Strain Name:
C57BL/6J-MtgxR1028Btlr/Mmmh
Stock Number:
039130-MU
Citation ID:
RRID:MMRRC_039130-MU
Other Names:
R1028 (G1), C57BL/6J-MtgxR1028Btlr
Major Collection:

Gene Information

Kat2b
Name: K(lysine) acetyltransferase 2B
Synonyms: A930006P13Rik, Pcaf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18519
HGNC: HGNC:8638
Homologene: 20834
Fuz
Name: fuzzy planar cell polarity protein
Synonyms: 2600013E07Rik, b2b1273Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70300
Homologene: 11840
Mtor
Name: mechanistic target of rapamycin kinase
Synonyms: FKBP-rapamycin-associated protein FRAP, 2610315D21Rik, RAPT1, RAFT1, flat, Frap1, mechanistic target of rapamycin (serine/threonine kinase)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56717
HGNC: HGNC:3942
Homologene: 3637
Net1
Name: neuroepithelial cell transforming gene 1
Synonyms: mNET1, Net1 homolog, 9530071N24Rik, 0610025H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56349
VEGA: 13
Homologene: 4283
Gprin3
Name: GPRIN family member 3
Synonyms: C030038J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243385
Homologene: 52334
Ak7
Name: adenylate kinase 7
Synonyms: 4930502N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 78801
VEGA: 12
Homologene: 14268
Cdh19
Name: cadherin 19, type 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227485
HGNC: HGNC:1758
Homologene: 23286
Rabgef1
Name: RAB guanine nucleotide exchange factor (GEF) 1
Synonyms: Ras negative regulator Rabex-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56715
Homologene: 8720
Rufy1
Name: RUN and FYVE domain containing 1
Synonyms: Rabip4, 3000002E04Rik, ZFYVE12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216724
Homologene: 23522
Itpr3
Name: inositol 1,4,5-triphosphate receptor 3
Synonyms: Itpr-3, Ip3r3, tf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16440
HGNC: HGNC:6182
Homologene: 1675
Colec12
Name: collectin sub-family member 12
Synonyms: SRCL, CL-P1, Scara4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 140792
VEGA: 18
Homologene: 34248
Entpd3
Name: ectonucleoside triphosphate diphosphohydrolase 3
Synonyms: NTPDase-3, HB6, Cd39l3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 215446
HGNC: HGNC:3365
Homologene: 68171
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Myh13
Name: myosin, heavy polypeptide 13, skeletal muscle
Synonyms: extraocular myosin, EO Myosin, MyHC-eo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 544791
HGNC: HGNC:7571
Homologene: 55780
Sh3rf1
Name: SH3 domain containing ring finger 1
Synonyms: Posh, 2200003J05Rik, Sh3md2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 59009
Homologene: 10988
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: ENSMUSG00000044873, OTTMUSG00000020804, Heatr7b1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100040766
Homologene: 85300
Vwa8
Name: von Willebrand factor A domain containing 8
Synonyms: 4932416F07Rik, 1300010F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219189
VEGA: 14
Homologene: 44881
Dpp6
Name: dipeptidylpeptidase 6
Synonyms: Dpp-6, Peplb, In(5)6H-p, Rw, LOC384168, B930011P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13483
HGNC: HGNC:3010
Homologene: 22560
Bpifb9a
Name: BPI fold containing family B, member 9A
Synonyms: vomeromodulin, 4833413D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71425
Homologene: 128535
Cmah
Name: cytidine monophospho-N-acetylneuraminic acid hydroxylase
Synonyms: CMP-NeuAc hydroxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 12763
HGNC: HGNC:2098
Homologene: 7269
Itga10
Name: integrin, alpha 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 213119
HGNC: HGNC:6135
Homologene: 2697
Sec16b
Name: SEC16 homolog B (S. cerevisiae)
Synonyms: Rgpr-p117, Rgpr, Lztr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 89867
Homologene: 13227
Dixdc1
Name: DIX domain containing 1
Synonyms: 4930563F16Rik, Ccd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 330938
Homologene: 82369
Ano8
Name: anoctamin 8
Synonyms: Tmem16h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 382014
Homologene: 124473
Or4k47
Name: olfactory receptor family 4 subfamily K member 47
Synonyms: GA_x6K02T2Q125-72673494-72672556, MOR248-4, Olfr1297
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258890
Homologene: 115545
B3galt4
Name: UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
Synonyms: Gal-T2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 54218
HGNC: HGNC:919
Homologene: 2805
Nlrp4e
Name: NLR family, pyrin domain containing 4E
Synonyms: Nalp-epsilon, Nalp4e, 4930406H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 446099
Homologene: 75315
Ovch2
Name: ovochymase 2
Synonyms: 9230106D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244199
Homologene: 18255
Zp1
Name: zona pellucida glycoprotein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 22786
Homologene: 33483
Or9i16
Name: olfactory receptor family 9 subfamily I member 16
Synonyms: GA_x6K02T2RE5P-4223635-4222688, MOR212-2, Olfr1504
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258627
Homologene: 45020
Phf1
Name: PHD finger protein 1
Synonyms: Tctex-3, D17Ertd455e, PHF2, Tctex3, mPcl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 21652
VEGA: 17
HGNC: HGNC:8919
Homologene: 7567
Or2y15
Name: olfactory receptor family 2 subfamily Y member 15
Synonyms: GA_x6K02T2QP88-5975166-5974231, MOR256-22, Olfr1387
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258465
Homologene: 74034
Prxl2c
Name: peroxiredoxin like 2C
Synonyms: 1110018J18Rik, Aaed1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66129
VEGA: 13
Homologene: 7192
Slc26a8
Name: solute carrier family 26, member 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224661
Homologene: 27095
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 20,117,726 bp
  • G to A, chromosome 1 at 88,235,376 bp
  • T to C, chromosome 1 at 110,954,584 bp
  • T to C, chromosome 1 at 157,560,917 bp
  • A to T, chromosome 2 at 111,621,525 bp
  • G to C, chromosome 2 at 154,262,407 bp
  • C to T, chromosome 3 at 96,651,738 bp
  • G to C, chromosome 4 at 148,538,830 bp
  • A to G, chromosome 5 at 27,666,427 bp
  • T to G, chromosome 5 at 130,212,862 bp
  • T to C, chromosome 6 at 59,354,609 bp
  • T to C, chromosome 7 at 23,321,744 bp
  • T to C, chromosome 7 at 44,896,926 bp
  • T to C, chromosome 7 at 107,796,548 bp
  • A to G, chromosome 8 at 61,393,787 bp
  • GCCTCCTCCTCCTCCTC to GCCTCCTCCTCCTC, chromosome 8 at 71,480,971 bp
  • C to T, chromosome 9 at 50,703,246 bp
  • A to G, chromosome 9 at 120,558,361 bp
  • G to A, chromosome 11 at 49,460,220 bp
  • A to T, chromosome 11 at 50,414,598 bp
  • T to C, chromosome 11 at 67,356,181 bp
  • AGAGGAGGAGGAGGAGGAGGA to AGAGGAGGAGGAGGAGGA, chromosome 12 at 105,710,189 bp
  • A to T, chromosome 13 at 3,884,375 bp
  • A to G, chromosome 13 at 24,435,662 bp
  • A to T, chromosome 13 at 64,309,154 bp
  • C to T, chromosome 14 at 78,908,230 bp
  • A to G, chromosome 17 at 26,934,333 bp
  • G to T, chromosome 17 at 27,091,369 bp
  • A to G, chromosome 17 at 28,672,798 bp
  • G to A, chromosome 17 at 33,950,839 bp
  • A to G, chromosome 17 at 53,629,423 bp
  • T to C, chromosome 18 at 9,866,837 bp
  • G to A, chromosome 19 at 10,918,911 bp
  • C to A, chromosome 19 at 13,887,795 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1028 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039130-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.