Strain Name:
C57BL/6J-MtgxR3843Btlr/Mmmh
Stock Number:
040783-MU
Citation ID:
RRID:MMRRC_040783-MU
Other Names:
R3843 (G1), C57BL/6J-MtgxR3843Btlr
Major Collection:

Gene Information

Col6a1
Name: collagen, type VI, alpha 1
Synonyms: Col6a-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 12833
HGNC: HGNC:2211
Homologene: 1391
Elp3
Name: elongator acetyltransferase complex subunit 3
Synonyms: 2610507P14Rik, KAT9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 74195
VEGA: 14
Homologene: 7105
Kdm2b
Name: lysine (K)-specific demethylase 2B
Synonyms: Fbxl10, Jhdm1b, Cxxc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 30841
Homologene: 13069
Atxn2l
Name: ataxin 2-like
Synonyms: A2LG, A2lp, A2D, A2RP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233871
Homologene: 16513
Nup214
Name: nucleoporin 214
Synonyms: D2H9S46E, CAN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227720
HGNC: HGNC:8064
Homologene: 38008
Lgr4
Name: leucine-rich repeat-containing G protein-coupled receptor 4
Synonyms: A930009A08Rik, A330106J01Rik, Gpr48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 107515
Homologene: 10226
Heatr1
Name: HEAT repeat containing 1
Synonyms: B130016L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 217995
VEGA: 13
Homologene: 34562
Tlk1
Name: tousled-like kinase 1
Synonyms: 4930545J15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228012
Homologene: 130657
Amt
Name: aminomethyltransferase
Synonyms: EG434437
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 434437
HGNC: HGNC:473
Homologene: 409
Cdhr1
Name: cadherin-related family member 1
Synonyms: Pcdh21, Prcad
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 170677
VEGA: 14
Homologene: 13215
Ppfia1
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
Synonyms: liprin, C030014K08Rik, Liprin-alpha1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233977
HGNC: HGNC:9245
Homologene: 20802
Dennd1b
Name: DENN/MADD domain containing 1B
Synonyms: 4632404N19Rik, 4930467M19Rik, 6820401H01Rik, F730008N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 329260
Homologene: 11739
Trim71
Name: tripartite motif-containing 71
Synonyms: LOC382112, 2610206G21Rik, Lin41, 636931, lin-41, mlin-41, mLin41
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 636931
Homologene: 9076
Pdp1
Name: pyruvate dehyrogenase phosphatase catalytic subunit 1
Synonyms: Ppm2c, LOC381511
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 381511
HGNC: HGNC:9279
Homologene: 31928
Pip4p2
Name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2
Synonyms: Tmem55a, 2610319K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 72519
Homologene: 23117
Ckap2
Name: cytoskeleton associated protein 2
Synonyms: LB1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 80986
HGNC: HGNC:1990
Homologene: 10070
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 269700
Homologene: 28297
Tmco3
Name: transmembrane and coiled-coil domains 3
Synonyms: B230339H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234076
Homologene: 32376
E2f1
Name: E2F transcription factor 1
Synonyms: E2F-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 13555
HGNC: HGNC:3113
Homologene: 3828
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: FPC, tigmin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Plcz1
Name: phospholipase C, zeta 1
Synonyms: 1700041H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 114875
Homologene: 23815
Pnp2
Name: purine-nucleoside phosphorylase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 667034
HGNC: HGNC:7892
Homologene: 227
Nlrc3
Name: NLR family, CARD domain containing 3
Synonyms: D230007K08Rik, CLR16.2, Caterpiller 16.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 268857
Homologene: 18720
Eef1akmt2
Name: EEF1A lysine methyltransferase 2
Synonyms: Mettl10, 2010208K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 72096
Homologene: 6175
Hnf4g
Name: hepatocyte nuclear factor 4, gamma
Synonyms: NR2A2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 30942
HGNC: HGNC:5026
Homologene: 37886
Kif26b
Name: kinesin family member 26B
Synonyms: D230039L06Rik, N-11 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 269152
Homologene: 18623
Aass
Name: aminoadipate-semialdehyde synthase
Synonyms: LOR/SDH, Lorsdh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 30956
Homologene: 4212
Zfp651
Name: zinc finger protein 651
Synonyms: 4732420M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 270210
VEGA: 9
Homologene: 136302
Olfr1032
Name: olfactory receptor 1032
Synonyms: GA_x6K02T2Q125-47485813-47486745, MOR199-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258572
Homologene: 17299
Ccdc8
Name: coiled-coil domain containing 8
Synonyms: ENSMUSG00000041117
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 434130
Homologene: 49977
Hrh4
Name: histamine receptor H4
Synonyms: H4R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225192
VEGA: 18
Homologene: 11002
Sidt1
Name: SID1 transmembrane family, member 1
Synonyms: B830021E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 320007
Homologene: 41189
Gm12830
Name: predicted gene 12830
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 433746
Phtf2
Name: putative homeodomain transcription factor 2
Synonyms: 9530062N20Rik, 1110054G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 68770
Homologene: 10713
Grap
Name: GRB2-related adaptor protein
Synonyms: 8430435N19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 71520
Homologene: 4822
Slc50a1
Name: solute carrier family 50 (sugar transporter), member 1
Synonyms: Rga, Rag1ap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 19729
Homologene: 40647
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 20,558,723 bp
  • C to A, chromosome 1 at 139,053,354 bp
  • T to C, chromosome 1 at 178,928,177 bp
  • T to C, chromosome 2 at 32,051,100 bp
  • T to A, chromosome 2 at 70,749,327 bp
  • A to G, chromosome 2 at 86,008,204 bp
  • C to T, chromosome 2 at 109,996,773 bp
  • A to G, chromosome 2 at 154,560,828 bp
  • G to A, chromosome 3 at 3,651,302 bp
  • A to T, chromosome 3 at 89,269,900 bp
  • T to C, chromosome 4 at 11,961,961 bp
  • T to A, chromosome 4 at 14,886,553 bp
  • A to T, chromosome 4 at 114,845,128 bp
  • G to A, chromosome 5 at 20,774,022 bp
  • G to T, chromosome 5 at 121,259,873 bp
  • A to T, chromosome 5 at 122,934,793 bp
  • A to T, chromosome 6 at 23,092,496 bp
  • G to T, chromosome 6 at 140,016,245 bp
  • T to C, chromosome 7 at 16,995,114 bp
  • T to A, chromosome 7 at 126,497,478 bp
  • C to T, chromosome 7 at 132,831,576 bp
  • C to T, chromosome 7 at 144,504,970 bp
  • A to G, chromosome 8 at 13,296,114 bp
  • A to T, chromosome 8 at 22,175,758 bp
  • C to T, chromosome 9 at 108,297,221 bp
  • T to C, chromosome 9 at 114,515,846 bp
  • T to A, chromosome 9 at 121,763,433 bp
  • C to T, chromosome 10 at 76,711,341 bp
  • T to G, chromosome 11 at 61,660,325 bp
  • T to C, chromosome 13 at 12,435,121 bp
  • G to T, chromosome 14 at 37,084,927 bp
  • T to A, chromosome 14 at 50,963,421 bp
  • A to T, chromosome 14 at 65,565,483 bp
  • G to A, chromosome 16 at 3,964,964 bp
  • A to T, chromosome 16 at 44,284,224 bp
  • A to G, chromosome 18 at 13,022,286 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3843 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040783-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.