Strain Name:
C57BL/6J-MtgxR1196Btlr/Mmmh
Stock Number:
039268-MU
Citation ID:
RRID:MMRRC_039268-MU
Other Names:
R1196 (G1), C57BL/6J-MtgxR1196Btlr
Major Collection:

Gene Information

Pank4
Name: pantothenate kinase 4
Synonyms: D030031I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 269614
Homologene: 41235
Jmjd1c
Name: jumonji domain containing 1C
Synonyms: TRIP8, 5430433L24Rik, D630035I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 108829
Homologene: 3129
Fbrsl1
Name: fibrosin-like 1
Synonyms: LOC381668, Gm29766, 2410025L10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 381668
Homologene: 45966
Sf3b1
Name: splicing factor 3b, subunit 1
Synonyms: SF3b155, 2810001M05Rik, Prp10, Targ4, SAP155
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 81898
Homologene: 6696
Ranbp2
Name: RAN binding protein 2
Synonyms: A430087B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 19386
VEGA: 10
Homologene: 87808
Ash1l
Name: ASH1 like histone lysine methyltransferase
Synonyms: E430018P19Rik, 8030453L17Rik, KMT2H, chromatin remodeling factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 192195
Homologene: 10225
Chpf2
Name: chondroitin polymerizing factor 2
Synonyms: 2010209O12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100910
Homologene: 14763
Krr1
Name: KRR1, small subunit (SSU) processome component, homolog (yeast)
Synonyms: 2610511F02Rik, Hrb2, D10Ertd773e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 52705
HGNC: HGNC:5176
Homologene: 5114
Hmces
Name: 5-hydroxymethylcytosine (hmC) binding, ES cell specific
Synonyms: Srap1, 8430410A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232210
Homologene: 6636
Noc4l
Name: NOC4 like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100608
Homologene: 40545
Nrbp1
Name: nuclear receptor binding protein 1
Synonyms: Nrbp, B230344L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 192292
HGNC: HGNC:7993
Homologene: 8373
Dna2
Name: DNA replication helicase/nuclease 2
Synonyms: Dna2l, E130315B21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 327762
HGNC: HGNC:2939
Homologene: 6124
Zfc3h1
Name: zinc finger, C3H1-type containing
Synonyms: Psrc2, Ccdc131
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216345
Homologene: 17017
Agtpbp1
Name: ATP/GTP binding protein 1
Synonyms: 5730402G09Rik, 2310001G17Rik, Ccp1, 4930445M19Rik, 2900054O13Rik, Nna1, 1700020N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 67269
Homologene: 9067
Myo7a
Name: myosin VIIA
Synonyms: USH1B, Hdb, Myo7, polka, nmf371
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 17921
HGNC: HGNC:7606
Homologene: 219
Itga2
Name: integrin alpha 2
Synonyms: DX5, CD49B, VLA-2 receptor, alpha 2 subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 16398
VEGA: 13
HGNC: HGNC:6137
Homologene: 1662
Myof
Name: myoferlin
Synonyms: E030042N20Rik, Fer1l3, 2310051D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 226101
VEGA: 19
HGNC: HGNC:3656
Homologene: 40882
Acacb
Name: acetyl-Coenzyme A carboxylase beta
Synonyms: Accb, Acc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100705
HGNC: HGNC:85
Homologene: 74382
Zfp791
Name: zinc finger protein 791
Synonyms: EG244556
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 244556
Homologene: 27420
Unc13a
Name: unc-13 homolog A
Synonyms: Munc13-1, 2410078G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 382018
Homologene: 11279
Tent5c
Name: terminal nucleotidyltransferase 5C
Synonyms: Fam46c, 4930431B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 74645
Homologene: 56783
Notch4
Name: notch 4
Synonyms: Int-3, Int3, N4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 18132
HGNC: HGNC:7884
Homologene: 3351
Olfr859
Name: olfactory receptor 859
Synonyms: MOR146-3, MOR146-10_p, GA_x6K02T2PVTD-13548326-13549255
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258519
Homologene: 134093
Ttc28
Name: tetratricopeptide repeat domain 28
Synonyms: 2310015L07Rik, TPRBK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 209683
Homologene: 41023
D6Ertd527e
Name: DNA segment, Chr 6, ERATO Doi 527, expressed
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 52372
Krt83
Name: keratin 83
Synonyms: 5430421N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 100126226
HGNC: HGNC:6460
Homologene: 68248
Olfr1180
Name: olfactory receptor 1180
Synonyms: GA_x6K02T2Q125-49900552-49899623, MOR225-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258920
Homologene: 74240
Aspg
Name: asparaginase
Synonyms: A530050D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 104816
VEGA: 12
Homologene: 113390
Prl2c2
Name: prolactin family 2, subfamily c, member 2
Synonyms: Plf, Plf1, PLF-1, MRP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 18811
VEGA: 13
Homologene: 40763
Krtap5-2
Name: keratin associated protein 5-2
Synonyms: 4833428E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 71623
Krtap24-1
Name: keratin associated protein 24-1
Synonyms: LOC239932, Gm312
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 239932
VEGA: 16
Homologene: 88056
Ddah2
Name: dimethylarginine dimethylaminohydrolase 2
Synonyms: Clone 7u, NG30, Ddah, G6a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 51793
HGNC: HGNC:2716
Homologene: 8510
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to G, chromosome 1 at 55,019,395 bp
  • A to T, chromosome 2 at 88,412,546 bp
  • T to C, chromosome 3 at 88,983,316 bp
  • T to C, chromosome 3 at 100,473,000 bp
  • T to C, chromosome 4 at 154,978,173 bp
  • T to C, chromosome 5 at 24,589,648 bp
  • T to A, chromosome 5 at 31,245,813 bp
  • T to A, chromosome 5 at 110,374,519 bp
  • C to T, chromosome 5 at 110,650,584 bp
  • G to A, chromosome 5 at 111,225,677 bp
  • T to C, chromosome 5 at 114,245,092 bp
  • C to G, chromosome 6 at 87,111,524 bp
  • T to A, chromosome 6 at 87,936,182 bp
  • T to G, chromosome 7 at 98,097,673 bp
  • A to T, chromosome 7 at 142,174,883 bp
  • A to G, chromosome 8 at 71,654,986 bp
  • T to A, chromosome 8 at 85,110,954 bp
  • A to G, chromosome 9 at 19,808,632 bp
  • T to A, chromosome 10 at 58,477,053 bp
  • C to T, chromosome 10 at 62,949,187 bp
  • T to C, chromosome 10 at 67,239,236 bp
  • T to A, chromosome 10 at 111,975,657 bp
  • A to G, chromosome 10 at 115,411,961 bp
  • A to G, chromosome 12 at 112,116,524 bp
  • G to C, chromosome 13 at 13,002,201 bp
  • C to A, chromosome 13 at 59,450,318 bp
  • C to T, chromosome 13 at 114,866,155 bp
  • C to T, chromosome 15 at 101,491,433 bp
  • T to C, chromosome 16 at 88,611,642 bp
  • T to C, chromosome 17 at 34,568,863 bp
  • G to T, chromosome 17 at 35,061,527 bp
  • G to A, chromosome 19 at 37,910,960 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1196 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039268-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.