Strain Name:
C57BL/6J-MtgxR1290Btlr/Mmmh
Stock Number:
039356-MU
Citation ID:
RRID:MMRRC_039356-MU
Other Names:
R1290 (G1), C57BL/6J-MtgxR1290Btlr
Major Collection:

Strain Information

Mef2c
Name: myocyte enhancer factor 2C
Synonyms: 9930028G15Rik, 5430401D19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17260
HGNC: HGNC:6996
Homologene: 31087
Ints1
Name: integrator complex subunit 1
Synonyms: 1110015K06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68510
Homologene: 53111
Recql4
Name: RecQ protein-like 4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 79456
VEGA: 15
HGNC: HGNC:9949
Homologene: 3144
Iqgap2
Name: IQ motif containing GTPase activating protein 2
Synonyms: 4933417J23Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 544963
VEGA: 13
HGNC: HGNC:6111
Homologene: 101543
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: 9930018I23Rik, MAP1C, Swl, Dnec1, Loa, Dnchc1, dynein heavy chain, retrograde transport
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Mbd1
Name: methyl-CpG binding domain protein 1
Synonyms: Cxxc3, PCM1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17190
VEGA: 18
HGNC: HGNC:6916
Homologene: 8414
Borcs5
Name: BLOC-1 related complex subunit 5
Synonyms: Loh12cr1, 5830457J20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67774
Homologene: 12188
Gprin3
Name: GPRIN family member 3
Synonyms: C030038J10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243385
Homologene: 52334
Mmp16
Name: matrix metallopeptidase 16
Synonyms: MT3-MMP, Membrane type 3-MMP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17389
HGNC: HGNC:7162
Homologene: 55939
Nolc1
Name: nucleolar and coiled-body phosphoprotein 1
Synonyms: 3230402K17Rik, P130, NOPP140
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 70769
VEGA: 19
Efl1
Name: elongation factor like GTPase 1
Synonyms: 4932434J20Rik, D7Ertd791e, 6030468D11Rik, Eftud1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101592
Homologene: 11599
Spink5
Name: serine peptidase inhibitor, Kazal type 5
Synonyms: 2310065D10Rik, LEKT1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 72432
Homologene: 4987
Zfyve28
Name: zinc finger, FYVE domain containing 28
Synonyms: 9630058O20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231125
Homologene: 15119
Gramd1b
Name: GRAM domain containing 1B
Synonyms: A930008A22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235283
Homologene: 18223
St6gal1
Name: beta galactoside alpha 2,6 sialyltransferase 1
Synonyms: Siat1, ST6Gal I, St6Gal-I
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20440
Homologene: 2281
Wnk4
Name: WNK lysine deficient protein kinase 4
Synonyms: 2010002J11Rik, Prkwnk4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69847
Homologene: 13020
Synj1
Name: synaptojanin 1
Synonyms: A930006D20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 104015
Homologene: 48252
Tas2r104
Name: taste receptor, type 2, member 104
Synonyms: Tas2r4, mGR04, T2R04, mt2r45
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387340
Homologene: 130072
Pcdhb1
Name: protocadherin beta 1
Synonyms: PcdhbA
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93872
HGNC: HGNC:8680
Homologene: 8348
Spg21
Name: SPG21, maspardin
Synonyms: D9Wsu18e, BM-019, GL010, ACP33
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 27965
VEGA: 9
Homologene: 9603
Exd2
Name: exonuclease 3'-5' domain containing 2
Synonyms: 4930539P14Rik, Exdl2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 97827
VEGA: 12
Homologene: 10066
Fnip2
Name: folliculin interacting protein 2
Synonyms: D630023B12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329679
Homologene: 46417
P3h2
Name: prolyl 3-hydroxylase 2
Synonyms: Leprel1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 210530
Homologene: 10062
Slc22a14
Name: solute carrier family 22 (organic cation transporter), member 14
Synonyms: LOC382113
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382113
HGNC: HGNC:8495
Homologene: 3530
Slc22a8
Name: solute carrier family 22 (organic anion transporter), member 8
Synonyms: Roct, mOat3, OAT3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19879
VEGA: 19
Homologene: 20901
Kcnh3
Name: potassium voltage-gated channel, subfamily H (eag-related), member 3
Synonyms: ether a go-go like, Elk2, C030044P22Rik, Melk2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16512
VEGA: 15
HGNC: HGNC:6252
Homologene: 32150
4921506M07Rik
Name: RIKEN cDNA 4921506M07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Neurod2
Name: neurogenic differentiation 2
Synonyms: bHLHa1, Ndrf
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18013
HGNC: HGNC:7763
Homologene: 4489
Arfrp1
Name: ADP-ribosylation factor related protein 1
Synonyms: 1500006I01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76688
HGNC: HGNC:662
Homologene: 2425
Dok6
Name: docking protein 6
Synonyms: Dok-6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 623279
Homologene: 45143
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 2 at 181,364,604 bp
  • T to C, chromosome 3 at 79,465,693 bp
  • A to T, chromosome 4 at 18,051,725 bp
  • A to T, chromosome 5 at 34,198,801 bp
  • A to T, chromosome 5 at 139,771,410 bp
  • A to G, chromosome 6 at 59,354,464 bp
  • A to T, chromosome 6 at 131,684,845 bp
  • A to G, chromosome 6 at 134,644,368 bp
  • T to C, chromosome 7 at 82,671,728 bp
  • A to G, chromosome 9 at 40,316,821 bp
  • A to G, chromosome 9 at 65,475,832 bp
  • A to C, chromosome 9 at 119,178,452 bp
  • A to T, chromosome 11 at 98,327,288 bp
  • C to G, chromosome 11 at 101,276,340 bp
  • G to A, chromosome 12 at 57,660,413 bp
  • T to A, chromosome 12 at 80,484,326 bp
  • G to A, chromosome 12 at 110,636,509 bp
  • A to T, chromosome 13 at 83,662,359 bp
  • A to T, chromosome 13 at 95,668,513 bp
  • G to A, chromosome 15 at 76,703,943 bp
  • G to A, chromosome 15 at 99,227,120 bp
  • A to G, chromosome 16 at 23,321,661 bp
  • C to T, chromosome 16 at 25,987,203 bp
  • A to G, chromosome 16 at 90,979,929 bp
  • A to G, chromosome 18 at 37,265,230 bp
  • A to G, chromosome 18 at 44,007,711 bp
  • T to C, chromosome 18 at 74,269,486 bp
  • T to C, chromosome 18 at 89,598,803 bp
  • G to A, chromosome 19 at 8,609,911 bp
  • G to T, chromosome 19 at 46,082,386 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1290 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039356-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.