Beutler Mutagenetix

Strain Name:
C57BL/6J-MtgxR1054Btlr/Mmmh
Stock Number:
039144-MU
Citation ID:
RRID:MMRRC_039144-MU
Other Names:
R1054 (G1), C57BL/6J-MtgxR1054Btlr
Major Collection:

Gene Information

Npc2
Name: NPC intracellular cholesterol transporter 2
Synonyms: 2700012J19Rik, HE1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 67963
VEGA: 12
Homologene: 4697
Fn1
Name: fibronectin 1
Synonyms: Fn-1, Fn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 14268
HGNC: HGNC:3778
Homologene: 1533
Col3a1
Name: collagen, type III, alpha 1
Synonyms: Tsk-2, Tsk2, Col3a-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12825
HGNC: HGNC:2201
Homologene: 55433
Arhgap39
Name: Rho GTPase activating protein 39
Synonyms: D15Wsu169e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223666
Homologene: 27825
Timmdc1
Name: translocase of inner mitochondrial membrane domain containing 1
Synonyms: 4930455C21Rik, 2810021C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 76916
HGNC: HGNC:1321
Homologene: 9578
Pdzd2
Name: PDZ domain containing 2
Synonyms: A930022H17Rik, Pdzk3, Gm21706, 4930537L06Rik, LOC223364
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 68070
Homologene: 23393
Cdc42bpb
Name: CDC42 binding protein kinase beta
Synonyms: DMPK-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217866
VEGA: 12
HGNC: HGNC:1738
Homologene: 55945
Pop1
Name: processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)
Synonyms: 4932434G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 67724
Homologene: 41000
Med25
Name: mediator complex subunit 25
Synonyms: ESTM2, 2610529E18Rik, 2610034E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 75613
Homologene: 12614
Txnrd3
Name: thioredoxin reductase 3
Synonyms: Tgr, TR2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232223
Homologene: 60033
Cramp1l
Name: cramped chromatin regulator homolog 1
Synonyms: Tce4, 5830477H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 57354
VEGA: 17
Homologene: 35373
Wipf2
Name: WAS/WASL interacting protein family, member 2
Synonyms: 5730509C05Rik, 1110014J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 68524
Homologene: 15777
Gnat1
Name: guanine nucleotide binding protein, alpha transducing 1
Synonyms: Ird2, Gnat-1, irdr, Ird1, transducin, Tralpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 14685
HGNC: HGNC:4393
Homologene: 20084
Lepr
Name: leptin receptor
Synonyms: Leprb, LEPROT, Modb1, OB-RGRP, leptin receptor gene-related protein, obl, obese-like, Obr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 16847
HGNC: HGNC:6554
Homologene: 1731
Dhx32
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 32
Synonyms: Ddx32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 101437
Homologene: 56798
Ptprm
Name: protein tyrosine phosphatase, receptor type, M
Synonyms: RPTPmu
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 19274
VEGA: 17
HGNC: HGNC:9675
Homologene: 37694
Gtf2f2
Name: general transcription factor IIF, polypeptide 2
Synonyms: 1110031C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 68705
VEGA: 14
HGNC: HGNC:4653
Homologene: 37884
Taf4b
Name: TATA-box binding protein associated factor 4b
Synonyms: 105kDa, 2610524B04Rik, TAFII105, Taf2c2, 4932409F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 72504
VEGA: 18
Homologene: 28266
Dna2
Name: DNA replication helicase/nuclease 2
Synonyms: Dna2l, E130315B21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 327762
HGNC: HGNC:2939
Homologene: 6124
Med12l
Name: mediator complex subunit 12-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 329650
Homologene: 43143
Cfap70
Name: cilia and flagella associated protein 70
Synonyms: 5330402L21Rik, Ttc18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 76670
Homologene: 17048
Col28a1
Name: collagen, type XXVIII, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 213945
Homologene: 66345
Olfr648
Name: olfactory receptor 648
Synonyms: GA_x6K02T2PBJ9-6914780-6913830, MOR31-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258746
Homologene: 82999
Myo1g
Name: myosin IG
Synonyms: E430002D17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 246177
Homologene: 27996
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 4632412F08Rik, 5330435L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237979
Homologene: 10406
Dusp8
Name: dual specificity phosphatase 8
Synonyms: Nttp1, 5530400B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 18218
HGNC: HGNC:3074
Homologene: 31239
Ccdc175
Name: coiled-coil domain containing 175
Synonyms: 4930403N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 73936
VEGA: 12
Homologene: 79144
Eif3f
Name: eukaryotic translation initiation factor 3, subunit F
Synonyms: Eif3s5, 0610037M02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 66085
HGNC: HGNC:3275
Homologene: 2783
Elmod1
Name: ELMO/CED-12 domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 270162
VEGA: 9
Homologene: 10280
Gm4934
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
Zfp282
Name: zinc finger protein 282
Synonyms: HUB1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 101095
Homologene: 2647
Vwf
Name: Von Willebrand factor
Synonyms: B130011O06Rik, 6820430P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 22371
Homologene: 466
Sdr16c6
Name: short chain dehydrogenase/reductase family 16C, member 6
Synonyms: 4833413O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 242286
Homologene: 135698
Arhgef38
Name: Rho guanine nucleotide exchange factor (GEF) 38
Synonyms: 9130221D24Rik, D630013G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 77669
Homologene: 137396
Pou3f2
Name: POU domain, class 3, transcription factor 2
Synonyms: Otf7, Brn-2, 9430075J19Rik, A230098E07Rik, Brn2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 18992
HGNC: HGNC:9215
Homologene: 4095
Mup5
Name: major urinary protein 5
Synonyms: Mup V
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 17844
HGNC: null
Homologene: 74304
Olfr414
Name: olfactory receptor 414
Synonyms: MOR103-10, GA_x6K02T2P20D-20749615-20748662
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 258756
Homologene: 17383
Tmbim7
Name: transmembrane BAX inhibitor motif containing 7
Synonyms: 4930511M11Rik, 4930500J03Rik, Lfg5, Tmbim1b, 4930403J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 75010
Homologene: 81927
Qrsl1
Name: glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
Synonyms: GatA, 2700038P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 76563
Homologene: 6699
Kcnh8
Name: potassium voltage-gated channel, subfamily H (eag-related), member 8
Synonyms: C130090D05Rik, Kv12.1, ELK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 211468
Homologene: 14332
Cdh15
Name: cadherin 15
Synonyms: Mcad, Cdh14, M cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 12555
HGNC: HGNC:1754
Homologene: 3622
Gm8765
Name: predicted gene 8765
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 667693
HGNC: null
Homologene: 134512
Otulinl
Name: OTU deubiquitinase with linear linkage specificity like
Synonyms: Fam105a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223433
VEGA: 15
Homologene: 41302
Dsc1
Name: desmocollin 1
Synonyms: Dsc1a, Dsc1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 13505
VEGA: 18
HGNC: HGNC:3035
Homologene: 22761
Tmem74b
Name: transmembrane protein 74B
Synonyms: 5430405G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 108832
Homologene: 10148
Cpne4
Name: copine IV
Synonyms: 3632411M23Rik, 4933406O10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 74020
HGNC: HGNC:2317
Homologene: 26078
Vmn1r200
Name: vomeronasal 1 receptor 200
Synonyms: V1rh3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 171246
HGNC: null
Homologene: 110880
Hacd4
Name: 3-hydroxyacyl-CoA dehydratase 4
Synonyms: Ptplad2, 4933428I03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 66775
Homologene: 12033
Gm12800
Name: predicted gene 12800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 381535
HGNC: null
Homologene: null
Gm17661
Name: predicted gene, 17661
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: null
VEGA: null
HGNC: null
Homologene: null
Arv1
Name: ARV1 homolog, fatty acid homeostasis modulator
Synonyms: 1110067L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 68865
Homologene: 41498
Rpl13-ps3
Name: ribosomal protein L13, pseudogene 3
Synonyms: Gm9026
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 668182
VEGA: 14
HGNC: null
Homologene: null
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 45,311,843 bp
  • A to G, chromosome 1 at 71,586,214 bp
  • A to G, chromosome 1 at 174,430,853 bp
  • GA to GAA, chromosome 2 at 90,917,709 bp
  • C to T, chromosome 2 at 151,706,419 bp
  • C to T, chromosome 3 at 59,248,651 bp
  • T to C, chromosome 3 at 133,116,465 bp
  • A to G, chromosome 4 at 4,069,908 bp
  • A to G, chromosome 4 at 22,487,536 bp
  • A to T, chromosome 4 at 61,832,634 bp
  • A to T, chromosome 4 at 88,423,027 bp
  • T to C, chromosome 4 at 101,782,596 bp
  • A to G, chromosome 4 at 101,909,164 bp
  • A to T, chromosome 5 at 3,664,343 bp
  • C to T, chromosome 6 at 8,175,534 bp
  • T to A, chromosome 6 at 47,904,599 bp
  • T to A, chromosome 6 at 89,650,561 bp
  • G to A, chromosome 6 at 125,590,227 bp
  • C to T, chromosome 7 at 44,880,380 bp
  • A to G, chromosome 7 at 104,180,291 bp
  • G to A, chromosome 7 at 108,937,817 bp
  • T to A, chromosome 7 at 133,725,272 bp
  • ACTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGC to ACTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGC, chromosome 7 at 142,082,067 bp
  • T to C, chromosome 8 at 122,864,337 bp
  • T to A, chromosome 8 at 124,731,872 bp
  • T to C, chromosome 9 at 53,912,774 bp
  • A to G, chromosome 9 at 105,022,401 bp
  • A to G, chromosome 9 at 107,677,439 bp
  • C to T, chromosome 10 at 43,882,081 bp
  • T to A, chromosome 10 at 62,963,823 bp
  • A to G, chromosome 11 at 6,518,987 bp
  • G to A, chromosome 11 at 98,896,315 bp
  • C to T, chromosome 11 at 113,838,646 bp
  • A to G, chromosome 12 at 72,178,544 bp
  • A to G, chromosome 12 at 84,760,718 bp
  • A to T, chromosome 12 at 111,313,353 bp
  • T to A, chromosome 13 at 22,395,454 bp
  • T to C, chromosome 13 at 50,702,396 bp
  • C to A, chromosome 13 at 59,717,518 bp
  • G to A, chromosome 14 at 20,439,654 bp
  • C to A, chromosome 14 at 58,893,945 bp
  • T to C, chromosome 14 at 75,995,445 bp
  • A to G, chromosome 15 at 12,371,639 bp
  • T to C, chromosome 15 at 27,664,549 bp
  • T to C, chromosome 15 at 34,509,809 bp
  • T to C, chromosome 15 at 76,751,559 bp
  • A to G, chromosome 16 at 38,522,428 bp
  • T to A, chromosome 17 at 24,983,177 bp
  • A to G, chromosome 17 at 52,803,484 bp
  • A to T, chromosome 17 at 67,042,318 bp
  • T to A, chromosome 18 at 14,821,473 bp
  • G to A, chromosome 18 at 20,086,635 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1054 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039144-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.