Strain Name:
C57BL/6J-MtgxR3817Btlr/Mmmh
Stock Number:
040771-MU
Citation ID:
RRID:MMRRC_040771-MU
Other Names:
R3817 (G1), C57BL/6J-MtgxR3817Btlr
Major Collection:

Gene Information

Tns3
Name: tensin 3
Synonyms: Tens1, TEM6, F830010I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 319939
Homologene: 49713
Appbp2
Name: amyloid beta precursor protein (cytoplasmic tail) binding protein 2
Synonyms: PAT1, 1300003O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66884
HGNC: HGNC:622
Homologene: 31378
Lig3
Name: ligase III, DNA, ATP-dependent
Synonyms: D11Wsu78e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16882
HGNC: HGNC:6600
Homologene: 32109
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: A330063D19Rik, 1810014J18Rik, AD013, 9030205D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 109151
Homologene: 11844
Atp1b1
Name: ATPase, Na+/K+ transporting, beta 1 polypeptide
Synonyms: Atpb, sodium/potassium ATPase beta subunit, Atpb-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11931
HGNC: HGNC:804
Homologene: 37509
Nav2
Name: neuron navigator 2
Synonyms: HELAD1, RAINB2, Rainb1, 5330421F07Rik, POMFIL2, Unc53H2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 78286
Homologene: 52330
Secisbp2l
Name: SECIS binding protein 2-like
Synonyms: 3110001I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70354
Homologene: 18923
B3galt2
Name: UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 26878
HGNC: HGNC:917
Homologene: 74512
Lrrtm4
Name: leucine rich repeat transmembrane neuronal 4
Synonyms: 7530419J18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243499
Homologene: 11807
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: LR11, mSorLA, 2900010L19Rik, Sorla
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20660
Homologene: 2336
Pomgnt1
Name: protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase
Synonyms: 0610016I07Rik, 4930467B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68273
Homologene: 9806
Ppp2r5c
Name: protein phosphatase 2, regulatory subunit B', gamma
Synonyms: 2610043M05Rik, Band 8A, D12Bwg0916e, 2700063L20Rik, B56/PP2A gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 26931
VEGA: 12
HGNC: HGNC:9311
Homologene: 128665
Exph5
Name: exophilin 5
Synonyms: AC079869.22gm5, Slac2b, B130009M24Rik, slac2-b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320051
Homologene: 9007
Hivep2
Name: human immunodeficiency virus type I enhancer binding protein 2
Synonyms: Gm20114, Schnurri-2, Shn-2, MIBP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15273
HGNC: HGNC:4921
Homologene: 4900
Olfr965
Name: olfactory receptor 965
Synonyms: GA_x6K02T2PVTD-33416730-33417668, MOR171-28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258165
VEGA: 9
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Vmn2r19
Name: vomeronasal 2, receptor 19
Synonyms: EG232358
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232358
Homologene: 84037
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242627
Homologene: 135888
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 435626
Homologene: 52359
Myo1a
Name: myosin IA
Synonyms: Myhl, brush border myosin 1, BBM-I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 432516
VEGA: 10
HGNC: HGNC:7595
Homologene: 21113
Slc27a1
Name: solute carrier family 27 (fatty acid transporter), member 1
Synonyms: FATP1, Fatp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 26457
Homologene: 8063
Tnfrsf11a
Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Synonyms: TRANCE-R, Rank
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21934
Homologene: 2848
Zfp672
Name: zinc finger protein 672
Synonyms: 4930511N19Rik, 4930488P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 319475
Homologene: 23493
Cyp4a12b
Name: cytochrome P450, family 4, subfamily a, polypeptide 12B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13118
Homologene: 134044
Olfr889
Name: olfactory receptor 889
Synonyms: MOR162-2, GA_x6K02T2PVTD-31795028-31795957
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258475
Homologene: 138311
Cyb561a3
Name: cytochrome b561 family, member A3
Synonyms: 2310004G04Rik, Cybasc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225912
VEGA: 19
Homologene: 15558
Cyp2c67
Name: cytochrome P450, family 2, subfamily c, polypeptide 67
Synonyms: C730004C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 545288
Homologene: 74936
Ly9
Name: lymphocyte antigen 9
Synonyms: T100, SLAMF3, CD229, Lgp100
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17085
HGNC: HGNC:6730
Homologene: 1759
Olfr483
Name: olfactory receptor 483
Synonyms: GA_x6K02T2PBJ9-10432095-10433042, MOR204-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258730
Homologene: 133602
Cts7
Name: cathepsin 7
Synonyms: Epcs71, CTS1, Epcs24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56092
VEGA: 13
Homologene: 75110
Clec4a4
Name: C-type lectin domain family 4, member a4
Synonyms: Dcir2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 474145
Homologene: 133910
Olfr876
Name: olfactory receptor 876
Synonyms: GA_x6K02T2PVTD-31489645-31490577, MOR161-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258883
Homologene: 74154
Olfr922
Name: olfactory receptor 922
Synonyms: GA_x6K02T2PVTD-32518237-32519172, MOR161-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258777
VEGA: 9
Homologene: 27262
Gjb2
Name: gap junction protein, beta 2
Synonyms: Gjb-2, Cx26, connexin 26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14619
HGNC: HGNC:4284
Homologene: 2975
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 74,147,663 bp
  • C to T, chromosome 1 at 105,809,360 bp
  • G to T, chromosome 1 at 143,647,073 bp
  • C to T, chromosome 1 at 164,443,305 bp
  • G to T, chromosome 1 at 171,589,085 bp
  • T to C, chromosome 2 at 40,876,658 bp
  • C to T, chromosome 2 at 125,740,737 bp
  • A to G, chromosome 4 at 113,629,122 bp
  • A to T, chromosome 4 at 115,432,470 bp
  • T to A, chromosome 4 at 116,153,942 bp
  • A to G, chromosome 6 at 80,022,061 bp
  • A to C, chromosome 6 at 122,990,407 bp
  • A to T, chromosome 6 at 123,309,642 bp
  • A to G, chromosome 7 at 49,464,562 bp
  • A to G, chromosome 7 at 108,103,498 bp
  • T to C, chromosome 8 at 71,584,478 bp
  • T to C, chromosome 8 at 90,984,265 bp
  • C to T, chromosome 9 at 37,804,169 bp
  • A to T, chromosome 9 at 38,116,626 bp
  • A to G, chromosome 9 at 38,816,426 bp
  • A to G, chromosome 9 at 39,720,108 bp
  • A to G, chromosome 9 at 42,064,049 bp
  • C to T, chromosome 9 at 53,375,494 bp
  • T to C, chromosome 10 at 14,143,941 bp
  • C to T, chromosome 10 at 127,707,428 bp
  • G to C, chromosome 11 at 8,434,619 bp
  • G to T, chromosome 11 at 58,316,636 bp
  • G to A, chromosome 11 at 82,796,115 bp
  • G to T, chromosome 11 at 85,198,108 bp
  • T to C, chromosome 12 at 110,544,187 bp
  • T to C, chromosome 13 at 61,356,536 bp
  • A to G, chromosome 14 at 57,100,073 bp
  • T to C, chromosome 19 at 10,582,364 bp
  • A to T, chromosome 19 at 39,638,683 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3817 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040771-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.