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Strain Name:
C57BL/6J-MtgxR1983Btlr/Mmmh
Stock Number:
039995-MU
Citation ID:
RRID:MMRRC_039995-MU
Other Names:
R1983 (G1), C57BL/6J-MtgxR1983Btlr
Major Collection:

Strain Information

Hps5
Name: HPS5, biogenesis of lysosomal organelles complex 2 subunit 2
Synonyms: ru-2, ruby eye 2, ru2, Hermansky-Pudlak syndrome 5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 246694
Homologene: 35333
Adora2a
Name: adenosine A2a receptor
Synonyms: A2aR, A2AAR, AA2AR, A2a, Rs, ARA2A
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11540
VEGA: 10
HGNC: HGNC:263
Homologene: 20166
Hgf
Name: hepatocyte growth factor
Synonyms: scatter factor, NK1, SF/HGF, HGF/SF, NK2, C230052L06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15234
HGNC: HGNC:4893
Homologene: 503
Lcor
Name: ligand dependent nuclear receptor corepressor
Synonyms: 3110023F06Rik, Mlr2, A630025C20Rik, LOC381224, Gm340
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 212391
VEGA: 19
Homologene: 18153
Wnk1
Name: WNK lysine deficient protein kinase 1
Synonyms: 6430573H23Rik, Prkwnk1, EG406236, Hsn2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232341
Homologene: 14253
Bbx
Name: bobby sox HMG box containing
Synonyms: 5730403O13Rik, 5530401J07Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70508
Homologene: 10634
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, C130061D10Rik, Phr1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105689
Homologene: 9005
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 80,213,647 bp
  • C to T, chromosome 2 at 41,511,404 bp
  • T to A, chromosome 2 at 76,756,760 bp
  • T to C, chromosome 2 at 76,789,025 bp
  • G to T, chromosome 2 at 82,979,831 bp
  • T to A, chromosome 2 at 86,445,076 bp
  • A to G, chromosome 2 at 89,406,426 bp
  • T to C, chromosome 2 at 101,899,985 bp
  • T to C, chromosome 2 at 103,981,062 bp
  • T to A, chromosome 2 at 121,371,037 bp
  • T to A, chromosome 2 at 125,098,845 bp
  • T to G, chromosome 2 at 138,283,688 bp
  • A to G, chromosome 2 at 158,208,421 bp
  • A to G, chromosome 3 at 36,887,865 bp
  • T to G, chromosome 3 at 94,176,294 bp
  • T to C, chromosome 3 at 129,868,545 bp
  • G to A, chromosome 4 at 40,175,845 bp
  • A to G, chromosome 4 at 41,603,232 bp
  • A to T, chromosome 4 at 48,460,059 bp
  • A to T, chromosome 4 at 62,460,603 bp
  • A to G, chromosome 4 at 63,984,630 bp
  • G to T, chromosome 4 at 96,738,977 bp
  • A to G, chromosome 4 at 99,228,575 bp
  • A to T, chromosome 4 at 108,689,189 bp
  • A to G, chromosome 4 at 112,146,492 bp
  • T to C, chromosome 4 at 116,151,869 bp
  • C to A, chromosome 4 at 116,151,920 bp
  • G to A, chromosome 4 at 133,689,043 bp
  • T to A, chromosome 4 at 147,541,292 bp
  • C to A, chromosome 4 at 152,384,666 bp
  • A to G, chromosome 5 at 16,561,012 bp
  • G to T, chromosome 5 at 37,415,931 bp
  • A to T, chromosome 5 at 134,736,340 bp
  • A to T, chromosome 6 at 83,487,128 bp
  • T to A, chromosome 6 at 86,419,141 bp
  • A to T, chromosome 6 at 90,345,369 bp
  • A to T, chromosome 6 at 119,937,578 bp
  • G to T, chromosome 6 at 142,770,586 bp
  • A to T, chromosome 7 at 12,193,661 bp
  • T to C, chromosome 7 at 29,059,472 bp
  • A to G, chromosome 7 at 46,763,226 bp
  • T to C, chromosome 7 at 80,253,616 bp
  • C to T, chromosome 7 at 107,845,412 bp
  • A to T, chromosome 8 at 45,087,434 bp
  • A to T, chromosome 8 at 71,678,375 bp
  • A to G, chromosome 8 at 71,688,136 bp
  • A to T, chromosome 8 at 84,890,910 bp
  • T to C, chromosome 8 at 107,083,008 bp
  • T to A, chromosome 9 at 7,578,897 bp
  • T to C, chromosome 9 at 9,017,017 bp
  • T to C, chromosome 9 at 21,959,400 bp
  • T to C, chromosome 9 at 57,740,053 bp
  • T to A, chromosome 9 at 79,860,092 bp
  • G to A, chromosome 9 at 120,016,629 bp
  • A to G, chromosome 9 at 123,640,587 bp
  • A to C, chromosome 10 at 75,333,646 bp
  • T to A, chromosome 10 at 81,362,256 bp
  • T to A, chromosome 10 at 85,001,838 bp
  • T to C, chromosome 10 at 85,907,953 bp
  • A to G, chromosome 10 at 127,903,752 bp
  • C to T, chromosome 10 at 128,123,959 bp
  • T to C, chromosome 11 at 48,915,356 bp
  • C to T, chromosome 11 at 70,800,714 bp
  • T to A, chromosome 11 at 114,735,856 bp
  • A to G, chromosome 12 at 105,662,727 bp
  • T to A, chromosome 12 at 113,144,796 bp
  • G to T, chromosome 13 at 3,574,853 bp
  • A to G, chromosome 13 at 11,585,402 bp
  • C to T, chromosome 13 at 12,278,810 bp
  • G to C, chromosome 13 at 13,002,201 bp
  • G to T, chromosome 13 at 23,821,115 bp
  • C to T, chromosome 13 at 53,110,408 bp
  • T to C, chromosome 13 at 74,304,000 bp
  • A to G, chromosome 13 at 99,952,150 bp
  • A to G, chromosome 14 at 32,217,696 bp
  • T to C, chromosome 14 at 45,279,971 bp
  • T to C, chromosome 14 at 55,480,023 bp
  • G to A, chromosome 14 at 55,544,068 bp
  • T to C, chromosome 14 at 103,145,971 bp
  • A to G, chromosome 14 at 111,680,389 bp
  • T to C, chromosome 15 at 81,693,896 bp
  • A to G, chromosome 15 at 82,405,999 bp
  • A to T, chromosome 15 at 83,892,962 bp
  • A to G, chromosome 16 at 27,361,038 bp
  • T to A, chromosome 16 at 50,209,117 bp
  • T to C, chromosome 16 at 57,571,274 bp
  • T to A, chromosome 17 at 14,944,010 bp
  • G to A, chromosome 17 at 29,850,605 bp
  • C to A, chromosome 17 at 32,822,110 bp
  • G to T, chromosome 17 at 34,970,962 bp
  • G to A, chromosome 18 at 60,916,651 bp
  • A to G, chromosome 19 at 13,095,384 bp
  • A to G, chromosome 19 at 17,020,642 bp
  • C to T, chromosome 19 at 37,390,776 bp
  • T to A, chromosome 19 at 41,558,367 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1983 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039995-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.