Strain Name:
C57BL/6J-MtgxR3811Btlr/Mmmh
Stock Number:
040767-MU
Citation ID:
RRID:MMRRC_040767-MU
Other Names:
R3811 (G1), C57BL/6J-MtgxR3811Btlr
Major Collection:

Gene Information

Slc32a1
Name: solute carrier family 32 (GABA vesicular transporter), member 1
Synonyms: Viaat, R75019, VGAT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22348
Homologene: 56451
Cacybp
Name: calcyclin binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12301
Homologene: 7649
Psmd1
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
Synonyms: P112, S1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70247
HGNC: HGNC:9554
Homologene: 2100
Kat7
Name: K(lysine) acetyltransferase 7
Synonyms: Hboa, Hbo1, Myst2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217127
Homologene: 5134
Arid2
Name: AT rich interactive domain 2 (ARID, RFX-like)
Synonyms: 4432409D24Rik, zipzap/p200, 1700124K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 77044
Homologene: 14601
Rbbp5
Name: retinoblastoma binding protein 5, histone lysine methyltransferase complex subunit
Synonyms: 4933411J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 213464
HGNC: HGNC:9888
Homologene: 3709
Atp1b1
Name: ATPase, Na+/K+ transporting, beta 1 polypeptide
Synonyms: Atpb-1, Atpb, sodium/potassium ATPase beta subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11931
HGNC: HGNC:804
Homologene: 37509
Dock4
Name: dedicator of cytokinesis 4
Synonyms: EST N28122, 6330411N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238130
VEGA: 12
Homologene: 56680
Mdn1
Name: midasin AAA ATPase 1
Synonyms: LOC213784, 4833432B22Rik, D4Abb1e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100019
Homologene: 39689
Psmd9
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
Synonyms: 1500011J20Rik, Bridge-1, P27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67151
HGNC: HGNC:9567
Homologene: 2106
Lamc1
Name: laminin, gamma 1
Synonyms: laminin B2, Lamb2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226519
HGNC: HGNC:6492
Homologene: 1724
Glrx5
Name: glutaredoxin 5
Synonyms: 2310004O13Rik, 2900070E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 73046
VEGA: 12
Homologene: 31984
Crnkl1
Name: crooked neck pre-mRNA splicing factor 1
Synonyms: 5730590A01Rik, crn, 1200013P10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66877
Homologene: 6462
Med23
Name: mediator complex subunit 23
Synonyms: Crsp3, ESTM7, X83317, 3000002A17Rik, Sur2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70208
HGNC: HGNC:2372
Homologene: 3552
Metap2
Name: methionine aminopeptidase 2
Synonyms: 4930584B20Rik, p67, eIF-2-associated p67, A930035J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 56307
Homologene: 4981
Txndc5
Name: thioredoxin domain containing 5
Synonyms: PC-TRP, ERp46
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105245
Homologene: 11125
Arhgap28
Name: Rho GTPase activating protein 28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268970
Homologene: 18264
Tsc2
Name: TSC complex subunit 2
Synonyms: Nafld, tuberin, tuberous sclerosis 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22084
VEGA: 17
Homologene: 462
Creb3
Name: cAMP responsive element binding protein 3
Synonyms: LZIP, LZIP-2, LZIP-1, Luman
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12913
HGNC: HGNC:2347
Homologene: 31375
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 545370
Homologene: 23741
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: Dnahc6, A730004I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Chsy3
Name: chondroitin sulfate synthase 3
Synonyms: 4833446K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 78923
VEGA: 18
Homologene: 28624
Hivep2
Name: human immunodeficiency virus type I enhancer binding protein 2
Synonyms: Gm20114, MIBP1, Schnurri-2, Shn-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15273
HGNC: HGNC:4921
Homologene: 4900
Agbl3
Name: ATP/GTP binding protein-like 3
Synonyms: 4930431N21Rik, Ccp3, Ccp3, 6530406M24Rik, 2900053G10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 76223
Homologene: 35330
Galntl5
Name: UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5
Synonyms: 1700021B12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67909
Homologene: 12210
Steap4
Name: STEAP family member 4
Synonyms: Tiarp, Tnfaip9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 117167
Homologene: 36422
Olfr1066
Name: olfactory receptor 1066
Synonyms: MOR188-8, GA_x6K02T2Q125-47925557-47924616, MOR256-52P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 257880
Homologene: 79468
Ilvbl
Name: ilvB (bacterial acetolactate synthase)-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216136
VEGA: 10
HGNC: HGNC:6041
Homologene: 68532
Kcnd3
Name: potassium voltage-gated channel, Shal-related family, member 3
Synonyms: potassium channel Kv4.3M, Kv4.3, potassium channel Kv4.3L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56543
HGNC: HGNC:6239
Homologene: 21036
Cyth4
Name: cytohesin 4
Synonyms: Pscd4, 2510004M07Rik, 5830469K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72318
VEGA: 15
HGNC: HGNC:9505
Homologene: 22750
Tymp
Name: thymidine phosphorylase
Synonyms: 2900072D10Rik, PDECGF, PD-ECGF, Pdgfec, Ecgf1, gliostatin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72962
VEGA: 15
HGNC: HGNC:3148
Homologene: 1474
Gm9602
Name: predicted gene 9602
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 673676
Homologene: 115686
Spem2
Name: SPEM family member 2
Synonyms: 4933402P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 108803
Homologene: 52178
Mall
Name: mal, T cell differentiation protein-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228576
HGNC: HGNC:6818
Homologene: 3965
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 86,132,715 bp
  • T to C, chromosome 1 at 132,492,587 bp
  • A to G, chromosome 1 at 150,649,577 bp
  • A to T, chromosome 1 at 153,262,708 bp
  • T to C, chromosome 1 at 160,203,652 bp
  • C to T, chromosome 1 at 164,443,305 bp
  • A to T, chromosome 2 at 86,455,347 bp
  • T to A, chromosome 2 at 127,708,854 bp
  • C to A, chromosome 2 at 145,931,306 bp
  • G to T, chromosome 2 at 158,614,736 bp
  • C to T, chromosome 3 at 105,658,766 bp
  • A to T, chromosome 4 at 32,693,506 bp
  • C to T, chromosome 4 at 43,565,501 bp
  • A to G, chromosome 5 at 7,977,017 bp
  • T to C, chromosome 5 at 25,186,180 bp
  • C to T, chromosome 5 at 123,234,590 bp
  • G to T, chromosome 6 at 34,799,729 bp
  • T to C, chromosome 6 at 73,191,498 bp
  • A to G, chromosome 10 at 14,130,357 bp
  • A to T, chromosome 10 at 24,892,592 bp
  • G to A, chromosome 10 at 24,892,593 bp
  • G to A, chromosome 10 at 78,579,035 bp
  • A to T, chromosome 10 at 93,870,164 bp
  • T to C, chromosome 11 at 69,817,164 bp
  • A to G, chromosome 11 at 95,291,615 bp
  • T to A, chromosome 12 at 40,779,124 bp
  • C to G, chromosome 12 at 105,032,888 bp
  • T to C, chromosome 13 at 38,523,405 bp
  • T to A, chromosome 14 at 4,776,499 bp
  • A to G, chromosome 15 at 78,604,649 bp
  • T to C, chromosome 15 at 89,373,679 bp
  • T to C, chromosome 15 at 96,289,086 bp
  • T to C, chromosome 17 at 24,629,037 bp
  • G to A, chromosome 17 at 67,896,093 bp
  • C to G, chromosome 18 at 59,176,170 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3811 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040767-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.