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Strain Name:
C57BL/6J-MtgxR0848Btlr/Mmmh
Stock Number:
039027-MU
Citation ID:
RRID:MMRRC_039027-MU
Other Names:
R0848 (G1), C57BL/6J-MtgxR0848Btlr
Major Collection:

Strain Information

Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Ptpra
Name: protein tyrosine phosphatase receptor type A
Synonyms: RPTRalpha, PTPalpha, PTP[a], Ptpa, RPTPalpha
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19262
HGNC: HGNC:9664
Homologene: 20621
Col6a1
Name: collagen, type VI, alpha 1
Synonyms: Col6a-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12833
HGNC: HGNC:2211
Homologene: 1391
Morf4l1
Name: mortality factor 4 like 1
Synonyms: TEG-189, MRG15, MORFRG15, Tex189
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21761
Homologene: 86043
Pcm1
Name: pericentriolar material 1
Synonyms: 9430077F19Rik, 2600002H09Rik, C030044G17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18536
HGNC: HGNC:8727
Homologene: 4518
Chd1
Name: chromodomain helicase DNA binding protein 1
Synonyms: 4930525N21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12648
HGNC: HGNC:1915
Homologene: 68174
Phf3
Name: PHD finger protein 3
Synonyms: 2310061N19Rik, AU020177
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213109
HGNC: HGNC:8921
Homologene: 9040
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 30,863,172 bp
  • G to A, chromosome 1 at 34,462,702 bp
  • T to A, chromosome 1 at 93,019,898 bp
  • T to C, chromosome 1 at 100,255,163 bp
  • A to T, chromosome 1 at 119,549,954 bp
  • T to A, chromosome 2 at 79,927,792 bp
  • A to T, chromosome 2 at 85,430,021 bp
  • T to C, chromosome 2 at 120,695,823 bp
  • T to A, chromosome 2 at 130,518,991 bp
  • G to A, chromosome 2 at 144,253,806 bp
  • G to T, chromosome 2 at 167,106,267 bp
  • A to G, chromosome 3 at 89,995,633 bp
  • A to T, chromosome 3 at 98,619,355 bp
  • A to T, chromosome 3 at 108,414,338 bp
  • A to G, chromosome 4 at 9,282,003 bp
  • A to G, chromosome 4 at 19,818,866 bp
  • A to G, chromosome 4 at 128,616,291 bp
  • A to G, chromosome 4 at 156,223,564 bp
  • A to G, chromosome 5 at 72,667,840 bp
  • A to G, chromosome 5 at 107,419,889 bp
  • A to G, chromosome 5 at 117,990,948 bp
  • C to T, chromosome 6 at 6,863,665 bp
  • A to T, chromosome 6 at 23,114,985 bp
  • T to C, chromosome 6 at 48,723,723 bp
  • G to A, chromosome 6 at 55,318,286 bp
  • A to G, chromosome 6 at 124,508,506 bp
  • T to C, chromosome 7 at 16,237,601 bp
  • G to A, chromosome 7 at 19,057,670 bp
  • G to T, chromosome 7 at 39,536,559 bp
  • A to G, chromosome 7 at 45,157,617 bp
  • T to C, chromosome 7 at 86,615,640 bp
  • C to T, chromosome 7 at 104,261,124 bp
  • A to G, chromosome 7 at 106,914,993 bp
  • C to A, chromosome 7 at 135,701,043 bp
  • T to C, chromosome 8 at 41,282,683 bp
  • A to T, chromosome 8 at 71,506,882 bp
  • T to C, chromosome 8 at 71,545,778 bp
  • T to A, chromosome 9 at 55,655,898 bp
  • A to G, chromosome 9 at 90,100,449 bp
  • A to G, chromosome 10 at 76,713,624 bp
  • A to C, chromosome 10 at 90,071,125 bp
  • C to T, chromosome 10 at 127,553,362 bp
  • C to T, chromosome 10 at 129,755,208 bp
  • T to A, chromosome 11 at 9,682,011 bp
  • C to T, chromosome 11 at 20,072,584 bp
  • G to A, chromosome 11 at 52,011,267 bp
  • T to C, chromosome 11 at 55,498,626 bp
  • G to T, chromosome 11 at 70,615,413 bp
  • C to A, chromosome 11 at 97,060,524 bp
  • A to T, chromosome 11 at 100,204,264 bp
  • A to T, chromosome 11 at 102,155,866 bp
  • T to A, chromosome 11 at 110,028,190 bp
  • A to G, chromosome 11 at 116,295,248 bp
  • A to T, chromosome 12 at 69,741,810 bp
  • AAGAG to AAGAGAGAG, chromosome 12 at 76,097,959 bp
  • AGAGTGAG to AGAGTGAGTGAG, chromosome 12 at 76,097,960 bp
  • G to A, chromosome 13 at 13,634,930 bp
  • A to T, chromosome 13 at 33,899,305 bp
  • T to G, chromosome 13 at 33,972,478 bp
  • A to T, chromosome 13 at 59,533,939 bp
  • T to A, chromosome 14 at 66,309,125 bp
  • C to A, chromosome 15 at 50,661,549 bp
  • T to A, chromosome 15 at 82,790,233 bp
  • A to G, chromosome 15 at 94,540,512 bp
  • C to T, chromosome 16 at 37,062,130 bp
  • C to T, chromosome 17 at 15,770,241 bp
  • T to A, chromosome 17 at 20,890,171 bp
  • T to C, chromosome 17 at 88,694,229 bp
  • G to A, chromosome 18 at 37,267,422 bp
  • T to A, chromosome 18 at 41,935,224 bp
  • T to A, chromosome 18 at 46,608,047 bp
  • C to T, chromosome 19 at 10,183,065 bp
  • G to C, chromosome 19 at 10,218,162 bp
  • A to G, chromosome 19 at 12,804,037 bp
  • A to C, chromosome 19 at 16,698,897 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0848 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039027-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.