Strain Name:
C57BL/6J-MtgxR3417Btlr/Mmmh
Stock Number:
040635-MU
Citation ID:
RRID:MMRRC_040635-MU
Other Names:
R3417 (G1), C57BL/6J-MtgxR3417Btlr
Major Collection:

Gene Information

Map4k5
Name: mitogen-activated protein kinase kinase kinase kinase 5
Synonyms: KHS, MAPKKKK5, GCKR, 4432415E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 399510
HGNC: HGNC:6867
Homologene: 38199
Myd88
Name: myeloid differentiation primary response gene 88
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17874
HGNC: HGNC:7562
Homologene: 1849
Kdm5b
Name: lysine (K)-specific demethylase 5B
Synonyms: PLU-1, Plu1, Rb-Bp2, Jarid1b, 2210016I17Rik, D1Ertd202e, 2010009J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 75605
Homologene: 48448
Exoc6b
Name: exocyst complex component 6B
Synonyms: Sec15l2, 4930569O18Rik, G430127E12Rik, Sec15b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 75914
Homologene: 44781
Col6a1
Name: collagen, type VI, alpha 1
Synonyms: Col6a-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12833
HGNC: HGNC:2211
Homologene: 1391
Scn8a
Name: sodium channel, voltage-gated, type VIII, alpha
Synonyms: NMF335, Nav1.6, mnd-2, NaCh6, motor end-plate disease, nmf2, seal, ataxia 3, mnd2, nur14, nmf58, C630029C19Rik, med, nmf335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20273
Homologene: 7927
Ankrd17
Name: ankyrin repeat domain 17
Synonyms: 4933425K22Rik, Gtar, A130069E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 81702
Homologene: 82403
Jrk
Name: jerky
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16469
HGNC: HGNC:6199
Homologene: 2762
St13
Name: suppression of tumorigenicity 13
Synonyms: 3110002K08Rik, p48, SNC6, HSPABP1, PRO0786, 1110007I03Rik, Hsp70 interacting protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 70356
Homologene: 2921
Adgrl2
Name: adhesion G protein-coupled receptor L2
Synonyms: Lphn2, Lphh1, Lec1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99633
Homologene: 22712
Pds5a
Name: PDS5 cohesin associated factor A
Synonyms: E230024D05Rik, 9030416H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71521
Homologene: 22877
Sptlc2
Name: serine palmitoyltransferase, long chain base subunit 2
Synonyms: LCB2, Spt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20773
Homologene: 21610
Smg1
Name: SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
Synonyms: C130002K18Rik, 5430435M13Rik, 2610207I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233789
Homologene: 56697
Cep170
Name: centrosomal protein 170
Synonyms: A330004A13Rik, 4933426L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 545389
Homologene: 22844
Slc44a1
Name: solute carrier family 44, member 1
Synonyms: CHTL1, CTL1, Cdw92, 4833416H08Rik, 2210409B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100434
Homologene: 11137
Abcc5
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 5
Synonyms: 2900011L11Rik, Abcc5b, Abcc5a, Mrp5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 27416
HGNC: HGNC:56
Homologene: 21164
Mcm9
Name: minichromosome maintenance 9 homologous recombination repair factor
Synonyms: Mcmdc1, 9030408O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71567
VEGA: 10
Homologene: 13546
Crmp1
Name: collapsin response mediator protein 1
Synonyms: DRP-1, Ulip3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12933
HGNC: HGNC:2365
Homologene: 20347
Ero1l
Name: ERO1-like (S. cerevisiae)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 50527
VEGA: 14
Homologene: 49392
Vrk3
Name: vaccinia related kinase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101568
Homologene: 9509
Strbp
Name: spermatid perinuclear RNA binding protein
Synonyms: Spnr, C230082I21Rik, 6430510M02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20744
Homologene: 7548
Tgm3
Name: transglutaminase 3, E polypeptide
Synonyms: we, TG E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 21818
Homologene: 20690
Tas2r124
Name: taste receptor, type 2, member 124
Synonyms: T2R24, mGR24, Tas2r24, mt2r50
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387351
Homologene: 87293
Ttn
Name: titin
Synonyms: mdm, 2310036G12Rik, D830007G01Rik, shru, L56, 2310074I15Rik, 2310057K23Rik, connectin, D330041I19Rik, 1100001C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Tnr
Name: tenascin R
Synonyms: J1-tenascin, janusin, restrictin, TN-R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21960
Homologene: 124416
Lrp12
Name: low density lipoprotein-related protein 12
Synonyms: C820005L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239393
Homologene: 8385
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241516
Homologene: 110349
Nqo2
Name: N-ribosyldihydronicotinamide quinone reductase 2
Synonyms: NRH: quinone oxidoreductase, Ox2, Nmor2, Ox-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18105
VEGA: 13
HGNC: HGNC:7856
Homologene: 696
Naip6
Name: NLR family, apoptosis inhibitory protein 6
Synonyms: Naip-rs4A, Birc1f, Naip-rs4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17952
HGNC: HGNC:7634
Homologene: 113589
Gm884
Name: predicted gene 884
Synonyms: LOC380730
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380730
Homologene: 134511
Prpsap1
Name: phosphoribosyl pyrophosphate synthetase-associated protein 1
Synonyms: PAP39, 5730409F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67763
HGNC: HGNC:9466
Homologene: 55687
Klhl42
Name: kelch-like 42
Synonyms: C230080I20Rik, Klhdc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232539
Homologene: 45842
Ankar
Name: ankyrin and armadillo repeat containing
Synonyms: 4932422E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 319695
Homologene: 85163
Atp6v0d2
Name: ATPase, H+ transporting, lysosomal V0 subunit D2
Synonyms: 1620401A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242341
Homologene: 72090
Sla2
Name: Src-like-adaptor 2
Synonyms: A930009E21Rik, SLAP2, SLAP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 77799
Homologene: 49989
Plxnb1
Name: plexin B1
Synonyms: 2900002G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235611
HGNC: HGNC:9103
Homologene: 130508
Igsf9b
Name: immunoglobulin superfamily, member 9B
Synonyms: LOC235086
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235086
Homologene: 19472
Cyp4f39
Name: cytochrome P450, family 4, subfamily f, polypeptide 39
Synonyms: 4732474A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 320997
VEGA: 17
Homologene: 69814
Crocc
Name: ciliary rootlet coiled-coil, rootletin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230872
Homologene: 16811
Mrgprb2
Name: MAS-related GPR, member B2
Synonyms: 4833406I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243979
Homologene: 86246
Tex55
Name: testis expressed 55
Synonyms: 4930435E12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74663
Homologene: 17614
Pcdhb15
Name: protocadherin beta 15
Synonyms: Pcdhb7, PcdhbO
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93886
HGNC: HGNC:8692
Homologene: 32429
Mterf1a
Name: mitochondrial transcription termination factor 1a
Synonyms: Mterf1, 9230106K09Rik, 4931431L11Rik, Mterf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 545725
Homologene: 5073
Olfr730
Name: olfactory receptor 730
Synonyms: MOR247-1, GA_x6K02T2PMLR-5881670-5880717
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258486
Homologene: 17269
Icosl
Name: icos ligand
Synonyms: ICOS-L, B7-H2, LICOS, GL50, B7RP-1, B7h, GL50-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 50723
VEGA: 10
Homologene: 49412
Mrvi1
Name: MRV integration site 1
Synonyms: Ris1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17540
HGNC: HGNC:7237
Homologene: 4425
Cfc1
Name: cripto, FRL-1, cryptic family 1
Synonyms: b2b970Clo, cryptic
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12627
Homologene: 50007
CAAA01083517.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Rtl4
Name: retrotransposon Gag like 4
Synonyms: Mar4, Zcchc16, C230031A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 619287
Homologene: 53503
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 34,536,376 bp
  • A to G, chromosome 1 at 72,658,976 bp
  • T to C, chromosome 1 at 134,587,977 bp
  • T to C, chromosome 1 at 159,895,042 bp
  • G to T, chromosome 1 at 176,756,044 bp
  • T to A, chromosome 1 at 183,362,100 bp
  • C to G, chromosome 2 at 37,590,725 bp
  • A to T, chromosome 2 at 76,785,564 bp
  • G to A, chromosome 2 at 82,986,510 bp
  • G to A, chromosome 2 at 130,047,772 bp
  • G to A, chromosome 2 at 156,875,942 bp
  • T to C, chromosome 3 at 148,859,329 bp
  • A to G, chromosome 4 at 19,888,829 bp
  • G to A, chromosome 4 at 53,553,549 bp
  • G to A, chromosome 4 at 141,046,447 bp
  • A to G, chromosome 5 at 3,890,795 bp
  • A to T, chromosome 5 at 37,268,687 bp
  • A to G, chromosome 5 at 65,637,892 bp
  • G to A, chromosome 5 at 90,243,913 bp
  • C to G, chromosome 6 at 84,890,565 bp
  • A to T, chromosome 6 at 132,755,638 bp
  • G to A, chromosome 6 at 147,107,880 bp
  • C to T, chromosome 7 at 44,775,442 bp
  • C to A, chromosome 7 at 48,552,533 bp
  • T to C, chromosome 7 at 110,876,954 bp
  • G to C, chromosome 7 at 118,148,853 bp
  • G to A, chromosome 9 at 27,309,478 bp
  • C to A, chromosome 9 at 109,100,760 bp
  • T to C, chromosome 9 at 119,337,490 bp
  • T to C, chromosome 10 at 53,537,407 bp
  • C to T, chromosome 10 at 76,712,369 bp
  • A to T, chromosome 10 at 78,072,035 bp
  • A to T, chromosome 11 at 103,614,609 bp
  • T to C, chromosome 11 at 116,478,584 bp
  • A to T, chromosome 12 at 69,809,264 bp
  • A to G, chromosome 12 at 87,346,808 bp
  • G to T, chromosome 13 at 33,979,633 bp
  • C to T, chromosome 13 at 100,300,600 bp
  • T to C, chromosome 14 at 45,287,866 bp
  • T to A, chromosome 14 at 50,186,612 bp
  • A to G, chromosome 15 at 39,878,282 bp
  • A to G, chromosome 15 at 74,706,885 bp
  • A to T, chromosome 15 at 81,369,450 bp
  • A to G, chromosome 15 at 100,971,668 bp
  • A to G, chromosome 16 at 20,405,552 bp
  • A to C, chromosome 16 at 38,828,740 bp
  • T to C, chromosome 17 at 32,489,742 bp
  • A to T, chromosome 18 at 37,475,163 bp
  • C to T, chromosome X at 145,119,905 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3417 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040635-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.