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Strain Name:
C57BL/6J-MtgxR1893Btlr/Mmmh
Stock Number:
039913-MU
Citation ID:
RRID:MMRRC_039913-MU
Other Names:
R1893 (G1), C57BL/6J-MtgxR1893Btlr
Major Collection:

Strain Information

Lrrn1
Name: leucine rich repeat protein 1, neuronal
Synonyms: NLRR-1, 2810047E21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16979
Homologene: 32036
Sptan1
Name: spectrin alpha, non-erythrocytic 1
Synonyms: alpha-fodrin, Spna-2, 2610027H02Rik, Spna2, alphaII-spectrin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20740
Homologene: 2353
Zfp688
Name: zinc finger protein 688
Synonyms: 2810407K09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69234
Homologene: 17058
Mnx1
Name: motor neuron and pancreas homeobox 1
Synonyms: HB9, MNR2, Hlxb9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15285
HGNC: HGNC:4979
Homologene: 21137
Tlr6
Name: toll-like receptor 6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21899
Homologene: 21223
Ube2o
Name: ubiquitin-conjugating enzyme E2O
Synonyms: B230113M03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217342
Homologene: 11113
Carmil1
Name: capping protein regulator and myosin 1 linker 1
Synonyms: 1110037D04Rik, Lrrc16, Carmil, Lrrc16a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68732
Homologene: 9757
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 12,894,472 bp
  • T to A, chromosome 1 at 40,001,557 bp
  • T to A, chromosome 1 at 74,696,821 bp
  • G to A, chromosome 1 at 83,278,966 bp
  • T to C, chromosome 1 at 131,757,547 bp
  • A to T, chromosome 1 at 135,134,903 bp
  • T to A, chromosome 1 at 139,479,867 bp
  • A to T, chromosome 1 at 168,203,410 bp
  • T to C, chromosome 1 at 171,217,223 bp
  • T to C, chromosome 1 at 182,431,628 bp
  • A to G, chromosome 1 at 190,160,518 bp
  • T to C, chromosome 1 at 195,155,187 bp
  • C to T, chromosome 2 at 28,834,362 bp
  • T to A, chromosome 2 at 30,020,460 bp
  • T to C, chromosome 2 at 58,829,740 bp
  • A to G, chromosome 2 at 91,114,357 bp
  • G to A, chromosome 2 at 104,433,256 bp
  • T to C, chromosome 2 at 179,933,030 bp
  • G to A, chromosome 3 at 18,096,567 bp
  • G to T, chromosome 3 at 142,630,172 bp
  • G to A, chromosome 4 at 32,601,541 bp
  • C to A, chromosome 4 at 115,326,667 bp
  • T to G, chromosome 4 at 156,000,748 bp
  • C to T, chromosome 4 at 156,217,883 bp
  • G to A, chromosome 5 at 21,375,671 bp
  • C to T, chromosome 5 at 29,477,830 bp
  • G to A, chromosome 5 at 33,733,415 bp
  • A to G, chromosome 5 at 64,953,213 bp
  • A to G, chromosome 5 at 87,980,035 bp
  • A to G, chromosome 5 at 110,009,203 bp
  • T to C, chromosome 5 at 124,754,317 bp
  • A to T, chromosome 6 at 107,568,122 bp
  • T to C, chromosome 6 at 128,670,832 bp
  • A to G, chromosome 6 at 136,401,827 bp
  • T to C, chromosome 6 at 141,834,616 bp
  • T to C, chromosome 7 at 14,225,889 bp
  • G to A, chromosome 7 at 23,866,148 bp
  • T to A, chromosome 7 at 29,936,045 bp
  • T to A, chromosome 7 at 31,099,348 bp
  • A to T, chromosome 7 at 35,802,627 bp
  • A to T, chromosome 7 at 85,234,659 bp
  • A to T, chromosome 7 at 88,490,716 bp
  • T to C, chromosome 7 at 99,823,420 bp
  • T to A, chromosome 7 at 115,544,568 bp
  • A to T, chromosome 7 at 120,340,553 bp
  • G to A, chromosome 7 at 127,419,237 bp
  • A to G, chromosome 7 at 130,625,325 bp
  • T to C, chromosome 7 at 140,162,821 bp
  • T to C, chromosome 8 at 40,279,803 bp
  • T to C, chromosome 8 at 45,023,856 bp
  • A to G, chromosome 8 at 61,516,621 bp
  • G to A, chromosome 8 at 94,913,543 bp
  • G to T, chromosome 8 at 105,246,501 bp
  • A to T, chromosome 9 at 40,022,974 bp
  • G to A, chromosome 9 at 51,059,565 bp
  • A to G, chromosome 9 at 56,849,214 bp
  • G to A, chromosome 9 at 69,197,496 bp
  • G to A, chromosome 10 at 6,900,680 bp
  • G to A, chromosome 10 at 31,249,613 bp
  • G to T, chromosome 10 at 83,492,536 bp
  • T to C, chromosome 10 at 115,290,900 bp
  • A to G, chromosome 10 at 128,364,394 bp
  • T to A, chromosome 11 at 4,672,305 bp
  • T to C, chromosome 11 at 5,835,574 bp
  • T to C, chromosome 11 at 9,331,526 bp
  • T to C, chromosome 11 at 69,946,572 bp
  • T to A, chromosome 11 at 70,134,167 bp
  • T to C, chromosome 11 at 83,757,314 bp
  • C to A, chromosome 11 at 108,942,706 bp
  • C to T, chromosome 11 at 116,548,835 bp
  • T to A, chromosome 11 at 118,066,968 bp
  • T to A, chromosome 11 at 119,416,448 bp
  • A to C, chromosome 12 at 8,985,994 bp
  • T to C, chromosome 13 at 24,024,463 bp
  • T to A, chromosome 13 at 45,520,947 bp
  • A to G, chromosome 13 at 54,539,715 bp
  • T to A, chromosome 13 at 65,152,992 bp
  • T to C, chromosome 13 at 77,267,809 bp
  • A to T, chromosome 13 at 111,768,033 bp
  • C to T, chromosome 14 at 8,151,507 bp
  • C to G, chromosome 14 at 51,104,938 bp
  • G to A, chromosome 14 at 75,255,963 bp
  • A to T, chromosome 14 at 96,240,206 bp
  • A to T, chromosome 15 at 11,991,044 bp
  • A to G, chromosome 15 at 35,300,462 bp
  • T to A, chromosome 15 at 55,557,668 bp
  • T to A, chromosome 15 at 81,631,646 bp
  • T to C, chromosome 15 at 82,452,606 bp
  • C to T, chromosome 15 at 89,387,695 bp
  • A to G, chromosome 16 at 36,831,883 bp
  • A to G, chromosome 16 at 63,568,399 bp
  • A to G, chromosome 16 at 79,071,418 bp
  • T to A, chromosome 17 at 23,953,267 bp
  • A to G, chromosome 17 at 29,621,550 bp
  • A to T, chromosome 17 at 29,849,226 bp
  • T to G, chromosome 17 at 34,194,941 bp
  • A to T, chromosome 17 at 37,672,856 bp
  • G to A, chromosome 17 at 45,514,799 bp
  • T to C, chromosome 17 at 56,271,894 bp
  • A to T, chromosome 17 at 84,722,833 bp
  • A to G, chromosome 18 at 23,853,717 bp
  • C to A, chromosome 18 at 37,437,083 bp
  • C to A, chromosome 19 at 10,056,504 bp
  • A to T, chromosome X at 104,342,536 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1893 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039913-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.