Strain Name:
C57BL/6J-MtgxR2364Btlr/Mmmh
Stock Number:
040345-MU
Citation ID:
RRID:MMRRC_040345-MU
Other Names:
R2364 (G1), C57BL/6J-MtgxR2364Btlr
Major Collection:

Gene Information

Zfp143
Name: zinc finger protein 143
Synonyms: D7Ertd805e, pHZ-1, KRAB14, Zfp79, Zfp80-rs1, Staf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20841
Homologene: 56444
Hsp90aa1
Name: heat shock protein 90, alpha (cytosolic), class A member 1
Synonyms: hsp4, Hsp90, Hsp86-1, Hsp89, Hspca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 15519
HGNC: HGNC:5253
Homologene: 68464
Kif2a
Name: kinesin family member 2A
Synonyms: Kns2, M-kinesin, Kif2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 16563
HGNC: HGNC:6318
Homologene: 3320
Hnrnpr
Name: heterogeneous nuclear ribonucleoprotein R
Synonyms: hnRNPR, 2610003J05Rik, Hnrpr, 2610528B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74326
HGNC: HGNC:5047
Homologene: 4251
Cdk5rap2
Name: CDK5 regulatory subunit associated protein 2
Synonyms: 2900018K03Rik, an
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 214444
Homologene: 49533
Os9
Name: amplified in osteosarcoma
Synonyms: 4632413K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216440
VEGA: 10
Homologene: 31409
Tmem245
Name: transmembrane protein 245
Synonyms: A630051L19Rik, D730040F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242474
HGNC: HGNC:1363
Homologene: 41841
Ubfd1
Name: ubiquitin family domain containing 1
Synonyms: D7Wsu105e, D7Wsu128e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 28018
Homologene: 10430
Zfp317
Name: zinc finger protein 317
Synonyms: Zfp67, KRAB9, D230022C05Rik, Zfp75
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244713
Homologene: 36389
Pros1
Name: protein S (alpha)
Synonyms: protein S
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19128
HGNC: HGNC:9456
Homologene: 264
Hs6st1
Name: heparan sulfate 6-O-sulfotransferase 1
Synonyms: 6OST1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 50785
HGNC: HGNC:5201
Homologene: 75051
Wwtr1
Name: WW domain containing transcription regulator 1
Synonyms: 2610021I22Rik, TAZ, 2310058J06Rik, transcriptional coactivator with PDZ binding motif
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 97064
Homologene: 9159
Tpcn1
Name: two pore channel 1
Synonyms: 5730403B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 252972
Homologene: 9905
4930579F01Rik
Name: RIKEN cDNA 4930579F01 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67741
Homologene: 12962
Srp72
Name: signal recognition particle 72
Synonyms: 72kDa, 5730576P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66661
Homologene: 38254
Myh8
Name: myosin, heavy polypeptide 8, skeletal muscle, perinatal
Synonyms: MyHC-pn, Myhs-p, Myhsp, 4832426G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17885
HGNC: HGNC:7578
Homologene: 68256
Insr
Name: insulin receptor
Synonyms: IR, CD220, 4932439J01Rik, D630014A15Rik, IR-B, IR-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16337
HGNC: HGNC:6091
Homologene: 20090
Adam6a
Name: a disintegrin and metallopeptidase domain 6A
Synonyms: Adam6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238406
HGNC: HGNC:213
Homologene: 128362
Zfp628
Name: zinc finger protein 628
Synonyms: Zec
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232816
Homologene: 72200
Cabs1
Name: calcium binding protein, spermatid specific 1
Synonyms: 4931407G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 70977
Homologene: 13225
Zfp651
Name: zinc finger protein 651
Synonyms: 4732420M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270210
VEGA: 9
Homologene: 136302
Olfr1328
Name: olfactory receptor 1328
Synonyms: GA_x6K02T2QD9B-18602750-18603691, MOR259-1, MOR259-1, MOR259-13, Olfr1519
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 258394
Homologene: 121524
Olfr357
Name: olfactory receptor 357
Synonyms: GA_x6K02T2NLDC-33688556-33689482, MOR138-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258616
HGNC: HGNC:8223
Homologene: 17320
Fpr1
Name: formyl peptide receptor 1
Synonyms: FPR, fMLF-R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14293
HGNC: HGNC:3826
Homologene: 20466
Cep250
Name: centrosomal protein 250
Synonyms: Inmp, B230210E21Rik, Cep2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16328
HGNC: HGNC:1859
Homologene: 38286
Olfr1457
Name: olfactory receptor 1457
Synonyms: GA_x6K02T2RE5P-3423041-3422097, MOR202-20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258568
Homologene: 133676
Asb3
Name: ankyrin repeat and SOCS box-containing 3
Synonyms: 2400011J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 65257
Homologene: 9391
Anks6
Name: ankyrin repeat and sterile alpha motif domain containing 6
Synonyms: LOC269533, 2210417J20Rik, Samd6, SamCystin, b2b1801.1Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 75691
Homologene: 19545
Olfr731
Name: olfactory receptor 731
Synonyms: GA_x6K02T2PMLR-5936117-5935137, MOR246-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258360
Homologene: 84579
Gstm5
Name: glutathione S-transferase, mu 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14866
HGNC: HGNC:4635
Homologene: 658
Blvrb
Name: biliverdin reductase B (flavin reductase (NADPH))
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233016
HGNC: HGNC:1063
Homologene: 573
Pcdhb20
Name: protocadherin beta 20
Synonyms: Pcdhb14, PcdhbT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93891
HGNC: HGNC:8685
Homologene: 134303
Mapk10
Name: mitogen-activated protein kinase 10
Synonyms: p493F12, JNK3, Serk2, C230008H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26414
HGNC: HGNC:6872
Homologene: 56439
Dnajc28
Name: DnaJ heat shock protein family (Hsp40) member C28
Synonyms: ORF28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 246738
HGNC: HGNC:1297
Homologene: 9869
Vamp1
Name: vesicle-associated membrane protein 1
Synonyms: VAMP-1, Syb-1, Syb1, lew
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22317
Homologene: 40678
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 36,068,719 bp
  • T to C, chromosome 2 at 36,997,565 bp
  • G to A, chromosome 2 at 155,992,632 bp
  • T to C, chromosome 3 at 57,462,603 bp
  • A to G, chromosome 3 at 107,896,371 bp
  • A to G, chromosome 3 at 138,165,823 bp
  • A to G, chromosome 4 at 47,027,248 bp
  • A to G, chromosome 4 at 56,899,391 bp
  • A to G, chromosome 4 at 70,360,809 bp
  • C to T, chromosome 4 at 118,934,033 bp
  • A to G, chromosome 4 at 136,327,329 bp
  • A to G, chromosome 5 at 76,984,362 bp
  • A to T, chromosome 5 at 87,980,233 bp
  • G to T, chromosome 5 at 103,038,641 bp
  • G to T, chromosome 5 at 120,553,494 bp
  • A to T, chromosome 6 at 125,240,343 bp
  • A to G, chromosome 7 at 4,920,687 bp
  • A to G, chromosome 7 at 27,448,133 bp
  • C to A, chromosome 7 at 110,083,242 bp
  • T to A, chromosome 7 at 122,068,944 bp
  • T to C, chromosome 8 at 3,174,820 bp
  • A to G, chromosome 9 at 19,647,735 bp
  • C to T, chromosome 9 at 121,767,594 bp
  • T to A, chromosome 10 at 127,119,138 bp
  • A to G, chromosome 11 at 31,101,192 bp
  • A to G, chromosome 11 at 67,294,518 bp
  • A to T, chromosome 12 at 110,692,753 bp
  • A to G, chromosome 12 at 113,544,630 bp
  • A to T, chromosome 13 at 106,976,836 bp
  • A to T, chromosome 14 at 50,238,155 bp
  • T to G, chromosome 16 at 62,913,848 bp
  • G to A, chromosome 16 at 91,616,867 bp
  • A to T, chromosome 17 at 17,877,610 bp
  • A to T, chromosome 18 at 37,505,938 bp
  • A to G, chromosome 19 at 13,094,754 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2364 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040345-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.