Strain Name:
C57BL/6J-MtgxR1123Btlr/Mmmh
Stock Number:
039196-MU
Citation ID:
RRID:MMRRC_039196-MU
Other Names:
R1123 (G1), C57BL/6J-MtgxR1123Btlr
Major Collection:

Gene Information

Arhgap12
Name: Rho GTPase activating protein 12
Synonyms: 2810011M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 75415
Homologene: 23089
Suclg1
Name: succinate-CoA ligase, GDP-forming, alpha subunit
Synonyms: 1500000I01Rik, Sucla1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56451
Homologene: 55785
Nckap1
Name: NCK-associated protein 1
Synonyms: Nap1, Hem2, mh19, H19, Hem-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 50884
HGNC: HGNC:7666
Homologene: 8384
Evi5
Name: ecotropic viral integration site 5
Synonyms: NB4S
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14020
HGNC: HGNC:3501
Homologene: 121902
Ube4b
Name: ubiquitination factor E4B
Synonyms: UFD2, D4Bwg0973e, 4933406G05Rik, 4930551I19Rik, Ufd2p, UFD2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 63958
Homologene: 107623
Prpf8
Name: pre-mRNA processing factor 8
Synonyms: D11Bwg0410e, DBF3/PRP8, Prp8, Sfprp8l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192159
Homologene: 4706
Psmb7
Name: proteasome (prosome, macropain) subunit, beta type 7
Synonyms: MC14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19177
HGNC: HGNC:9544
Homologene: 2093
Erap1
Name: endoplasmic reticulum aminopeptidase 1
Synonyms: Arts1, ERAAP, PILSAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 80898
VEGA: 13
Homologene: 56754
Acaca
Name: acetyl-Coenzyme A carboxylase alpha
Synonyms: acetyl-CoA carboxylase, Acc1, A530025K05Rik, LOC327983, Acac
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 107476
HGNC: HGNC:84
Homologene: 31015
Map3k2
Name: mitogen-activated protein kinase kinase kinase 2
Synonyms: Mekk2, 9630061B06Rik, MEK kinase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 26405
VEGA: 18
HGNC: HGNC:6854
Homologene: 74576
Isoc1
Name: isochorismatase domain containing 1
Synonyms: 2610034N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 66307
VEGA: 18
Homologene: 9361
Nbeal1
Name: neurobeachin like 1
Synonyms: ALS2CR17, A530050O19Rik, 2310076G13Rik, A530083I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269198
Homologene: 16453
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269700
Homologene: 28297
Akap3
Name: A kinase (PRKA) anchor protein 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 11642
HGNC: HGNC:373
Homologene: 4688
Hephl1
Name: hephaestin-like 1
Synonyms: LOC244698, Zp, zyklopen, thd, cw
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244698
Homologene: 9112
Slc35e1
Name: solute carrier family 35, member E1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 270066
Homologene: 49075
Pik3r4
Name: phosphoinositide-3-kinase regulatory subunit 4
Synonyms: p150, Vps15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75669
HGNC: HGNC:8982
Homologene: 24678
Esyt1
Name: extended synaptotagmin-like protein 1
Synonyms: vp115, Mbc2, Fam62a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 23943
VEGA: 10
Homologene: 40794
Slc16a7
Name: solute carrier family 16 (monocarboxylic acid transporters), member 7
Synonyms: 4921534N07Rik, D630004K10Rik, 9030411M13Rik, MCT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 20503
Homologene: 20990
Olfr1225
Name: olfactory receptor 1225
Synonyms: GA_x6K02T2Q125-50650037-50649102, MOR233-11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258893
Homologene: 17427
Slc35g2
Name: solute carrier family 35, member G2
Synonyms: Tmem22, LOC245020
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 245020
Homologene: 11893
Kcnt2
Name: potassium channel, subfamily T, member 2
Synonyms: E330038N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240776
Homologene: 16121
Cyp2c40
Name: cytochrome P450, family 2, subfamily c, polypeptide 40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 13099
Homologene: 74936
Cel
Name: carboxyl ester lipase
Synonyms: BAL, 1810036E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12613
HGNC: HGNC:1848
Homologene: 37529
Thoc2l
Name: THO complex subunit 2-like
Synonyms: Gm3179, BC005561
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100042165
Olfr1154
Name: olfactory receptor 1154
Synonyms: GA_x6K02T2Q125-49403456-49402524, MOR173-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258641
Homologene: 74192
Dtx3l
Name: deltex 3-like, E3 ubiquitin ligase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 209200
Homologene: 51375
Cfap157
Name: cilia and flagella associated protein 157
Synonyms: 1700019L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227736
Homologene: 53056
Ccdc122
Name: coiled-coil domain containing 122
Synonyms: 4933415L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 108811
Homologene: 51651
Etnk2
Name: ethanolamine kinase 2
Synonyms: 4933417N20Rik, Eki2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 214253
Homologene: 10072
Fam221b
Name: family with sequence similarity 221, member B
Synonyms: 4930412F15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242408
Homologene: 52184
Lrfn1
Name: leucine rich repeat and fibronectin type III domain containing 1
Synonyms: SALM2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 80749
Homologene: 12729
Olfr180
Name: olfactory receptor 180
Synonyms: MOR184-11P, Olfr1563-ps1, GA_x54KRFPKG5P-55134972-55134019, MOR184-11P, MOR184-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 258178
Homologene: 79337
Fem1a
Name: fem 1 homolog a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14154
VEGA: 17
Homologene: 7713
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 60,260,269 bp
  • A to G, chromosome 1 at 133,373,272 bp
  • A to T, chromosome 1 at 140,573,608 bp
  • T to C, chromosome 2 at 28,556,740 bp
  • C to T, chromosome 2 at 32,777,923 bp
  • C to T, chromosome 2 at 38,633,839 bp
  • C to T, chromosome 2 at 80,517,942 bp
  • A to C, chromosome 2 at 87,902,904 bp
  • A to G, chromosome 2 at 89,170,868 bp
  • T to G, chromosome 4 at 43,665,753 bp
  • A to G, chromosome 4 at 149,425,871 bp
  • T to C, chromosome 5 at 104,518,470 bp
  • T to G, chromosome 5 at 107,820,578 bp
  • T to C, chromosome 5 at 121,286,736 bp
  • A to G, chromosome 6 at 73,256,227 bp
  • A to G, chromosome 6 at 126,865,966 bp
  • G to T, chromosome 7 at 28,467,119 bp
  • T to C, chromosome 8 at 72,492,571 bp
  • T to C, chromosome 9 at 15,080,140 bp
  • A to T, chromosome 9 at 100,552,994 bp
  • G to A, chromosome 9 at 105,663,129 bp
  • A to C, chromosome 10 at 125,231,147 bp
  • A to T, chromosome 10 at 128,516,558 bp
  • T to C, chromosome 11 at 75,495,285 bp
  • T to A, chromosome 11 at 84,264,080 bp
  • A to G, chromosome 13 at 74,673,643 bp
  • T to C, chromosome 14 at 77,067,911 bp
  • C to T, chromosome 16 at 35,933,268 bp
  • A to T, chromosome 16 at 58,916,334 bp
  • G to C, chromosome 17 at 56,257,791 bp
  • A to C, chromosome 18 at 6,031,822 bp
  • T to C, chromosome 18 at 32,218,352 bp
  • T to C, chromosome 18 at 58,671,623 bp
  • C to G, chromosome 19 at 39,812,677 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1123 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039196-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.