Strain Name:
C57BL/6J-MtgxR0574Btlr/Mmmh
Stock Number:
038764-MU
Citation ID:
RRID:MMRRC_038764-MU
Other Names:
R0574 (G1), C57BL/6J-MtgxR0574Btlr
Major Collection:

Gene Information

Stx8
Name: syntaxin 8
Synonyms: 4930571E13Rik, 0610007H08Rik, 1110002H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 55943
Homologene: 37973
Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: D230017O13Rik, 2610103K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 268281
Homologene: 6489
Lhx3
Name: LIM homeobox protein 3
Synonyms: P-LIM, mLim-3, Lim3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16871
HGNC: HGNC:6595
Homologene: 7814
Rprd2
Name: regulation of nuclear pre-mRNA domain containing 2
Synonyms: 6720469I21Rik, 2810036A19Rik, 4930535B03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 75137
Homologene: 19997
Snx3
Name: sorting nexin 3
Synonyms: SDP3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 54198
Homologene: 36144
Mynn
Name: myoneurin
Synonyms: SBBIZ1, 2810011C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80732
Homologene: 10253
Bptf
Name: bromodomain PHD finger transcription factor
Synonyms: Falz, 9430093H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 207165
HGNC: HGNC:3581
Homologene: 114397
Pole2
Name: polymerase (DNA directed), epsilon 2 (p59 subunit)
Synonyms: DNA polymerase epsilon small subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 18974
VEGA: 12
HGNC: HGNC:9178
Homologene: 2015
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Usp54
Name: ubiquitin specific peptidase 54
Synonyms: 4930429G18Rik, C030002J06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 78787
Homologene: 90902
Ddr2
Name: discoidin domain receptor family, member 2
Synonyms: Ntrkr3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18214
HGNC: HGNC:2731
Homologene: 68505
Aldh1a2
Name: aldehyde dehydrogenase family 1, subfamily A2
Synonyms: retinaldehyde dehydrogenase, Aldh1a7, Raldh2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 19378
Homologene: 68368
Actrt3
Name: actin related protein T3
Synonyms: Arpm1, 1700119I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76652
Homologene: 13038
Man2b1
Name: mannosidase 2, alpha B1
Synonyms: lysosomal alpha-mannosidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17159
HGNC: HGNC:6826
Homologene: 37322
Arhgap29
Name: Rho GTPase activating protein 29
Synonyms: B130017I01Rik, 6720461J18Rik, C76601, Parg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 214137
Homologene: 3539
Ppargc1b
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 beta
Synonyms: 4631412G21Rik, PGC-1beta/ERRL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 170826
Homologene: 15776
Tbc1d17
Name: TBC1 domain family, member 17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233204
Homologene: 11656
Ush1c
Name: USH1 protein network component harmonin
Synonyms: harmonin, Usher syndrome 1C, 2010016F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72088
Homologene: 77476
Mpo
Name: myeloperoxidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17523
HGNC: HGNC:7218
Homologene: 55450
Ift140
Name: intraflagellar transport 140
Synonyms: Wdtc2, Tce5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106633
Homologene: 40979
Itga1
Name: integrin alpha 1
Synonyms: CD49A, E130012M19Rik, Vla1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 109700
VEGA: 13
HGNC: HGNC:6134
Homologene: 57137
Abca14
Name: ATP-binding cassette, sub-family A (ABC1), member 14
Synonyms: 1700110B15Rik, 4930539G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67928
Homologene: 86128
Vmn1r214
Name: vomeronasal 1 receptor 214
Synonyms: V1rh5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171248
Homologene: 110880
Mmp15
Name: matrix metallopeptidase 15
Synonyms: Membrane type 2-MMP, MT2-MMP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17388
HGNC: HGNC:7161
Homologene: 20549
Adamts5
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
Synonyms: 9530092O11Rik, ADAM-TS5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 23794
VEGA: 16
HGNC: HGNC:221
Homologene: 5109
Olfr727
Name: olfactory receptor 727
Synonyms: MOR246-2, GA_x6K02T2PMLR-5817082-5818056
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258316
Homologene: 84571
Olfr421-ps1
Name: olfactory receptor 421, pseudogene 1
Synonyms: Olfr421, MOR105-3, Olfr422-ps1, GA_x6K02T2P20D-21006310-21006124, GA_x6K02T2P20D-21002372-21001425
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 258715
Prl8a2
Name: prolactin family 8, subfamily a, member 2
Synonyms: mdPRP, D/tPRP, DPRP, Dtprp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13529
Homologene: 49230
Rhno1
Name: RAD9-HUS1-RAD1 interacting nuclear orphan 1
Synonyms: 5930416I19Rik, 2510047L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 72440
Nfkbib
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta
Synonyms: IkB, IKappaBbeta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18036
HGNC: HGNC:7798
Homologene: 37631
Klk1b27
Name: kallikrein 1-related peptidase b27
Synonyms: Klk21l, mGK-27, Klk27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16619
HGNC: HGNC:6364
Homologene: 68141
Olfr98
Name: olfactory receptor 98
Synonyms: MOR156-4, GA_x6K02T2PSCP-1703582-1702653
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258503
Homologene: 133051
2610044O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 169,981,963 bp
  • T to C, chromosome 1 at 174,151,566 bp
  • T to C, chromosome 2 at 26,201,311 bp
  • T to C, chromosome 3 at 30,599,680 bp
  • T to C, chromosome 3 at 30,616,739 bp
  • T to C, chromosome 3 at 95,774,357 bp
  • A to G, chromosome 3 at 122,007,625 bp
  • A to T, chromosome 6 at 128,358,150 bp
  • C to T, chromosome 7 at 28,761,788 bp
  • T to A, chromosome 7 at 44,056,101 bp
  • A to G, chromosome 7 at 44,843,123 bp
  • A to G, chromosome 7 at 46,196,804 bp
  • A to G, chromosome 7 at 120,224,497 bp
  • T to G, chromosome 8 at 85,096,776 bp
  • G to A, chromosome 8 at 95,365,401 bp
  • T to C, chromosome 9 at 71,281,708 bp
  • T to C, chromosome 10 at 11,163,077 bp
  • T to A, chromosome 10 at 42,502,387 bp
  • C to T, chromosome 11 at 67,973,252 bp
  • A to T, chromosome 11 at 87,796,076 bp
  • T to C, chromosome 11 at 107,076,527 bp
  • G to A, chromosome 12 at 69,211,457 bp
  • T to A, chromosome 13 at 11,731,669 bp
  • A to G, chromosome 13 at 23,034,493 bp
  • T to A, chromosome 13 at 27,348,900 bp
  • A to C, chromosome 13 at 114,966,561 bp
  • A to G, chromosome 14 at 20,556,254 bp
  • A to T, chromosome 14 at 50,126,682 bp
  • A to G, chromosome 16 at 85,899,484 bp
  • T to A, chromosome 17 at 25,051,760 bp
  • G to T, chromosome 17 at 37,262,881 bp
  • T to C, chromosome 17 at 94,761,491 bp
  • C to T, chromosome 18 at 61,302,739 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0574 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038764-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.