Strain Name:
C57BL/6J-MtgxR0710Btlr/Mmmh
Stock Number:
038893-MU
Citation ID:
RRID:MMRRC_038893-MU
Other Names:
R0710 (G1), C57BL/6J-MtgxR0710Btlr
Major Collection:

Strain Information

Hgf
Name: hepatocyte growth factor
Synonyms: scatter factor, NK1, SF/HGF, NK2, C230052L06Rik, HGF/SF
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15234
HGNC: HGNC:4893
Homologene: 503
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20269
Homologene: 56005
Tnpo3
Name: transportin 3
Synonyms: D6Ertd313e, 5730544L10Rik, C430013M08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320938
Homologene: 40848
Poli
Name: polymerase (DNA directed), iota
Synonyms: Rad30b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 26447
HGNC: HGNC:9182
Homologene: 5209
Fbxl3
Name: F-box and leucine-rich repeat protein 3
Synonyms: Fbxl3a, Play68, Ovtm, Fbl3a
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50789
Homologene: 8127
Mtor
Name: mechanistic target of rapamycin kinase
Synonyms: flat, RAPT1, 2610315D21Rik, RAFT1, Frap1, mechanistic target of rapamycin (serine/threonine kinase), FKBP-rapamycin-associated protein FRAP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56717
HGNC: HGNC:3942
Homologene: 3637
Sinhcaf
Name: SIN3-HDAC complex associated factor
Synonyms: Tera, Pptcs1, Fam60a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56306
Homologene: 10494
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: A130030D10Rik, Zfp650, 4833421P10Rik, 1110059H15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68795
Homologene: 52092
Rasa3
Name: RAS p21 protein activator 3
Synonyms: R-Ras gap, hlb381, Ras GTPase-activating protein III, GAPIII, GAPIII activator 3, scat
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 19414
Homologene: 7217
Ubr2
Name: ubiquitin protein ligase E3 component n-recognin 2
Synonyms: ENSMUSG00000043296, 9930021A08Rik, E130209G04Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224826
VEGA: 17
Homologene: 26151
Hmg20a
Name: high mobility group 20A
Synonyms: 5730490E10Rik, Hmgxb1, 1200004E06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66867
VEGA: 9
HGNC: HGNC:5001
Homologene: 32399
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269700
Homologene: 28297
Gpatch8
Name: G patch domain containing 8
Synonyms: Fbm1, ENSMUSG00000075516, 5430405G24Rik, Gpatc8
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237943
Homologene: 46117
Krt74
Name: keratin 74
Synonyms: Kb37
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 406222
VEGA: 15
Kcnj11
Name: potassium inwardly rectifying channel, subfamily J, member 11
Synonyms: Kir6.2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16514
HGNC: HGNC:6257
Homologene: 441
Iqch
Name: IQ motif containing H
Synonyms: 4921504K03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78250
Homologene: 11258
Celsr2
Name: cadherin, EGF LAG seven-pass G-type receptor 2
Synonyms: EGFL2, mfmi1, Adgrc2, flamingo
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 53883
HGNC: HGNC:3231
Homologene: 1078
Sis
Name: sucrase isomaltase
Synonyms: sucrase-isomaltase, 2010204N08Rik, Si-s
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69983
Homologene: 37424
Plb1
Name: phospholipase B1
Synonyms: 4632413E21Rik, 4930433E17Rik, 4930539A06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 665270
Homologene: 82108
Zfp282
Name: zinc finger protein 282
Synonyms: HUB1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101095
Homologene: 2647
Farp1
Name: FERM, ARH/RhoGEF and pleckstrin domain protein 1
Synonyms: Cdep
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 223254
HGNC: HGNC:3591
Homologene: 38098
Tulp2
Name: TUB like protein 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56734
Homologene: 2492
Wnk4
Name: WNK lysine deficient protein kinase 4
Synonyms: 2010002J11Rik, Prkwnk4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69847
Homologene: 13020
Vmn1r171
Name: vomeronasal 1 receptor 171
Synonyms: V3R7, V1rd7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81012
Homologene: 128341
Glra3
Name: glycine receptor, alpha 3 subunit
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 110304
HGNC: HGNC:4328
Homologene: 142
Kif1c
Name: kinesin family member 1C
Synonyms: N-3 kinsin, B430105J22Rik, D11Bwg1349e, Orch3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16562
HGNC: HGNC:6317
Homologene: 4821
Mypop
Name: Myb-related transcription factor, partner of profilin
Synonyms: P42pop, Myodysa
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232934
Homologene: 17083
Mlc1
Name: megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)
Synonyms: WKL1, Kiaa0027-hp
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 170790
Homologene: 15775
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 2 at 65,469,046 bp
  • T to C, chromosome 2 at 69,952,837 bp
  • T to C, chromosome 3 at 72,952,531 bp
  • A to G, chromosome 3 at 108,412,712 bp
  • T to C, chromosome 4 at 148,464,391 bp
  • C to A, chromosome 5 at 16,566,763 bp
  • T to A, chromosome 5 at 32,328,497 bp
  • G to A, chromosome 5 at 121,336,628 bp
  • T to C, chromosome 6 at 29,586,075 bp
  • C to T, chromosome 6 at 47,880,384 bp
  • A to G, chromosome 6 at 148,933,000 bp
  • A to T, chromosome 7 at 19,000,560 bp
  • C to A, chromosome 7 at 23,633,001 bp
  • T to A, chromosome 7 at 45,520,808 bp
  • T to C, chromosome 7 at 46,099,125 bp
  • C to A, chromosome 8 at 13,583,830 bp
  • C to T, chromosome 8 at 56,125,364 bp
  • G to A, chromosome 9 at 56,474,670 bp
  • A to T, chromosome 9 at 63,525,136 bp
  • A to G, chromosome 11 at 70,726,497 bp
  • G to A, chromosome 11 at 101,274,106 bp
  • A to G, chromosome 11 at 102,481,933 bp
  • G to T, chromosome 14 at 103,089,315 bp
  • C to T, chromosome 14 at 121,237,143 bp
  • G to T, chromosome 15 at 88,977,864 bp
  • T to A, chromosome 15 at 101,761,418 bp
  • G to A, chromosome 17 at 46,938,681 bp
  • A to T, chromosome 18 at 70,522,890 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0710 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038893-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.