Strain Name:
C57BL/6J-MtgxR1718Btlr/Mmmh
Stock Number:
039751-MU
Citation ID:
RRID:MMRRC_039751-MU
Other Names:
R1718 (G1), C57BL/6J-MtgxR1718Btlr
Major Collection:

Strain Information

Ip6k1
Name: inositol hexaphosphate kinase 1
Synonyms: Ihpk1, 1200016D08Rik, InsP6, InsP6k1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 27399
Homologene: 56602
Tti1
Name: TELO2 interacting protein 1
Synonyms: 2610036D13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75425
Homologene: 40969
Agrn
Name: agrin
Synonyms: nmf380, NMF380, Agrin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11603
HGNC: HGNC:329
Homologene: 27907
Ralgapb
Name: Ral GTPase activating protein, beta subunit (non-catalytic)
Synonyms: B230339M05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228850
Homologene: 10666
Smchd1
Name: SMC hinge domain containing 1
Synonyms: MommeD1, 4931400A14Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74355
Homologene: 23665
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: Ki67, Ki-67, D630048A14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Zik1
Name: zinc finger protein interacting with K protein 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22775
Homologene: 32076
Lrrfip1
Name: leucine rich repeat (in FLII) interacting protein 1
Synonyms: Fliiap1, FLAP (FLI LRR associated protein)
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16978
HGNC: HGNC:6702
Homologene: 48301
Slc7a6os
Name: solute carrier family 7, member 6 opposite strand
Synonyms: 2400002F02Rik, 2010007L18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66432
Homologene: 41853
Apob
Name: apolipoprotein B
Synonyms: apob-48, apob-100
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Camta1
Name: calmodulin binding transcription activator 1
Synonyms: 1810059M14Rik, 2310058O09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100072
Homologene: 18942
Map3k1
Name: mitogen-activated protein kinase kinase kinase 1
Synonyms: MEKK1, Mekk
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26401
HGNC: HGNC:6848
Homologene: 8056
Cemip
Name: cell migration inducing protein, hyaluronan binding
Synonyms: Hybid, 6330404C01Rik, 12H19.01.T7, 9930013L23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80982
Homologene: 10268
Hapln3
Name: hyaluronan and proteoglycan link protein 3
Synonyms: 4930554N11Rik, Lpr3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67666
Homologene: 18654
Cyp4x1
Name: cytochrome P450, family 4, subfamily x, polypeptide 1
Synonyms: Cyp4a28-ps
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 81906
Homologene: 75853
Enpp7
Name: ectonucleotide pyrophosphatase/phosphodiesterase 7
Synonyms: LOC238011, Alk-SMase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 238011
Homologene: 110852
Mgme1
Name: mitochondrial genome maintenance exonuclease 1
Synonyms: 8430406I07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74528
Homologene: 12573
Tnks1bp1
Name: tankyrase 1 binding protein 1
Synonyms: TAB182
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228140
Homologene: 14117
Retsat
Name: retinol saturase (all trans retinol 13,14 reductase)
Synonyms: 0610039N19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67442
Homologene: 41195
Bpifb1
Name: BPI fold containing family B, member 1
Synonyms: U46068, von Ebner minor salivary protein, LPlunc1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228801
Homologene: 50047
Smarcc2
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
Synonyms: 5930405J04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 68094
VEGA: 10
Homologene: 2312
2410017I17Rik
Name: RIKEN cDNA 2410017I17 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 675325
Ccdc116
Name: coiled-coil domain containing 116
Synonyms: 4930432J16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 76872
Homologene: 51873
Mcoln2
Name: mucolipin 2
Synonyms: mucolipidin 2, 3300002C04Rik, TRPML2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68279
Homologene: 12258
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: Dnahc9, D11Ertd686e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Rtcb
Name: RNA 2',3'-cyclic phosphate and 5'-OH ligase
Synonyms: HSPC117, D10Wsu52e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 28088
Homologene: 36344
Vmn2r61
Name: vomeronasal 2, receptor 61
Synonyms: Gprc2a-rs2, EG637873, Casr-rs2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637873
Homologene: 129683
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: E130113P14Rik, bl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Phldb3
Name: pleckstrin homology like domain, family B, member 3
Synonyms: EG232970, Gm10102
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232970
Homologene: 109375
Btn2a2
Name: butyrophilin, subfamily 2, member A2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238555
Homologene: 56012
Tulp4
Name: TUB like protein 4
Synonyms: 2210038L17Rik, 1110057P05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68842
Homologene: 32467
Adamts19
Name: ADAM metallopeptidase with thrombospondin type 1 motif 19
Synonyms: D230034E10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240322
VEGA: 18
Homologene: 15860
Rab11fip2
Name: RAB11 family interacting protein 2 (class I)
Synonyms: nRip11, Rab11-FIP2, 4930470G04Rik, A830046J09Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74998
Homologene: 8937
Pla2g4a
Name: phospholipase A2, group IVA (cytosolic, calcium-dependent)
Synonyms: cytosolic PLA2, cytosolic phospholipase A2, cPLA2, Pla2g4, cPLA2alpha, Type IV PLA2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18783
HGNC: HGNC:9035
Homologene: 32059
Rem2
Name: rad and gem related GTP binding protein 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 140743
Homologene: 11222
Speg
Name: SPEG complex locus
Synonyms: D1Bwg1450e, BPEG, Apeg1, SPEG, SPEGalpha, SPEGbeta
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11790
Homologene: 55619
Notch4
Name: notch 4
Synonyms: Int-3, N4, Int3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18132
HGNC: HGNC:7884
Homologene: 3351
Mfsd2b
Name: MFSD2 lysolipid transporter B, sphingolipid
Synonyms: Gm1964, major facilitator superfamily domain containing 2B
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 432628
Homologene: 47753
Pla2g4b
Name: phospholipase A2, group IVB (cytosolic)
Synonyms: A030011C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 211429
Homologene: 3730
2210408I21Rik
Name: RIKEN cDNA 2210408I21 gene
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72371
Homologene: 89234
Klk1b4
Name: kallikrein 1-related pepidase b4
Synonyms: mGk-4, Ngfa, Ngfa
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18048
Homologene: 68141
Or8c10
Name: olfactory receptor family 8 subfamily C member 10
Synonyms: MOR170-14, MOR170-8, GA_x6K02T2PVTD-32060891-32061865, Olfr899, Olfr250, GA_x6K02T2MYUG-19447-18473
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 404312
VEGA: 9
Homologene: 74151
Or5ak25
Name: olfactory receptor family 5 subfamily AK member 25
Synonyms: GA_x6K02T2Q125-46915844-46914897, MOR203-3, Olfr995
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258426
Homologene: 105170
Clip2
Name: CAP-GLY domain containing linker protein 2
Synonyms: CLIP-115, WSCR4, Cyln2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269713
HGNC: HGNC:2586
Homologene: 20718
Dip2a
Name: disco interacting protein 2 homolog A
Synonyms: Kiaa0184-hp, Dip2, 4931420H10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64451
Homologene: 41012
Zfp184
Name: zinc finger protein 184 (Kruppel-like)
Synonyms: 4930500C15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 193452
Homologene: 113602
Cyp2d12
Name: cytochrome P450, family 2, subfamily d, polypeptide 12
Synonyms: 9030605E09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 380997
VEGA: 15
Homologene: 86099
Sp110
Name: Sp110 nuclear body protein
Synonyms: 5830484A20Rik, Ifi75, 5031415C07Rik, 52kDa, Ipr1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109032
HGNC: HGNC:5401
Homologene: 82192
Rnf141
Name: ring finger protein 141
Synonyms: 2610110L04Rik, ZFP36, ZNF230
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67150
Homologene: 9503
Tktl2
Name: transketolase-like 2
Synonyms: 4933401I19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74419
Homologene: 69456
Glra3
Name: glycine receptor, alpha 3 subunit
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 110304
HGNC: HGNC:4328
Homologene: 142
Acox1
Name: acyl-Coenzyme A oxidase 1, palmitoyl
Synonyms: AOX, D130055E20Rik, Acyl-CoA oxidase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11430
HGNC: HGNC:119
Homologene: 38299
Papss1
Name: 3'-phosphoadenosine 5'-phosphosulfate synthase 1
Synonyms: Asapk, SK1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 23971
HGNC: HGNC:8603
Homologene: 81740
Acot3
Name: acyl-CoA thioesterase 3
Synonyms: PTE-Ia, Pte2a
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 171281
Homologene: 134585
Mrps9
Name: mitochondrial ribosomal protein S9
Synonyms: 2310002A08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 69527
Homologene: 32565
Sprtn
Name: SprT-like N-terminal domain
Synonyms: LOC244666, Gm505
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244666
Homologene: 32764
Or5t15
Name: olfactory receptor family 5 subfamily T member 15
Synonyms: MOR179-1, Olfr1095, GA_x6K02T2Q125-48336843-48335917
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258725
Homologene: 28042
Ndst1
Name: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
Synonyms: glucosaminyl N-deacetylase/N-sulfotransferase 1, Ndst-1, Hsst, 1200015G06Rik, b2b2230Clo
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 15531
VEGA: 18
HGNC: HGNC:7680
Homologene: 20386
Or8b9
Name: olfactory receptor family 8 subfamily B member 9
Synonyms: MOR161-5, GA_x6K02T2PVTD-31540342-31541277, Olfr877
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258412
Homologene: 121556
Gpr61
Name: G protein-coupled receptor 61
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229714
Homologene: 12910
Mfsd4b5
Name: major facilitator superfamily domain containing 4B5
Synonyms: BC021785
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215928
Homologene: 129849
Nedd9
Name: neural precursor cell expressed, developmentally down-regulated gene 9
Synonyms: Cas-L, CasL, HEF1, E230025G09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18003
VEGA: 13
HGNC: HGNC:7733
Homologene: 4669
Mob3c
Name: MOB kinase activator 3C
Synonyms: MOB3C, D130076I06Rik, Mobkl2c
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100465
Homologene: 64826
Gm7808
Name: predicted pseudogene 7808
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 665823
AU016765
Name: expressed sequence AU016765
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100043582
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 42,903,399 bp
  • G to A, chromosome 1 at 75,417,863 bp
  • A to G, chromosome 1 at 75,421,744 bp
  • G to A, chromosome 1 at 85,594,385 bp
  • A to G, chromosome 1 at 91,115,555 bp
  • C to T, chromosome 1 at 149,871,523 bp
  • G to T, chromosome 2 at 85,071,738 bp
  • T to C, chromosome 2 at 85,438,805 bp
  • A to T, chromosome 2 at 86,851,187 bp
  • T to A, chromosome 2 at 120,036,391 bp
  • T to A, chromosome 2 at 144,272,318 bp
  • T to A, chromosome 2 at 154,213,983 bp
  • A to T, chromosome 2 at 158,008,224 bp
  • T to A, chromosome 2 at 158,443,280 bp
  • C to T, chromosome 3 at 108,150,380 bp
  • C to A, chromosome 3 at 131,619,185 bp
  • A to G, chromosome 3 at 146,190,474 bp
  • A to G, chromosome 4 at 115,111,670 bp
  • A to G, chromosome 4 at 115,831,644 bp
  • A to G, chromosome 4 at 151,084,024 bp
  • GCTCT to GCTCTCT, chromosome 4 at 156,166,519 bp
  • A to T, chromosome 5 at 96,554,889 bp
  • A to T, chromosome 5 at 134,502,929 bp
  • T to C, chromosome 6 at 72,602,671 bp
  • T to A, chromosome 7 at 10,492,341 bp
  • C to A, chromosome 7 at 10,492,342 bp
  • G to A, chromosome 7 at 24,617,246 bp
  • A to G, chromosome 7 at 42,300,697 bp
  • A to G, chromosome 7 at 44,209,672 bp
  • A to G, chromosome 7 at 79,123,450 bp
  • A to G, chromosome 7 at 83,935,658 bp
  • G to T, chromosome 7 at 110,821,273 bp
  • A to G, chromosome 7 at 135,695,494 bp
  • G to T, chromosome 8 at 55,940,907 bp
  • G to A, chromosome 8 at 66,512,347 bp
  • A to G, chromosome 8 at 106,204,339 bp
  • T to C, chromosome 8 at 124,898,357 bp
  • T to A, chromosome 9 at 19,928,003 bp
  • G to A, chromosome 9 at 37,855,453 bp
  • A to G, chromosome 9 at 38,367,594 bp
  • G to A, chromosome 9 at 108,040,996 bp
  • C to T, chromosome 10 at 39,975,203 bp
  • T to C, chromosome 10 at 76,274,976 bp
  • C to A, chromosome 10 at 85,942,017 bp
  • T to C, chromosome 10 at 128,468,998 bp
  • T to A, chromosome 11 at 66,168,079 bp
  • A to T, chromosome 11 at 116,174,682 bp
  • A to G, chromosome 11 at 118,990,983 bp
  • G to A, chromosome 12 at 4,869,037 bp
  • A to G, chromosome 12 at 8,016,087 bp
  • T to G, chromosome 12 at 84,053,943 bp
  • A to G, chromosome 13 at 21,959,272 bp
  • A to G, chromosome 13 at 23,481,936 bp
  • T to C, chromosome 13 at 41,338,926 bp
  • G to T, chromosome 13 at 77,245,370 bp
  • A to G, chromosome 13 at 111,755,419 bp
  • T to C, chromosome 14 at 54,479,150 bp
  • T to A, chromosome 15 at 82,558,050 bp
  • T to C, chromosome 16 at 17,141,908 bp
  • A to G, chromosome 17 at 6,222,440 bp
  • G to A, chromosome 17 at 34,576,763 bp
  • A to G, chromosome 17 at 36,161,784 bp
  • A to C, chromosome 17 at 64,555,438 bp
  • A to T, chromosome 17 at 71,448,833 bp
  • G to A, chromosome 18 at 58,972,825 bp
  • T to C, chromosome 18 at 60,707,803 bp
  • A to G, chromosome 19 at 59,935,649 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1718 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039751-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.