Strain Name:
C57BL/6J-MtgxR1077Btlr/Mmmh
Stock Number:
039163-MU
Citation ID:
RRID:MMRRC_039163-MU
Other Names:
R1077 (G1), C57BL/6J-MtgxR1077Btlr
Major Collection:

Gene Information

Sbf2
Name: SET binding factor 2
Synonyms: SBF2, mMTMH1, B430219L04Rik, 4833411B01Rik, Mtmr13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 319934
HGNC: HGNC:2135
Homologene: 41810
Tfap2b
Name: transcription factor AP-2 beta
Synonyms: Tcfap2b, E130018K07Rik, AP-2(beta)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 21419
Homologene: 20688
Fis1
Name: fission, mitochondrial 1
Synonyms: Ttc11, 2010003O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 66437
Homologene: 41099
Prkci
Name: protein kinase C, iota
Synonyms: 2310021H13Rik, Pkcl, Pkci, aPKClambda, PKClambda, Prkcl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 18759
HGNC: HGNC:9404
Homologene: 37667
Wac
Name: WW domain containing adaptor with coiled-coil
Synonyms: Wwp4, 1110067P07Rik, A230035H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225131
Homologene: 41148
Nedd4l
Name: neural precursor cell expressed, developmentally down-regulated gene 4-like
Synonyms: 1300012C07Rik, Nedd4b, Nedd4-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 83814
VEGA: 18
HGNC: HGNC:7728
Homologene: 86986
Smpd4
Name: sphingomyelin phosphodiesterase 4
Synonyms: neutral membrane (neutral sphingomyelinase-3), 4122402O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 77626
Homologene: 9813
Wdr33
Name: WD repeat domain 33
Synonyms: 8430413N20Rik, 2810021O11Rik, 1110001N06Rik, 2310011G05Rik, WDC146
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 74320
VEGA: 18
Homologene: 56807
Rttn
Name: rotatin
Synonyms: C530033I08Rik, 4921538A15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 246102
VEGA: 18
Homologene: 65275
Ric8b
Name: RIC8 guanine nucleotide exchange factor B
Synonyms: Ric-8b, Ric-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 237422
VEGA: 10
Homologene: 23080
Ttk
Name: Ttk protein kinase
Synonyms: Mps1, Esk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 22137
Homologene: 2489
Krt33a
Name: keratin 33A
Synonyms: 2310015J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 71888
Homologene: 74433
Apob
Name: apolipoprotein B
Synonyms: apob-100, apob-48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Cdc25c
Name: cell division cycle 25C
Synonyms: Cdc25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 12532
VEGA: 18
HGNC: HGNC:1727
Homologene: 1356
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: 2900010L19Rik, mSorLA, Sorla, LR11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 20660
Homologene: 2336
Grk6
Name: G protein-coupled receptor kinase 6
Synonyms: Gprk6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 26385
VEGA: 13
HGNC: HGNC:4545
Homologene: 37570
Wdcp
Name: WD repeat and coiled coil containing
Synonyms: BC068281
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238037
VEGA: 12
Homologene: 49822
Atp8b1
Name: ATPase, class I, type 8B, member 1
Synonyms: FIC1, Ic
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 54670
VEGA: 18
HGNC: HGNC:3706
Homologene: 21151
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: D12Ertd777e, nesprin-2, syne-2, dice, Nesp2g, Cpfl8, diminished cone electroretinogram, 6820443O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 319565
Homologene: 56700
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 4632412F08Rik, 5330435L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237979
Homologene: 10406
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 672511
Homologene: 45439
Lrrc7
Name: leucine rich repeat containing 7
Synonyms: densin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 242274
Homologene: 10817
Il23r
Name: interleukin 23 receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 209590
Homologene: 16930
Vmn2r26
Name: vomeronasal 2, receptor 26
Synonyms: V2r1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 56552
Homologene: 135915
Kcnh4
Name: potassium voltage-gated channel, subfamily H (eag-related), member 4
Synonyms: BEC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 380728
HGNC: HGNC:6253
Homologene: 8180
Cntln
Name: centlein, centrosomal protein
Synonyms: D530005L17Rik, B430108F07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 338349
Homologene: 9805
Naalad2
Name: N-acetylated alpha-linked acidic dipeptidase 2
Synonyms: NAADALASE2, NAALADASE2, Folh1b, GCP3, D9Ertd285e, GCPIII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 72560
Homologene: 3294
4921528I07Rik
Name: RIKEN cDNA 4921528I07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 77049
VEGA: 9
Homologene: 132183
Kdr
Name: kinase insert domain protein receptor
Synonyms: Flk1, Flk-1, VEGFR-2, VEGF receptor-2, vascular endothelial growth factor receptor- 2, VEGFR2, orv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 16542
HGNC: HGNC:6307
Homologene: 55639
Tex14
Name: testis expressed gene 14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 83560
Homologene: 12838
Ceacam15
Name: carcinoembryonic antigen-related cell adhesion molecule 15
Synonyms: C430002N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 101434
Homologene: 131210
Fsd1
Name: fibronectin type 3 and SPRY domain-containing protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 240121
VEGA: 17
Homologene: 11531
Slc6a21
Name: solute carrier family 6 member 21
Synonyms: 1700039E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 76713
Homologene: 66347
Dhx34
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 34
Synonyms: 1810012L18Rik, Ddx34, 1200013B07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 71723
Homologene: 69171
Psg18
Name: pregnancy specific glycoprotein 18
Synonyms: Cea3, mmCGM6, Cea-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 26438
Homologene: 110989
Slc26a3
Name: solute carrier family 26, member 3
Synonyms: 9030623B18Rik, Dra, 9130013M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 13487
HGNC: HGNC:3018
Homologene: 55435
Tex44
Name: testis expressed 44
Synonyms: 1700019O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 71863
Homologene: 51874
Pramel7
Name: preferentially expressed antigen in melanoma like 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 347712
Homologene: 87261
Defa41
Name: defensin, alpha, 41
Synonyms: Gm15293
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 100041759
Homologene: 113382
Slc17a1
Name: solute carrier family 17 (sodium phosphate), member 1
Synonyms: NAPI-1, Npt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 20504
Homologene: 48324
Sfta2
Name: surfactant associated 2
Synonyms: EG433102
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 433102
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 19,234,149 bp
  • A to G, chromosome 1 at 86,427,055 bp
  • A to G, chromosome 2 at 87,491,190 bp
  • A to G, chromosome 3 at 31,050,192 bp
  • T to G, chromosome 3 at 158,161,143 bp
  • T to C, chromosome 4 at 84,996,479 bp
  • T to C, chromosome 5 at 75,956,231 bp
  • G to A, chromosome 5 at 136,965,146 bp
  • A to T, chromosome 6 at 67,473,810 bp
  • G to A, chromosome 6 at 124,053,913 bp
  • A to G, chromosome 7 at 16,218,368 bp
  • T to C, chromosome 7 at 16,672,075 bp
  • G to A, chromosome 7 at 18,351,075 bp
  • G to A, chromosome 7 at 45,288,202 bp
  • A to T, chromosome 7 at 110,367,172 bp
  • T to A, chromosome 8 at 21,202,433 bp
  • C to T, chromosome 9 at 18,347,506 bp
  • T to C, chromosome 9 at 42,014,490 bp
  • T to A, chromosome 9 at 83,844,149 bp
  • T to C, chromosome 9 at 114,301,702 bp
  • T to A, chromosome 10 at 84,970,717 bp
  • T to C, chromosome 11 at 87,519,745 bp
  • T to A, chromosome 11 at 100,015,937 bp
  • C to T, chromosome 11 at 100,752,338 bp
  • C to T, chromosome 11 at 113,838,646 bp
  • T to C, chromosome 11 at 119,485,998 bp
  • T to A, chromosome 12 at 4,850,685 bp
  • A to G, chromosome 12 at 8,006,017 bp
  • G to A, chromosome 12 at 31,447,769 bp
  • A to G, chromosome 12 at 76,042,035 bp
  • T to A, chromosome 13 at 23,878,450 bp
  • T to C, chromosome 13 at 55,454,527 bp
  • T to C, chromosome 16 at 17,623,969 bp
  • T to C, chromosome 17 at 35,650,127 bp
  • T to C, chromosome 17 at 55,990,542 bp
  • A to G, chromosome 18 at 7,921,916 bp
  • A to G, chromosome 18 at 31,835,461 bp
  • A to T, chromosome 18 at 34,748,973 bp
  • A to T, chromosome 18 at 64,573,262 bp
  • A to T, chromosome 18 at 65,167,499 bp
  • T to C, chromosome 18 at 89,064,249 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1077 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039163-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.