Strain Name:
C57BL/6J-MtgxR1294Btlr/Mmmh
Stock Number:
039360-MU
Citation ID:
RRID:MMRRC_039360-MU
Other Names:
R1294 (G1), C57BL/6J-MtgxR1294Btlr
Major Collection:

Strain Information

Serpinc1
Name: serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
Synonyms: antithrombin, ATIII, At-3, At3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11905
HGNC: HGNC:775
Homologene: 20139
Elavl2
Name: ELAV like RNA binding protein 1
Synonyms: mel-N1, Hub
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15569
HGNC: HGNC:3313
Homologene: 20930
Tbc1d22a
Name: TBC1 domain family, member 22a
Synonyms: D15Ertd781e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223754
VEGA: 15
HGNC: HGNC:1309
Homologene: 105406
Pcbp3
Name: poly(rC) binding protein 3
Synonyms: AlphaCP-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 59093
HGNC: HGNC:8651
Homologene: 23233
Setd2
Name: SET domain containing 2
Synonyms: 4921524K10Rik, KMT3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235626
Homologene: 56493
Fxr1
Name: FMR1 autosomal homolog 1
Synonyms: 1110050J02Rik, Fxr1p, 9530073J07Rik, Fxr1h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14359
HGNC: HGNC:4023
Homologene: 3573
Polr1a
Name: polymerase (RNA) I polypeptide A
Synonyms: mRPA1, RPA194, 194kDa, 3010014K16Rik, Rpo1-4, 2900087K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20019
Homologene: 7033
Rapsn
Name: receptor-associated protein of the synapse
Synonyms: rapsyn, Raps, 43kDa acetylcholine receptor-associated protein, Nraps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19400
HGNC: HGNC:9863
Homologene: 3708
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Lap3
Name: leucine aminopeptidase 3
Synonyms: Pep-S, Pep-7, LAP, peptidase S, Pep7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66988
Homologene: 41072
Slc25a20
Name: solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20
Synonyms: mCAC, Cact, 1110007P09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 57279
HGNC: HGNC:1421
Homologene: 331
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94109
Homologene: 69536
Skiv2l
Name: superkiller viralicidic activity 2-like (S. cerevisiae)
Synonyms: Ski2w, 4930534J06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 108077
Homologene: 123971
Ghr
Name: growth hormone receptor
Synonyms: GHBP, GHR/BP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 14600
HGNC: HGNC:4263
Homologene: 134
Trim58
Name: tripartite motif-containing 58
Synonyms: LOC216781, LOC386443
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216781
Homologene: 9135
Tdrd1
Name: tudor domain containing 1
Synonyms: MTR-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 83561
Homologene: 12850
Slc24a1
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 214111
VEGA: 9
Homologene: 3472
Dhh
Name: desert hedgehog
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13363
VEGA: 15
HGNC: HGNC:2865
Homologene: 22431
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: C130004B06Rik, LOC384050, 1110020C03Rik, Wdr65
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68625
Homologene: 51350
Zfp27
Name: zinc finger protein 27
Synonyms: mkr-4, Zfp-27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22689
Homologene: 81823
Spam1
Name: sperm adhesion molecule 1
Synonyms: Ph-20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20690
Homologene: 7547
Vmn1r25
Name: vomeronasal 1 receptor 25
Synonyms: V1rc8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 113865
Homologene: 137652
Plaat5
Name: phospholipase A and acyltransferase 5
Synonyms: 1700086E08Rik, 1700055A14Rik, 4921526K24Rik, iNAT, Hrasls5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 66727
Homologene: 12019
C2cd2
Name: C2 calcium-dependent domain containing 2
Synonyms: ORF25, 5830404H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 207781
VEGA: 16
HGNC: HGNC:1266
Homologene: 18368
Rxrg
Name: retinoid X receptor gamma
Synonyms: Nr2b3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20183
Homologene: 21373
Csta2
Name: cystatin A family member 2
Synonyms: 2010005H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 76770
HGNC: HGNC:2481
Homologene: 3819
Cnn2
Name: calponin 2
Synonyms: h2-calponin, Calpo2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12798
HGNC: HGNC:2156
Homologene: 3215
Gm10471
Name: predicted gene 10471
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100039045
Homologene: 69402
Klk1b3
Name: kallikrein 1-related peptidase b3
Synonyms: mGk-3, Ngfg, Ngfg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18050
Homologene: 68141
AC119271.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Rab3c
Name: RAB3C, member RAS oncogene family
Synonyms: 3110037E15Rik, 3110015B08Rik, 2700062I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67295
VEGA: 13
Homologene: 23420
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 160,989,641 bp
  • G to T, chromosome 1 at 167,613,901 bp
  • A to T, chromosome 2 at 91,036,775 bp
  • T to C, chromosome 2 at 180,190,921 bp
  • T to A, chromosome 3 at 34,047,052 bp
  • G to A, chromosome 4 at 91,311,589 bp
  • A to T, chromosome 4 at 118,606,534 bp
  • G to A, chromosome 5 at 26,088,107 bp
  • T to C, chromosome 5 at 45,498,521 bp
  • A to G, chromosome 6 at 24,796,907 bp
  • A to G, chromosome 6 at 57,978,479 bp
  • A to T, chromosome 6 at 71,912,902 bp
  • T to A, chromosome 7 at 29,896,312 bp
  • C to A, chromosome 7 at 44,200,296 bp
  • T to C, chromosome 7 at 68,619,114 bp
  • T to C, chromosome 8 at 16,698,036 bp
  • A to T, chromosome 9 at 64,936,013 bp
  • A to G, chromosome 9 at 108,677,639 bp
  • A to G, chromosome 9 at 110,549,507 bp
  • A to G, chromosome 10 at 76,763,321 bp
  • A to G, chromosome 10 at 79,993,525 bp
  • T to A, chromosome 11 at 58,643,127 bp
  • T to C, chromosome 13 at 110,260,565 bp
  • A to G, chromosome 15 at 3,388,646 bp
  • T to A, chromosome 15 at 86,496,826 bp
  • T to C, chromosome 15 at 98,894,383 bp
  • T to A, chromosome 16 at 36,257,252 bp
  • A to G, chromosome 16 at 97,922,269 bp
  • T to C, chromosome 17 at 34,841,064 bp
  • A to G, chromosome 19 at 7,614,650 bp
  • A to G, chromosome 19 at 56,848,776 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1294 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039360-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.