Strain Name:
C57BL/6J-MtgxR0578Btlr/Mmmh
Stock Number:
038768-MU
Citation ID:
RRID:MMRRC_038768-MU
Other Names:
R0578 (G1), C57BL/6J-MtgxR0578Btlr
Major Collection:

Gene Information

B4galt6
Name: UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 56386
VEGA: 18
HGNC: HGNC:929
Homologene: 3506
Got1
Name: glutamic-oxaloacetic transaminase 1, soluble
Synonyms: Got-1, cytosolic aspartate aminotransferase, cAspAT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 14718
HGNC: HGNC:4432
Homologene: 1571
Srsf11
Name: serine/arginine-rich splicing factor 11
Synonyms: 2610019N13Rik, 0610009J05Rik, Sfrs11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 69207
Homologene: 36164
Ncoa7
Name: nuclear receptor coactivator 7
Synonyms: 9030406N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 211329
VEGA: 10
Homologene: 65245
Dusp16
Name: dual specificity phosphatase 16
Synonyms: MKP7, D6Ertd213e, 3830417M17Rik, MKP-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 70686
Homologene: 15604
Rxra
Name: retinoid X receptor alpha
Synonyms: RXRalpha1, 9530071D11Rik, RXR alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20181
Homologene: 2220
Faf2
Name: Fas associated factor family member 2
Synonyms: Ubxd8, 2210404D11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 76577
Homologene: 8753
Cabin1
Name: calcineurin binding protein 1
Synonyms: Cain, Ppp3in, A330070M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 104248
VEGA: 10
Homologene: 49307
Kat7
Name: K(lysine) acetyltransferase 7
Synonyms: Hbo1, Hboa, Myst2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217127
Homologene: 5134
Cad
Name: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Synonyms: 2410008J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 69719
HGNC: HGNC:1424
Homologene: 1412
Helz
Name: helicase with zinc finger domain
Synonyms: 3110078M01Rik, 9430093I07Rik, 9630002H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 78455
Homologene: 8918
R3hdm1
Name: R3H domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226412
HGNC: HGNC:9757
Homologene: 9108
Eif2ak4
Name: eukaryotic translation initiation factor 2 alpha kinase 4
Synonyms: GCN2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 27103
Homologene: 40891
Dennd4c
Name: DENN/MADD domain containing 4C
Synonyms: 1700065A05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 329877
Homologene: 23057
Inppl1
Name: inositol polyphosphate phosphatase-like 1
Synonyms: SHIP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 16332
HGNC: HGNC:6080
Homologene: 1204
Gas2l3
Name: growth arrest-specific 2 like 3
Synonyms: LOC237436, 8430435B07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 237436
VEGA: 10
Homologene: 18386
Mtch2
Name: mitochondrial carrier 2
Synonyms: HSPC032, 2310034D24Rik, 4930539J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 56428
Homologene: 8645
Nuf2
Name: NUF2, NDC80 kinetochore complex component
Synonyms: Nuf2R, Cdca1, 2410003C07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 66977
Homologene: 40205
Htr1a
Name: 5-hydroxytryptamine (serotonin) receptor 1A
Synonyms: 5-HT1A receptor, Gpcr18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 15550
VEGA: 13
HGNC: HGNC:5286
Homologene: 20148
Capns1
Name: calpain, small subunit 1
Synonyms: Capa-4, Capa4, Capn4, D7Ertd146e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 12336
HGNC: HGNC:1481
Homologene: 1327
Plec
Name: plectin
Synonyms: Plec1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 18810
HGNC: HGNC:9069
Homologene: 384
Isl2
Name: insulin related protein 2 (islet 2)
Synonyms: islet 2, 3110001N10Rik, islet-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 104360
Homologene: 10730
Adam18
Name: a disintegrin and metallopeptidase domain 18
Synonyms: Adam27, Dtgn3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 13524
HGNC: HGNC:196
Homologene: 74941
Dsg2
Name: desmoglein 2
Synonyms: D18Ertd293e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 13511
HGNC: HGNC:3049
Homologene: 1464
Atad2
Name: ATPase family, AAA domain containing 2
Synonyms: 2610509G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 70472
VEGA: 15
Homologene: 6044
Cachd1
Name: cache domain containing 1
Synonyms: B430218L07Rik, Vwcd1, 1190007F10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 320508
Homologene: 10854
Btg3
Name: B cell translocation gene 3
Synonyms: ANA, tob5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 12228
HGNC: HGNC:1132
Homologene: 4953
Acr
Name: acrosin prepropeptide
Synonyms: preproacrosin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 11434
VEGA: 15
HGNC: HGNC:126
Homologene: 855
Cdipt
Name: CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
Synonyms: D7Bwg0575e, 9530042F15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 52858
HGNC: HGNC:1769
Homologene: 7159
Pla2g4e
Name: phospholipase A2, group IVE
Synonyms: 2310026J01Rik, Pla2epsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 329502
Homologene: 65339
Pced1a
Name: PC-esterase domain containing 1A
Synonyms: Fam113a, A930025D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 319513
Homologene: 11241
C87499
Name: expressed sequence C87499
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 381590
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Olfr994
Name: olfactory receptor 994
Synonyms: GA_x6K02T2Q125-46907515-46906571, MOR203-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258425
Homologene: 17245
Vmn2r19
Name: vomeronasal 2, receptor 19
Synonyms: EG232358
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232358
Homologene: 84037
Poln
Name: DNA polymerase N
Synonyms: POL4P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 272158
Homologene: 131253
Akna
Name: AT-hook transcription factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100182
Homologene: 49947
Catsperg2
Name: cation channel sperm associated auxiliary subunit gamma 2
Synonyms: CATSPERG, 1700067C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 76718
Homologene: 10915
Atp2a1
Name: ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
Synonyms: SERCA1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 11937
HGNC: HGNC:811
Homologene: 7635
Ccdc61
Name: coiled-coil domain containing 61
Synonyms: C530028I08Rik, LOC232933
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 232933
Homologene: 19256
Plce1
Name: phospholipase C, epsilon 1
Synonyms: 4933403A21Rik, PLCepsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 74055
Homologene: 9478
4930407I10Rik
Name: RIKEN cDNA 4930407I10 gene
Synonyms: LOC328573
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 328573
VEGA: 15
Homologene: 130065
Scnn1a
Name: sodium channel, nonvoltage-gated 1 alpha
Synonyms: Scnn1, ENaC alpha, mENaC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 20276
Homologene: 811
Afap1l2
Name: actin filament associated protein 1-like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 226250
Homologene: 13057
Abca5
Name: ATP-binding cassette, sub-family A (ABC1), member 5
Synonyms: ABC13, B930033A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217265
HGNC: HGNC:35
Homologene: 10263
Hadhb
Name: hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit
Synonyms: 4930479F15Rik, Mtpb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231086
HGNC: HGNC:4803
Homologene: 153
Olfr767
Name: olfactory receptor 767
Synonyms: GA_x6K02T2PULF-10765431-10764502, MOR115-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 258315
Homologene: 105186
Gabbr2
Name: gamma-aminobutyric acid (GABA) B receptor, 2
Synonyms: Gababr2, Gpr51, GB2, LOC242425
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 242425
HGNC: HGNC:4507
Homologene: 55902
Smg9
Name: smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans)
Synonyms: N28092, 1500002O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 71997
Homologene: 10426
Cyp2d12
Name: cytochrome P450, family 2, subfamily d, polypeptide 12
Synonyms: 9030605E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 380997
VEGA: 15
Homologene: 86099
Klhl30
Name: kelch-like 30
Synonyms: 4631423F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 70788
Homologene: 18891
Best3
Name: bestrophin 3
Synonyms: mBest4, Vmd2l3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 382427
VEGA: 10
Homologene: 33850
Pi15
Name: peptidase inhibitor 15
Synonyms: P24TI, P25TI, SugarCrisp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 94227
HGNC: HGNC:8946
Homologene: 22935
Gpr149
Name: G protein-coupled receptor 149
Synonyms: PGR10, Ieda, R35, 9630018L10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229357
Homologene: 16359
Rps4l
Name: ribosomal protein S4-like
Synonyms: Rps4y2, 1110033J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 66184
AC238840.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
Senp5
Name: SUMO/sentrin specific peptidase 5
Synonyms: 6230429P13Rik, A730063F07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 320213
Homologene: 17647
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 17,602,849 bp
  • A to T, chromosome 1 at 91,354,352 bp
  • C to T, chromosome 1 at 128,231,437 bp
  • T to A, chromosome 1 at 169,510,549 bp
  • C to T, chromosome 2 at 27,759,570 bp
  • T to C, chromosome 2 at 85,430,673 bp
  • T to C, chromosome 2 at 90,852,830 bp
  • T to G, chromosome 2 at 118,474,991 bp
  • C to T, chromosome 2 at 120,244,681 bp
  • T to A, chromosome 2 at 130,419,843 bp
  • T to A, chromosome 3 at 62,602,689 bp
  • C to T, chromosome 3 at 158,012,067 bp
  • A to G, chromosome 4 at 46,749,508 bp
  • A to G, chromosome 4 at 63,370,910 bp
  • C to A, chromosome 4 at 86,812,422 bp
  • T to A, chromosome 4 at 88,634,139 bp
  • A to C, chromosome 4 at 100,994,842 bp
  • A to G, chromosome 5 at 30,178,806 bp
  • T to C, chromosome 5 at 31,058,776 bp
  • A to G, chromosome 5 at 34,014,338 bp
  • T to C, chromosome 6 at 123,335,972 bp
  • G to A, chromosome 6 at 125,322,244 bp
  • G to C, chromosome 6 at 134,718,321 bp
  • C to T, chromosome 6 at 148,355,218 bp
  • T to C, chromosome 7 at 18,903,475 bp
  • A to G, chromosome 7 at 24,415,043 bp
  • T to A, chromosome 7 at 29,704,691 bp
  • A to T, chromosome 7 at 30,194,028 bp
  • C to A, chromosome 7 at 38,448,275 bp
  • T to C, chromosome 7 at 101,831,588 bp
  • T to G, chromosome 7 at 126,450,143 bp
  • T to A, chromosome 7 at 126,979,530 bp
  • T to C, chromosome 8 at 24,641,847 bp
  • A to G, chromosome 9 at 55,545,035 bp
  • A to C, chromosome 10 at 30,701,917 bp
  • A to T, chromosome 10 at 75,713,610 bp
  • A to G, chromosome 10 at 89,417,075 bp
  • A to G, chromosome 10 at 117,008,999 bp
  • A to G, chromosome 10 at 129,079,193 bp
  • T to C, chromosome 11 at 95,291,524 bp
  • T to A, chromosome 11 at 107,686,400 bp
  • A to T, chromosome 11 at 110,276,489 bp
  • C to T, chromosome 13 at 54,621,845 bp
  • T to A, chromosome 13 at 105,445,087 bp
  • G to A, chromosome 15 at 58,105,568 bp
  • A to G, chromosome 15 at 76,176,884 bp
  • A to G, chromosome 15 at 82,059,355 bp
  • G to A, chromosome 15 at 82,556,383 bp
  • C to G, chromosome 15 at 89,569,475 bp
  • T to A, chromosome 16 at 31,989,345 bp
  • C to A, chromosome 16 at 32,755,690 bp
  • A to T, chromosome 16 at 78,364,946 bp
  • G to A, chromosome 18 at 20,594,234 bp
  • T to C, chromosome 18 at 20,727,956 bp
  • A to T, chromosome 19 at 38,777,939 bp
  • G to T, chromosome 19 at 43,515,783 bp
  • T to A, chromosome 19 at 56,915,782 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0578 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038768-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.