Strain Name:
C57BL/6J-MtgxR1138Btlr/Mmmh
Stock Number:
039211-MU
Citation ID:
RRID:MMRRC_039211-MU
Other Names:
R1138 (G1), C57BL/6J-MtgxR1138Btlr
Major Collection:

Gene Information

Pkd1
Name: polycystin 1, transient receptor poteintial channel interacting
Synonyms: polycystin-1, PC1, PC-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Igfbp2
Name: insulin-like growth factor binding protein 2
Synonyms: IGFBP-2, Igfbp-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16008
HGNC: HGNC:5471
Homologene: 499
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, C130061D10Rik, Phr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105689
Homologene: 9005
Bzw1
Name: basic leucine zipper and W2 domains 1
Synonyms: 1200015E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66882
Homologene: 41651
Sh3gl1
Name: SH3-domain GRB2-like 1
Synonyms: SH3P8, EEN, endophilin II, Sh3d2b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20405
VEGA: 17
Homologene: 55709
Lin54
Name: lin-54 homolog (C. elegans)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231506
Homologene: 18212
Adcy4
Name: adenylate cyclase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 104110
VEGA: 14
HGNC: HGNC:235
Homologene: 23149
Hpgd
Name: hydroxyprostaglandin dehydrogenase 15 (NAD)
Synonyms: 15-PGDH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 15446
HGNC: HGNC:5154
Homologene: 68095
Ntng1
Name: netrin G1
Synonyms: Lmnt1, A930010C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80883
Homologene: 8949
Bub1b
Name: BUB1B, mitotic checkpoint serine/threonine kinase
Synonyms: BUBR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12236
HGNC: HGNC:1149
Homologene: 933
Sh2d3c
Name: SH2 domain containing 3C
Synonyms: Shep1, SH2-containing Eph receptor-binding protein 1, Cas/HEF1-associated signal transducer, Chat, Nsp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 27387
Homologene: 69145
Tmem108
Name: transmembrane protein 108
Synonyms: B130017P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 81907
Homologene: 18688
Nr4a2
Name: nuclear receptor subfamily 4, group A, member 2
Synonyms: HZF-3, RNR-1, Nurr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18227
HGNC: HGNC:7981
Homologene: 4509
Mmp9
Name: matrix metallopeptidase 9
Synonyms: gelatinase B, Gel B, B/MMP9, MMP-9, Clg4b, Gelatinase B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17395
HGNC: HGNC:7176
Homologene: 3659
Abca4
Name: ATP-binding cassette, sub-family A (ABC1), member 4
Synonyms: Rim protein, RmP, Abc10, D430003I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11304
HGNC: HGNC:34
Homologene: 298
Scyl3
Name: SCY1-like 3 (S. cerevisiae)
Synonyms: Pace1, 1200016D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240880
Homologene: 10706
Chl1
Name: cell adhesion molecule L1-like
Synonyms: CALL, A530023M13Rik, close homolog of L1, LICAM2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12661
HGNC: HGNC:1939
Homologene: 21314
Brd8dc
Name: BRD8 domain containing
Synonyms: 4933408B17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 271508
Dstyk
Name: dual serine/threonine and tyrosine protein kinase
Synonyms: A930019K20Rik, C430014H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 213452
Homologene: 19711
Map7d1
Name: MAP7 domain containing 1
Synonyms: Parcc1, Rprc1, Mtap7d1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 245877
Homologene: 17009
Ap1g2
Name: adaptor protein complex AP-1, gamma 2 subunit
Synonyms: gamma 2-adaptin, Adtg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 11766
HGNC: HGNC:556
Homologene: 49141
Olfr1233
Name: olfactory receptor 1233
Synonyms: GA_x6K02T2Q125-50784973-50784056, MOR238-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258974
Homologene: 74243
Oacyl
Name: O-acyltransferase like
Synonyms: 5330437I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 319888
Homologene: 129774
Siae
Name: sialic acid acetylesterase
Synonyms: LSE, clone 165, Ysg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22619
Homologene: 8001
Glra3
Name: glycine receptor, alpha 3 subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 110304
HGNC: HGNC:4328
Homologene: 142
Mfsd4b5
Name: major facilitator superfamily domain containing 4B5
Synonyms: BC021785
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215928
Homologene: 129849
Dnajc22
Name: DnaJ heat shock protein family (Hsp40) member C22
Synonyms: 2810451A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72778
Homologene: 11777
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 58,401,386 bp
  • A to G, chromosome 1 at 72,849,098 bp
  • A to G, chromosome 1 at 132,463,486 bp
  • A to G, chromosome 1 at 163,933,665 bp
  • G to T, chromosome 2 at 32,749,405 bp
  • T to C, chromosome 2 at 57,112,379 bp
  • T to C, chromosome 2 at 89,340,090 bp
  • C to T, chromosome 2 at 118,623,089 bp
  • T to A, chromosome 2 at 164,951,097 bp
  • T to A, chromosome 3 at 109,935,213 bp
  • T to A, chromosome 3 at 122,173,848 bp
  • T to C, chromosome 4 at 126,242,119 bp
  • A to G, chromosome 5 at 100,444,134 bp
  • A to G, chromosome 6 at 103,693,179 bp
  • A to G, chromosome 8 at 56,088,976 bp
  • G to A, chromosome 8 at 56,307,677 bp
  • G to A, chromosome 9 at 37,642,692 bp
  • T to C, chromosome 9 at 103,498,969 bp
  • C to T, chromosome 10 at 39,975,154 bp
  • G to T, chromosome 14 at 55,101,190 bp
  • A to G, chromosome 14 at 55,770,018 bp
  • G to T, chromosome 14 at 103,174,826 bp
  • AGACACT to A, chromosome 15 at 99,104,427 bp
  • C to A, chromosome 17 at 24,586,032 bp
  • A to G, chromosome 17 at 56,018,118 bp
  • C to T, chromosome 18 at 34,580,244 bp
  • T to A, chromosome 18 at 65,725,450 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1138 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039211-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.