Strain Name:
C57BL/6J-MtgxR0948Btlr/Mmmh
Stock Number:
039087-MU
Citation ID:
RRID:MMRRC_039087-MU
Other Names:
R0948 (G1), C57BL/6J-MtgxR0948Btlr
Major Collection:

Gene Information

Sim1
Name: single-minded family bHLH transcription factor 1
Synonyms: bHLHe14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 20464
VEGA: 10
Homologene: 3715
Mga
Name: MAX gene associated
Synonyms: Mad5, Mga, C130042M01Rik, D030062C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 29808
Homologene: 49351
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Strn4
Name: striatin, calmodulin binding protein 4
Synonyms: ZIN, zinedin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 97387
Homologene: 8378
Anxa4
Name: annexin A4
Synonyms: Xanx-4, Anx4, AIV, annexin IV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 11746
HGNC: HGNC:542
Homologene: 68164
Ptpn12
Name: protein tyrosine phosphatase, non-receptor type 12
Synonyms: PTP-P19, P19-PTP, PTP-PEST
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19248
HGNC: HGNC:9645
Homologene: 37691
Wfs1
Name: wolframin ER transmembrane glycoprotein
Synonyms: wolframin, Wolfram syndrome 1 homolog (human)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22393
Homologene: 4380
Dock6
Name: dedicator of cytokinesis 6
Synonyms: 4931431C02Rik, C330023D02Rik, 2410095B20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319899
VEGA: 9
Homologene: 83291
E2f3
Name: E2F transcription factor 3
Synonyms: E2f3a, E2F3b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13557
HGNC: HGNC:3115
Homologene: 74413
Zfp532
Name: zinc finger protein 532
Synonyms: C530030I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 328977
Homologene: 138627
U2surp
Name: U2 snRNP-associated SURP domain containing
Synonyms: 2610101N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67958
Homologene: 13964
Txnl1
Name: thioredoxin-like 1
Synonyms: 32kDa, TRP32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 53382
VEGA: 18
Homologene: 3515
Slc38a1
Name: solute carrier family 38, member 1
Synonyms: NAT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105727
VEGA: 15
Homologene: 12745
Fkbp15
Name: FK506 binding protein 15
Synonyms: FKBP133, C430014M02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 338355
Homologene: 28743
Ifrd1
Name: interferon-related developmental regulator 1
Synonyms: Ifnl, Tis7, PC4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 15982
HGNC: HGNC:5456
Homologene: 31043
Fam129b
Name: family with sequence similarity 129, member B
Synonyms: 9130404D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227737
Homologene: 11269
Dmbt1
Name: deleted in malignant brain tumors 1
Synonyms: MUCLIN, gp300, Crpd, hensin, CRP-[a], ebnerin, vomeroglandin, CRP-[b]
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12945
HGNC: HGNC:2926
Homologene: 68990
Zfp74
Name: zinc finger protein 74
Synonyms: KRAB8, Zfp66, 2810054M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72723
Homologene: 51861
Il31ra
Name: interleukin 31 receptor A
Synonyms: GLM-R, GPL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218624
VEGA: 13
Homologene: 51395
Osbpl10
Name: oxysterol binding protein-like 10
Synonyms: 4933433D06Rik, OPR-10, C820004B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74486
Homologene: 69240
Wnt8b
Name: wingless-type MMTV integration site family, member 8B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 22423
VEGA: 19
Homologene: 2550
Trpc6
Name: transient receptor potential cation channel, subfamily C, member 6
Synonyms: Trrp6, mtrp6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22068
VEGA: 9
Homologene: 37944
Olfr914
Name: olfactory receptor 914
Synonyms: GA_x6K02T2PVTD-32308823-32309773, MOR165-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258782
VEGA: 9
Homologene: 115511
Hsh2d
Name: hematopoietic SH2 domain containing
Synonyms: Hsh2, ALX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 209488
Homologene: 13142
Ccdc175
Name: coiled-coil domain containing 175
Synonyms: 4930403N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 73936
VEGA: 12
Homologene: 79144
Ahrr
Name: aryl-hydrocarbon receptor repressor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 11624
HGNC: HGNC:346
Homologene: 49215
Fer1l6
Name: fer-1-like 6 (C. elegans)
Synonyms: EG631797
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 631797
Homologene: 53396
Ect2l
Name: epithelial cell transforming sequence 2 oncogene-like
Synonyms: C330021H03Rik, Gm10331
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 100045792
Homologene: 46005
Col19a1
Name: collagen, type XIX, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12823
HGNC: HGNC:2196
Homologene: 55608
Vwce
Name: von Willebrand factor C and EGF domains
Synonyms: 1300015B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 71768
VEGA: 19
Homologene: 17651
Igsf10
Name: immunoglobulin superfamily, member 10
Synonyms: 6530405F15Rik, CMF608, Adlican2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242050
Homologene: 18712
Zfp329
Name: zinc finger protein 329
Synonyms: 4632409L22Rik, 2810439M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67230
Homologene: 23459
Sobp
Name: sine oculis binding protein
Synonyms: Jxc1, 5330439J01Rik, 2900009C16Rik, jc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 109205
Homologene: 41216
Nwd2
Name: NACHT and WD repeat domain containing 2
Synonyms: B830017A01Rik, 3110047P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 319807
Homologene: 14974
Vmn2r74
Name: vomeronasal 2, receptor 74
Synonyms: EG546980
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 546980
Homologene: 115466
Gm7647
Name: predicted gene 7647
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 108169099
AC168120.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Doxl2
Name: diamine oxidase-like protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243376
Homologene: 19443
Smpdl3b
Name: sphingomyelin phosphodiesterase, acid-like 3B
Synonyms: 1110054A24Rik, Asml3b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100340
Homologene: 8708
Cyp2a4
Name: cytochrome P450, family 2, subfamily a, polypeptide 4
Synonyms: D7Ucla4, testosterone 15alpha-hydroxylase, Cyp15a1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13086
Homologene: 85917
Abcb1a
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 1A
Synonyms: MDR3, Pgp, Pgy-3, P-glycoprotein, Pgy3, mdr-3, Mdr1a, multiple drug resistant 1a, Evi32, P-gp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18671
HGNC: HGNC:40
Homologene: 55496
Rnase4
Name: ribonuclease, RNase A family 4
Synonyms: C730049F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 58809
VEGA: 14
Homologene: 10576
Hao1
Name: hydroxyacid oxidase 1, liver
Synonyms: Hao-1, GOX, Gox1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 15112
HGNC: HGNC:4809
Homologene: 6578
Mfsd1
Name: major facilitator superfamily domain containing 1
Synonyms: 1200003O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66868
Homologene: 11228
Tacstd2
Name: tumor-associated calcium signal transducer 2
Synonyms: Ly97, GA733-1, EGP-1, TROP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56753
Homologene: 1763
Olfr906
Name: olfactory receptor 906
Synonyms: MOR167-2, GA_x6K02T2PVTD-32194085-32195020
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258799
VEGA: 9
Homologene: 132439
Spns3
Name: spinster homolog 3
Synonyms: 9830002I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 77577
Homologene: 45648
Gm5434
Name: predicted gene 5434
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 432649
VEGA: 12
Pdxk-ps
Name: pyridoxal (pyridoxine, vitamin B6) kinase, pseudogene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 435518
1810009A15Rik
Name: RIKEN cDNA 1810009A15 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66276
Homologene: 84408
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 24,296,801 bp
  • A to G, chromosome 2 at 32,922,860 bp
  • T to A, chromosome 2 at 119,941,659 bp
  • A to C, chromosome 2 at 134,530,773 bp
  • A to G, chromosome 3 at 59,331,104 bp
  • A to G, chromosome 3 at 67,596,734 bp
  • A to C, chromosome 3 at 75,450,851 bp
  • A to G, chromosome 4 at 62,306,883 bp
  • T to C, chromosome 4 at 132,745,200 bp
  • T to A, chromosome 5 at 8,740,621 bp
  • T to C, chromosome 5 at 20,998,043 bp
  • T to C, chromosome 5 at 36,967,561 bp
  • T to C, chromosome 5 at 63,807,312 bp
  • T to C, chromosome 5 at 94,962,980 bp
  • A to G, chromosome 6 at 48,976,344 bp
  • T to A, chromosome 6 at 67,535,118 bp
  • T to A, chromosome 6 at 86,741,931 bp
  • T to A, chromosome 7 at 12,811,468 bp
  • T to A, chromosome 7 at 16,837,713 bp
  • A to G, chromosome 7 at 26,310,788 bp
  • A to G, chromosome 7 at 29,935,937 bp
  • T to C, chromosome 7 at 85,958,023 bp
  • T to C, chromosome 7 at 131,093,117 bp
  • G to A, chromosome 8 at 72,200,460 bp
  • A to G, chromosome 9 at 8,610,415 bp
  • A to T, chromosome 9 at 21,801,533 bp
  • T to G, chromosome 9 at 38,488,948 bp
  • G to A, chromosome 9 at 38,606,491 bp
  • A to T, chromosome 9 at 53,495,958 bp
  • A to G, chromosome 9 at 95,461,497 bp
  • T to A, chromosome 9 at 115,167,119 bp
  • A to T, chromosome 10 at 18,140,586 bp
  • A to T, chromosome 10 at 43,022,209 bp
  • C to A, chromosome 10 at 50,981,327 bp
  • A to T, chromosome 11 at 72,545,940 bp
  • A to T, chromosome 12 at 36,090,935 bp
  • A to T, chromosome 12 at 40,216,180 bp
  • A to G, chromosome 12 at 72,131,123 bp
  • C to T, chromosome 13 at 29,985,533 bp
  • T to C, chromosome 13 at 74,213,769 bp
  • A to G, chromosome 13 at 112,530,378 bp
  • G to T, chromosome 14 at 51,104,905 bp
  • A to G, chromosome 15 at 58,564,075 bp
  • C to A, chromosome 15 at 76,205,687 bp
  • A to G, chromosome 15 at 96,590,527 bp
  • C to T, chromosome 17 at 32,082,624 bp
  • G to T, chromosome 18 at 63,692,120 bp
  • C to A, chromosome 18 at 65,623,818 bp
  • C to T, chromosome 19 at 8,890,026 bp
  • A to G, chromosome 19 at 10,653,077 bp
  • A to C, chromosome 19 at 44,510,529 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0948 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039087-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.