Strain Name:
C57BL/6J-MtgxR3805Btlr/Mmmh
Stock Number:
040762-MU
Citation ID:
RRID:MMRRC_040762-MU
Other Names:
R3805 (G1), C57BL/6J-MtgxR3805Btlr
Major Collection:

Gene Information

Herc3
Name: hect domain and RLD 3
Synonyms: 5730409F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 73998
HGNC: HGNC:4876
Homologene: 57095
Oxtr
Name: oxytocin receptor
Synonyms: OTR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 18430
HGNC: HGNC:8529
Homologene: 20255
Get4
Name: golgi to ER traffic protein 4
Synonyms: 1110007L15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67604
Homologene: 41080
Crct1
Name: cysteine-rich C-terminal 1
Synonyms: Nice-1, 2300002G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74175
Morf4l1
Name: mortality factor 4 like 1
Synonyms: MRG15, Tex189, TEG-189, MORFRG15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21761
Homologene: 86043
Fam169a
Name: family with sequence similarity 169, member A
Synonyms: B230112C05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 320557
VEGA: 13
Homologene: 52656
Aebp2
Name: AE binding protein 2
Synonyms: B230313N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 11569
Homologene: 40690
Bicd1
Name: BICD cargo adaptor 1
Synonyms: B830009D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12121
HGNC: HGNC:1049
Homologene: 37518
Ccdc138
Name: coiled-coil domain containing 138
Synonyms: 6230424H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 76138
VEGA: 10
Homologene: 44912
Npnt
Name: nephronectin
Synonyms: 1110009H02Rik, POEM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 114249
Homologene: 14138
Htt
Name: huntingtin
Synonyms: IT15, HD, huntingtin, C430023I11Rik, Hdh, htt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15194
HGNC: HGNC:4851
Homologene: 1593
Robo4
Name: roundabout guidance receptor 4
Synonyms: Magic roundabout, 1200012D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74144
Homologene: 10397
Trpv1
Name: transient receptor potential cation channel, subfamily V, member 1
Synonyms: Vr1, VR-1, capsaicin receptor, OTRPC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 193034
Homologene: 12920
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: MDHC7, E030034C22Rik, B230373P09Rik, Dnahc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Col1a-2, Cola2, Cola-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Cercam
Name: cerebral endothelial cell adhesion molecule
Synonyms: Ceecam1, CerCAM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99151
Homologene: 22954
Nlrp9a
Name: NLR family, pyrin domain containing 9A
Synonyms: Nalp-theta, D7Ertd565e, Nalp9a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233001
Homologene: 116072
Slc9b2
Name: solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
Synonyms: nha-oc, C80638, Nhedc2, NHE10, NHA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 97086
Homologene: 45381
Ppp6r2
Name: protein phosphatase 6, regulatory subunit 2
Synonyms: 8430411H09Rik, Pp6r2, Saps2, B230107H12Rik, 1110033O10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71474
VEGA: 15
Homologene: 36455
Lrrc7
Name: leucine rich repeat containing 7
Synonyms: densin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242274
Homologene: 10817
Vmn2r77
Name: vomeronasal 2, receptor 77
Synonyms: EG546983
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 546983
Homologene: 115466
Lingo4
Name: leucine rich repeat and Ig domain containing 4
Synonyms: LERN4, A530050P17Rik, Lrrn6d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 320747
Homologene: 18563
St18
Name: suppression of tumorigenicity 18
Synonyms: Myt3, Nzf3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240690
Homologene: 8792
Naaladl1
Name: N-acetylated alpha-linked acidic dipeptidase-like 1
Synonyms: LOC381204
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 381204
Homologene: 21124
Tmem184c
Name: transmembrane protein 184C
Synonyms: Tmem34, 8430433H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234463
Homologene: 32403
Ppp4r4
Name: protein phosphatase 4, regulatory subunit 4
Synonyms: 8430415E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 74521
Homologene: 12571
Map7d1
Name: MAP7 domain containing 1
Synonyms: Mtap7d1, Parcc1, Rprc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 245877
Homologene: 17009
Rsph10b
Name: radial spoke head 10 homolog B (Chlamydomonas)
Synonyms: 4930526H21Rik, Rsph10b2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Homologene: 18321
Speer4a
Name: spermatogenesis associated glutamate (E)-rich protein 4A
Synonyms: SPEER-4A, 1700027N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75657
Homologene: 69402
Eri2
Name: exoribonuclease 2
Synonyms: 4933424N09Rik, Exod1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71151
Homologene: 12383
Hdac3
Name: histone deacetylase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 15183
HGNC: HGNC:4854
Homologene: 48250
Dhrs2
Name: dehydrogenase/reductase member 2
Synonyms: 5430405K24Rik, SDR family
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 71412
Homologene: 69438
Olfr1187-ps1
Name: olfactory receptor 1187, pseudogene 1
Synonyms: GA_x6K02T2Q125-50027818-50027495
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 404484
VEGA: 2
Ano5
Name: anoctamin 5
Synonyms: Gdd1, Tmem16e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233246
Homologene: 100071
Ctu1
Name: cytosolic thiouridylase subunit 1
Synonyms: Atpbd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233189
Homologene: 102140
1700012B07Rik
Name: RIKEN cDNA 1700012B07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69324
Homologene: 78000
Ifit1
Name: interferon-induced protein with tetratricopeptide repeats 1
Synonyms: Ifi56, ISG56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 15957
Homologene: 22462
Gm4222
Name: predicted gene 4222
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 6,802,353 bp
  • G to T, chromosome 2 at 29,872,708 bp
  • A to T, chromosome 2 at 88,540,356 bp
  • T to G, chromosome 2 at 90,148,461 bp
  • C to A, chromosome 3 at 93,014,707 bp
  • A to G, chromosome 3 at 94,402,100 bp
  • A to G, chromosome 3 at 132,908,471 bp
  • T to C, chromosome 3 at 135,324,588 bp
  • T to C, chromosome 3 at 158,185,493 bp
  • A to T, chromosome 4 at 126,237,291 bp
  • C to T, chromosome 5 at 26,035,084 bp
  • A to G, chromosome 5 at 34,877,204 bp
  • G to T, chromosome 5 at 139,252,531 bp
  • G to A, chromosome 5 at 143,958,388 bp
  • G to A, chromosome 6 at 4,518,822 bp
  • C to A, chromosome 6 at 58,916,850 bp
  • T to C, chromosome 6 at 112,477,186 bp
  • GCGGCC to GCGGCCGGCC, chromosome 6 at 140,643,949 bp
  • T to A, chromosome 6 at 149,518,991 bp
  • T to A, chromosome 7 at 26,564,852 bp
  • T to C, chromosome 7 at 43,676,673 bp
  • T to C, chromosome 7 at 51,576,650 bp
  • T to A, chromosome 7 at 86,795,160 bp
  • A to T, chromosome 7 at 119,786,008 bp
  • C to A, chromosome 8 at 77,596,875 bp
  • A to T, chromosome 9 at 37,404,438 bp
  • A to G, chromosome 9 at 90,095,143 bp
  • T to C, chromosome 10 at 58,561,997 bp
  • A to T, chromosome 11 at 73,253,053 bp
  • G to T, chromosome 11 at 109,794,154 bp
  • T to A, chromosome 12 at 103,600,366 bp
  • G to A, chromosome 13 at 97,097,684 bp
  • A to T, chromosome 14 at 31,294,763 bp
  • A to T, chromosome 14 at 55,234,748 bp
  • T to C, chromosome 15 at 89,265,639 bp
  • A to G, chromosome 18 at 37,945,692 bp
  • A to G, chromosome 19 at 6,114,865 bp
  • A to G, chromosome 19 at 34,648,156 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3805 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040762-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.