Strain Name:
C57BL/6J-MtgxR3551Btlr/Mmmh
Stock Number:
040668-MU
Citation ID:
RRID:MMRRC_040668-MU
Other Names:
R3551 (G1), C57BL/6J-MtgxR3551Btlr
Major Collection:

Gene Information

Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: HALR, Mll3, E330008K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231051
Homologene: 46480
Kcnmb4
Name: potassium large conductance calcium-activated channel, subfamily M, beta member 4
Synonyms: Slowpoke beta 4, 2900045G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 58802
HGNC: HGNC:6289
Homologene: 8721
Aldh7a1
Name: aldehyde dehydrogenase family 7, member A1
Synonyms: D18Wsu181e, Atq1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 110695
HGNC: HGNC:877
Homologene: 913
Magi1
Name: membrane associated guanylate kinase, WW and PDZ domain containing 1
Synonyms: WWP3, AIP3, Gukmi1, BAP1, Baiap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14924
HGNC: HGNC:946
Homologene: 31257
Nup210l
Name: nucleoporin 210-like
Synonyms: 4930548O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 77595
Homologene: 28122
Zfp704
Name: zinc finger protein 704
Synonyms: Gig1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 170753
Homologene: 64370
Ptpn12
Name: protein tyrosine phosphatase, non-receptor type 12
Synonyms: PTP-P19, P19-PTP, PTP-PEST
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19248
HGNC: HGNC:9645
Homologene: 37691
Slc4a2
Name: solute carrier family 4 (anion exchanger), member 2
Synonyms: Ae2, B3RP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20535
Homologene: 128699
Ubap2l
Name: ubiquitin-associated protein 2-like
Synonyms: 3110083O19Rik, A430103N23Rik, 4932431F02Rik, NICE-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74383
Homologene: 136291
Orc4
Name: origin recognition complex, subunit 4
Synonyms: Orc4P, Orc4, Orc4l, mMmORC4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 26428
HGNC: HGNC:8490
Homologene: 8059
Adgrl2
Name: adhesion G protein-coupled receptor L2
Synonyms: Lphn2, Lphh1, Lec1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99633
Homologene: 22712
Mms19
Name: MMS19 cytosolic iron-sulfur assembly component
Synonyms: C86341, Mms19l, Mms19, 2610042O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 72199
Homologene: 41480
Ccni
Name: cyclin I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12453
HGNC: HGNC:1595
Homologene: 4979
Acaca
Name: acetyl-Coenzyme A carboxylase alpha
Synonyms: A530025K05Rik, LOC327983, acetyl-CoA carboxylase, Acc1, Acac
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 107476
HGNC: HGNC:84
Homologene: 31015
Dsg4
Name: desmoglein 4
Synonyms: CDHF13, lah
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16769
Homologene: 65341
Bicra
Name: BRD4 interacting chromatin remodeling complex associated protein
Synonyms: Gltscr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243842
HGNC: HGNC:4332
Homologene: 9250
Edc4
Name: enhancer of mRNA decapping 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234699
Homologene: 40937
Pgap1
Name: post-GPI attachment to proteins 1
Synonyms: 5033403E17Rik, PGAP1, D230012E17Rik, 9030223K07Rik, oto
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241062
Homologene: 41605
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: Ryr, calcium release channel isoform 1, skrr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20190
Homologene: 68069
Myo15
Name: myosin XV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17910
HGNC: HGNC:7594
Homologene: 56504
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: HL19, DHC3, LOC380889, Hdhc3, Dnahc7l, Dnahc12, 4921531P07Rik, HL-19, DLP12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Hrc
Name: histidine rich calcium binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 15464
HGNC: HGNC:5178
Homologene: 137234
Kng2
Name: kininogen 2
Synonyms: Kininogen-II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 385643
HGNC: HGNC:6383
Homologene: 88343
Gm5134
Name: predicted gene 5134
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 333669
Homologene: 129891
Cdkl3
Name: cyclin-dependent kinase-like 3
Synonyms: B230379H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 213084
Homologene: 49467
Clca3a2
Name: chloride channel accessory 3A2
Synonyms: Clca2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80797
Homologene: 77224
Ect2l
Name: epithelial cell transforming sequence 2 oncogene-like
Synonyms: Gm10331, C330021H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 100045792
Homologene: 46005
Pear1
Name: platelet endothelial aggregation receptor 1
Synonyms: 3110045G13Rik, Jedi-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 73182
Homologene: 12492
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC9, MUC5, 2300002I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
C4b
Name: complement component 4B (Chido blood group)
Synonyms: Ss, C4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12268
Homologene: 36030
Ercc6l2
Name: excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2
Synonyms: 1700019D06Rik, 0610007P08Rik, 9330134C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76251
Homologene: 32564
Gm20605
Name: predicted gene 20605
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100316903
Gm4922
Name: predicted gene 4922
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237300
VEGA: 10
Homologene: 50497
Dcaf7
Name: DDB1 and CUL4 associated factor 7
Synonyms: 2610037L01Rik, 1700012F10Rik, Wdr68
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71833
Homologene: 55930
Adam24
Name: a disintegrin and metallopeptidase domain 24 (testase 1)
Synonyms: Dtgn5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13526
HGNC: HGNC:203
Homologene: 137232
Spice1
Name: spindle and centriole associated protein 1
Synonyms: Ccdc52, D16Ertd480e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 212514
Homologene: 16931
Zfp759
Name: zinc finger protein 759
Synonyms: Rslcan-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 268670
VEGA: 13
Zfp692
Name: zinc finger protein 692
Synonyms: Zfp692-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103836
Homologene: 9889
Ipo4
Name: importin 4
Synonyms: 8430408O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 75751
Homologene: 5835
Nup43
Name: nucleoporin 43
Synonyms: p42, 43kDa, 2610529I12Rik, 2610016K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 69912
Homologene: 11639
Sema4c
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
Synonyms: Semaf, Semacl1, Semai, Semacl1, M-Sema F
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20353
Homologene: 23047
Olfr378
Name: olfactory receptor 378
Synonyms: MOR135-2, GA_x6K02T2P1NL-3586282-3585338
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 259026
Homologene: 74110
AC154271.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Gm5724
Name: predicted gene 5724
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 435927
Aqp7
Name: aquaporin 7
Synonyms: AQPap, AQP7L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11832
HGNC: HGNC:640
Homologene: 48000
Lrfn1
Name: leucine rich repeat and fibronectin type III domain containing 1
Synonyms: SALM2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 80749
Homologene: 12729
Npas2
Name: neuronal PAS domain protein 2
Synonyms: MOP4, bHLHe9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18143
HGNC: HGNC:7895
Homologene: 1887
Gm10369
Name: predicted gene 10369
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100038504
Gm3269
Name: predicted gene 3269
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Homologene: 115686
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to C, chromosome 1 at 36,553,723 bp
  • A to T, chromosome 1 at 39,287,562 bp
  • A to G, chromosome 1 at 54,530,143 bp
  • G to A, chromosome 2 at 48,937,489 bp
  • A to G, chromosome 3 at 9,474,525 bp
  • A to G, chromosome 3 at 87,758,132 bp
  • G to T, chromosome 3 at 90,015,451 bp
  • T to C, chromosome 3 at 90,122,672 bp
  • T to A, chromosome 3 at 144,803,081 bp
  • A to T, chromosome 3 at 148,858,963 bp
  • T to A, chromosome 4 at 41,045,329 bp
  • T to C, chromosome 5 at 20,989,049 bp
  • C to T, chromosome 5 at 24,430,101 bp
  • A to T, chromosome 5 at 25,354,330 bp
  • T to C, chromosome 5 at 93,187,761 bp
  • T to C, chromosome 5 at 134,679,375 bp
  • A to G, chromosome 5 at 137,636,732 bp
  • T to A, chromosome 6 at 93,699,629 bp
  • T to C, chromosome 6 at 141,708,596 bp
  • T to A, chromosome 7 at 15,979,733 bp
  • T to C, chromosome 7 at 28,460,054 bp
  • T to A, chromosome 7 at 29,056,997 bp
  • G to C, chromosome 7 at 45,336,333 bp
  • A to G, chromosome 7 at 141,861,335 bp
  • G to C, chromosome 8 at 40,679,593 bp
  • A to T, chromosome 8 at 105,885,494 bp
  • A to G, chromosome 10 at 7,675,014 bp
  • A to G, chromosome 10 at 18,163,393 bp
  • A to T, chromosome 10 at 18,784,496 bp
  • G to T, chromosome 10 at 76,000,447 bp
  • A to C, chromosome 10 at 116,443,920 bp
  • C to A, chromosome 10 at 116,443,927 bp
  • T to C, chromosome 11 at 52,025,942 bp
  • C to T, chromosome 11 at 58,309,428 bp
  • C to T, chromosome 11 at 60,509,663 bp
  • T to C, chromosome 11 at 73,425,852 bp
  • T to A, chromosome 11 at 84,261,624 bp
  • A to G, chromosome 11 at 106,054,796 bp
  • T to A, chromosome 13 at 63,844,595 bp
  • T to C, chromosome 13 at 67,138,967 bp
  • C to T, chromosome 13 at 85,127,150 bp
  • T to A, chromosome 14 at 4,845,893 bp
  • G to A, chromosome 14 at 26,770,972 bp
  • A to G, chromosome 14 at 55,633,103 bp
  • A to G, chromosome 16 at 23,011,995 bp
  • G to T, chromosome 16 at 44,357,869 bp
  • T to C, chromosome 17 at 34,741,872 bp
  • G to A, chromosome 18 at 20,451,756 bp
  • T to C, chromosome 18 at 56,550,292 bp
  • T to C, chromosome 19 at 41,949,798 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3551 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040668-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.