Strain Name:
C57BL/6J-MtgxR3889Btlr/Mmmh
Stock Number:
040801-MU
Citation ID:
RRID:MMRRC_040801-MU
Other Names:
R3889 (G1), C57BL/6J-MtgxR3889Btlr
Major Collection:

Gene Information

Fn1
Name: fibronectin 1
Synonyms: Fn-1, Fn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14268
HGNC: HGNC:3778
Homologene: 1533
Stub1
Name: STIP1 homology and U-Box containing protein 1
Synonyms: CHIP, 0610033N24Rik, 2210017D18Rik, 2310040B03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56424
VEGA: 17
Homologene: 4281
Adcy10
Name: adenylate cyclase 10
Synonyms: soluble adenylyl cyclase, sAC, 4930431D04Rik, Sacy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 271639
Homologene: 10188
Rgs11
Name: regulator of G-protein signaling 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 50782
HGNC: HGNC:9993
Homologene: 77719
Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56381
Homologene: 124461
Prpf6
Name: pre-mRNA splicing factor 6
Synonyms: 1190003A07Rik, U5-102K, ANT-1, 2610031L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68879
Homologene: 5368
Lcor
Name: ligand dependent nuclear receptor corepressor
Synonyms: 3110023F06Rik, Mlr2, A630025C20Rik, LOC381224, Gm340
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 212391
VEGA: 19
Homologene: 18153
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Prkca
Name: protein kinase C, alpha
Synonyms: Pkca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18750
HGNC: HGNC:9393
Homologene: 55679
Etl4
Name: enhancer trap locus 4
Synonyms: Etl-4, E330027G05Rik, 6620402G01Rik, 9430077C05Rik, Skt, Sickle tail
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 208618
Homologene: 10477
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Rsf1
Name: remodeling and spacing factor 1
Synonyms: p325, XAP8, Hbxap, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233532
Homologene: 41142
Cct3
Name: chaperonin containing Tcp1, subunit 3 (gamma)
Synonyms: TriC-P5, Cctg, Tcp1-rs3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12462
HGNC: HGNC:1616
Homologene: 4373
Elp1
Name: elongator complex protein 1
Synonyms: 3110040G09Rik, C78473, IKAP, Ikbkap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230233
HGNC: HGNC:5959
Homologene: 2699
Fgd6
Name: FYVE, RhoGEF and PH domain containing 6
Synonyms: ZFYVE24, Etohd4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 13998
Homologene: 14209
Trak1
Name: trafficking protein, kinesin binding 1
Synonyms: 2310001H13Rik, hyrt
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67095
Homologene: 25103
Eif2ak1
Name: eukaryotic translation initiation factor 2 alpha kinase 1
Synonyms: Hri
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15467
Homologene: 8290
Rreb1
Name: ras responsive element binding protein 1
Synonyms: 1110037N09Rik, B930013M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 68750
Homologene: 2218
Pcmt1
Name: protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
Synonyms: protein carboxyl methyltransferase, PIMT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18537
HGNC: HGNC:8728
Homologene: 135759
Plekhm2
Name: pleckstrin homology domain containing, family M (with RUN domain) member 2
Synonyms: 2310034J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69582
Homologene: 19575
Irf4
Name: interferon regulatory factor 4
Synonyms: Spip, IRF-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 16364
HGNC: HGNC:6119
Homologene: 1842
Tpsb2
Name: tryptase beta 2
Synonyms: MMCP-6, Mcp-6, Mcpt6, Mcp6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17229
VEGA: 17
Homologene: 55729
Fat2
Name: FAT atypical cadherin 2
Synonyms: LOC245827, mKIAA0811, Fath2, EMI2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Epha3
Name: Eph receptor A3
Synonyms: Tyro4, Mek4, Hek4, Hek, Cek4, End3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13837
VEGA: 16
HGNC: HGNC:3387
Homologene: 21083
Chd3
Name: chromodomain helicase DNA binding protein 3
Synonyms: Mi-2 alpha, Prp9-1, Prp7, 2600010P09Rik, Chd7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216848
HGNC: HGNC:1918
Homologene: 62693
Snapc4
Name: small nuclear RNA activating complex, polypeptide 4
Synonyms: 5730436L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227644
Homologene: 2321
Tbc1d17
Name: TBC1 domain family, member 17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233204
Homologene: 11656
Ltbp2
Name: latent transforming growth factor beta binding protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 16997
HGNC: HGNC:6715
Homologene: 369
Slc25a45
Name: solute carrier family 25, member 45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107375
Homologene: 76679
Slc15a2
Name: solute carrier family 15 (H+/peptide transporter), member 2
Synonyms: Pept2, 8430408C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 57738
Homologene: 56912
Baiap2l1
Name: BAI1-associated protein 2-like 1
Synonyms: 1300006M19Rik, IRTKS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66898
Homologene: 23123
Dclre1a
Name: DNA cross-link repair 1A
Synonyms: mSNM1, SNM1, 2810043H12Rik, SMN1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 55947
Homologene: 8920
Adamtsl4
Name: ADAMTS-like 4
Synonyms: Tsrc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229595
Homologene: 23141
Cps1
Name: carbamoyl-phosphate synthetase 1
Synonyms: CPS, CPSase I, 4732433M03Rik, D1Ucla3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227231
HGNC: HGNC:2323
Homologene: 68208
Atp6v0a2
Name: ATPase, H+ transporting, lysosomal V0 subunit A2
Synonyms: TJ6s, Tj6, Atp6n2, ATP6a2, 8430408C20Rik, V-ATPase a2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 21871
Homologene: 56523
Gjc3
Name: gap junction protein, gamma 3
Synonyms: connexin 29, Cx29, Gje1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 118446
Homologene: 15399
Zfp820
Name: zinc finger protein 820
Synonyms: 2610036F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 75424
VEGA: 17
AC149051.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Hip1r
Name: huntingtin interacting protein 1 related
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 29816
Homologene: 78348
Fsd1
Name: fibronectin type 3 and SPRY domain-containing protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240121
VEGA: 17
Homologene: 11531
Stac
Name: src homology three (SH3) and cysteine rich domain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20840
Homologene: 2371
4933407L21Rik
Name: RIKEN cDNA 4933407L21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71141
Gpc5
Name: glypican 5
Synonyms: A230034F01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 103978
HGNC: HGNC:4453
Homologene: 3285
Xrra1
Name: X-ray radiation resistance associated 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 446101
Homologene: 19547
Vmn1r177
Name: vomeronasal 1 receptor 177
Synonyms: V1rd12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384572
Homologene: 122945
H6pd
Name: hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
Synonyms: Gpd-1, Gpd1, G6pd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100198
HGNC: HGNC:4795
Homologene: 48275
Tmem40
Name: transmembrane protein 40
Synonyms: 9030407H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 94346
Homologene: 10124
Adamts5
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
Synonyms: ADAM-TS5, 9530092O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 23794
VEGA: 16
HGNC: HGNC:221
Homologene: 5109
Psme3
Name: proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)
Synonyms: Ki, pa28g, PA28gamma, REGgamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19192
HGNC: HGNC:9570
Homologene: 2111
Serpina1e
Name: serine (or cysteine) peptidase inhibitor, clade A, member 1E
Synonyms: PI5, Spi1-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20704
HGNC: HGNC:8941
Homologene: 20103
Tll1
Name: tolloid-like
Synonyms: Tll-1, b2b2476Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 21892
Homologene: 49202
Taar8a
Name: trace amine-associated receptor 8A
Synonyms: LOC215859
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215859
Homologene: 77586
Foxd2
Name: forkhead box D2
Synonyms: Mf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17301
HGNC: HGNC:3803
Homologene: 3292
Il6
Name: interleukin 6
Synonyms: Il-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16193
HGNC: HGNC:6018
Homologene: 502
Tacr2
Name: tachykinin receptor 2
Synonyms: Tac2r
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 21337
VEGA: 10
Homologene: 55548
AC115763.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
B930094E09Rik
Name: RIKEN cDNA B930094E09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 67,165,500 bp
  • T to C, chromosome 1 at 71,640,306 bp
  • T to A, chromosome 1 at 85,940,551 bp
  • G to T, chromosome 1 at 165,518,412 bp
  • C to T, chromosome 2 at 20,529,961 bp
  • G to A, chromosome 2 at 26,365,498 bp
  • T to C, chromosome 2 at 181,622,150 bp
  • A to T, chromosome 3 at 88,321,027 bp
  • G to T, chromosome 3 at 95,680,857 bp
  • G to A, chromosome 4 at 56,759,852 bp
  • T to C, chromosome 4 at 114,908,286 bp
  • A to G, chromosome 4 at 141,477,881 bp
  • C to T, chromosome 4 at 141,641,990 bp
  • T to A, chromosome 4 at 149,995,773 bp
  • A to G, chromosome 5 at 30,018,068 bp
  • C to T, chromosome 5 at 124,001,791 bp
  • G to A, chromosome 5 at 124,639,265 bp
  • T to A, chromosome 5 at 137,957,843 bp
  • A to T, chromosome 5 at 143,884,661 bp
  • T to C, chromosome 5 at 144,278,535 bp
  • T to C, chromosome 6 at 115,733,986 bp
  • T to C, chromosome 7 at 23,865,864 bp
  • T to A, chromosome 7 at 44,845,938 bp
  • GGCG to GGCGACGGCTGCG, chromosome 7 at 97,579,906 bp
  • T to C, chromosome 7 at 99,876,301 bp
  • T to C, chromosome 8 at 63,927,743 bp
  • A to T, chromosome 8 at 64,205,224 bp
  • T to C, chromosome 9 at 53,506,636 bp
  • A to C, chromosome 9 at 111,604,187 bp
  • A to G, chromosome 9 at 121,445,873 bp
  • C to T, chromosome 10 at 7,649,050 bp
  • A to G, chromosome 10 at 24,077,025 bp
  • G to A, chromosome 10 at 62,265,086 bp
  • G to A, chromosome 10 at 94,089,637 bp
  • C to A, chromosome 11 at 55,281,763 bp
  • C to T, chromosome 11 at 69,359,185 bp
  • C to A, chromosome 11 at 101,319,456 bp
  • C to T, chromosome 11 at 107,979,240 bp
  • A to G, chromosome 12 at 84,784,907 bp
  • A to T, chromosome 12 at 103,950,873 bp
  • T to C, chromosome 13 at 30,761,490 bp
  • G to T, chromosome 13 at 37,893,965 bp
  • T to C, chromosome 14 at 115,370,060 bp
  • A to G, chromosome 15 at 85,494,091 bp
  • A to G, chromosome 16 at 36,782,304 bp
  • A to G, chromosome 16 at 63,610,964 bp
  • A to G, chromosome 16 at 85,868,121 bp
  • T to C, chromosome 17 at 21,818,896 bp
  • G to A, chromosome 17 at 25,367,483 bp
  • T to C, chromosome 17 at 25,831,302 bp
  • T to C, chromosome 17 at 26,207,587 bp
  • A to G, chromosome 17 at 55,993,893 bp
  • G to A, chromosome 18 at 31,609,689 bp
  • T to A, chromosome 18 at 49,878,259 bp
  • C to T, chromosome 19 at 5,880,633 bp
  • T to A, chromosome 19 at 41,558,356 bp
  • A to T, chromosome 19 at 56,545,320 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3889 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040801-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.