Strain Name:
C57BL/6J-MtgxR3946Btlr/Mmmh
Stock Number:
040827-MU
Citation ID:
RRID:MMRRC_040827-MU
Other Names:
R3946 (G1), C57BL/6J-MtgxR3946Btlr
Major Collection:

Gene Information

Tle4
Name: transducin-like enhancer of split 4
Synonyms: ESTM13, 5730411M05Rik, Grg4, Bce1, ESTM14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 21888
VEGA: 19
Homologene: 38259
Maco1
Name: macoilin 1
Synonyms: C61, 9230118A01Rik, Tmem57, 1110007C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66146
Homologene: 14449
Trp53bp1
Name: transformation related protein 53 binding protein 1
Synonyms: p53BP1, 53BP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 27223
Homologene: 4137
Trmt13
Name: tRNA methyltransferase 13
Synonyms: 4631408H19Rik, A930028L21Rik, Ccdc76
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229780
Homologene: 6875
Cabin1
Name: calcineurin binding protein 1
Synonyms: A330070M20Rik, Cain, Ppp3in
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 104248
VEGA: 10
Homologene: 49307
Caprin1
Name: cell cycle associated protein 1
Synonyms: RNG105, Gpiap1, MMGPIP137, caprin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 53872
HGNC: HGNC:6743
Homologene: 4310
Nr2c2
Name: nuclear receptor subfamily 2, group C, member 2
Synonyms: Tr4, TAK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22026
HGNC: HGNC:7972
Homologene: 2475
Abi2
Name: abl-interactor 2
Synonyms: 8430425M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 329165
Homologene: 4209
Serbp1
Name: serpine1 mRNA binding protein 1
Synonyms: 1200009K13Rik, 9330147J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66870
Homologene: 134277
Tg
Name: thyroglobulin
Synonyms: Tgn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 21819
Homologene: 2430
Rad17
Name: RAD17 checkpoint clamp loader component
Synonyms: 9430035O09Rik, MmRad24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19356
VEGA: 13
HGNC: HGNC:9807
Homologene: 32117
Pex1
Name: peroxisomal biogenesis factor 1
Synonyms: 5430414H02Rik, peroxisome biogenesis factor 1, ZWS1, E330005K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71382
HGNC: HGNC:8850
Homologene: 27006
Sec23b
Name: SEC23 homolog B, COPII coat complex component
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 27054
Homologene: 74571
Traf3
Name: TNF receptor-associated factor 3
Synonyms: CD40bp, LAP1, CAP-1, CRAF1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 22031
Homologene: 7981
Pikfyve
Name: phosphoinositide kinase, FYVE type zinc finger containing
Synonyms: PipkIII, Pip5k3, 5230400C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18711
Homologene: 32115
Cic
Name: capicua transcriptional repressor
Synonyms: 1200010B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71722
Homologene: 87637
Coch
Name: cochlin
Synonyms: D12H14S564E, Coch-5B2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 12810
VEGA: 12
HGNC: HGNC:2180
Homologene: 20868
Scube2
Name: signal peptide, CUB domain, EGF-like 2
Synonyms: ICRFP703N2430Q5.1, ICRFP703B1614Q5.1, Cegf1, 4932442O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56788
Homologene: 36383
Got2
Name: glutamatic-oxaloacetic transaminase 2, mitochondrial
Synonyms: Kyat4, plasma membrane fatty acid binding protein, FABP-pm, mitochondrial aspartate aminotransferase, mAspAT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14719
HGNC: HGNC:4433
Homologene: 1572
Zfp335
Name: zinc finger protein 335
Synonyms: 1810045J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329559
Homologene: 11129
Agr3
Name: anterior gradient 3
Synonyms: E030025L21Rik, LOC380754
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 403205
Homologene: 45551
Brca2
Name: breast cancer 2, early onset
Synonyms: RAB163, Fancd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12190
HGNC: HGNC:1101
Homologene: 41
Pin1
Name: protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
Synonyms: D9Bwg1161e, 0610025L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 23988
VEGA: 9
HGNC: HGNC:8988
Homologene: 4531
Ncstn
Name: nicastrin
Synonyms: nicastrin, D1Dau13e, Nct, 9430068N19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 59287
Homologene: 41029
Eef1g
Name: eukaryotic translation elongation factor 1 gamma
Synonyms: 2610301D06Rik, EF1G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67160
HGNC: HGNC:3213
Homologene: 20363
Ilkap
Name: integrin-linked kinase-associated serine/threonine phosphatase 2C
Synonyms: PP2C-DELTA, 0710007A14Rik, 1600009O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67444
Homologene: 31525
Fam135a
Name: family with sequence similarity 135, member A
Synonyms: 4921533L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68187
Homologene: 32665
Med6
Name: mediator complex subunit 6
Synonyms: 1500012F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 69792
Homologene: 3990
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 665700
Homologene: 90772
Ptprq
Name: protein tyrosine phosphatase, receptor type, Q
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Ush2a
Name: usherin
Synonyms: Ush2a, A930037M10Rik, MUSH2A, LOC269160, A930011D15Rik, Ushrn, LOC381317
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22283
Homologene: 66151
Myo1g
Name: myosin IG
Synonyms: E430002D17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 246177
Homologene: 27996
Plb1
Name: phospholipase B1
Synonyms: 4632413E21Rik, 4930433E17Rik, 4930539A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 665270
Homologene: 82108
Vinac1
Name: vinculin/alpha-catenin family member 1
Synonyms: Gm14025
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 668894
Homologene: 86340
Mmp23
Name: matrix metallopeptidase 23
Synonyms: cysteine array matrix metalloproteinase, CA-MMP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 26561
HGNC: HGNC:7171
Homologene: 3424
Vmn2r25
Name: vomeronasal 2, receptor 25
Synonyms: EG545874
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 545874
Homologene: 135915
Rbbp8
Name: retinoblastoma binding protein 8, endonuclease
Synonyms: 9930104E21Rik, CtIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225182
VEGA: 18
HGNC: HGNC:9891
Homologene: 28546
Stk19
Name: serine/threonine kinase 19
Synonyms: G11, RP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 54402
Homologene: 10449
Gm14412
Name: predicted gene 14412
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 102640477
Homologene: 134324
Dtx1
Name: deltex 1, E3 ubiquitin ligase
Synonyms: Fxit1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14357
HGNC: HGNC:3060
Homologene: 74522
Dglucy
Name: D-glutamate cyclase
Synonyms: 9030617O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217830
Homologene: 11798
Mep1a
Name: meprin 1 alpha
Synonyms: Mep-1a, meprin A alpha-subunit, Mep1, meprin alpha, Mep-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17287
HGNC: HGNC:7015
Homologene: 31323
Calr3
Name: calreticulin 3
Synonyms: 6330586I20Rik, calsperin, Crt2, 1700031L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 73316
Homologene: 57091
Synj1
Name: synaptojanin 1
Synonyms: A930006D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 104015
Homologene: 48252
Olfr1309
Name: olfactory receptor 1309
Synonyms: GA_x6K02T2Q125-73031456-73030518, MOR245-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258439
Homologene: 74054
Slc22a23
Name: solute carrier family 22, member 23
Synonyms: 3110004L20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 73102
Homologene: 41457
Tmx3
Name: thioredoxin-related transmembrane protein 3
Synonyms: Txndc10, A730024F05Rik, 6430411B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67988
VEGA: 18
Homologene: 10381
Pgm2
Name: phosphoglucomutase 2
Synonyms: Pgm1, 3230402E02Rik, Pgm-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66681
HGNC: HGNC:8906
Homologene: 6693
Pilrb1
Name: paired immunoglobin-like type 2 receptor beta 1
Synonyms: Pilrb, Fdact
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 170741
Homologene: 114502
Syne3
Name: spectrin repeat containing, nuclear envelope family member 3
Synonyms: nesprin-3beta, nesprin-3, 4831426I19Rik, nesprin-3alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 212073
VEGA: 12
Homologene: 17625
H2-M11
Name: histocompatibility 2, M region locus 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224754
Homologene: 52241
CT485612.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Hoxd12
Name: homeobox D12
Synonyms: Hox-4.7, Hox-5.6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 15432
HGNC: HGNC:5135
Homologene: 7369
Prxl2c
Name: peroxiredoxin like 2C
Synonyms: Aaed1, 1110018J18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66129
VEGA: 13
Homologene: 7192
Cdk5rap1
Name: CDK5 regulatory subunit associated protein 1
Synonyms: 2310066P17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66971
Homologene: 9502
Svs2
Name: seminal vesicle secretory protein 2
Synonyms: semenoclotin, SVS II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 53878
Homologene: 49325
Rtkn
Name: rhotekin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20166
Homologene: 7522
Slc14a1
Name: solute carrier family 14 (urea transporter), member 1
Synonyms: 2610507K20Rik, UT-B, 3021401A05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 108052
Homologene: 9285
Otub2
Name: OTU domain, ubiquitin aldehyde binding 2
Synonyms: 2010015L18Rik, OTU2, OTB2, 4930586I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 68149
Homologene: 57056
Defa25
Name: defensin, alpha, 25
Synonyms: Defcr25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13236
Homologene: 113382
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 24,030,394 bp
  • A to G, chromosome 1 at 60,453,754 bp
  • T to C, chromosome 1 at 65,196,681 bp
  • A to C, chromosome 1 at 91,387,250 bp
  • T to C, chromosome 1 at 172,067,494 bp
  • T to G, chromosome 1 at 188,728,504 bp
  • T to A, chromosome 2 at 31,382,394 bp
  • G to T, chromosome 2 at 74,675,427 bp
  • T to A, chromosome 2 at 103,796,766 bp
  • G to A, chromosome 2 at 111,983,297 bp
  • T to A, chromosome 2 at 121,228,626 bp
  • A to G, chromosome 2 at 129,039,601 bp
  • A to G, chromosome 2 at 144,581,973 bp
  • T to C, chromosome 2 at 154,348,716 bp
  • T to C, chromosome 2 at 164,237,127 bp
  • T to C, chromosome 2 at 164,892,189 bp
  • A to T, chromosome 2 at 177,314,685 bp
  • A to G, chromosome 3 at 116,581,518 bp
  • A to G, chromosome 4 at 134,804,481 bp
  • T to C, chromosome 4 at 155,652,023 bp
  • C to T, chromosome 5 at 3,626,084 bp
  • T to A, chromosome 5 at 32,328,052 bp
  • C to T, chromosome 5 at 64,112,061 bp
  • T to G, chromosome 5 at 120,681,286 bp
  • T to G, chromosome 5 at 137,857,392 bp
  • T to A, chromosome 5 at 150,536,704 bp
  • T to A, chromosome 6 at 67,272,220 bp
  • A to T, chromosome 6 at 83,135,976 bp
  • C to T, chromosome 6 at 92,163,138 bp
  • A to G, chromosome 6 at 123,840,098 bp
  • C to A, chromosome 7 at 25,272,346 bp
  • T to A, chromosome 7 at 109,857,590 bp
  • G to A, chromosome 8 at 21,084,490 bp
  • A to G, chromosome 8 at 72,443,620 bp
  • A to G, chromosome 8 at 95,888,230 bp
  • C to T, chromosome 9 at 20,655,364 bp
  • T to G, chromosome 10 at 75,745,259 bp
  • A to G, chromosome 10 at 107,686,392 bp
  • A to G, chromosome 11 at 6,520,760 bp
  • C to A, chromosome 12 at 35,947,513 bp
  • A to G, chromosome 12 at 51,601,812 bp
  • T to C, chromosome 12 at 81,581,851 bp
  • T to C, chromosome 12 at 88,286,042 bp
  • T to C, chromosome 12 at 100,838,700 bp
  • T to A, chromosome 12 at 103,392,826 bp
  • T to A, chromosome 12 at 104,958,066 bp
  • G to A, chromosome 12 at 111,255,245 bp
  • A to G, chromosome 13 at 34,183,126 bp
  • T to C, chromosome 13 at 64,309,098 bp
  • G to A, chromosome 13 at 100,622,863 bp
  • T to C, chromosome 15 at 66,674,023 bp
  • A to G, chromosome 16 at 91,010,096 bp
  • A to T, chromosome 17 at 34,824,747 bp
  • A to G, chromosome 17 at 36,549,231 bp
  • A to T, chromosome 17 at 43,475,041 bp
  • A to G, chromosome 18 at 11,718,868 bp
  • C to A, chromosome 18 at 78,111,392 bp
  • G to A, chromosome 18 at 90,524,335 bp
  • T to C, chromosome 19 at 8,969,977 bp
  • A to T, chromosome 19 at 14,597,388 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3946 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040827-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.