Strain Name:
C57BL/6J-MtgxR1293Btlr/Mmmh
Stock Number:
039359-MU
Citation ID:
RRID:MMRRC_039359-MU
Other Names:
R1293 (G1), C57BL/6J-MtgxR1293Btlr
Major Collection:

Gene Information

Med1
Name: mediator complex subunit 1
Synonyms: TRAP 220, TRAP220, CRSP210, DRIP205, Pparbp, l11Jus15, PBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19014
HGNC: HGNC:9234
Homologene: 21002
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Spred1
Name: sprouty protein with EVH-1 domain 1, related sequence
Synonyms: Spred-1, 5730461F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 114715
Homologene: 24919
Kat8
Name: K(lysine) acetyltransferase 8
Synonyms: 5830450F21Rik, D7Ertd629e, 2010203C02Rik, MOF, Myst1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67773
Homologene: 41676
Dmtf1
Name: cyclin D binding myb like transcription factor 1
Synonyms: Dmp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 23857
Homologene: 8017
Usp24
Name: ubiquitin specific peptidase 24
Synonyms: 2810030C21Rik, 2700066K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329908
Homologene: 35420
Ate1
Name: arginyltransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11907
HGNC: HGNC:782
Homologene: 31420
Wtip
Name: WT1 interacting protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101543
Homologene: 64353
Sgcb
Name: sarcoglycan, beta (dystrophin-associated glycoprotein)
Synonyms: beta-SG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 24051
Homologene: 195
Adgrl4
Name: adhesion G protein-coupled receptor L4
Synonyms: EGF-TM7 receptor, Etl, 1110033N21Rik, Eltd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 170757
Homologene: 11170
Olfm3
Name: olfactomedin 3
Synonyms: optimedin, B230206G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229759
Homologene: 17103
Rsrc1
Name: arginine/serine-rich coiled-coil 1
Synonyms: SRrp53, 1200013F24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66880
Homologene: 41147
Fam118b
Name: family with sequence similarity 118, member B
Synonyms: 2310022O21Rik, 2700018L24Rik, C030004A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 109229
Homologene: 11584
Zfp984
Name: zinc finger protein 984
Synonyms: Gm13157
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100041677
Homologene: 133076
Efhc1
Name: EF-hand domain (C-terminal) containing 1
Synonyms: 1700029F22Rik, mRib72-1, myoclonin1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71877
Homologene: 10003
Unc13b
Name: unc-13 homolog B
Synonyms: Unc13h2, Munc13-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 22249
Homologene: 31376
Siglec1
Name: sialic acid binding Ig-like lectin 1, sialoadhesin
Synonyms: CD169, Siglec-1, Sn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20612
Homologene: 124458
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, 2810003K23Rik, Dnahcl1, Dnahc17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Unc13c
Name: unc-13 homolog C
Synonyms: Munc13-3, Unc13h3, D9Ertd414e, 1500037O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208898
Homologene: 45443
Lrrc10
Name: leucine rich repeat containing 10
Synonyms: D330003I11Rik, Hrlrrp, Serdin1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237560
VEGA: 10
Homologene: 17154
Cntn4
Name: contactin 4
Synonyms: BIG-2A, Axcam
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 269784
HGNC: HGNC:2174
Homologene: 14257
Vmn1r53
Name: vomeronasal 1 receptor 53
Synonyms: VN5, V1rb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 113853
Homologene: 113975
Samd9l
Name: sterile alpha motif domain containing 9-like
Synonyms: ESTM25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 209086
HGNC: HGNC:1349
Homologene: 7707
Olfr992
Name: olfactory receptor 992
Synonyms: GA_x6K02T2Q125-46877170-46876241, MOR203-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258865
Homologene: 121517
Pelo
Name: pelota mRNA surveillance and ribosome rescue factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105083
VEGA: 13
HGNC: HGNC:8829
Homologene: 6835
Olfr697
Name: olfactory receptor 697
Synonyms: GA_x6K02T2PBJ9-9119301-9118348, MOR283-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258592
Olfr1382
Name: olfactory receptor 1382
Synonyms: GA_x6K02T2QP88-5901165-5900230, MOR256-43P, MOR256-57
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 257971
Gm6320
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Spata22
Name: spermatogenesis associated 22
Synonyms: LOC380709
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380709
Homologene: 13076
Gm10142
Name: predicted gene 10142
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 100502921
VEGA: 10
Homologene: 135713
Antxrl
Name: anthrax toxin receptor-like
Synonyms: 1700112N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239029
VEGA: 14
Homologene: 52111
Trabd2b
Name: TraB domain containing 2B
Synonyms: Gm12824, Hkat
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 666048
Homologene: 85034
Acss2
Name: acyl-CoA synthetase short-chain family member 2
Synonyms: acetyl-CoA synthetase 1, ACAS, AceCS1, Acas1, Acs1, Acas2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 60525
Homologene: 6469
Olfr849
Name: olfactory receptor 849
Synonyms: GA_x6K02T2PVTD-13176842-13177780, MOR151-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258520
Homologene: 74179
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 20,978,772 bp
  • T to C, chromosome 2 at 69,523,302 bp
  • T to A, chromosome 2 at 85,400,353 bp
  • C to T, chromosome 2 at 117,177,408 bp
  • A to G, chromosome 2 at 131,073,531 bp
  • G to A, chromosome 2 at 155,551,221 bp
  • G to A, chromosome 3 at 67,356,279 bp
  • A to G, chromosome 3 at 115,101,930 bp
  • G to A, chromosome 3 at 151,507,444 bp
  • T to A, chromosome 4 at 43,235,190 bp
  • A to G, chromosome 4 at 106,423,553 bp
  • T to A, chromosome 4 at 114,580,450 bp
  • T to A, chromosome 4 at 147,755,941 bp
  • T to A, chromosome 5 at 9,140,383 bp
  • C to A, chromosome 5 at 73,635,527 bp
  • G to T, chromosome 6 at 3,373,947 bp
  • T to A, chromosome 6 at 90,224,214 bp
  • T to C, chromosome 6 at 106,353,724 bp
  • T to C, chromosome 7 at 34,110,221 bp
  • A to G, chromosome 7 at 106,741,851 bp
  • T to C, chromosome 7 at 127,922,250 bp
  • G to A, chromosome 7 at 130,394,725 bp
  • C to A, chromosome 7 at 141,651,990 bp
  • A to T, chromosome 9 at 19,441,432 bp
  • A to T, chromosome 9 at 35,221,425 bp
  • C to T, chromosome 9 at 73,574,074 bp
  • T to C, chromosome 10 at 77,716,035 bp
  • A to G, chromosome 10 at 117,045,933 bp
  • G to A, chromosome 11 at 49,535,566 bp
  • G to T, chromosome 11 at 73,340,593 bp
  • G to A, chromosome 11 at 98,157,036 bp
  • C to A, chromosome 11 at 118,127,137 bp
  • A to G, chromosome 13 at 112,997,392 bp
  • A to G, chromosome 13 at 115,088,973 bp
  • T to A, chromosome 14 at 34,070,451 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1293 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039359-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.