Strain Name:
C57BL/6J-MtgxR3752Btlr/Mmmh
Stock Number:
040737-MU
Citation ID:
RRID:MMRRC_040737-MU
Other Names:
R3752 (G1), C57BL/6J-MtgxR3752Btlr
Major Collection:

Strain Information

Ext1
Name: exostosin glycosyltransferase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 14042
HGNC: HGNC:3512
Homologene: 30957
Slc6a5
Name: solute carrier family 6 (neurotransmitter transporter, glycine), member 5
Synonyms: Glyt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 104245
Homologene: 37901
Vldlr
Name: very low density lipoprotein receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 22359
Homologene: 443
Snx1
Name: sorting nexin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56440
Homologene: 99716
Snx2
Name: sorting nexin 2
Synonyms: 0610030A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67804
VEGA: 18
Homologene: 2332
Slit1
Name: slit guidance ligand 1
Synonyms: Slil1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20562
Homologene: 2302
Hmgcr
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
Synonyms: HMG-CoAR, 3-hydroxy-3-methylglutaryl-CoA reductase, Red
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 15357
HGNC: HGNC:5006
Homologene: 30994
Vps35
Name: VPS35 retromer complex component
Synonyms: Mem3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 65114
Homologene: 6221
Traf3ip1
Name: TRAF3 interacting protein 1
Synonyms: 3930402D05Rik, MIP-T3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74019
Homologene: 22913
Cep170
Name: centrosomal protein 170
Synonyms: 4933426L22Rik, A330004A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 545389
Homologene: 22844
Mdc1
Name: mediator of DNA damage checkpoint 1
Synonyms: NFBD1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240087
Homologene: 67092
Brd1
Name: bromodomain containing 1
Synonyms: 1110059H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223770
HGNC: HGNC:1102
Homologene: 40956
Slc9a8
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 8
Synonyms: NHE8, 1200006P13Rik, 6430709P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 77031
Homologene: 75041
Irak4
Name: interleukin-1 receptor-associated kinase 4
Synonyms: NY-REN-64, IRAK-4, 9330209D03Rik, 8430405M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 266632
Homologene: 41109
Cramp1
Name: cramped chromatin regulator 1
Synonyms: 5830477H08Rik, Tce4, Cramp1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 57354
VEGA: 17
Homologene: 35373
Mib2
Name: mindbomb E3 ubiquitin protein ligase 2
Synonyms: 2210008I11Rik, Zzank1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76580
Homologene: 16062
Plxnb2
Name: plexin B2
Synonyms: Debt, 1110007H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 140570
HGNC: HGNC:9104
Homologene: 66630
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Fbf1
Name: Fas (TNFRSF6) binding factor 1
Synonyms: 1110033G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217335
Homologene: 16531
Mei1
Name: meiotic double-stranded break formation protein 1
Synonyms: mei1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 74369
Homologene: 46535
Fbln1
Name: fibulin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 14114
HGNC: HGNC:3600
Homologene: 21295
Zfp644
Name: zinc finger protein 644
Synonyms: 1110068L01Rik, BM-005, Zep-2, D5Ertd689e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 52397
Homologene: 12971
Dnajc19
Name: DnaJ heat shock protein family (Hsp40) member C19
Synonyms: 1810055D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67713
Homologene: 87176
Rag2
Name: recombination activating gene 2
Synonyms: Rag-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19374
HGNC: HGNC:9832
Homologene: 7507
Col4a4
Name: collagen, type IV, alpha 4
Synonyms: [a]4(IV), E130010M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12829
HGNC: HGNC:2206
Homologene: 20071
E2f1
Name: E2F transcription factor 1
Synonyms: E2F-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13555
HGNC: HGNC:3113
Homologene: 3828
Rbp3
Name: retinol binding protein 3, interstitial
Synonyms: Irbp, Rbp-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19661
VEGA: 14
HGNC: HGNC:9921
Homologene: 9261
Nobox
Name: NOBOX oogenesis homeobox
Synonyms: Og2x
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 18291
Homologene: 51066
Tex15
Name: testis expressed gene 15
Synonyms: 2210014E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 104271
Homologene: 12837
Lama3
Name: laminin, alpha 3
Synonyms: nicein, 150kDa, [a]3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Ralgapa2
Name: Ral GTPase activating protein, alpha subunit 2 (catalytic)
Synonyms: A230067G21Rik, RGC2, AS250
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241694
Homologene: 28131
Lrrd1
Name: leucine rich repeats and death domain containing 1
Synonyms: 4932412H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 242838
Homologene: 18247
Perm1
Name: PPARGC1 and ESRR induced regulator, muscle 1
Synonyms: 2310042D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74183
Homologene: 135954
Skint6
Name: selection and upkeep of intraepithelial T cells 6
Synonyms: OTTMUSG00000008519
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230622
Homologene: 135888
Ogn
Name: osteoglycin
Synonyms: OG, 3110079A16Rik, mimican, SLRR3A, mimecan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18295
VEGA: 13
HGNC: HGNC:8126
Homologene: 8542
Eml6
Name: echinoderm microtubule associated protein like 6
Synonyms: 2900083P10Rik, C230094A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237711
Homologene: 104282
Sh2b1
Name: SH2B adaptor protein 1
Synonyms: Irip, SH2-Bb, SH2-B, Sh2bpsm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20399
Homologene: 32122
Hapln4
Name: hyaluronan and proteoglycan link protein 4
Synonyms: Bral2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 330790
Homologene: 11304
Lrrc9
Name: leucine rich repeat containing 9
Synonyms: 4930432K16Rik, 4921529O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 78257
Homologene: 12692
Paqr8
Name: progestin and adipoQ receptor family member VIII
Synonyms: 3110001D06Rik, 1700019B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74229
Homologene: 32702
Pcdhb15
Name: protocadherin beta 15
Synonyms: Pcdhb7, PcdhbO
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93886
HGNC: HGNC:8692
Homologene: 32429
A830018L16Rik
Name: RIKEN cDNA A830018L16 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 320492
Homologene: 14194
Rab3il1
Name: RAB3A interacting protein (rabin3)-like 1
Synonyms: 1200014K04Rik, Rab3ail1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 74760
HGNC: HGNC:9780
Homologene: 40880
Slc47a1
Name: solute carrier family 47, member 1
Synonyms: 1300013J15Rik, MATE1, mMATE1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67473
Homologene: 34364
Or10ag59
Name: olfactory receptor family 10 subfamily AG member 59
Synonyms: GA_x6K02T2Q125-49078087-49079031, MOR264-9P, MOR264-23, Olfr1129
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258111
Homologene: 133705
Adh1
Name: alcohol dehydrogenase 1 (class I)
Synonyms: ADH-AA, class I alcohol dehydrogenase, Adh-1-t, Adh-1, Adh-1t, Adh1-t, Adh1-e, Adh1tl, Adh-1e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11522
Homologene: 73888
Tymp
Name: thymidine phosphorylase
Synonyms: PDECGF, PD-ECGF, gliostatin, Pdgfec, 2900072D10Rik, Ecgf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72962
VEGA: 15
HGNC: HGNC:3148
Homologene: 1474
Or6a2
Name: olfactory receptor family 6 subfamily A member 2
Synonyms: I54, I7, Olfr41, MOR103-15, GA_x6K02T2PBJ9-9381439-9380456, Olfr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18317
Homologene: 2743
Dhrs7c
Name: dehydrogenase/reductase (SDR family) member 7C
Synonyms: 1110001P11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68460
Homologene: 19108
Tbc1d30
Name: TBC1 domain family, member 30
Synonyms: 4930505D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 74694
VEGA: 10
Homologene: 18930
Gm10521
Name: predicted gene 10521
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
VEGA: 1
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 11,518,680 bp
  • A to G, chromosome 1 at 20,935,632 bp
  • G to A, chromosome 1 at 82,480,494 bp
  • T to C, chromosome 1 at 91,500,917 bp
  • A to G, chromosome 1 at 91,518,297 bp
  • A to G, chromosome 1 at 171,896,145 bp
  • A to G, chromosome 1 at 176,782,495 bp
  • A to G, chromosome 2 at 87,575,713 bp
  • A to T, chromosome 2 at 101,630,776 bp
  • A to T, chromosome 2 at 146,421,631 bp
  • C to G, chromosome 2 at 154,564,022 bp
  • C to A, chromosome 2 at 167,457,352 bp
  • C to T, chromosome 2 at 180,187,222 bp
  • A to T, chromosome 3 at 34,078,857 bp
  • G to A, chromosome 3 at 138,288,794 bp
  • T to C, chromosome 4 at 112,842,899 bp
  • A to G, chromosome 4 at 155,655,284 bp
  • A to T, chromosome 4 at 156,217,946 bp
  • T to A, chromosome 5 at 3,850,282 bp
  • A to G, chromosome 5 at 106,636,383 bp
  • T to G, chromosome 6 at 43,307,233 bp
  • T to C, chromosome 7 at 49,936,314 bp
  • A to T, chromosome 7 at 107,001,475 bp
  • A to G, chromosome 7 at 126,468,787 bp
  • T to A, chromosome 8 at 33,571,415 bp
  • A to T, chromosome 8 at 70,086,965 bp
  • A to G, chromosome 8 at 85,274,831 bp
  • A to T, chromosome 9 at 66,105,651 bp
  • T to A, chromosome 10 at 121,272,168 bp
  • C to A, chromosome 11 at 29,809,360 bp
  • C to T, chromosome 11 at 61,344,381 bp
  • A to G, chromosome 11 at 67,811,455 bp
  • C to T, chromosome 11 at 116,147,796 bp
  • T to G, chromosome 12 at 72,460,806 bp
  • C to T, chromosome 13 at 49,622,831 bp
  • T to C, chromosome 13 at 96,663,116 bp
  • A to T, chromosome 14 at 33,956,012 bp
  • A to T, chromosome 15 at 53,075,910 bp
  • C to T, chromosome 15 at 82,086,182 bp
  • T to A, chromosome 15 at 85,227,078 bp
  • C to T, chromosome 15 at 88,689,618 bp
  • G to A, chromosome 15 at 89,157,255 bp
  • C to A, chromosome 15 at 89,373,923 bp
  • T to C, chromosome 15 at 94,561,595 bp
  • A to T, chromosome 17 at 24,971,558 bp
  • C to T, chromosome 17 at 35,845,929 bp
  • T to A, chromosome 18 at 12,507,029 bp
  • T to A, chromosome 18 at 37,473,757 bp
  • T to C, chromosome 18 at 53,212,970 bp
  • A to T, chromosome 19 at 10,030,477 bp
  • G to A, chromosome 19 at 27,238,331 bp
  • C to T, chromosome 19 at 41,646,967 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3752 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040737-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.