Strain Name:
C57BL/6J-MtgxR1137Btlr/Mmmh
Stock Number:
039210-MU
Citation ID:
RRID:MMRRC_039210-MU
Other Names:
R1137 (G1), C57BL/6J-MtgxR1137Btlr
Major Collection:

Gene Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: E330008K23Rik, HALR, Mll3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231051
Homologene: 46480
Htr4
Name: 5 hydroxytryptamine (serotonin) receptor 4
Synonyms: 5-HT4L, 5-HT4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 15562
VEGA: 18
HGNC: HGNC:5299
Homologene: 20243
Vcan
Name: versican
Synonyms: PG-M, hdf, heart defect, 5430420N07Rik, DPEAAE, Cspg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Ppp1cb
Name: protein phosphatase 1 catalytic subunit beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19046
HGNC: HGNC:9282
Homologene: 37659
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Exoc6b
Name: exocyst complex component 6B
Synonyms: 4930569O18Rik, G430127E12Rik, Sec15b, Sec15l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 75914
Homologene: 44781
Nup155
Name: nucleoporin 155
Synonyms: D930027M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 170762
VEGA: 15
HGNC: HGNC:8063
Homologene: 43155
Ahdc1
Name: AT hook, DNA binding motif, containing 1
Synonyms: D030015G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230793
Homologene: 17144
Pepd
Name: peptidase D
Synonyms: Pep-4, peptidase D, Pep4, dal
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18624
HGNC: HGNC:8840
Homologene: 239
Rarg
Name: retinoic acid receptor, gamma
Synonyms: RARgamma2, RAR gamma 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 19411
HGNC: HGNC:9866
Homologene: 20263
Ppp1r9a
Name: protein phosphatase 1, regulatory subunit 9A
Synonyms: 4930518N04Rik, A230094E16Rik, neurabin-I, 2810430P21Rik, Neurabin I, NRB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243725
Homologene: 14247
Fkbp9
Name: FK506 binding protein 9
Synonyms: FKBP60, FKBP63
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 27055
HGNC: HGNC:3725
Homologene: 31434
Elp3
Name: elongator acetyltransferase complex subunit 3
Synonyms: 2610507P14Rik, KAT9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 74195
VEGA: 14
Homologene: 7105
Kif20b
Name: kinesin family member 20B
Synonyms: N-6 kinesin, C330014J10Rik, Kif20b, Mphosph1, 33cex, magoo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 240641
VEGA: 19
HGNC: HGNC:7212
Homologene: 9418
Gnb1
Name: guanine nucleotide binding protein (G protein), beta 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14688
HGNC: HGNC:4396
Homologene: 55532
Mdn1
Name: midasin AAA ATPase 1
Synonyms: LOC213784, 4833432B22Rik, D4Abb1e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100019
Homologene: 39689
Akap8l
Name: A kinase (PRKA) anchor protein 8-like
Synonyms: Nakap95
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 54194
VEGA: 17
Homologene: 8658
Chmp7
Name: charged multivesicular body protein 7
Synonyms: 4930596K11Rik, 6330407G04Rik, CHMP family, member 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105513
VEGA: 14
Homologene: 14613
Sucla2
Name: succinate-Coenzyme A ligase, ADP-forming, beta subunit
Synonyms: 4930547K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 20916
Homologene: 2856
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: 4833421P10Rik, A130030D10Rik, 1110059H15Rik, Zfp650
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68795
Homologene: 52092
Rfwd3
Name: ring finger and WD repeat domain 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234736
Homologene: 41230
Clca4a
Name: chloride channel accessory 4A
Synonyms: 9130020L07Rik, Clca6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99663
HGNC: HGNC:2018
Homologene: 40808
Creld2
Name: cysteine-rich with EGF-like domains 2
Synonyms: 5730592L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 76737
VEGA: 15
Homologene: 11526
Tpm1
Name: tropomyosin 1, alpha
Synonyms: Tpm-1, alpha-TM, TM2, Tm3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22003
Homologene: 128637
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, P1-Loop, Dnahc8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Cp
Name: ceruloplasmin
Synonyms: D3Ertd555e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12870
HGNC: HGNC:2295
Homologene: 75
Iqch
Name: IQ motif containing H
Synonyms: 4921504K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 78250
Homologene: 11258
Lama4
Name: laminin, alpha 4
Synonyms: laminin [a]4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16775
HGNC: HGNC:6484
Homologene: 37604
Myh7b
Name: myosin, heavy chain 7B, cardiac muscle, beta
Synonyms: Myh14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 668940
Homologene: 66117
Sos2
Name: SOS Ras/Rho guanine nucleotide exchange factor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20663
Homologene: 38253
Srgap1
Name: SLIT-ROBO Rho GTPase activating protein 1
Synonyms: 4930572H05Rik, Arhgap13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 117600
Homologene: 56898
Llgl1
Name: LLGL1 scribble cell polarity complex component
Synonyms: Lgl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16897
HGNC: HGNC:6628
Homologene: 31220
Slc5a7
Name: solute carrier family 5 (choline transporter), member 7
Synonyms: CHT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 63993
VEGA: 17
Homologene: 32516
Cep250
Name: centrosomal protein 250
Synonyms: Inmp, B230210E21Rik, Cep2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16328
HGNC: HGNC:1859
Homologene: 38286
Tigit
Name: T cell immunoreceptor with Ig and ITIM domains
Synonyms: ENSMUSG00000071552, Vstm3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 100043314
VEGA: 16
Homologene: 18358
Tmem132b
Name: transmembrane protein 132B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 208151
Homologene: 28135
Lrwd1
Name: leucine-rich repeats and WD repeat domain containing 1
Synonyms: 1200011O22Rik, Orca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71735
Homologene: 17678
Muc1
Name: mucin 1, transmembrane
Synonyms: EMA, CD227, Muc-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 17829
HGNC: HGNC:7508
Homologene: 137248
Vmn1r16
Name: vomeronasal 1 receptor 16
Synonyms: V1rc29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 171202
Homologene: 123821
Tedc2
Name: tubulin epsilon and delta complex 2
Synonyms: 1600002H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72016
Homologene: 45943
Clec4n
Name: C-type lectin domain family 4, member n
Synonyms: dectin-2, Clecsf10, Nkcl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56620
Homologene: 84615
2410002F23Rik
Name: RIKEN cDNA 2410002F23 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 668661
Homologene: 105477
Lif
Name: leukemia inhibitory factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16878
HGNC: HGNC:6596
Homologene: 1734
Lyrm7
Name: LYR motif containing 7
Synonyms: 9330147L21Rik, 1700024C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75530
Homologene: 18762
Aaas
Name: achalasia, adrenocortical insufficiency, alacrimia
Synonyms: Aladin, GL003, D030041N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223921
VEGA: 15
Homologene: 9232
Impa2
Name: inositol monophosphatase 2
Synonyms: 2210415D20Rik, inositol (myo)-1(or 4)-monophosphatase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 114663
VEGA: 18
HGNC: HGNC:6051
Homologene: 22799
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 34,247,819 bp
  • A to G, chromosome 2 at 69,938,315 bp
  • T to C, chromosome 2 at 155,622,714 bp
  • A to G, chromosome 2 at 155,990,840 bp
  • G to T, chromosome 3 at 19,978,952 bp
  • A to T, chromosome 3 at 89,230,438 bp
  • A to G, chromosome 3 at 144,970,685 bp
  • T to A, chromosome 4 at 32,694,511 bp
  • A to G, chromosome 4 at 133,062,113 bp
  • T to C, chromosome 4 at 155,551,645 bp
  • C to A, chromosome 5 at 25,310,983 bp
  • T to C, chromosome 5 at 32,487,671 bp
  • C to T, chromosome 5 at 125,783,542 bp
  • T to C, chromosome 5 at 136,133,419 bp
  • T to C, chromosome 6 at 5,159,697 bp
  • G to T, chromosome 6 at 56,860,697 bp
  • T to G, chromosome 6 at 57,323,236 bp
  • A to G, chromosome 6 at 84,908,223 bp
  • G to A, chromosome 6 at 123,246,567 bp
  • T to C, chromosome 7 at 35,020,958 bp
  • T to A, chromosome 7 at 44,250,832 bp
  • C to T, chromosome 8 at 111,288,242 bp
  • G to A, chromosome 9 at 63,454,554 bp
  • T to C, chromosome 9 at 67,031,118 bp
  • A to G, chromosome 10 at 39,065,733 bp
  • A to T, chromosome 10 at 121,925,805 bp
  • A to G, chromosome 11 at 4,269,237 bp
  • T to A, chromosome 11 at 54,853,303 bp
  • C to A, chromosome 11 at 60,704,733 bp
  • A to C, chromosome 12 at 69,598,767 bp
  • T to A, chromosome 13 at 89,704,303 bp
  • A to G, chromosome 14 at 65,547,921 bp
  • C to T, chromosome 14 at 69,719,450 bp
  • C to T, chromosome 14 at 73,560,634 bp
  • A to T, chromosome 15 at 8,157,760 bp
  • G to A, chromosome 15 at 88,820,631 bp
  • T to C, chromosome 15 at 102,241,160 bp
  • A to G, chromosome 15 at 102,345,563 bp
  • G to T, chromosome 16 at 43,649,122 bp
  • T to A, chromosome 17 at 24,216,317 bp
  • C to A, chromosome 17 at 24,216,318 bp
  • A to G, chromosome 17 at 30,855,936 bp
  • C to T, chromosome 17 at 32,332,483 bp
  • G to A, chromosome 17 at 54,293,011 bp
  • A to G, chromosome 18 at 62,437,553 bp
  • G to A, chromosome 18 at 67,318,427 bp
  • T to C, chromosome 19 at 34,937,086 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1137 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039210-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.