T, chromosome 15 at 98,604,215 bp
  • C to A, chromosome 15 at 99,747,024 bp
  • C to A, chromosome 16 at 45,690,843 bp
  • A to T, chromosome 16 at 59,329,420 bp
  • G to A, chromosome 16 at 70,478,386 bp
  • A to C, chromosome 16 at 92,348,809 bp
  • A to T, chromosome 16 at 94,141,337 bp
  • C to T, chromosome 18 at 9,858,921 bp
  • T to C, chromosome 18 at 44,336,986 bp
  • A to G, chromosome 19 at 29,754,788 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0178 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038446-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.