Strain Name:
C57BL/6J-MtgxR2973Btlr/Mmmh
Stock Number:
040526-MU
Citation ID:
RRID:MMRRC_040526-MU
Other Names:
R2973 (G1), C57BL/6J-MtgxR2973Btlr
Major Collection:

Strain Information

Vcp
Name: valosin containing protein
Synonyms: CDC48, p97, p97/VCP, AAA ATPase p97
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269523
Homologene: 5168
Slit1
Name: slit guidance ligand 1
Synonyms: Slil1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20562
Homologene: 2302
Tpgs1
Name: tubulin polyglutamylase complex subunit 1
Synonyms: Gtrgeo22, Gm16517
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 110012
VEGA: 10
Homologene: 17525
Larp4b
Name: La ribonucleoprotein 4B
Synonyms: D13Wsu64e, Larp5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 217980
Homologene: 18195
Polr3b
Name: polymerase (RNA) III (DNA directed) polypeptide B
Synonyms: RPC2, 2700078H01Rik, A330032P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70428
VEGA: 10
Homologene: 6981
Cald1
Name: caldesmon 1
Synonyms: 4833423D12Rik, C920027I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 109624
HGNC: HGNC:1441
Homologene: 137254
Rtn1
Name: reticulon 1
Synonyms: Nsp, Rtn1-c, 0710005K15Rik, Rtn1-a, Rtn1-b, 4930441F12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104001
Homologene: 49654
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: A930005E13Rik, LOC381562, D930005K06Rik, 1810009A16Rik, Zubr1, p600
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69116
Homologene: 10804
Gab2
Name: growth factor receptor bound protein 2-associated protein 2
Synonyms: p97, D130058I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14389
Homologene: 69067
Angptl7
Name: angiopoietin-like 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 654812
Homologene: 133923
Cst9
Name: cystatin 9
Synonyms: testatin, M12, cresp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13013
Homologene: 49222
Crnkl1
Name: crooked neck pre-mRNA splicing factor 1
Synonyms: crn, 1200013P10Rik, 5730590A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66877
Homologene: 6462
Trpv5
Name: transient receptor potential cation channel, subfamily V, member 5
Synonyms: CaT2, ECaC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 194352
HGNC: HGNC:3145
Homologene: 10520
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Dhx36
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 36
Synonyms: Ddx36, 2810407E23Rik, RHAU
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72162
Homologene: 6356
Chd3
Name: chromodomain helicase DNA binding protein 3
Synonyms: Mi-2 alpha, Prp9-1, Prp7, 2600010P09Rik, Chd7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216848
HGNC: HGNC:1918
Homologene: 62693
Jakmip1
Name: janus kinase and microtubule interacting protein 1
Synonyms: Marlin-1, 5830437M04Rik, C330021K24Rik, Gababrbp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 76071
Homologene: 90789
Il5ra
Name: interleukin 5 receptor, alpha
Synonyms: IL-5 receptor alpha chain, CD125, Il5r, CDw125
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16192
HGNC: HGNC:6017
Homologene: 473
Ugt8a
Name: UDP galactosyltransferase 8A
Synonyms: Cgt, mCerGT, Ugt8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 22239
Homologene: 20715
4921528O07Rik
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Dcaf10
Name: DDB1 and CUL4 associated factor 10
Synonyms: Wdr32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242418
Homologene: 32581
Eps8l3
Name: EPS8-like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99662
Homologene: 15878
Gsdme
Name: gasdermin E
Synonyms: 4932441K13Rik, 2310037D07Rik, Fin15, Dfna5h, Dfna5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 54722
HGNC: HGNC:2810
Homologene: 3242
Ces5a
Name: carboxylesterase 5A
Synonyms: LOC244598, 1700081L16Rik, 1700122C07Rik, cauxin, Ces7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67935
Homologene: 74305
Ppef2
Name: protein phosphatase, EF hand calcium-binding domain 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19023
HGNC: HGNC:9244
Homologene: 55959
Vwa5a
Name: von Willebrand factor A domain containing 5A
Synonyms: BCSC-1, 5830475I06Rik, Loh11cr2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67776
HGNC: HGNC:6658
Homologene: 18222
Mefv
Name: Mediterranean fever
Synonyms: marenostrin, pyrin, FMF, TRIM20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 54483
VEGA: 16
HGNC: HGNC:6998
Homologene: 32441
Lrrc42
Name: leucine rich repeat containing 42
Synonyms: A930011F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 77809
Homologene: 12685
Or5d37
Name: olfactory receptor family 5 subfamily D member 37
Synonyms: GA_x6K02T2Q125-49585842-49584862, MOR174-11, Olfr1164
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258634
Homologene: 74077
Tm9sf1
Name: transmembrane 9 superfamily member 1
Synonyms: MP70, 1200014D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 74140
Homologene: 4671
Serpinb9e
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9e
Synonyms: Spi14, NK26, ovalbumin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20710
HGNC: HGNC:8955
Homologene: 69093
Or5ac22
Name: olfactory receptor family 5 subfamily AC member 22
Synonyms: GA_x54KRFPKG5P-55529713-55528796, MOR182-3, Olfr204
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 258994
Homologene: 79425
Sptlc3
Name: serine palmitoyltransferase, long chain base subunit 3
Synonyms: C130053K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228677
Homologene: 105590
Aoc1l1
Name: amine oxidase copper containing 1-like 1
Synonyms: Doxl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243376
HGNC: HGNC:80
Homologene: 19443
Vmn2r117
Name: vomeronasal 2, receptor 117
Synonyms: EG619788, V2Rp6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 619788
Homologene: 86604
Abca7
Name: ATP-binding cassette, sub-family A (ABC1), member 7
Synonyms: Abc51
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 27403
HGNC: HGNC:37
Homologene: 22783
Slc10a5
Name: solute carrier family 10 (sodium/bile acid cotransporter family), member 5
Synonyms: LOC241877
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 241877
Homologene: 78106
Septin14
Name: septin 14
Synonyms: 1700016K13Rik, Sept14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74222
Homologene: 87501
Hesx1
Name: homeobox gene expressed in ES cells
Synonyms: Rpx, HES-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 15209
HGNC: HGNC:4877
Homologene: 20831
Ube2e2
Name: ubiquitin-conjugating enzyme E2E 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218793
Homologene: 77337
Or12j2
Name: olfactory receptor family 12 subfamily J member 2
Synonyms: GA_x6K02T2PBJ9-42486061-42486978, MOR251-5, Olfr527
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 257939
Homologene: 73958
Rogdi
Name: rogdi homolog
Synonyms: 0610011C19Rik, Lzf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 66049
Homologene: 11605
BC048507
Name: cDNA sequence BC048507
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 408058
VEGA: 13
Homologene: 133712
Cstdc2
Name: cystatin domain containing 2
Synonyms: mCST E2, 9230104L09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 77705
Homologene: 87070
D930007J09Rik
Name: RIKEN cDNA D930007J09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 163,056,769 bp
  • A to C, chromosome 2 at 76,802,317 bp
  • A to G, chromosome 2 at 88,093,114 bp
  • A to G, chromosome 2 at 139,589,661 bp
  • A to G, chromosome 2 at 145,932,261 bp
  • G to T, chromosome 2 at 148,835,225 bp
  • T to C, chromosome 2 at 148,850,786 bp
  • A to T, chromosome 3 at 10,334,457 bp
  • T to A, chromosome 3 at 62,495,495 bp
  • C to G, chromosome 3 at 62,495,498 bp
  • T to C, chromosome 3 at 107,891,328 bp
  • T to C, chromosome 3 at 125,915,308 bp
  • T to A, chromosome 4 at 42,996,315 bp
  • T to C, chromosome 4 at 45,373,957 bp
  • A to T, chromosome 4 at 107,239,114 bp
  • T to C, chromosome 4 at 139,406,536 bp
  • T to A, chromosome 4 at 148,500,214 bp
  • A to G, chromosome 5 at 37,091,527 bp
  • T to C, chromosome 5 at 92,239,094 bp
  • T to C, chromosome 5 at 129,699,022 bp
  • A to G, chromosome 6 at 34,757,996 bp
  • T to C, chromosome 6 at 41,653,231 bp
  • A to G, chromosome 6 at 48,976,424 bp
  • A to G, chromosome 6 at 50,229,324 bp
  • G to A, chromosome 6 at 106,741,235 bp
  • A to G, chromosome 7 at 97,223,552 bp
  • T to G, chromosome 7 at 140,336,387 bp
  • A to G, chromosome 8 at 93,528,504 bp
  • C to T, chromosome 9 at 38,723,356 bp
  • A to G, chromosome 10 at 79,669,615 bp
  • T to G, chromosome 10 at 80,008,967 bp
  • A to G, chromosome 10 at 84,628,280 bp
  • A to G, chromosome 11 at 69,360,616 bp
  • C to A, chromosome 12 at 72,223,389 bp
  • T to C, chromosome 13 at 9,166,311 bp
  • C to T, chromosome 13 at 32,802,759 bp
  • T to A, chromosome 13 at 33,255,143 bp
  • T to C, chromosome 13 at 67,863,630 bp
  • T to C, chromosome 14 at 18,630,321 bp
  • A to G, chromosome 14 at 27,000,642 bp
  • T to A, chromosome 14 at 55,641,114 bp
  • C to G, chromosome 15 at 76,188,761 bp
  • G to A, chromosome 16 at 3,715,694 bp
  • G to T, chromosome 16 at 5,011,662 bp
  • A to C, chromosome 16 at 59,315,404 bp
  • A to G, chromosome 17 at 23,459,856 bp
  • G to A, chromosome 19 at 41,611,016 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2973 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040526-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.