Strain Name:
C57BL/6J-MtgxR2403Btlr/Mmmh
Stock Number:
040369-MU
Citation ID:
RRID:MMRRC_040369-MU
Other Names:
R2403 (G1), C57BL/6J-MtgxR2403Btlr
Major Collection:

Gene Information

Dnmt3a
Name: DNA methyltransferase 3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 13435
HGNC: HGNC:2978
Homologene: 7294
Dysf
Name: dysferlin
Synonyms: 2310004N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 26903
HGNC: HGNC:3097
Homologene: 20748
Fbxo36
Name: F-box protein 36
Synonyms: D1Ertd757e, 1110020F21Rik, 2410002G19Rik, 0610008D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 66153
Homologene: 11927
Zfp523
Name: zinc finger protein 523
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224656
Homologene: 2569
Arl5b
Name: ADP-ribosylation factor-like 5B
Synonyms: Arl8, 4930587A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 75869
Homologene: 101695
Lrp5
Name: low density lipoprotein receptor-related protein 5
Synonyms: LRP7, LR3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 16973
HGNC: HGNC:6697
Homologene: 1746
Cep290
Name: centrosomal protein 290
Synonyms: Nphp6, b2b1752Clo, Kiaa, b2b1454Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 216274
VEGA: 10
Homologene: 77213
Armc1
Name: armadillo repeat containing 1
Synonyms: Arcp, 2900046P06Rik, 2310016N05Rik, 3110009G21Rik, C330014L16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 74252
Homologene: 10015
Etl4
Name: enhancer trap locus 4
Synonyms: Sickle tail, 6620402G01Rik, 9430077C05Rik, Etl-4, Skt, E330027G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 208618
Homologene: 10477
Scamp2
Name: secretory carrier membrane protein 2
Synonyms: Sc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 24044
VEGA: 9
Homologene: 4163
Ascc1
Name: activating signal cointegrator 1 complex subunit 1
Synonyms: CGI-18, ASC1p50, 1810015P09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 69090
VEGA: 10
Homologene: 41079
Gapvd1
Name: GTPase activating protein and VPS9 domains 1
Synonyms: 4432404J10Rik, 2010005B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 66691
Homologene: 32637
Adgrl1
Name: adhesion G protein-coupled receptor L1
Synonyms: 2900070I05Rik, Lphn1, lectomedin-2, Lec2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 330814
Homologene: 8951
Gprin3
Name: GPRIN family member 3
Synonyms: C030038J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 243385
Homologene: 52334
Ptprc
Name: protein tyrosine phosphatase, receptor type, C
Synonyms: Lyt-4, CD45, Ly-5, T200, B220
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 19264
HGNC: HGNC:9666
Homologene: 2126
Cacna2d3
Name: calcium channel, voltage-dependent, alpha2/delta subunit 3
Synonyms: alpha 2 delta-3, alpha2delta3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 12294
Homologene: 74929
Fgfrl1
Name: fibroblast growth factor receptor-like 1
Synonyms: FGFR5, FGFR5beta, fibroblast growth factor receptor 5, FGFR5gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 116701
HGNC: HGNC:3693
Homologene: 11067
Ostf1
Name: osteoclast stimulating factor 1
Synonyms: C78236, Sh3d3, SH3P2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 20409
HGNC: HGNC:8510
Homologene: 8227
Hacd3
Name: 3-hydroxyacyl-CoA dehydratase 3
Synonyms: Hspc121, Ptplad1, B-ind1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 57874
VEGA: 9
Homologene: 9494
Zfp655
Name: zinc finger protein 655
Synonyms: 2700038I16Rik, 9030409O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 72611
Homologene: 12473
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Col1a-2, Cola-2, Cola2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Clcn1
Name: chloride channel, voltage-sensitive 1
Synonyms: SMCC1, Clc-1, NMF355, Clc1, nmf355
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12723
HGNC: HGNC:2019
Homologene: 63
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Siglec1
Name: sialic acid binding Ig-like lectin 1, sialoadhesin
Synonyms: Sn, Siglec-1, CD169
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20612
Homologene: 124458
Col28a1
Name: collagen, type XXVIII, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 213945
Homologene: 66345
Abca4
Name: ATP-binding cassette, sub-family A (ABC1), member 4
Synonyms: RmP, Rim protein, D430003I15Rik, Abc10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 11304
HGNC: HGNC:34
Homologene: 298
Fat3
Name: FAT atypical cadherin 3
Synonyms: LOC382129, 9430076A06Rik, LOC234973, D430038H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 270120
VEGA: 9
Homologene: 82252
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241516
Homologene: 110349
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20192
Homologene: 68151
Pnldc1
Name: poly(A)-specific ribonuclease (PARN)-like domain containing 1
Synonyms: LOC240023
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 240023
VEGA: 17
Homologene: 15054
Clec3b
Name: C-type lectin domain family 3, member b
Synonyms: Tna
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 21922
VEGA: 9
Homologene: 31145
Trim34b
Name: tripartite motif-containing 34B
Synonyms: Gm15134, Trim34-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 434218
Homologene: 128238
Nckap5
Name: NCK-associated protein 5
Synonyms: E030049G20Rik, D130011D22Rik, LOC380609
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 210356
Homologene: 35542
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 380698
Homologene: 70869
Sycp2
Name: synaptonemal complex protein 2
Synonyms: 4930518F03Rik, 3830402K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 320558
Homologene: 8604
Serpina3g
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3G
Synonyms: alpha-1 antiproteinase, alpha-1 antiproteinase,, Spi2A, 2A2, Spi2/eb.1, Spi2-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 20715
HGNC: HGNC:16
Homologene: 115927
Ankrd50
Name: ankyrin repeat domain 50
Synonyms: E430012K20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 99696
Homologene: 129859
Abca9
Name: ATP-binding cassette, sub-family A (ABC1), member 9
Synonyms: D630040K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217262
HGNC: HGNC:39
Homologene: 33332
Bche
Name: butyrylcholinesterase
Synonyms: C730038G20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 12038
HGNC: HGNC:983
Homologene: 20065
Itga1
Name: integrin alpha 1
Synonyms: CD49A, E130012M19Rik, Vla1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 109700
VEGA: 13
HGNC: HGNC:6134
Homologene: 57137
Tmprss15
Name: transmembrane protease, serine 15
Synonyms: enteropeptidase, A130097D21Rik, Prss7, enterokinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 19146
HGNC: HGNC:9490
Homologene: 2075
Fut1
Name: fucosyltransferase 1
Synonyms: H transferase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 14343
HGNC: HGNC:4012
Homologene: 120
Eml6
Name: echinoderm microtubule associated protein like 6
Synonyms: 2900083P10Rik, C230094A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 237711
Homologene: 104282
Dmwd
Name: dystrophia myotonica-containing WD repeat motif
Synonyms: DMR-N9, Dm9, 59
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 13401
HGNC: HGNC:2936
Homologene: 22559
F11
Name: coagulation factor XI
Synonyms: plasma thromboplastin antecedent, Cf11, 1600027G01Rik, FXI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 109821
HGNC: HGNC:3529
Homologene: 86654
Zfp715
Name: zinc finger protein 715
Synonyms: mszf15, 2610041B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 69930
Homologene: 74591
Ceacam3
Name: carcinoembryonic antigen-related cell adhesion molecule 3
Synonyms: cea12, EG384557, Psg24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 384557
Homologene: 86971
Rnf144a
Name: ring finger protein 144A
Synonyms: Rnf144, UIP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 108089
VEGA: 12
Homologene: 40982
Cts3
Name: cathepsin 3
Synonyms: 1600000I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 117066
VEGA: 13
Esp8
Name: exocrine gland secreted peptide 8
Synonyms: Gm17495
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 100126778
VEGA: 17
Homologene: 136357
Olfr361
Name: olfactory receptor 361
Synonyms: GA_x6K02T2NLDC-33777519-33776551, MOR159-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258365
Homologene: 27142
Mup4
Name: major urinary protein 4
Synonyms: Mup-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 17843
Homologene: 74304
Lsm8
Name: LSM8 homolog, U6 small nuclear RNA associated
Synonyms: 2010003I05Rik, Lsm8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 76522
Homologene: 9419
H2-Q4
Name: histocompatibility 2, Q region locus 4
Synonyms: H-2Q4, H2-Gs10, Qa-4, Qb-1, Qa4, Qb1, Qat-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 15015
HGNC: HGNC:4931
Homologene: 128352
Umad1
Name: UMAP1-MVP12 associated (UMA) domain containing 1
Synonyms: Gm16039
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 100036521
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 84,900,102 bp
  • G to A, chromosome 1 at 126,027,409 bp
  • A to G, chromosome 1 at 138,088,532 bp
  • T to C, chromosome 2 at 15,075,037 bp
  • T to A, chromosome 2 at 20,807,306 bp
  • A to C, chromosome 2 at 34,690,627 bp
  • T to C, chromosome 2 at 37,084,974 bp
  • T to C, chromosome 2 at 76,727,361 bp
  • T to C, chromosome 2 at 82,980,720 bp
  • C to T, chromosome 2 at 112,686,628 bp
  • G to T, chromosome 2 at 131,074,475 bp
  • G to A, chromosome 2 at 178,403,735 bp
  • T to C, chromosome 3 at 19,157,676 bp
  • T to A, chromosome 3 at 38,483,085 bp
  • A to G, chromosome 3 at 73,701,472 bp
  • A to G, chromosome 3 at 122,170,943 bp
  • T to A, chromosome 4 at 59,958,145 bp
  • T to C, chromosome 5 at 108,705,031 bp
  • C to T, chromosome 5 at 145,244,546 bp
  • G to A, chromosome 6 at 4,518,822 bp
  • T to C, chromosome 6 at 8,175,641 bp
  • T to C, chromosome 6 at 8,427,161 bp
  • C to T, chromosome 6 at 18,849,644 bp
  • T to C, chromosome 6 at 42,313,112 bp
  • G to A, chromosome 6 at 59,354,149 bp
  • T to C, chromosome 6 at 84,039,567 bp
  • C to A, chromosome 7 at 17,161,854 bp
  • T to C, chromosome 7 at 19,081,159 bp
  • G to A, chromosome 7 at 43,299,268 bp
  • A to G, chromosome 7 at 45,619,219 bp
  • C to T, chromosome 7 at 104,329,669 bp
  • A to G, chromosome 8 at 45,248,638 bp
  • T to A, chromosome 8 at 83,931,241 bp
  • T to G, chromosome 9 at 15,969,871 bp
  • T to C, chromosome 9 at 57,577,712 bp
  • A to G, chromosome 9 at 65,001,029 bp
  • G to A, chromosome 9 at 123,154,413 bp
  • T to C, chromosome 10 at 60,004,841 bp
  • C to T, chromosome 10 at 100,537,437 bp
  • A to G, chromosome 11 at 29,802,434 bp
  • T to C, chromosome 11 at 59,131,646 bp
  • T to G, chromosome 11 at 110,115,454 bp
  • G to A, chromosome 12 at 3,899,883 bp
  • A to G, chromosome 12 at 26,327,615 bp
  • C to A, chromosome 12 at 104,241,162 bp
  • A to G, chromosome 13 at 61,564,992 bp
  • A to T, chromosome 13 at 114,977,614 bp
  • A to G, chromosome 14 at 28,905,302 bp
  • T to G, chromosome 16 at 79,057,690 bp
  • A to T, chromosome 17 at 12,899,890 bp
  • A to G, chromosome 17 at 28,195,209 bp
  • A to G, chromosome 17 at 35,379,997 bp
  • T to A, chromosome 17 at 40,520,092 bp
  • C to A, chromosome 19 at 3,597,430 bp
  • T to C, chromosome 19 at 18,584,662 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2403 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040369-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.