Strain Name:
C57BL/6J-MtgxR4067Btlr/Mmmh
Stock Number:
040853-MU
Citation ID:
RRID:MMRRC_040853-MU
Other Names:
R4067 (G1), C57BL/6J-MtgxR4067Btlr
Major Collection:

Gene Information

Ntrk3
Name: neurotrophic tyrosine kinase, receptor, type 3
Synonyms: TrkC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18213
HGNC: HGNC:8033
Homologene: 49183
Dnajc7
Name: DnaJ heat shock protein family (Hsp40) member C7
Synonyms: mDj11, Ttc2, 2010003F24Rik, mTpr2, 2010004G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 56354
Homologene: 68306
Brpf3
Name: bromodomain and PHD finger containing, 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268936
Homologene: 16092
Gcn1
Name: GCN1 activator of EIF2AK4
Synonyms: GCN1L, G431004K08Rik, Gcn1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231659
HGNC: HGNC:4199
Homologene: 5887
Ltn1
Name: listerin E3 ubiquitin protein ligase 1
Synonyms: 4930528H02Rik, Zfp294, Listerin, Rnf160
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 78913
VEGA: 16
Homologene: 32272
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: 1810014J18Rik, AD013, A330063D19Rik, 9030205D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 109151
Homologene: 11844
Usp24
Name: ubiquitin specific peptidase 24
Synonyms: 2810030C21Rik, 2700066K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329908
Homologene: 35420
Otof
Name: otoferlin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 83762
HGNC: HGNC:8515
Homologene: 12892
Asb4
Name: ankyrin repeat and SOCS box-containing 4
Synonyms: 8430401O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 65255
Homologene: 9392
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Aktip
Name: AKT interacting protein
Synonyms: Ft1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14339
Homologene: 7721
Fut8
Name: fucosyltransferase 8
Synonyms: alpha (1,6) fucosyltransferase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 53618
VEGA: 12
HGNC: HGNC:4019
Homologene: 9650
Kirrel
Name: kirre like nephrin family adhesion molecule 1
Synonyms: Neph1, Kirrel1, 6720469N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 170643
Homologene: 10089
Dync2i2
Name: dynein 2 intermediate chain 2
Synonyms: 3200002I06Rik, Wdr34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71820
Homologene: 14156
Plxna2
Name: plexin A2
Synonyms: OCT, Plxn2, 2810428A13Rik, PlexA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Trhde
Name: TRH-degrading enzyme
Synonyms: 9330155P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237553
Homologene: 75007
Sf3a1
Name: splicing factor 3a, subunit 1
Synonyms: 1200014H24Rik, 5930416L09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67465
Homologene: 4294
Enam
Name: enamelin
Synonyms: abte
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13801
HGNC: HGNC:3344
Homologene: 9698
Trpc5
Name: transient receptor potential cation channel, subfamily C, member 5
Synonyms: CCE2, TRP5, Trrp5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 22067
Homologene: 74915
Col9a2
Name: collagen, type IX, alpha 2
Synonyms: Col9a-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12840
HGNC: HGNC:2218
Homologene: 37535
Rel
Name: reticuloendotheliosis oncogene
Synonyms: c-Rel
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19696
HGNC: HGNC:9954
Homologene: 2182
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Klk1
Name: kallikrein 1
Synonyms: mGk-6, 0610007D04Rik, Klk6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16612
Homologene: 68141
Gvin3
Name: GTPase, very large interferon inducible, family member 3
Synonyms: Gm1966
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434223
Homologene: 32708
Spic
Name: Spi-C transcription factor (Spi-1/PU.1 related)
Synonyms: Spi-C, Prf, C76795
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 20728
Homologene: 7953
Slc47a2
Name: solute carrier family 47, member 2
Synonyms: 4933429E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380701
Homologene: 134426
Stil
Name: Scl/Tal1 interrupting locus
Synonyms: Sil
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 20460
Homologene: 2283
Oas3
Name: 2'-5' oligoadenylate synthetase 3
Synonyms: 2'-5' oligoadenylate synthetase-like 10, Oasl10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 246727
HGNC: HGNC:8088
Homologene: 4510
Slc8a1
Name: solute carrier family 8 (sodium/calcium exchanger), member 1
Synonyms: Ncx1, D930008O12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20541
VEGA: 17
Homologene: 69090
Bace1
Name: beta-site APP cleaving enzyme 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 23821
HGNC: HGNC:933
Homologene: 8014
Gm11437
Name: predicted gene 11437
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 628813
Homologene: 82346
Pign
Name: phosphatidylinositol glycan anchor biosynthesis, class N
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 27392
HGNC: HGNC:8967
Homologene: 6330
Slc4a10
Name: solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
Synonyms: NCBE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94229
Homologene: 23340
Mrps2
Name: mitochondrial ribosomal protein S2
Synonyms: 1500019M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 118451
Homologene: 99837
Plekha6
Name: pleckstrin homology domain containing, family A member 6
Synonyms: Pepp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240753
Homologene: 135779
Tex10
Name: testis expressed gene 10
Synonyms: clone 18330, 2810462N03Rik, 2610206N19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269536
Homologene: 32361
Ppm1d
Name: protein phosphatase 1D magnesium-dependent, delta isoform
Synonyms: Wip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 53892
HGNC: HGNC:9277
Homologene: 31185
Pcdhb2
Name: protocadherin beta 2
Synonyms: PcdhbB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93873
HGNC: HGNC:8687
Homologene: 69266
Man1c1
Name: mannosidase, alpha, class 1C, member 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230815
Homologene: 69303
Car6
Name: carbonic anhydrase 6
Synonyms: DOC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12353
HGNC: HGNC:1380
Homologene: 20324
Etnppl
Name: ethanolamine phosphate phospholyase
Synonyms: 1300019H02Rik, Agxt2l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71760
Homologene: 69440
Gm597
Name: predicted gene 597
Synonyms: LOC210962
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 210962
Il22b
Name: interleukin 22B
Synonyms: IL-TIFb, Iltifb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 116849
Homologene: 9669
Or8k24
Name: olfactory receptor family 8 subfamily K member 24
Synonyms: GA_x6K02T2Q125-47855818-47854868, MOR190-2, Olfr1058
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258386
Homologene: 74093
Slc30a1
Name: solute carrier family 30 (zinc transporter), member 1
Synonyms: Znt1, C130040I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22782
Homologene: 6681
Itfg2
Name: integrin alpha FG-GAP repeat containing 2
Synonyms: 2700050P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101142
Homologene: 10211
Slc9a7
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 7
Synonyms: NHE7, A530087D17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 236727
Homologene: 32785
Bglap
Name: bone gamma carboxyglutamate protein
Synonyms: osteocalcin, mOC-A, bone Gla protein, OG1, OC, Bglap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12096
HGNC: HGNC:1043
Homologene: 104130
Stk26
Name: serine/threonine kinase 26
Synonyms: Mst4, 2610018G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 70415
Homologene: 84402
Rd3l
Name: retinal degeneration 3-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217874
Homologene: 19151
Cybc1
Name: cytochrome b 245 chaperone 1
Synonyms: BC017643
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217370
Homologene: 51645
Klra7
Name: killer cell lectin-like receptor, subfamily A, member 7
Synonyms: LGL-1, Ly49g, Ly-49G.3, Ly-49G.2, Ly-49G.1, Ly49g2, Ly49g1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16638
Homologene: 110821
Zfp783
Name: zinc finger protein 783
Synonyms: ENSMUSG00000072653, A230106D06Rik, Gm20494
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232785
1700025G04Rik
Name: RIKEN cDNA 1700025G04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 69399
Homologene: 12776
Ak1
Name: adenylate kinase 1
Synonyms: Ak-1, B430205N08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11636
HGNC: HGNC:361
Homologene: 20135
Gm9989
Name: predicted gene 9989
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 102640985
Fgf20
Name: fibroblast growth factor 20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 80857
HGNC: HGNC:3677
Homologene: 10527
Pudp
Name: pseudouridine 5'-phosphatase
Synonyms: GS1, 1700121L12Rik, Hdhd1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67365
VEGA: 18
Homologene: 8093
4930503E14Rik
Name: RIKEN cDNA 4930503E14 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 74954
Homologene: 115686
Adgrg4
Name: adhesion G protein-coupled receptor G4
Synonyms: LOC236798, PGR17, Gpr112
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 236798
Homologene: 72131
Ighv10-1
Name: immunoglobulin heavy variable 10-1
Synonyms: Gm16696
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 380808
Gsdmcl2
Name: gasdermin C-like 2
Synonyms: 4921501E01Rik, 4930453O09Rik, Gm7779
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 665769
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 28,777,631 bp
  • A to T, chromosome 1 at 105,587,978 bp
  • G to A, chromosome 1 at 133,294,678 bp
  • T to A, chromosome 1 at 151,893,399 bp
  • G to C, chromosome 1 at 191,907,289 bp
  • C to T, chromosome 1 at 194,749,317 bp
  • A to G, chromosome 2 at 28,469,770 bp
  • A to G, chromosome 2 at 30,032,808 bp
  • G to A, chromosome 2 at 32,629,581 bp
  • A to T, chromosome 2 at 62,046,645 bp
  • A to T, chromosome 2 at 86,386,087 bp
  • T to C, chromosome 3 at 81,922,242 bp
  • G to A, chromosome 3 at 87,088,467 bp
  • A to T, chromosome 3 at 88,384,437 bp
  • T to A, chromosome 3 at 130,631,793 bp
  • A to T, chromosome 4 at 48,459,355 bp
  • C to T, chromosome 4 at 106,359,089 bp
  • T to C, chromosome 4 at 115,014,125 bp
  • T to A, chromosome 4 at 121,052,389 bp
  • G to C, chromosome 4 at 134,703,438 bp
  • G to A, chromosome 4 at 150,197,459 bp
  • C to T, chromosome 5 at 30,399,291 bp
  • A to G, chromosome 5 at 88,503,377 bp
  • T to G, chromosome 5 at 115,599,088 bp
  • A to G, chromosome 5 at 120,766,212 bp
  • T to A, chromosome 6 at 5,423,651 bp
  • A to T, chromosome 6 at 47,945,565 bp
  • A to G, chromosome 6 at 85,621,289 bp
  • T to A, chromosome 6 at 128,410,450 bp
  • T to C, chromosome 6 at 130,231,649 bp
  • C to T, chromosome 7 at 44,227,544 bp
  • T to A, chromosome 7 at 78,517,437 bp
  • T to A, chromosome 7 at 106,599,565 bp
  • A to T, chromosome 8 at 40,279,855 bp
  • A to T, chromosome 8 at 91,023,574 bp
  • A to C, chromosome 8 at 91,125,838 bp
  • G to A, chromosome 9 at 45,854,664 bp
  • T to C, chromosome 10 at 88,675,683 bp
  • T to A, chromosome 10 at 114,444,680 bp
  • T to C, chromosome 10 at 118,290,210 bp
  • T to A, chromosome 11 at 4,167,824 bp
  • A to C, chromosome 11 at 23,753,215 bp
  • T to C, chromosome 11 at 61,303,947 bp
  • A to G, chromosome 11 at 84,164,511 bp
  • A to G, chromosome 11 at 85,345,852 bp
  • T to C, chromosome 11 at 100,601,781 bp
  • A to T, chromosome 11 at 121,224,702 bp
  • T to A, chromosome 12 at 77,464,061 bp
  • T to G, chromosome 12 at 111,979,511 bp
  • A to T, chromosome 12 at 114,479,023 bp
  • T to C, chromosome 14 at 44,169,184 bp
  • A to T, chromosome 15 at 63,893,887 bp
  • A to T, chromosome 16 at 32,751,051 bp
  • T to C, chromosome 16 at 87,416,230 bp
  • T to C, chromosome 17 at 28,821,259 bp
  • T to A, chromosome 17 at 81,648,274 bp
  • A to T, chromosome 18 at 37,297,314 bp
  • A to G, chromosome 18 at 50,568,258 bp
  • C to T, chromosome X at 20,205,554 bp
  • A to G, chromosome X at 50,889,033 bp
  • A to G, chromosome X at 56,959,960 bp
  • T to A, chromosome X at 144,419,598 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4067 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040853-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.