Strain Name:
C57BL/6J-MtgxR1424Btlr/Mmmh
Stock Number:
039480-MU
Citation ID:
RRID:MMRRC_039480-MU
Other Names:
R1424 (G1), C57BL/6J-MtgxR1424Btlr
Major Collection:

Gene Information

Fgb
Name: fibrinogen beta chain
Synonyms: 2510049G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 110135
HGNC: HGNC:3662
Homologene: 3772
Kcnj10
Name: potassium inwardly-rectifying channel, subfamily J, member 10
Synonyms: BIR10, BIRK-1, Kir4.1, Kir4.1, Kir1.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 16513
HGNC: HGNC:6256
Homologene: 1689
Rptor
Name: regulatory associated protein of MTOR, complex 1
Synonyms: raptor, Rap, 4932417H02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 74370
Homologene: 80210
Sbf2
Name: SET binding factor 2
Synonyms: B430219L04Rik, SBF2, 4833411B01Rik, mMTMH1, Mtmr13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 319934
HGNC: HGNC:2135
Homologene: 41810
Ptprz1
Name: protein tyrosine phosphatase, receptor type Z, polypeptide 1
Synonyms: PTPbeta, DSD-1-PG, Ptprz, Ptpz, Rptpbeta, PTPzeta, RPTPz, phosphacan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Dgka
Name: diacylglycerol kinase, alpha
Synonyms: Dagk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 13139
VEGA: 10
HGNC: HGNC:2849
Homologene: 1028
Taok1
Name: TAO kinase 1
Synonyms: 2810468K05Rik, D130018F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216965
Homologene: 27041
Ube2o
Name: ubiquitin-conjugating enzyme E2O
Synonyms: B230113M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217342
Homologene: 11113
Rere
Name: arginine glutamic acid dipeptide (RE) repeats
Synonyms: eyem03Jus, Atr2, 1110033A15Rik, atrophin-2, eyes3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 68703
HGNC: HGNC:9965
Homologene: 8101
Fndc3a
Name: fibronectin type III domain containing 3A
Synonyms: sys, F730017H24Rik, 1700094E19Rik, Fndc3, D14Ertd453e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 319448
Homologene: 8952
Mmp16
Name: matrix metallopeptidase 16
Synonyms: Membrane type 3-MMP, MT3-MMP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 17389
HGNC: HGNC:7162
Homologene: 55939
Eif4g1
Name: eukaryotic translation initiation factor 4, gamma 1
Synonyms: E030015G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 208643
HGNC: HGNC:3296
Homologene: 110725
Dtl
Name: denticleless E3 ubiquitin protein ligase
Synonyms: 5730564G15Rik, 2810047L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 76843
Homologene: 32313
Casp2
Name: caspase 2
Synonyms: Caspase-2, Ich-1, Nedd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12366
HGNC: HGNC:1503
Homologene: 7254
Anxa5
Name: annexin A5
Synonyms: annexin V, Anx5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 11747
HGNC: HGNC:543
Homologene: 20312
Dnajc6
Name: DnaJ heat shock protein family (Hsp40) member C6
Synonyms: 2810027M23Rik, auxilin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 72685
Homologene: 8865
Tab2
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 2
Synonyms: Tak1 binding protein 2, A530078N03Rik, 1110030N06Rik, Map3k7ip2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 68652
Homologene: 9019
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 545370
Homologene: 23741
Pcsk2
Name: proprotein convertase subtilisin/kexin type 2
Synonyms: PC2, 6330411F23Rik, prohormone convertase 2, Phpp-2, SPC2, Nec-2, Nec2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 18549
HGNC: HGNC:8744
Homologene: 37640
Ush2a
Name: usherin
Synonyms: Ush2a, Ushrn, MUSH2A, A930037M10Rik, A930011D15Rik, LOC269160, LOC381317
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 22283
Homologene: 66151
Lama3
Name: laminin, alpha 3
Synonyms: nicein, 150kDa, [a]3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Dock3
Name: dedicator of cyto-kinesis 3
Synonyms: Moca, PBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 208869
HGNC: HGNC:2989
Homologene: 21030
Tuba8
Name: tubulin, alpha 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 53857
Homologene: 56766
Olfr1260
Name: olfactory receptor 1260
Synonyms: GA_x6K02T2Q125-51409740-51410672, MOR232-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258983
HGNC: null
Homologene: 17455
Shank2
Name: SH3 and multiple ankyrin repeat domains 2
Synonyms: ProSAP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 210274
Homologene: 105965
Olfr729
Name: olfactory receptor 729
Synonyms: MOR246-6, GA_x6K02T2PMLR-5839874-5838903
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 258275
Homologene: 17167
Acad12
Name: acyl-Coenzyme A dehydrogenase family, member 12
Synonyms: 9330129D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 338350
HGNC: null
Homologene: null
Matn3
Name: matrilin 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 17182
HGNC: HGNC:6909
Homologene: 1785
Top2b
Name: topoisomerase (DNA) II beta
Synonyms: Top-2, D230016L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 21974
Homologene: 134711
Fam227a
Name: family with sequence similarity 227, member A
Synonyms: 4933432B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 75729
Homologene: 123434
Gli3
Name: GLI-Kruppel family member GLI3
Synonyms: Bph, brachyphalangy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 14634
HGNC: HGNC:4319
Homologene: 139
Nsd3
Name: nuclear receptor binding SET domain protein 3
Synonyms: WHISTLE, Whsc1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234135
Homologene: 56960
Olfr749
Name: olfactory receptor 749
Synonyms: MOR106-1, GA_x6K02T2PMLR-6484046-6483105
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 56858
Homologene: 10652
Sdk1
Name: sidekick cell adhesion molecule 1
Synonyms: 6720466O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 330222
Homologene: 27395
Ap1m2
Name: adaptor protein complex AP-1, mu 2 subunit
Synonyms: D9Ertd818e, [m]1B, mu1B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 11768
VEGA: 9
HGNC: HGNC:558
Homologene: 55906
Olfr412
Name: olfactory receptor 412
Synonyms: GA_x6K02T2P1NL-4500587-4501525, MOR127-5P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 258153
HGNC: HGNC:8183
Homologene: 37634
Pcdhb12
Name: protocadherin beta 12
Synonyms: Pcdhb5F, Pcdh3, PcdhbL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 93883
HGNC: null
Homologene: 87126
Sh3bp1
Name: SH3-domain binding protein 1
Synonyms: 3BP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 20401
Homologene: 7534
Fmo1
Name: flavin containing monooxygenase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 14261
HGNC: HGNC:3769
Homologene: 55520
Cel
Name: carboxyl ester lipase
Synonyms: BAL, 1810036E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 12613
HGNC: HGNC:1848
Homologene: 37529
Abcb10
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 10
Synonyms: ABC-me
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 56199
HGNC: HGNC:41
Homologene: 6474
Tmprss11b
Name: transmembrane protease, serine 11B
Synonyms: 9930019B18Rik, Tmprss11bnl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 319875
Homologene: 64599
Acox2
Name: acyl-Coenzyme A oxidase 2, branched chain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 93732
HGNC: HGNC:120
Homologene: 74473
Gtpbp6
Name: GTP binding protein 6 (putative)
Synonyms: pgpl, Pgbpll
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 107999
Homologene: 8157
Tmem117
Name: transmembrane protein 117
Synonyms: B930062P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 320709
VEGA: 15
Homologene: 12992
Gtsf1
Name: gametocyte specific factor 1
Synonyms: Cue110, 1700006H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 74174
Homologene: 16942
Fam98a
Name: family with sequence similarity 98, member A
Synonyms: 2810405J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 72722
Homologene: 41042
Vmn2r23
Name: vomeronasal 2, receptor 23
Synonyms: EG435916
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 435916
HGNC: null
Homologene: 135826
4930447C04Rik
Name: RIKEN cDNA 4930447C04 gene
Synonyms: Six6os1, Six6as
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 75801
Homologene: 49922
Prdm12
Name: PR domain containing 12
Synonyms: LOC381359
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 381359
Homologene: 10999
Tas2r121
Name: taste receptor, type 2, member 121
Synonyms: Tas2r21, T2R21, mGR21, mT2r48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 387349
Homologene: 41542
D830014E11Rik
Name: RIKEN cDNA D830014E11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 320751
Ensembl: null
VEGA: 5
HGNC: null
Homologene: null
Depp1
Name: DEPP1 autophagy regulator
Synonyms: Depp, 8430408G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 213393
Homologene: 48491
Tmtc2
Name: transmembrane and tetratricopeptide repeat containing 2
Synonyms: 8430438D04Rik, D330034A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 278279
Homologene: 25521
Tsga10ip
Name: testis specific 10 interacting protein
Synonyms: 1810013N20Rik, Fam161c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 78306
VEGA: 19
Homologene: 17663
Gm3443
Name: predicted gene 3443
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: null
VEGA: null
Homologene: null
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 150,646,794 bp
  • C to T, chromosome 1 at 162,830,066 bp
  • T to A, chromosome 1 at 172,369,255 bp
  • T to G, chromosome 1 at 188,542,878 bp
  • T to C, chromosome 1 at 191,561,537 bp
  • C to T, chromosome 2 at 28,559,624 bp
  • C to T, chromosome 2 at 31,643,811 bp
  • C to T, chromosome 2 at 89,978,071 bp
  • T to C, chromosome 2 at 143,573,428 bp
  • A to T, chromosome 3 at 36,452,292 bp
  • A to T, chromosome 3 at 83,046,763 bp
  • A to G, chromosome 4 at 18,112,121 bp
  • A to G, chromosome 4 at 101,639,347 bp
  • C to T, chromosome 4 at 150,617,038 bp
  • T to C, chromosome 5 at 86,664,973 bp
  • G to A, chromosome 5 at 105,826,916 bp
  • C to T, chromosome 5 at 110,104,289 bp
  • C to T, chromosome 5 at 121,604,322 bp
  • C to T, chromosome 5 at 142,161,866 bp
  • A to G, chromosome 6 at 23,000,383 bp
  • T to C, chromosome 6 at 42,276,791 bp
  • A to G, chromosome 6 at 116,652,005 bp
  • A to G, chromosome 6 at 121,220,511 bp
  • T to A, chromosome 6 at 123,713,270 bp
  • A to G, chromosome 6 at 132,700,682 bp
  • A to T, chromosome 7 at 110,315,026 bp
  • T to A, chromosome 7 at 144,052,372 bp
  • A to G, chromosome 8 at 25,700,566 bp
  • C to T, chromosome 8 at 123,962,052 bp
  • A to T, chromosome 9 at 21,298,204 bp
  • T to C, chromosome 9 at 106,913,193 bp
  • A to C, chromosome 10 at 7,920,048 bp
  • G to T, chromosome 10 at 105,413,368 bp
  • A to T, chromosome 10 at 128,733,333 bp
  • C to A, chromosome 11 at 74,364,954 bp
  • G to T, chromosome 11 at 77,549,364 bp
  • A to G, chromosome 11 at 116,543,732 bp
  • T to A, chromosome 11 at 119,780,593 bp
  • G to T, chromosome 12 at 8,961,132 bp
  • C to A, chromosome 12 at 72,892,895 bp
  • C to A, chromosome 13 at 15,726,314 bp
  • T to A, chromosome 14 at 8,230,247 bp
  • G to A, chromosome 14 at 16,383,177 bp
  • C to A, chromosome 14 at 50,148,465 bp
  • A to T, chromosome 14 at 50,737,064 bp
  • C to T, chromosome 14 at 72,574,371 bp
  • T to C, chromosome 15 at 78,903,699 bp
  • T to A, chromosome 15 at 79,634,108 bp
  • A to G, chromosome 15 at 94,931,808 bp
  • A to T, chromosome 15 at 103,409,643 bp
  • T to C, chromosome 16 at 20,678,942 bp
  • G to A, chromosome 16 at 37,086,528 bp
  • A to G, chromosome 17 at 75,540,178 bp
  • C to A, chromosome 18 at 12,519,991 bp
  • T to A, chromosome 18 at 37,438,079 bp
  • C to T, chromosome 19 at 5,390,914 bp
  • A to T, chromosome 19 at 21,557,595 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1424 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039480-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.