Strain Name:
C57BL/6J-MtgxR1191Btlr/Mmmh
Stock Number:
039263-MU
Citation ID:
RRID:MMRRC_039263-MU
Other Names:
R1191 (G1), C57BL/6J-MtgxR1191Btlr
Major Collection:

Gene Information

Utrn
Name: utrophin
Synonyms: G-utrophin, DRP, Dmdl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 22288
VEGA: 10
Homologene: 21398
Strn
Name: striatin, calmodulin binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 268980
Homologene: 2380
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, Phr1, C130061D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 105689
Homologene: 9005
Ubap2l
Name: ubiquitin-associated protein 2-like
Synonyms: 3110083O19Rik, NICE-4, A430103N23Rik, 4932431F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 74383
Homologene: 136291
Dcaf4
Name: DDB1 and CUL4 associated factor 4
Synonyms: Wdr21, 1110018E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 73828
VEGA: 12
Homologene: 9210
Ankrd27
Name: ankyrin repeat domain 27 (VPS9 domain)
Synonyms: Varp, D330003H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 245886
Homologene: 12956
Fam81a
Name: family with sequence similarity 81, member A
Synonyms: 6430514L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 76886
Homologene: 17584
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: A130030D10Rik, 1110059H15Rik, 4833421P10Rik, Zfp650
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 68795
Homologene: 52092
Rfwd3
Name: ring finger and WD repeat domain 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234736
Homologene: 41230
Zfp369
Name: zinc finger protein 369
Synonyms: D230020H11Rik, B930030B22Rik, NRIF2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 170936
Homologene: 129707
Mmp27
Name: matrix metallopeptidase 27
Synonyms: LOC234911
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 234911
Homologene: 23345
Vav2
Name: vav 2 oncogene
Synonyms: 2810040F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22325
Homologene: 2530
Pcdhb16
Name: protocadherin beta 16
Synonyms: Pcdhb8, PcdhbP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 93887
HGNC: HGNC:8693
Homologene: 99843
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 94109
Homologene: 69536
Cfi
Name: complement component factor i
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 12630
HGNC: HGNC:5394
Homologene: 171
C8b
Name: complement component 8, beta polypeptide
Synonyms: 4930439B20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 110382
HGNC: HGNC:1353
Homologene: 48
Hmgcll1
Name: 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 208982
Homologene: 27863
Il12rb2
Name: interleukin 12 receptor, beta 2
Synonyms: A930027I18Rik, IL-12RB2, Ifnm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 16162
HGNC: HGNC:5972
Homologene: 1197
Vwf
Name: Von Willebrand factor
Synonyms: 6820430P06Rik, B130011O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 22371
Homologene: 466
Iqcg
Name: IQ motif containing G
Synonyms: stubby12d, repro1, G1-374-12, 2400003L07Rik, esgd12d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 69707
Homologene: 32776
Skint3
Name: selection and upkeep of intraepithelial T cells 3
Synonyms: A430090E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 195564
Taar2
Name: trace amine-associated receptor 2
Synonyms: Gpr58
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 209512
HGNC: HGNC:4514
Homologene: 110760
Unc79
Name: unc-79 homolog
Synonyms: Mlca3, 9030205A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217843
Homologene: 41397
Acss1
Name: acyl-CoA synthetase short-chain family member 1
Synonyms: Acas2, 1110032O15Rik, Acas2l, AceCS2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 68738
Homologene: 56037
Grik5
Name: glutamate receptor, ionotropic, kainate 5 (gamma 2)
Synonyms: GluRgamma2, KA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 14809
HGNC: HGNC:4583
Homologene: 1578
Idh3b
Name: isocitrate dehydrogenase 3 (NAD+) beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 170718
HGNC: HGNC:5385
Homologene: 5035
Olfr50
Name: olfactory receptor 50
Synonyms: GA_x6K02T2NLDC-33487752-33488690, MOR136-6, ID3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 18350
Homologene: 74212
Col15a1
Name: collagen, type XV, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 12819
HGNC: HGNC:2192
Homologene: 1396
Gde1
Name: glycerophosphodiester phosphodiesterase 1
Synonyms: 1200003M13Rik, MIR16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 56209
Homologene: 41149
Pde3b
Name: phosphodiesterase 3B, cGMP-inhibited
Synonyms: 9830102A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 18576
HGNC: HGNC:8779
Homologene: 709
Irx6
Name: Iroquois homeobox 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 64379
Homologene: 41481
Crlf1
Name: cytokine receptor-like factor 1
Synonyms: cytokine receptor like molecule 3, CRLM3, CLF-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 12931
HGNC: HGNC:2364
Homologene: 3489
Itgb6
Name: integrin beta 6
Synonyms: 4831415H04Rik, 2210409C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16420
HGNC: HGNC:6161
Homologene: 685
Trpt1
Name: tRNA phosphotransferase 1
Synonyms: TPT1, Tpt1h, EST-MNCb3719
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 107328
VEGA: 19
Homologene: 12878
Olfr143
Name: olfactory receptor 143
Synonyms: MOR170-6, K18, GA_x6K02T2PVTD-31941084-31942025
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258802
Homologene: 133627
Olfr452
Name: olfactory receptor 452
Synonyms: MOR257-5P, GA_x6K02T2P3E9-4769843-4768890
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 258207
HGNC: HGNC:8247
Homologene: 128141
Zfp760
Name: zinc finger protein 760
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 240034
VEGA: 17
Hspa2
Name: heat shock protein 2
Synonyms: Hsp70-2, 70kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 15512
VEGA: 12
HGNC: HGNC:5235
Homologene: 68564
Olfr175
Name: olfactory receptor 175
Synonyms: MOR184-10P, GA_x54KRFPKG5P-55026345-55025418, GA_x54KRFPKG5P-54993816-54992890, Olfr175-ps1, Olfr174, MOR184-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 259004
Homologene: 17461
Vps9d1
Name: VPS9 domain containing 1
Synonyms: 2410004N05Rik, 1300018I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 72325
Homologene: 21021
Zswim2
Name: zinc finger SWIM-type containing 2
Synonyms: MEX, 4933437F18Rik, 1700025P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 71861
Homologene: 32689
Gpt2
Name: glutamic pyruvate transaminase (alanine aminotransferase) 2
Synonyms: ALT2, 4631422C05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 108682
Homologene: 68832
Olfr976
Name: olfactory receptor 976
Synonyms: MOR224-10, GA_x6K02T2PVTD-33657378-33656440
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258364
VEGA: 9
Homologene: 64863
1700065D16Rik
Name: RIKEN cDNA 1700065D16 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 73410
Ighv3-8
Name: immunoglobulin heavy variable V3-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 780831
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 2 at 27,292,780 bp
  • T to A, chromosome 2 at 36,793,338 bp
  • C to T, chromosome 2 at 60,653,137 bp
  • C to T, chromosome 2 at 70,021,181 bp
  • A to C, chromosome 2 at 83,923,695 bp
  • A to T, chromosome 2 at 130,281,890 bp
  • T to C, chromosome 2 at 150,625,129 bp
  • T to C, chromosome 3 at 90,023,575 bp
  • C to A, chromosome 3 at 129,868,527 bp
  • G to T, chromosome 4 at 47,254,083 bp
  • C to T, chromosome 4 at 104,793,323 bp
  • T to A, chromosome 4 at 112,235,742 bp
  • C to A, chromosome 6 at 42,790,517 bp
  • C to T, chromosome 6 at 67,298,216 bp
  • T to A, chromosome 6 at 125,599,252 bp
  • G to A, chromosome 7 at 25,058,325 bp
  • T to C, chromosome 7 at 35,602,487 bp
  • A to T, chromosome 7 at 114,519,575 bp
  • A to T, chromosome 7 at 118,705,441 bp
  • A to G, chromosome 8 at 16,185,347 bp
  • G to A, chromosome 8 at 70,498,828 bp
  • A to T, chromosome 8 at 85,509,272 bp
  • T to A, chromosome 8 at 92,676,952 bp
  • C to T, chromosome 8 at 111,288,242 bp
  • A to T, chromosome 8 at 123,247,967 bp
  • A to T, chromosome 9 at 7,579,066 bp
  • G to T, chromosome 9 at 38,254,205 bp
  • A to T, chromosome 9 at 39,956,968 bp
  • A to C, chromosome 9 at 70,099,202 bp
  • T to C, chromosome 9 at 76,056,564 bp
  • G to A, chromosome 9 at 95,857,414 bp
  • T to A, chromosome 10 at 12,634,033 bp
  • T to G, chromosome 10 at 23,941,029 bp
  • C to T, chromosome 12 at 76,405,881 bp
  • A to T, chromosome 12 at 83,535,967 bp
  • T to A, chromosome 12 at 103,047,012 bp
  • T to C, chromosome 12 at 114,322,803 bp
  • T to A, chromosome 13 at 65,291,962 bp
  • G to T, chromosome 14 at 103,243,040 bp
  • A to G, chromosome 16 at 33,049,943 bp
  • T to A, chromosome 16 at 58,824,559 bp
  • C to T, chromosome 17 at 21,723,305 bp
  • T to C, chromosome 17 at 78,692,426 bp
  • A to G, chromosome 18 at 37,479,873 bp
  • G to T, chromosome 19 at 6,996,770 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1191 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039263-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.