Strain Name:
C57BL/6J-MtgxR1385Btlr/Mmmh
Stock Number:
039447-MU
Citation ID:
RRID:MMRRC_039447-MU
Other Names:
R1385 (G1), C57BL/6J-MtgxR1385Btlr
Major Collection:

Gene Information

Sphk2
Name: sphingosine kinase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56632
Homologene: 32456
Prkcd
Name: protein kinase C, delta
Synonyms: PKCdelta, PKC[d], Pkcd, D14Ertd420e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18753
HGNC: HGNC:9399
Homologene: 55963
Aldh7a1
Name: aldehyde dehydrogenase family 7, member A1
Synonyms: Atq1, D18Wsu181e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 110695
HGNC: HGNC:877
Homologene: 913
Nup155
Name: nucleoporin 155
Synonyms: D930027M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 170762
VEGA: 15
HGNC: HGNC:8063
Homologene: 43155
Pdzd2
Name: PDZ domain containing 2
Synonyms: 4930537L06Rik, LOC223364, A930022H17Rik, Pdzk3, Gm21706
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 68070
Homologene: 23393
Arhgef6
Name: Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
Synonyms: 1700038J06Rik, 1600028C08Rik, 4930592P22Rik, alpha-PIX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 73341
HGNC: HGNC:685
Homologene: 3561
Dhx9
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 9
Synonyms: leukophysin, nuclear DNA helicase II, RNA helicase, Ddx9, NDH II, NDHII, RHA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13211
HGNC: HGNC:2750
Homologene: 1039
Kat6b
Name: K(lysine) acetyltransferase 6B
Synonyms: qkf, querkopf, Morf, B130044K16Rik, monocytic leukemia, Myst4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 54169
Homologene: 136480
Xpo1
Name: exportin 1
Synonyms: Crm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103573
Homologene: 2554
Hunk
Name: hormonally upregulated Neu-associated kinase
Synonyms: Mak-v, Bstk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 26559
VEGA: 16
Homologene: 8742
Uhrf1bp1l
Name: UHRF1 (ICBP90) binding protein 1-like
Synonyms: 4930506D01Rik, 2010319N22Rik, E030041M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 75089
VEGA: 10
Homologene: 12590
Anapc2
Name: anaphase promoting complex subunit 2
Synonyms: expressed during mesenchymal induction 4, Emi4, APC2, 9230107K09Rik, Imi4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99152
Homologene: 8359
Zfp407
Name: zinc finger protein 407
Synonyms: LOC381139, LOC240469, 6430585N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240476
Homologene: 86402
Nr2c2
Name: nuclear receptor subfamily 2, group C, member 2
Synonyms: TAK1, Tr4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22026
HGNC: HGNC:7972
Homologene: 2475
Ncapd2
Name: non-SMC condensin I complex, subunit D2
Synonyms: CNAP1, CAP-D2, 2810406C15Rik, 2810465G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68298
Homologene: 6497
Sucla2
Name: succinate-Coenzyme A ligase, ADP-forming, beta subunit
Synonyms: 4930547K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 20916
Homologene: 2856
Iws1
Name: IWS1, SUPT6 interacting protein
Synonyms: 1700069O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 73473
Homologene: 134421
Prkcq
Name: protein kinase C, theta
Synonyms: PKC-0, Pkcq, A130035A12Rik, PKC-theta, PKC theta, PKCtheta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18761
HGNC: HGNC:9410
Homologene: 21263
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: A930005E13Rik, LOC381562, D930005K06Rik, 1810009A16Rik, Zubr1, p600
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69116
Homologene: 10804
Gemin2
Name: gem nuclear organelle associated protein 2
Synonyms: 1700012N19Rik, Sip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 66603
Homologene: 37827
Prune2
Name: prune homolog 2
Synonyms: 6330414G02Rik, A330102H22Rik, A230083H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 353211
VEGA: 19
Homologene: 18939
Treml1
Name: triggering receptor expressed on myeloid cells-like 1
Synonyms: TLT-1, 5430401J17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 71326
VEGA: 17
Homologene: 52257
Cndp1
Name: carnosine dipeptidase 1 (metallopeptidase M20 family)
Synonyms: Cn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 338403
Homologene: 57178
Cep76
Name: centrosomal protein 76
Synonyms: 6230425F05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225659
VEGA: 18
Homologene: 11774
Trim33
Name: tripartite motif-containing 33
Synonyms: Tif1g, 8030451N04Rik, ectodermin, Ecto
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 94093
Homologene: 9296
Arhgap1
Name: Rho GTPase activating protein 1
Synonyms: B230365D05Rik, p50rhoGAP, Cdc42GAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228359
HGNC: HGNC:673
Homologene: 20909
Slc5a2
Name: solute carrier family 5 (sodium/glucose cotransporter), member 2
Synonyms: Sglt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 246787
Homologene: 2289
Col9a2
Name: collagen, type IX, alpha 2
Synonyms: Col9a-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12840
HGNC: HGNC:2218
Homologene: 37535
Lama2
Name: laminin, alpha 2
Synonyms: merosin, mer
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hy-3, hy3, 1700034M11Rik, 4930545D19Rik, hyrh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244653
Homologene: 52118
Zfand4
Name: zinc finger, AN1-type domain 4
Synonyms: 2810002D23Rik, Anubl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67492
VEGA: 6
Homologene: 18373
Ptpro
Name: protein tyrosine phosphatase, receptor type, O
Synonyms: D28, PTPROt, PTP-phi, PTP-BK, PTP-U2, GLEPP1, PTP-oc, Ptpn15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
Nynrin
Name: NYN domain and retroviral integrase containing
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 277154
VEGA: 14
Homologene: 19483
Cfap44
Name: cilia and flagella associated protein 44
Synonyms: 6330444M21Rik, D16Ertd642e, Wdr52
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 212517
Homologene: 75085
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Scn9a
Name: sodium channel, voltage-gated, type IX, alpha
Synonyms: PN1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20274
Homologene: 2237
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC9, MUC5, 2300002I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Ccdc39
Name: coiled-coil domain containing 39
Synonyms: 4921507O14Rik, D3Ertd789e, b2b1735Clo, b2b1304Clo, b2b2025.1Clo, prh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 51938
Homologene: 12149
Edem1
Name: ER degradation enhancer, mannosidase alpha-like 1
Synonyms: A130059K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 192193
Homologene: 33836
Ppp1r9b
Name: protein phosphatase 1, regulatory subunit 9B
Synonyms: neurabin II, spinophilin, Spn, SPL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217124
HGNC: HGNC:9298
Homologene: 32787
Vmn2r82
Name: vomeronasal 2, receptor 82
Synonyms: EG624845
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 624845
Homologene: 83483
Erich6
Name: glutamate rich 6
Synonyms: 4932431H17Rik, Fam194a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 545527
Homologene: 65043
Polg2
Name: polymerase (DNA directed), gamma 2, accessory subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 50776
HGNC: HGNC:9180
Homologene: 5221
Itgbl1
Name: integrin, beta-like 1
Synonyms: with EGF-like repeat domains, B930011D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 223272
HGNC: HGNC:6164
Homologene: 3519
Ocstamp
Name: osteoclast stimulatory transmembrane protein
Synonyms: 4833422F24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74614
Homologene: 41768
Atxn7l3
Name: ataxin 7-like 3
Synonyms: E030022H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217218
Homologene: 35401
Zfp119a
Name: zinc finger protein 119a
Synonyms: Zfp119, Mzf13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 104349
Cntn6
Name: contactin 6
Synonyms: NB-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 53870
HGNC: HGNC:2176
Homologene: 8702
Lrrc56
Name: leucine rich repeat containing 56
Synonyms: 5730427C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 70552
Homologene: 115748
Ap5s1
Name: adaptor-related protein 5 complex, sigma 1 subunit
Synonyms: 0610038L13Rik, 2310035K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 69596
Homologene: 23095
Pllp
Name: plasma membrane proteolipid
Synonyms: 0610010I06Rik, plasmolipin, Tm4sf11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67801
Homologene: 9329
Tedc2
Name: tubulin epsilon and delta complex 2
Synonyms: 1600002H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72016
Homologene: 45943
Arf3
Name: ADP-ribosylation factor 3
Synonyms: 5430400P17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 11842
HGNC: HGNC:654
Homologene: 68195
Trpv6
Name: transient receptor potential cation channel, subfamily V, member 6
Synonyms: CaT1, Cac, CAT, Ecac2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 64177
Homologene: 56812
Insyn1
Name: inhibitory synaptic factor 1
Synonyms: 6030419C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319477
VEGA: 9
Homologene: 18538
Gm13318
Name: predicted gene 13318
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Serpinb5
Name: serine (or cysteine) peptidase inhibitor, clade B, member 5
Synonyms: Maspin, Spi7, ovalbumin, 1110036M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20724
HGNC: HGNC:8949
Homologene: 20580
Mxd1
Name: MAX dimerization protein 1
Synonyms: Mad, Mad1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17119
HGNC: HGNC:6761
Homologene: 1767
A930016O22Rik
Name: RIKEN cDNA A930016O22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100503495
Mageb11
Name: MAGE family member B11
Synonyms: LOC212952, Gm44
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 212952
VEGA: X
Homologene: 106177
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 106,876,123 bp
  • T to C, chromosome 1 at 153,458,050 bp
  • A to G, chromosome 2 at 11,256,286 bp
  • A to T, chromosome 2 at 16,042,228 bp
  • T to C, chromosome 2 at 25,273,795 bp
  • G to A, chromosome 2 at 66,563,542 bp
  • C to A, chromosome 2 at 91,670,831 bp
  • T to C, chromosome 2 at 131,213,156 bp
  • T to C, chromosome 2 at 165,396,039 bp
  • C to T, chromosome 3 at 33,821,412 bp
  • A to G, chromosome 3 at 58,636,830 bp
  • A to G, chromosome 3 at 103,310,950 bp
  • T to C, chromosome 4 at 121,052,032 bp
  • A to G, chromosome 4 at 139,402,612 bp
  • T to C, chromosome 6 at 41,621,129 bp
  • T to A, chromosome 6 at 86,651,567 bp
  • T to G, chromosome 6 at 92,154,470 bp
  • A to G, chromosome 6 at 104,861,900 bp
  • A to G, chromosome 6 at 108,846,684 bp
  • G to A, chromosome 6 at 116,273,638 bp
  • A to T, chromosome 6 at 125,173,115 bp
  • T to A, chromosome 6 at 137,443,594 bp
  • G to T, chromosome 7 at 19,426,027 bp
  • A to G, chromosome 7 at 45,712,291 bp
  • G to C, chromosome 7 at 128,270,631 bp
  • A to G, chromosome 7 at 141,205,525 bp
  • T to C, chromosome 7 at 141,862,137 bp
  • A to G, chromosome 8 at 94,679,368 bp
  • A to G, chromosome 8 at 110,523,204 bp
  • AGAGGAGGAGGAGGAGG to AGAGGAGGAGGAGG, chromosome 9 at 58,499,432 bp
  • C to A, chromosome 10 at 27,224,043 bp
  • A to T, chromosome 10 at 79,396,491 bp
  • A to G, chromosome 10 at 89,790,641 bp
  • T to C, chromosome 11 at 23,261,863 bp
  • T to C, chromosome 11 at 59,131,646 bp
  • A to G, chromosome 11 at 94,992,211 bp
  • C to G, chromosome 11 at 102,292,435 bp
  • A to G, chromosome 11 at 106,768,323 bp
  • A to G, chromosome 12 at 59,018,146 bp
  • C to T, chromosome 14 at 21,619,014 bp
  • G to A, chromosome 14 at 30,607,405 bp
  • A to T, chromosome 14 at 55,864,899 bp
  • C to T, chromosome 14 at 73,560,634 bp
  • A to G, chromosome 14 at 123,661,511 bp
  • A to T, chromosome 15 at 8,157,760 bp
  • T to C, chromosome 15 at 12,411,022 bp
  • A to G, chromosome 15 at 98,742,613 bp
  • A to G, chromosome 16 at 44,470,775 bp
  • T to A, chromosome 16 at 90,472,486 bp
  • T to A, chromosome 17 at 24,216,317 bp
  • C to A, chromosome 17 at 24,216,318 bp
  • T to G, chromosome 17 at 48,360,198 bp
  • T to A, chromosome 17 at 55,865,826 bp
  • T to A, chromosome 18 at 32,090,430 bp
  • A to G, chromosome 18 at 56,542,285 bp
  • A to G, chromosome 18 at 67,637,124 bp
  • C to T, chromosome 18 at 84,559,773 bp
  • G to A, chromosome 18 at 84,634,652 bp
  • A to G, chromosome 19 at 17,124,948 bp
  • T to C, chromosome X at 57,338,562 bp
  • T to A, chromosome X at 90,892,268 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1385 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039447-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.