Strain Name:
C57BL/6J-MtgxR1083Btlr/Mmmh
Stock Number:
039169-MU
Citation ID:
RRID:MMRRC_039169-MU
Other Names:
R1083 (G1), C57BL/6J-MtgxR1083Btlr
Major Collection:

Gene Information

Pitx2
Name: paired-like homeodomain transcription factor 2
Synonyms: Munc30, solurshin, Rieg, Brx1, Brx1a, Brx1b, Pitx2a, Pitx2b, Pitx2c, Otlx2, Ptx2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18741
HGNC: HGNC:9005
Homologene: 55454
Arhgap10
Name: Rho GTPase activating protein 10
Synonyms: A930033B01Rik, PSGAP-s, PSGAP-m
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 78514
Homologene: 12695
Rnf10
Name: ring finger protein 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 50849
Homologene: 40990
Yes1
Name: YES proto-oncogene 1, Src family tyrosine kinase
Synonyms: Yes
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22612
Homologene: 55900
Sf3b1
Name: splicing factor 3b, subunit 1
Synonyms: 2810001M05Rik, Prp10, Targ4, SF3b155, SAP155
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 81898
Homologene: 6696
Sulf1
Name: sulfatase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240725
Homologene: 49408
Zfp292
Name: zinc finger protein 292
Synonyms: 5730450D02Rik, Zn-16, Zn-15, Zfp-15, Krox-10, Zfp15, 9430062L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 30046
Homologene: 8493
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: opt, Pcp1, InsP3R type I, wblo, P400, Ip3r, Pcp-1, Itpr-1, IP3R1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Pparg
Name: peroxisome proliferator activated receptor gamma
Synonyms: Nr1c3, PPARgamma2, PPARgamma, Ppar-gamma2, PPAR-gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19016
HGNC: HGNC:9236
Homologene: 7899
Lamb2
Name: laminin, beta 2
Synonyms: Lams, Lamb-2, npht
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 16779
HGNC: HGNC:6487
Homologene: 1723
Wasf3
Name: WAS protein family, member 3
Synonyms: Wave3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 245880
Homologene: 68527
Jag1
Name: jagged 1
Synonyms: Ozz, Htu, Gsfabe2, Serrate-1, Headturner, ABE2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16449
HGNC: HGNC:6188
Homologene: 180
Srrm3
Name: serine/arginine repetitive matrix 3
Synonyms: SRm300-like, 2900083I11Rik, Srrm2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 58212
Homologene: 136723
Slx4
Name: SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
Synonyms: D16Bwg1016e, Btbd12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 52864
Homologene: 23770
Sfmbt1
Name: Scm-like with four mbt domains 1
Synonyms: 4930442N21Rik, Smr, 9330180L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 54650
Homologene: 9472
Atp11b
Name: ATPase, class VI, type 11B
Synonyms: 1110019I14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76295
Homologene: 32919
Cfap65
Name: cilia and flagella associated protein 65
Synonyms: B230363K08Rik, Ccdc108
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241116
Homologene: 28093
Fbxo2
Name: F-box protein 2
Synonyms: FBX2, NFB42, Fbs1, Prpl4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230904
Homologene: 8132
Sspo
Name: SCO-spondin
Synonyms: Scospondin, C79529
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243369
Homologene: 45453
Zfp541
Name: zinc finger protein 541
Synonyms: EG666528
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 666528
Homologene: 12991
Pcnx2
Name: pecanex homolog 2
Synonyms: E330039K12Rik, Pcnxl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
Cdh2
Name: cadherin 2
Synonyms: N-CAD, N-cadherin, Ncad
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12558
HGNC: HGNC:1759
Homologene: 20424
Dixdc1
Name: DIX domain containing 1
Synonyms: 4930563F16Rik, Ccd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 330938
Homologene: 82369
Dut
Name: deoxyuridine triphosphatase
Synonyms: 5031412I06Rik, D2Bwg0749e, Dutp, 5133400F09Rik, dUTPase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 110074
HGNC: HGNC:3078
Homologene: 31475
D7Ertd443e
Name: DNA segment, Chr 7, ERATO Doi 443, expressed
Synonyms: 4933400E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71007
Homologene: 18998
Adamts17
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17
Synonyms: AU023434
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233332
Homologene: 16373
Il12a
Name: interleukin 12a
Synonyms: p35, IL-12p35
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 16159
HGNC: HGNC:5969
Homologene: 681
Sbp
Name: spermine binding protein
Synonyms: p25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20234
Homologene: 117464
Gpam
Name: glycerol-3-phosphate acyltransferase, mitochondrial
Synonyms: GPAT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 14732
Homologene: 7343
Phf1
Name: PHD finger protein 1
Synonyms: D17Ertd455e, Tctex3, PHF2, mPcl1, Tctex-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 21652
VEGA: 17
HGNC: HGNC:8919
Homologene: 7567
AI987944
Name: expressed sequence AI987944
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233168
Vmn1r14
Name: vomeronasal 1 receptor 14
Synonyms: V1rc7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 113864
Homologene: 74373
A730049H05Rik
Name: RIKEN cDNA A730049H05 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74516
Map10
Name: microtubule-associated protein 10
Synonyms: 4933403G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74393
Homologene: 10416
Gm5174
Name: predicted gene 5174
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 382395
VEGA: 10
Homologene: 141143
Ccer1
Name: coiled-coil glutamate-rich protein 1
Synonyms: 4921510H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 66716
VEGA: 10
Homologene: 49839
Setbp1
Name: SET binding protein 1
Synonyms: Seb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240427
Homologene: 9192
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • AAGGGA to AAGGGAGGGA, chromosome 1 at 12,836,164 bp
  • C to G, chromosome 1 at 55,019,395 bp
  • G to T, chromosome 1 at 74,918,504 bp
  • GCGGC to GCGGCCGGC, chromosome 2 at 125,247,828 bp
  • G to A, chromosome 2 at 137,096,232 bp
  • G to A, chromosome 3 at 35,778,013 bp
  • C to T, chromosome 3 at 68,695,333 bp
  • A to G, chromosome 3 at 129,218,769 bp
  • T to C, chromosome 4 at 34,807,569 bp
  • A to G, chromosome 4 at 148,165,777 bp
  • T to C, chromosome 5 at 32,651,757 bp
  • A to T, chromosome 5 at 115,260,104 bp
  • T to A, chromosome 5 at 135,854,409 bp
  • T to G, chromosome 5 at 146,435,372 bp
  • T to A, chromosome 6 at 48,470,999 bp
  • T to A, chromosome 6 at 57,234,199 bp
  • T to C, chromosome 6 at 92,828,065 bp
  • T to A, chromosome 6 at 108,510,696 bp
  • A to G, chromosome 6 at 115,490,146 bp
  • A to G, chromosome 7 at 16,078,712 bp
  • A to G, chromosome 7 at 41,375,339 bp
  • G to A, chromosome 7 at 67,147,574 bp
  • G to A, chromosome 7 at 134,348,934 bp
  • T to C, chromosome 8 at 77,517,749 bp
  • T to A, chromosome 8 at 125,670,439 bp
  • C to T, chromosome 8 at 125,772,104 bp
  • C to T, chromosome 9 at 50,676,993 bp
  • A to C, chromosome 9 at 108,483,693 bp
  • T to C, chromosome 10 at 86,656,108 bp
  • T to A, chromosome 10 at 97,694,658 bp
  • A to T, chromosome 14 at 30,787,541 bp
  • G to A, chromosome 16 at 3,990,910 bp
  • T to C, chromosome 17 at 23,942,730 bp
  • T to C, chromosome 17 at 26,937,270 bp
  • T to C, chromosome 18 at 16,643,959 bp
  • A to T, chromosome 18 at 78,857,626 bp
  • A to G, chromosome 19 at 55,088,211 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1083 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039169-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.