Strain Name:
C57BL/6J-MtgxR0577Btlr/Mmmh
Stock Number:
038767-MU
Citation ID:
RRID:MMRRC_038767-MU
Other Names:
R0577 (G1), C57BL/6J-MtgxR0577Btlr
Major Collection:

Gene Information

Pias2
Name: protein inhibitor of activated STAT 2
Synonyms: Dib, 6330408K17Rik, ARIP3, PIASxbeta, PIASxalpha, PIASxb, Miz1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17344
VEGA: 18
Homologene: 20979
Bag3
Name: BCL2-associated athanogene 3
Synonyms: Bis, Bcl-2-interacting death suppressor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 29810
HGNC: HGNC:939
Homologene: 3162
Rps11
Name: ribosomal protein S11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 27207
Homologene: 88443
Klhdc4
Name: kelch domain containing 4
Synonyms: G430025P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234825
Homologene: 69234
Pdcd11
Name: programmed cell death 11
Synonyms: ALG-4, 1110021I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18572
VEGA: 19
Homologene: 74968
Klf12
Name: Kruppel-like factor 12
Synonyms: AP-2rep, B130052C06Rik, 2700063E05Rik, D530033K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16597
VEGA: 14
HGNC: HGNC:6346
Homologene: 21417
Bod1l
Name: biorientation of chromosomes in cell division 1-like
Synonyms: A230054D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 665775
Homologene: 45109
Aars
Name: alanyl-tRNA synthetase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234734
HGNC: HGNC:20
Homologene: 1213
Zfp141
Name: zinc finger protein 141
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434178
Gpc6
Name: glypican 6
Synonyms: 6720429C22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 23888
HGNC: HGNC:4454
Homologene: 55922
Cdk12
Name: cyclin-dependent kinase 12
Synonyms: 1810022J16Rik, Crk7, D11Ertd752e, Crkrs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69131
Homologene: 128632
Asph
Name: aspartate-beta-hydroxylase
Synonyms: cI-37, 2310005F16Rik, aspartyl beta-hydroxylase, calsequestrin-binding protein, Junctin, jumbug, BAH, 3110001L23Rik, junctate
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 65973
HGNC: HGNC:757
Homologene: 20910
Eef1g
Name: eukaryotic translation elongation factor 1 gamma
Synonyms: EF1G, 2610301D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67160
HGNC: HGNC:3213
Homologene: 20363
Mov10l1
Name: Mov10 like RISC complex RNA helicase 1
Synonyms: CHAMP, Csm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 83456
HGNC: HGNC:7201
Homologene: 56835
Dchs1
Name: dachsous cadherin related 1
Synonyms: C130033F22Rik, 3110041P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233651
Homologene: 2771
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 672511
Homologene: 45439
Rsc1a1
Name: regulatory solute carrier protein, family 1, member 1
Synonyms: RS1, mRS1, OTTMUSG00000010365
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69994
Homologene: 130554
Madd
Name: MAP-kinase activating death domain
Synonyms: 9630059K23Rik, Rab3 GEP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228355
HGNC: HGNC:6766
Homologene: 14249
Olfr205
Name: olfactory receptor 205
Synonyms: GA_x54KRFPKG5P-55543875-55542958, MOR182-11P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 257881
Homologene: 79469
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330267
Homologene: 46582
Zfp955a
Name: zinc finger protein 955A
Synonyms: AI842447
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 77652
VEGA: 17
Homologene: 104925
Abcc2
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Synonyms: multidrug resistance protein 2, Mrp2, Cmoat
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 12780
HGNC: HGNC:53
Homologene: 68052
Rrs1
Name: ribosome biogenesis regulator 1
Synonyms: 5730466A07Rik, D1Ertd701e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 59014
Homologene: 41014
Olfr725
Name: olfactory receptor 725
Synonyms: GA_x6K02T2PMLR-5725741-5724776, MOR246-3, MOR246-7_p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258314
Homologene: 44957
Fbxw17
Name: F-box and WD-40 domain protein 17
Synonyms: 1110064L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 109082
Homologene: 82571
Vmn2r86
Name: vomeronasal 2, receptor 86
Synonyms: EG625109
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 625109
Homologene: 129606
Mtif2
Name: mitochondrial translational initiation factor 2
Synonyms: IF-2mt, 2410112O06Rik, 2310038D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76784
HGNC: HGNC:7441
Homologene: 1840
Olfr1504
Name: olfactory receptor 1504
Synonyms: GA_x6K02T2RE5P-4223635-4222688, MOR212-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258627
Homologene: 45020
Mtmr6
Name: myotubularin related protein 6
Synonyms: 4022440C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219135
VEGA: 14
HGNC: HGNC:7453
Homologene: 55842
Macir
Name: macrophage immunometabolism regulator
Synonyms: D1Ertd622e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 52392
Homologene: 13239
Potea
Name: POTE ankyrin domain family member A
Synonyms: 4930430A15Rik, A26c3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67575
Homologene: 69410
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 9,545,801 bp
  • C to T, chromosome 1 at 97,661,826 bp
  • C to T, chromosome 2 at 91,138,395 bp
  • G to T, chromosome 2 at 111,194,349 bp
  • G to T, chromosome 4 at 9,604,620 bp
  • A to T, chromosome 4 at 141,684,507 bp
  • T to C, chromosome 5 at 41,794,887 bp
  • T to C, chromosome 6 at 12,321,048 bp
  • T to C, chromosome 7 at 42,476,514 bp
  • A to G, chromosome 7 at 45,122,850 bp
  • C to T, chromosome 7 at 105,764,255 bp
  • T to C, chromosome 7 at 128,523,887 bp
  • T to A, chromosome 8 at 111,043,278 bp
  • C to T, chromosome 8 at 121,821,351 bp
  • C to A, chromosome 10 at 130,452,575 bp
  • G to T, chromosome 11 at 29,540,862 bp
  • T to C, chromosome 11 at 98,203,506 bp
  • G to T, chromosome 11 at 119,443,280 bp
  • T to C, chromosome 13 at 50,431,583 bp
  • C to T, chromosome 14 at 50,034,792 bp
  • G to A, chromosome 14 at 60,296,638 bp
  • T to A, chromosome 14 at 100,023,149 bp
  • A to G, chromosome 14 at 117,436,008 bp
  • A to G, chromosome 15 at 89,005,727 bp
  • A to T, chromosome 16 at 59,328,698 bp
  • A to T, chromosome 17 at 33,242,094 bp
  • A to T, chromosome 18 at 77,097,281 bp
  • A to G, chromosome 19 at 8,973,042 bp
  • T to C, chromosome 19 at 13,887,803 bp
  • A to T, chromosome 19 at 43,819,401 bp
  • A to G, chromosome 19 at 47,098,832 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0577 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038767-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.