Strain Name:
C57BL/6J-MtgxR1224Btlr/Mmmh
Stock Number:
039293-MU
Citation ID:
RRID:MMRRC_039293-MU
Other Names:
R1224 (G1), C57BL/6J-MtgxR1224Btlr
Major Collection:

Gene Information

Ly6a
Name: lymphocyte antigen 6 complex, locus A
Synonyms: Sca-1, TAP, Ly-6A/E, Ly-6E.1, Ly-6A.2, Sca1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 110454
Homologene: 113718
Dock1
Name: dedicator of cytokinesis 1
Synonyms: D630004B07Rik, 9130006G06Rik, Dock180, b2b3190Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330662
HGNC: HGNC:2987
Homologene: 55575
Rapsn
Name: receptor-associated protein of the synapse
Synonyms: rapsyn, Raps, 43kDa acetylcholine receptor-associated protein, Nraps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19400
HGNC: HGNC:9863
Homologene: 3708
Aldh16a1
Name: aldehyde dehydrogenase 16 family, member A1
Synonyms: 2410004H02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69748
Homologene: 34938
Sox14
Name: SRY (sex determining region Y)-box 14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20669
Homologene: 31224
Tm9sf3
Name: transmembrane 9 superfamily member 3
Synonyms: 2810031D16Rik, 1810073M23Rik, Smbp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107358
VEGA: 19
Homologene: 10588
Slc44a4
Name: solute carrier family 44, member 4
Synonyms: NG22, 2210409B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 70129
Homologene: 11359
Kcng3
Name: potassium voltage-gated channel, subfamily G, member 3
Synonyms: KV6.3, Kv10.1b, Kv10.1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 225030
VEGA: 17
Homologene: 15168
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329178
Homologene: 122243
Mgam
Name: maltase-glucoamylase
Synonyms: 6030407P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232714
HGNC: HGNC:7043
Homologene: 130099
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: b2b012Clo, Jbts17, Hug, 2410089E03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 73692
Homologene: 11315
Aldh9a1
Name: aldehyde dehydrogenase 9, subfamily A1
Synonyms: TMABA-DH, ESTM40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 56752
HGNC: HGNC:412
Homologene: 55483
Ccdc39
Name: coiled-coil domain containing 39
Synonyms: 4921507O14Rik, D3Ertd789e, b2b1735Clo, b2b1304Clo, b2b2025.1Clo, prh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 51938
Homologene: 12149
Clstn3
Name: calsyntenin 3
Synonyms: Cst-3, CSTN3, alcadein-beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232370
Homologene: 22836
Abca8a
Name: ATP-binding cassette, sub-family A (ABC1), member 8a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217258
HGNC: HGNC:38
Homologene: 131160
Olfr144
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Igfn1
Name: immunoglobulin-like and fibronectin type III domain containing 1
Synonyms: 9830123M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226438
Homologene: 130054
Adamdec1
Name: ADAM-like, decysin 1
Synonyms: 2210414L24Rik, Dcsn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 58860
VEGA: 14
Homologene: 8711
Cd46
Name: CD46 antigen, complement regulatory protein
Synonyms: CD46, Mcp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17221
HGNC: HGNC:6953
Homologene: 7832
Zfp52
Name: zinc finger protein 52
Synonyms: zfec29, Zfp-52, KRAB11, Zfp76
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22710
VEGA: 17
Homologene: 77326
Adh4
Name: alcohol dehydrogenase 4 (class II), pi polypeptide
Synonyms: mouse class II type ADH, Adh2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 26876
HGNC: HGNC:252
Homologene: 20162
Abcb10
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 10
Synonyms: ABC-me
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56199
HGNC: HGNC:41
Homologene: 6474
Zdhhc7
Name: zinc finger, DHHC domain containing 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102193
Homologene: 41193
Map3k7cl
Name: Map3k7 C-terminal like
Synonyms: ORF63
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224419
Homologene: 23198
Krt31
Name: keratin 31
Synonyms: Ha1, Kha1, MKHA-1, Krt1-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16660
HGNC: HGNC:6448
Homologene: 74433
Atp6ap1l
Name: ATPase, H+ transporting, lysosomal accessory protein 1-like
Synonyms: EG435376
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 435376
Homologene: 28130
Ces3a
Name: carboxylesterase 3A
Synonyms: Es-male carboxylesterase, Es31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 382053
HGNC: HGNC:1865
Homologene: 84407
Tmem269
Name: transmembrane protein 269
Synonyms: 4930538K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 75180
Homologene: 28290
Sval2
Name: seminal vesicle antigen-like 2
Synonyms: SLP-M
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 84543
Homologene: 13055
Gimap8
Name: GTPase, IMAP family member 8
Synonyms: LOC243374, IAN9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243374
Homologene: 69703
Rhog
Name: ras homolog family member G
Synonyms: Sid10750, RhoG, Arhg, 2810426G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56212
HGNC: HGNC:672
Homologene: 68196
Gm10153
Name: predicted gene 10153
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 66,471,980 bp
  • A to G, chromosome 1 at 135,969,756 bp
  • T to A, chromosome 1 at 167,352,658 bp
  • A to T, chromosome 1 at 195,062,398 bp
  • T to C, chromosome 2 at 91,043,198 bp
  • T to C, chromosome 3 at 33,826,480 bp
  • T to C, chromosome 3 at 138,415,562 bp
  • T to C, chromosome 4 at 119,217,126 bp
  • A to G, chromosome 6 at 40,655,379 bp
  • G to A, chromosome 6 at 41,864,254 bp
  • G to A, chromosome 6 at 48,650,695 bp
  • T to C, chromosome 6 at 124,457,919 bp
  • T to C, chromosome 7 at 45,142,047 bp
  • C to A, chromosome 7 at 102,239,752 bp
  • A to G, chromosome 7 at 135,108,819 bp
  • A to G, chromosome 7 at 142,190,335 bp
  • A to T, chromosome 8 at 105,051,509 bp
  • T to A, chromosome 8 at 120,082,572 bp
  • C to T, chromosome 8 at 123,962,052 bp
  • G to C, chromosome 9 at 39,238,251 bp
  • G to C, chromosome 9 at 99,875,115 bp
  • C to T, chromosome 11 at 100,049,864 bp
  • T to A, chromosome 11 at 110,040,582 bp
  • G to A, chromosome 13 at 90,886,556 bp
  • T to A, chromosome 14 at 68,564,384 bp
  • T to A, chromosome 15 at 8,178,385 bp
  • A to G, chromosome 15 at 74,996,478 bp
  • T to A, chromosome 16 at 87,556,003 bp
  • T to C, chromosome 17 at 21,555,062 bp
  • T to C, chromosome 17 at 34,921,868 bp
  • A to G, chromosome 17 at 83,631,395 bp
  • A to T, chromosome 19 at 41,223,195 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1224 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039293-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.