Strain Name:
C57BL/6J-MtgxR0659Btlr/Mmmh
Stock Number:
038844-MU
Citation ID:
RRID:MMRRC_038844-MU
Other Names:
R0659 (G1), C57BL/6J-MtgxR0659Btlr
Major Collection:

Gene Information

Itpk1
Name: inositol 1,3,4-triphosphate 5/6 kinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217837
HGNC: HGNC:6177
Homologene: 8588
Tnrc6b
Name: trinucleotide repeat containing 6b
Synonyms: A730065C02Rik, D230019K20Rik, 2700090M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 213988
VEGA: 15
Homologene: 66194
Hdac5
Name: histone deacetylase 5
Synonyms: mHDA1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15184
Homologene: 3995
Comp
Name: cartilage oligomeric matrix protein
Synonyms: thrombospondin-5, TSP5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12845
HGNC: HGNC:2227
Homologene: 74
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320528
VEGA: 9
Homologene: 41188
Zranb2
Name: zinc finger, RAN-binding domain containing 2
Synonyms: Znf265, Zis, Zfp265
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 53861
Golga5
Name: golgi autoantigen, golgin subfamily a, 5
Synonyms: Ret-II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 27277
VEGA: 12
HGNC: HGNC:4428
Homologene: 38009
Asxl1
Name: ASXL transcriptional regulator 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228790
Homologene: 9098
Cep78
Name: centrosomal protein 78
Synonyms: 5730599I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 208518
VEGA: 19
Homologene: 11030
Trio
Name: triple functional domain (PTPRF interacting)
Synonyms: 6720464I07Rik, Solo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223435
VEGA: 15
Homologene: 20847
Tasor2
Name: transcription activation suppressor family member 2
Synonyms: BC016423, Fam208b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105203
VEGA: 13
Homologene: 26435
Slitrk5
Name: SLIT and NTRK-like family, member 5
Synonyms: 2610019D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 75409
VEGA: 14
Homologene: 9193
Zfp740
Name: zinc finger protein 740
Synonyms: 1110034O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 68744
Homologene: 129530
Tnfrsf17
Name: tumor necrosis factor receptor superfamily, member 17
Synonyms: BCM, Tnfrsf13, Tnfrsf13a, BCMA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 21935
Homologene: 920
Prune2
Name: prune homolog 2
Synonyms: 6330414G02Rik, A330102H22Rik, A230083H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 353211
VEGA: 19
Homologene: 18939
Chpf
Name: chondroitin polymerizing factor
Synonyms: 1700028N03Rik, D1Bwg1363e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74241
Homologene: 11574
Anxa6
Name: annexin A6
Synonyms: Camb, Anx6, AnxVI, Annexin VI, Cabm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11749
HGNC: HGNC:544
Homologene: 55558
Msh3
Name: mutS homolog 3
Synonyms: D13Em1, Rep-3, Rep3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17686
HGNC: HGNC:7326
Homologene: 1829
Mapk6
Name: mitogen-activated protein kinase 6
Synonyms: Prkm6, ERK3, Prkm4, Erk3, Mapk63, Mapk4, D130053K17Rik, 2610021I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 50772
HGNC: HGNC:6879
Homologene: 55683
Zfhx2
Name: zinc finger homeobox 2
Synonyms: zfh-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239102
Homologene: 52657
Rdh9
Name: retinol dehydrogenase 9
Synonyms: Crad3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103142
Homologene: 129514
Myo7a
Name: myosin VIIA
Synonyms: Myo7, USH1B, nmf371, polka, Hdb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17921
HGNC: HGNC:7606
Homologene: 219
Zfp420
Name: zinc finger protein 420
Synonyms: B230312I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233058
Homologene: 129731
Foxp2
Name: forkhead box P2
Synonyms: 2810043D05Rik, D0Kist7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 114142
Homologene: 134404
Ets1
Name: E26 avian leukemia oncogene 1, 5' domain
Synonyms: Ets-1, Tpl1, p51Ets-1, p42Ets-1, vs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 23871
HGNC: HGNC:3488
Homologene: 3837
Nlrp9a
Name: NLR family, pyrin domain containing 9A
Synonyms: D7Ertd565e, Nalp9a, Nalp-theta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233001
Homologene: 116072
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: ENSMUSG00000044873, OTTMUSG00000020804, Heatr7b1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100040766
Homologene: 85300
Cd109
Name: CD109 antigen
Synonyms: Gov platelet alloantigens, 9930012E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235505
Homologene: 25183
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: DY6, 2310047C17Rik, 1110004P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Grin2a
Name: glutamate receptor, ionotropic, NMDA2A (epsilon 1)
Synonyms: NR2A, NMDAR2A, GluRepsilon1, GluN2A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 14811
HGNC: HGNC:4585
Homologene: 645
Adamts19
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19
Synonyms: D230034E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240322
VEGA: 18
Homologene: 15860
Greb1
Name: gene regulated by estrogen in breast cancer protein
Synonyms: 5730583K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 268527
Homologene: 8780
Mto1
Name: mitochondrial tRNA translation optimization 1
Synonyms: 2310039H01Rik, 5730419A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 68291
Homologene: 5876
Tmem132d
Name: transmembrane protein 132D
Synonyms: C630028F04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243274
Homologene: 71684
Vmn2r74
Name: vomeronasal 2, receptor 74
Synonyms: EG546980
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 546980
Homologene: 115466
Ppef2
Name: protein phosphatase, EF hand calcium-binding domain 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19023
HGNC: HGNC:9244
Homologene: 55959
Hsd17b3
Name: hydroxysteroid (17-beta) dehydrogenase 3
Synonyms: 17(beta)HSD type 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 15487
VEGA: 13
HGNC: HGNC:5212
Homologene: 20089
Apol7c
Name: apolipoprotein L 7c
Synonyms: 2210421G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 108956
VEGA: 15
Homologene: 40940
Cacna2d4
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 4
Synonyms: 5730412N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 319734
Homologene: 26544
Osbpl5
Name: oxysterol binding protein-like 5
Synonyms: Obph1, ORP5, 1110006M06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 79196
Homologene: 98024
Ces4a
Name: carboxylesterase 4A
Synonyms: Ces8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234677
Homologene: 71949
Myo18b
Name: myosin XVIIIb
Synonyms: 4932408L24Rik, 4933411E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74376
Homologene: 53435
Hdac9
Name: histone deacetylase 9
Synonyms: HDRP, Hdac7b, Mitr, D030072B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 79221
Homologene: 128578
Tmem237
Name: transmembrane protein 237
Synonyms: LOC381259, Als2cr4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381259
Homologene: 17570
Slc5a9
Name: solute carrier family 5 (sodium/glucose cotransporter), member 9
Synonyms: SGLT4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230612
Homologene: 17081
Zfp82
Name: zinc finger protein 82
Synonyms: KRAB16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330502
Homologene: 51177
Pik3c2b
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
Synonyms: PI3K-C2beta, C330011J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240752
HGNC: HGNC:8972
Homologene: 20582
Cth
Name: cystathionase (cystathionine gamma-lyase)
Synonyms: 0610010I13Rik, CSE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 107869
HGNC: HGNC:2501
Homologene: 1432
Olfr181
Name: olfactory receptor 181
Synonyms: GA_x54KRFPKG5P-55145984-55145034, MOR184-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 259001
Homologene: 74112
Gm9875
Name: predicted gene 9875
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 105244085
VEGA: 2
Cyp2a12
Name: cytochrome P450, family 2, subfamily a, polypeptide 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13085
Homologene: 69128
Lin28a
Name: lin-28 homolog A (C. elegans)
Synonyms: Lin-28, Tex17, Lin28a, Lin28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 83557
Homologene: 32592
Pih1d1
Name: PIH1 domain containing 1
Synonyms: 4933413A04Rik, 1110061L23Rik, Nop17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68845
Homologene: 9914
Mmp21
Name: matrix metallopeptidase 21
Synonyms: b2b873Clo, b2b2458Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 214766
Homologene: 17519
Olfr970
Name: olfactory receptor 970
Synonyms: GA_x6K02T2PVTD-33517322-33518257, MOR171-16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258604
VEGA: 9
Homologene: 121532
Tmem229b
Name: transmembrane protein 229B
Synonyms: 6330442E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 268567
Homologene: 18700
Sult1c2
Name: sulfotransferase family, cytosolic, 1C, member 2
Synonyms: ST1C1, 1810008N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 69083
Homologene: 38201
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 59,114,094 bp
  • A to G, chromosome 1 at 75,477,723 bp
  • C to A, chromosome 1 at 88,242,420 bp
  • G to A, chromosome 1 at 88,250,342 bp
  • A to G, chromosome 1 at 133,071,200 bp
  • T to G, chromosome 2 at 13,558,184 bp
  • T to A, chromosome 2 at 153,400,724 bp
  • A to G, chromosome 3 at 157,541,763 bp
  • A to G, chromosome 3 at 157,920,115 bp
  • T to A, chromosome 4 at 111,883,871 bp
  • T to C, chromosome 4 at 134,008,099 bp
  • A to G, chromosome 5 at 92,230,509 bp
  • T to C, chromosome 5 at 112,760,327 bp
  • A to G, chromosome 5 at 127,984,287 bp
  • T to C, chromosome 6 at 15,254,279 bp
  • A to G, chromosome 6 at 119,345,106 bp
  • T to C, chromosome 7 at 26,557,278 bp
  • T to C, chromosome 7 at 27,034,138 bp
  • T to A, chromosome 7 at 29,875,539 bp
  • C to T, chromosome 7 at 30,056,329 bp
  • T to A, chromosome 7 at 45,159,975 bp
  • T to C, chromosome 7 at 85,955,914 bp
  • T to C, chromosome 7 at 98,054,338 bp
  • G to A, chromosome 7 at 133,677,667 bp
  • A to G, chromosome 7 at 143,705,030 bp
  • T to C, chromosome 8 at 70,379,101 bp
  • T to C, chromosome 8 at 105,144,922 bp
  • C to T, chromosome 9 at 32,738,293 bp
  • T to G, chromosome 9 at 39,819,816 bp
  • T to A, chromosome 9 at 67,920,935 bp
  • T to C, chromosome 9 at 75,397,962 bp
  • T to A, chromosome 9 at 78,457,508 bp
  • C to T, chromosome 9 at 78,470,790 bp
  • T to C, chromosome 9 at 78,680,170 bp
  • T to C, chromosome 10 at 127,776,575 bp
  • A to G, chromosome 11 at 54,983,347 bp
  • A to T, chromosome 11 at 102,196,024 bp
  • T to C, chromosome 12 at 16,680,212 bp
  • T to C, chromosome 12 at 34,437,222 bp
  • T to C, chromosome 12 at 78,965,134 bp
  • G to T, chromosome 12 at 102,476,208 bp
  • C to T, chromosome 12 at 102,606,078 bp
  • T to C, chromosome 13 at 3,574,448 bp
  • T to C, chromosome 13 at 64,073,936 bp
  • T to C, chromosome 13 at 92,345,096 bp
  • A to G, chromosome 14 at 55,073,801 bp
  • A to G, chromosome 14 at 111,680,689 bp
  • A to G, chromosome 15 at 27,831,399 bp
  • A to G, chromosome 15 at 77,526,273 bp
  • T to A, chromosome 15 at 80,923,446 bp
  • A to G, chromosome 15 at 102,212,659 bp
  • G to T, chromosome 16 at 9,992,472 bp
  • A to T, chromosome 16 at 11,319,819 bp
  • C to A, chromosome 16 at 58,926,409 bp
  • A to T, chromosome 17 at 53,831,778 bp
  • A to G, chromosome 18 at 59,007,493 bp
  • A to G, chromosome 19 at 9,015,002 bp
  • C to T, chromosome 19 at 15,956,190 bp
  • A to T, chromosome 19 at 17,122,835 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0659 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038844-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.