Strain Name:
C57BL/6J-MtgxR3687Btlr/Mmmh
Stock Number:
040683-MU
Citation ID:
RRID:MMRRC_040683-MU
Other Names:
R3687 (G1), C57BL/6J-MtgxR3687Btlr
Major Collection:

Gene Information

Ptprk
Name: protein tyrosine phosphatase, receptor type, K
Synonyms: PTPk, RPTPkappa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNA-PKcs, slip, DNAPDcs, XRCC7, DNA-PK, DOXNPH, dxnph
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Oxsr1
Name: oxidative-stress responsive 1
Synonyms: 2810422B09Rik, 2210022N24Rik, Osr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 108737
HGNC: HGNC:8508
Homologene: 31288
Rangap1
Name: RAN GTPase activating protein 1
Synonyms: Fug1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 19387
VEGA: 15
HGNC: HGNC:9854
Homologene: 55700
Atp11c
Name: ATPase, class VI, type 11C
Synonyms: Ig, A330005H02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 320940
Homologene: 27862
Bptf
Name: bromodomain PHD finger transcription factor
Synonyms: 9430093H17Rik, Falz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 207165
HGNC: HGNC:3581
Homologene: 114397
Slc25a17
Name: solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17
Synonyms: PMP34, 34kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20524
VEGA: 15
Homologene: 4637
Eftud2
Name: elongation factor Tu GTP binding domain containing 2
Synonyms: U5-116kD, 116kDa, Snrp116
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20624
Homologene: 3133
C2cd3
Name: C2 calcium-dependent domain containing 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 277939
Homologene: 19524
Hr
Name: lysine demethylase and nuclear receptor corepressor
Synonyms: N, ba, rh, rh-bmh, bldy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 15460
HGNC: HGNC:5172
Homologene: 3774
Atp4a
Name: ATPase, H+/K+ exchanging, gastric, alpha polypeptide
Synonyms: H+K+-transporting alpha 1, H+/K+-ATPase alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11944
HGNC: HGNC:819
Homologene: 68081
Agtpbp1
Name: ATP/GTP binding protein 1
Synonyms: Nna1, 2900054O13Rik, 4930445M19Rik, 1700020N17Rik, 5730402G09Rik, 2310001G17Rik, Ccp1, atms
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67269
Homologene: 9067
Bnip2
Name: BCL2/adenovirus E1B interacting protein 2
Synonyms: 5730523P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12175
HGNC: HGNC:1083
Homologene: 3194
Ksr2
Name: kinase suppressor of ras 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 333050
Homologene: 45469
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26875
Homologene: 69111
Efcab6
Name: EF-hand calcium binding domain 6
Synonyms: 4932408N08Rik, 4931407K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 77627
Homologene: 11259
Olfr888
Name: olfactory receptor 888
Synonyms: GA_x6K02T2PVTD-31787920-31788864, MOR162-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258416
Homologene: 84577
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 192190
Homologene: 16332
Cdcp3
Name: CUB domain containing protein 3
Synonyms: 5430419D17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71395
Homologene: 138430
Wdr24
Name: WD repeat domain 24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268933
Homologene: 6870
Gbp6
Name: guanylate binding protein 6
Synonyms: Mpa2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100702
Homologene: 128731
Rab3d
Name: RAB3D, member RAS oncogene family
Synonyms: C130057E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 19340
HGNC: HGNC:9779
Homologene: 20902
Myo3b
Name: myosin IIIB
Synonyms: A430065P19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329421
Homologene: 51393
Top2b
Name: topoisomerase (DNA) II beta
Synonyms: Top-2, D230016L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21974
Homologene: 134711
Elmo3
Name: engulfment and cell motility 3
Synonyms: CED-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234683
Homologene: 23475
Ppox
Name: protoporphyrinogen oxidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19044
HGNC: HGNC:9280
Homologene: 262
Zfp518b
Name: zinc finger protein 518B
Synonyms: 6820424L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100515
Homologene: 19115
Galnt13
Name: polypeptide N-acetylgalactosaminyltransferase 13
Synonyms: pp-GalNAc-T13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 271786
Homologene: 62167
Rmc1
Name: regulator of MON1-CCZ1
Synonyms: 3110002H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 76482
Homologene: 8341
Vwa5b2
Name: von Willebrand factor A domain containing 5B2
Synonyms: EG328644
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 328643
Homologene: 28056
Vmn2r4
Name: vomeronasal 2, receptor 4
Synonyms: EG637053
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 637053
Homologene: 129754
Olfr1451
Name: olfactory receptor 1451
Synonyms: GA_x6K02T2RE5P-3328502-3329434, MOR202-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258700
Homologene: 128082
Ppm1f
Name: protein phosphatase 1F (PP2C domain containing)
Synonyms: 4933427B07Rik, 1110021B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 68606
Homologene: 22828
Gm16485
Name: predicted gene 16485
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Parp8
Name: poly (ADP-ribose) polymerase family, member 8
Synonyms: 2810430O08Rik, D13Ertd275e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 52552
VEGA: 13
Homologene: 11621
Cd44
Name: CD44 antigen
Synonyms: Ly-24, Pgp-1, HERMES
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12505
HGNC: HGNC:1681
Homologene: 508
Col10a1
Name: collagen, type X, alpha 1
Synonyms: Col10a-1, Col10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12813
HGNC: HGNC:2185
Homologene: 55466
Adgra1
Name: adhesion G protein-coupled receptor A1
Synonyms: 2900059M17Rik, D7Ertd680e, Gpr123
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 52389
Homologene: 18582
Gpr18
Name: G protein-coupled receptor 18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 110168
VEGA: 14
HGNC: HGNC:4472
Homologene: 18814
Dgkk
Name: diacylglycerol kinase kappa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 331374
Homologene: 45867
3110039M20Rik
Name: RIKEN cDNA 3110039M20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 67293
Rab36
Name: RAB36, member RAS oncogene family
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 76877
HGNC: HGNC:9775
Homologene: 3610
Olfr819
Name: olfactory receptor 819
Synonyms: GA_x6K02T2PULF-11644164-11643823, MOR265-2_p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 100043200
Homologene: 73929
Trem3
Name: triggering receptor expressed on myeloid cells 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 58218
VEGA: 17
Homologene: 87012
Tas2r114
Name: taste receptor, type 2, member 114
Synonyms: Tas2r14, T2R14, mGR14, mt2r46
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387346
Homologene: 128355
Prl2c1
Name: Prolactin family 2, subfamily c, member 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 666317
Homologene: 40763
B230307C23Rik
Name: RIKEN cDNA B230307C23 gene
Synonyms: EG245305
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 245305
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 171,277,493 bp
  • A to T, chromosome 2 at 54,880,062 bp
  • A to G, chromosome 2 at 70,245,314 bp
  • G to A, chromosome 2 at 102,901,350 bp
  • T to A, chromosome 3 at 64,389,475 bp
  • A to G, chromosome 5 at 14,668,995 bp
  • A to T, chromosome 5 at 38,674,112 bp
  • A to T, chromosome 5 at 105,280,266 bp
  • A to G, chromosome 5 at 117,554,979 bp
  • T to C, chromosome 6 at 131,689,268 bp
  • G to A, chromosome 7 at 30,720,225 bp
  • C to T, chromosome 7 at 100,435,833 bp
  • A to G, chromosome 7 at 131,235,106 bp
  • G to A, chromosome 7 at 139,852,590 bp
  • G to A, chromosome 8 at 105,308,836 bp
  • T to C, chromosome 9 at 8,972,381 bp
  • A to T, chromosome 9 at 21,914,908 bp
  • A to G, chromosome 9 at 38,108,881 bp
  • T to A, chromosome 9 at 69,999,150 bp
  • A to C, chromosome 9 at 119,241,696 bp
  • A to T, chromosome 10 at 28,473,043 bp
  • A to G, chromosome 10 at 34,395,498 bp
  • G to A, chromosome 10 at 75,044,496 bp
  • A to T, chromosome 10 at 129,966,712 bp
  • T to C, chromosome 11 at 102,844,201 bp
  • C to A, chromosome 11 at 107,074,198 bp
  • C to T, chromosome 12 at 49,391,005 bp
  • T to C, chromosome 13 at 27,856,632 bp
  • G to A, chromosome 13 at 59,465,972 bp
  • A to T, chromosome 13 at 116,893,188 bp
  • T to G, chromosome 14 at 16,409,189 bp
  • T to A, chromosome 14 at 70,557,796 bp
  • T to C, chromosome 14 at 121,912,461 bp
  • T to C, chromosome 15 at 44,546,587 bp
  • A to G, chromosome 15 at 81,327,284 bp
  • A to T, chromosome 15 at 81,718,762 bp
  • G to A, chromosome 15 at 83,871,278 bp
  • T to C, chromosome 16 at 15,799,967 bp
  • T to C, chromosome 16 at 16,923,883 bp
  • C to A, chromosome 16 at 20,591,558 bp
  • T to A, chromosome 16 at 98,008,999 bp
  • A to G, chromosome 17 at 25,826,639 bp
  • T to A, chromosome 17 at 48,257,927 bp
  • T to C, chromosome 18 at 12,189,148 bp
  • G to A, chromosome 19 at 12,999,102 bp
  • T to C, chromosome X at 6,938,392 bp
  • T to C, chromosome X at 60,281,644 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3687 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040683-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.