Strain Name:
C57BL/6J-MtgxR2925Btlr/Mmmh
Stock Number:
040510-MU
Citation ID:
RRID:MMRRC_040510-MU
Other Names:
R2925 (G1), C57BL/6J-MtgxR2925Btlr
Major Collection:

Gene Information

Rc3h1
Name: RING CCCH (C3H) domains 1
Synonyms: 5730557L09Rik, roquin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381305
Homologene: 19036
Hsp90aa1
Name: heat shock protein 90, alpha (cytosolic), class A member 1
Synonyms: Hsp89, hsp4, Hsp90, Hsp86-1, Hspca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 15519
HGNC: HGNC:5253
Homologene: 68464
Syt3
Name: synaptotagmin III
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20981
Homologene: 9617
Tnks
Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Synonyms: 4930554K12Rik, tankyrase 1, mTNKS1, TANK1, D130072O21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 21951
Homologene: 18405
Vcl
Name: vinculin
Synonyms: metavinculin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 22330
VEGA: 14
Homologene: 7594
Nsf
Name: N-ethylmaleimide sensitive fusion protein
Synonyms: SKD2, N-ethylmaleimide sensitive factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18195
HGNC: HGNC:8016
Homologene: 4502
Ubr1
Name: ubiquitin protein ligase E3 component n-recognin 1
Synonyms: E3 alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22222
Homologene: 7582
Ncapg2
Name: non-SMC condensin II complex, subunit G2
Synonyms: mCAP-G2, Luzp5, Mtb, 5830426I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 76044
VEGA: 12
Homologene: 9820
Mtbp
Name: Mdm2, transformed 3T3 cell double minute p53 binding protein
Synonyms: MDM2BP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105837
HGNC: HGNC:7417
Homologene: 11102
Dhx15
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 15
Synonyms: Ddx15, DBP1, HRH2, mDEAH9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13204
HGNC: HGNC:2738
Homologene: 1040
Nup214
Name: nucleoporin 214
Synonyms: D2H9S46E, CAN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227720
HGNC: HGNC:8064
Homologene: 38008
4932438A13Rik
Name: RIKEN cDNA 4932438A13 gene
Synonyms: FSA, Tweek
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229227
Homologene: 52105
Slc30a6
Name: solute carrier family 30 (zinc transporter), member 6
Synonyms: ZnT-6, ZnT6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 210148
VEGA: 17
Homologene: 32380
Ecpas
Name: Ecm29 proteasome adaptor and scaffold
Synonyms: AI314180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230249
Homologene: 6056
Zic2
Name: zinc finger protein of the cerebellum 2
Synonyms: GENA 29, Ku, odd-paired homolog
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 22772
Homologene: 5171
Scaf4
Name: SR-related CTD-associated factor 4
Synonyms: Sra4, Srsf15, Sfrs15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224432
VEGA: 16
Homologene: 16227
Rpl24
Name: ribosomal protein L24
Synonyms: 0610008L05Rik, Bst
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 68193
Homologene: 763
Zbed5
Name: zinc finger, BED type containing 5
Synonyms: 2410018M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71970
Homologene: 84838
Cul9
Name: cullin 9
Synonyms: 1810035I07Rik, Parc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 78309
Homologene: 56696
Samd3
Name: sterile alpha motif domain containing 3
Synonyms: LOC268288
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 268288
VEGA: 10
Homologene: 67991
Ap4b1
Name: adaptor-related protein complex AP-4, beta 1
Synonyms: AP-4 beta-4, 1810038H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67489
HGNC: HGNC:572
Homologene: 38203
Btn2a2
Name: butyrophilin, subfamily 2, member A2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238555
HGNC: HGNC:1137
Homologene: 56012
Fbln2
Name: fibulin 2
Synonyms: 5730577E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14115
HGNC: HGNC:3601
Homologene: 1514
Dnaic1
Name: dynein, axonemal, intermediate chain 1
Synonyms: b2b1526Clo, 1110066F04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68922
HGNC: HGNC:2954
Homologene: 8122
Ces1d
Name: carboxylesterase 1D
Synonyms: Ces3, TGH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 104158
HGNC: HGNC:1863
Homologene: 35606
Acte1
Name: actin, epsilon 1
Synonyms: Gm498, LOC244239
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 102636989
Homologene: 131918
Ctcfl
Name: CCCTC-binding factor (zinc finger protein)-like
Synonyms: OTTMUSG00000016680, Boris
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 664799
Homologene: 46476
Usp4
Name: ubiquitin specific peptidase 4 (proto-oncogene)
Synonyms: Unp, F730026I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22258
Homologene: 20716
Alk
Name: anaplastic lymphoma kinase
Synonyms: CD246, Tcrz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 11682
VEGA: 17
HGNC: HGNC:427
Homologene: 68387
Akr1c21
Name: aldo-keto reductase family 1, member C21
Synonyms: 9430025F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 77337
Homologene: 134114
Nek4
Name: NIMA (never in mitosis gene a)-related expressed kinase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 23955
VEGA: 14
Homologene: 2376
Rnf215
Name: ring finger protein 215
Synonyms: 0610009J22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71673
Homologene: 12402
P2ry13
Name: purinergic receptor P2Y, G-protein coupled 13
Synonyms: Gpr86, 2010001L06Rik, SP174, P2Y13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74191
HGNC: HGNC:4537
Homologene: 12543
Selplg
Name: selectin, platelet (p-selectin) ligand
Synonyms: Psgl1, CD162, Psgl-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20345
Homologene: 2261
Il12a
Name: interleukin 12a
Synonyms: IL-12p35, p35
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 16159
HGNC: HGNC:5969
Homologene: 681
Kcnd3
Name: potassium voltage-gated channel, Shal-related family, member 3
Synonyms: potassium channel Kv4.3L, Kv4.3, potassium channel Kv4.3M
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56543
HGNC: HGNC:6239
Homologene: 21036
Man2b2
Name: mannosidase 2, alpha B2
Synonyms: 135 kDa alpha-D-mannosidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17160
Homologene: 7411
9530003J23Rik
Name: RIKEN cDNA 9530003J23 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 77397
HGNC: HGNC:6740
Homologene: 49931
Olfr460
Name: olfactory receptor 460
Synonyms: GA_x6K02T2P3E9-6947292-6946348, MOR120-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258381
Homologene: 64866
Gm15386
Name: predicted gene 15386
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Olfr206
Name: olfactory receptor 206
Synonyms: GA_x54KRFPKG5P-55560552-55559632, MOR182-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 258993
Homologene: 74262
Fuom
Name: fucose mutarotase
Synonyms: 1810014F10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69064
Homologene: 19598
Upk3a
Name: uroplakin 3A
Synonyms: 1110017C07Rik, Upk3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22270
VEGA: 15
Homologene: 5066
Olfr1079
Name: olfactory receptor 1079
Synonyms: MOR189-1, GA_x6K02T2Q125-48024195-48023254
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258402
Homologene: 74090
Olfr1029
Name: olfactory receptor 1029
Synonyms: MOR198-1P, GA_x6K02T2Q125-47454152-47455126
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258154
Homologene: 73972
4930503E14Rik
Name: RIKEN cDNA 4930503E14 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 74954
Homologene: 115686
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 18,260,633 bp
  • A to G, chromosome 1 at 160,954,976 bp
  • A to G, chromosome 2 at 31,998,003 bp
  • T to A, chromosome 2 at 85,975,781 bp
  • C to T, chromosome 2 at 86,538,547 bp
  • A to C, chromosome 2 at 120,970,514 bp
  • C to T, chromosome 2 at 173,094,696 bp
  • G to T, chromosome 3 at 37,007,122 bp
  • G to A, chromosome 3 at 59,209,380 bp
  • TCAC to TC, chromosome 3 at 68,697,987 bp
  • A to G, chromosome 3 at 103,820,681 bp
  • C to T, chromosome 3 at 105,658,766 bp
  • A to T, chromosome 4 at 41,597,919 bp
  • T to A, chromosome 4 at 58,833,928 bp
  • A to G, chromosome 5 at 36,824,102 bp
  • A to G, chromosome 5 at 52,171,414 bp
  • T to C, chromosome 5 at 113,820,179 bp
  • A to G, chromosome 5 at 129,903,198 bp
  • T to A, chromosome 6 at 40,571,408 bp
  • T to A, chromosome 6 at 91,265,855 bp
  • T to A, chromosome 7 at 44,395,798 bp
  • T to C, chromosome 7 at 140,099,949 bp
  • A to T, chromosome 7 at 143,883,999 bp
  • G to A, chromosome 8 at 34,965,661 bp
  • A to T, chromosome 8 at 93,175,018 bp
  • T to C, chromosome 9 at 108,367,856 bp
  • T to A, chromosome 10 at 26,251,887 bp
  • C to T, chromosome 10 at 117,234,431 bp
  • T to C, chromosome 11 at 4,137,201 bp
  • C to T, chromosome 11 at 103,930,752 bp
  • T to A, chromosome 12 at 110,695,680 bp
  • C to A, chromosome 12 at 110,695,681 bp
  • C to A, chromosome 12 at 116,438,729 bp
  • A to G, chromosome 13 at 4,576,350 bp
  • A to G, chromosome 13 at 23,481,814 bp
  • G to A, chromosome 14 at 21,001,294 bp
  • G to A, chromosome 14 at 30,951,710 bp
  • T to C, chromosome 14 at 44,170,298 bp
  • A to G, chromosome 14 at 122,478,717 bp
  • G to A, chromosome 15 at 55,619,814 bp
  • A to G, chromosome 15 at 76,178,252 bp
  • A to G, chromosome 15 at 85,018,149 bp
  • G to A, chromosome 16 at 55,974,084 bp
  • A to T, chromosome 16 at 59,345,343 bp
  • G to T, chromosome 16 at 90,250,289 bp
  • G to A, chromosome 17 at 46,510,981 bp
  • A to G, chromosome 17 at 72,603,207 bp
  • T to C, chromosome 17 at 74,402,004 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2925 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040510-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.