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Strain Name:
C57BL/6J-MtgxR1768Btlr/Mmmh
Stock Number:
039799-MU
Citation ID:
RRID:MMRRC_039799-MU
Other Names:
R1768 (G1), C57BL/6J-MtgxR1768Btlr
Major Collection:

Strain Information

Smarca4
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Synonyms: SNF2beta, Brg1, SW1/SNF, b2b692Clo, b2b508.1Clo
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20586
Homologene: 135927
Npy1r
Name: neuropeptide Y receptor Y1
Synonyms: Y1-R, Npyr
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18166
HGNC: HGNC:7956
Homologene: 700
Eya1
Name: EYA transcriptional coactivator and phosphatase 1
Synonyms: bor
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14048
HGNC: HGNC:3519
Homologene: 74943
U2af2
Name: U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22185
Homologene: 110853
Slc37a1
Name: solute carrier family 37 (glycerol-3-phosphate transporter), member 1
Synonyms: G3PP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224674
VEGA: 17
Homologene: 70486
Mast2
Name: microtubule associated serine/threonine kinase 2
Synonyms: MAST205, Mtssk
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17776
Homologene: 7428
Shmt1
Name: serine hydroxymethyltransferase 1 (soluble)
Synonyms: mshmt2, mshmt1, mshmt, Shmt
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20425
Homologene: 3074
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 14,253,075 bp
  • G to A, chromosome 1 at 38,813,276 bp
  • A to G, chromosome 1 at 52,660,805 bp
  • T to A, chromosome 1 at 58,354,195 bp
  • A to C, chromosome 1 at 79,816,815 bp
  • A to G, chromosome 1 at 87,194,928 bp
  • G to T, chromosome 1 at 91,153,957 bp
  • T to A, chromosome 2 at 18,162,846 bp
  • T to C, chromosome 2 at 27,112,862 bp
  • T to A, chromosome 2 at 69,222,977 bp
  • C to A, chromosome 2 at 72,225,787 bp
  • T to A, chromosome 2 at 87,191,698 bp
  • C to A, chromosome 2 at 132,075,641 bp
  • C to A, chromosome 3 at 93,443,575 bp
  • A to T, chromosome 3 at 100,027,352 bp
  • A to T, chromosome 3 at 100,153,870 bp
  • A to T, chromosome 3 at 107,213,500 bp
  • T to C, chromosome 4 at 22,385,950 bp
  • G to T, chromosome 4 at 70,307,233 bp
  • A to T, chromosome 4 at 111,454,241 bp
  • A to T, chromosome 4 at 115,752,919 bp
  • G to T, chromosome 4 at 116,306,959 bp
  • A to T, chromosome 4 at 116,804,879 bp
  • C to T, chromosome 4 at 118,569,728 bp
  • T to A, chromosome 4 at 124,793,276 bp
  • T to A, chromosome 4 at 134,371,138 bp
  • A to G, chromosome 5 at 9,118,548 bp
  • A to T, chromosome 5 at 111,277,168 bp
  • T to A, chromosome 5 at 121,358,303 bp
  • A to G, chromosome 5 at 147,672,709 bp
  • G to A, chromosome 6 at 30,745,139 bp
  • A to T, chromosome 6 at 33,758,050 bp
  • A to G, chromosome 6 at 34,956,961 bp
  • A to C, chromosome 6 at 35,315,352 bp
  • A to G, chromosome 6 at 42,460,677 bp
  • A to T, chromosome 6 at 97,306,764 bp
  • A to T, chromosome 7 at 3,717,190 bp
  • A to G, chromosome 7 at 4,633,692 bp
  • C to A, chromosome 7 at 5,067,545 bp
  • A to G, chromosome 7 at 6,305,067 bp
  • T to C, chromosome 7 at 19,765,618 bp
  • G to T, chromosome 7 at 26,312,772 bp
  • A to G, chromosome 7 at 27,280,954 bp
  • A to G, chromosome 7 at 28,413,892 bp
  • G to A, chromosome 7 at 43,648,494 bp
  • T to C, chromosome 7 at 43,938,333 bp
  • T to A, chromosome 7 at 45,188,803 bp
  • A to G, chromosome 7 at 45,308,612 bp
  • G to C, chromosome 7 at 81,300,723 bp
  • A to T, chromosome 7 at 98,065,597 bp
  • A to G, chromosome 7 at 102,670,301 bp
  • A to G, chromosome 7 at 103,893,277 bp
  • C to T, chromosome 7 at 103,929,725 bp
  • A to G, chromosome 7 at 105,035,950 bp
  • A to T, chromosome 7 at 106,891,977 bp
  • G to T, chromosome 7 at 106,891,978 bp
  • T to C, chromosome 7 at 109,723,174 bp
  • A to T, chromosome 7 at 118,726,024 bp
  • A to G, chromosome 7 at 126,390,462 bp
  • C to T, chromosome 7 at 143,459,121 bp
  • A to T, chromosome 8 at 3,159,561 bp
  • A to G, chromosome 8 at 12,649,686 bp
  • A to C, chromosome 8 at 48,232,104 bp
  • A to T, chromosome 8 at 54,673,654 bp
  • A to G, chromosome 8 at 66,704,525 bp
  • T to C, chromosome 8 at 69,373,558 bp
  • T to C, chromosome 9 at 21,403,142 bp
  • G to A, chromosome 9 at 21,701,183 bp
  • T to A, chromosome 9 at 37,804,303 bp
  • T to A, chromosome 9 at 106,080,100 bp
  • A to T, chromosome 9 at 109,494,772 bp
  • G to A, chromosome 9 at 111,392,927 bp
  • T to G, chromosome 9 at 119,146,007 bp
  • G to A, chromosome 10 at 26,887,861 bp
  • G to T, chromosome 10 at 26,887,862 bp
  • A to G, chromosome 10 at 36,833,169 bp
  • T to G, chromosome 10 at 39,103,501 bp
  • T to C, chromosome 10 at 62,957,084 bp
  • C to A, chromosome 10 at 74,991,870 bp
  • T to A, chromosome 10 at 77,875,116 bp
  • A to T, chromosome 10 at 81,512,120 bp
  • C to T, chromosome 10 at 87,003,008 bp
  • C to T, chromosome 10 at 94,844,322 bp
  • T to A, chromosome 10 at 95,996,960 bp
  • A to G, chromosome 10 at 115,427,801 bp
  • T to A, chromosome 10 at 123,013,763 bp
  • T to A, chromosome 11 at 35,809,638 bp
  • G to A, chromosome 11 at 50,176,861 bp
  • A to G, chromosome 11 at 58,310,176 bp
  • A to G, chromosome 11 at 58,529,776 bp
  • A to G, chromosome 11 at 60,792,964 bp
  • A to T, chromosome 11 at 77,013,252 bp
  • A to T, chromosome 11 at 98,912,217 bp
  • T to A, chromosome 11 at 106,806,351 bp
  • A to G, chromosome 12 at 16,680,432 bp
  • G to A, chromosome 12 at 71,075,338 bp
  • C to T, chromosome 12 at 84,386,211 bp
  • T to G, chromosome 13 at 50,473,116 bp
  • T to C, chromosome 13 at 67,619,251 bp
  • T to A, chromosome 13 at 112,948,240 bp
  • T to A, chromosome 14 at 7,974,104 bp
  • G to T, chromosome 14 at 124,676,512 bp
  • A to G, chromosome 15 at 66,005,906 bp
  • T to G, chromosome 15 at 79,243,069 bp
  • T to C, chromosome 16 at 29,620,810 bp
  • A to T, chromosome 16 at 49,163,135 bp
  • T to C, chromosome 17 at 12,841,699 bp
  • T to C, chromosome 17 at 17,850,300 bp
  • T to A, chromosome 17 at 23,665,949 bp
  • A to T, chromosome 17 at 28,962,850 bp
  • A to T, chromosome 17 at 28,966,781 bp
  • C to A, chromosome 17 at 31,333,678 bp
  • T to A, chromosome 17 at 34,027,108 bp
  • G to C, chromosome 18 at 6,623,470 bp
  • C to A, chromosome 19 at 7,021,797 bp
  • C to G, chromosome 19 at 34,226,721 bp
  • T to C, chromosome 19 at 41,917,705 bp
  • T to C, chromosome X at 101,540,894 bp
  • T to A, chromosome X at 106,200,308 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1768 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039799-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.