Strain Name:
C57BL/6J-MtgxR3834Btlr/Mmmh
Stock Number:
040889-MU
Citation ID:
RRID:MMRRC_040889-MU
Other Names:
R3834 (G1), C57BL/6J-MtgxR3834Btlr
Major Collection:

Strain Information

Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: slip, DNAPDcs, DNA-PK, dxnph, DNA-PKcs, XRCC7, DOXNPH
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Mtmr14
Name: myotubularin related protein 14
Synonyms: 1110061O04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 97287
Homologene: 11203
Rad54l
Name: RAD54 like (S. cerevisiae)
Synonyms: RAD54
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19366
HGNC: HGNC:9826
Homologene: 48227
Kif20b
Name: kinesin family member 20B
Synonyms: C330014J10Rik, magoo, 33cex, N-6 kinesin, Mphosph1, Kif20b
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240641
VEGA: 19
HGNC: HGNC:7212
Homologene: 9418
Bptf
Name: bromodomain PHD finger transcription factor
Synonyms: 9430093H17Rik, Falz
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207165
HGNC: HGNC:3581
Homologene: 114397
Nav2
Name: neuron navigator 2
Synonyms: 5330421F07Rik, RAINB2, POMFIL2, HELAD1, Unc53H2, Rainb1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78286
Homologene: 52330
Lrp6
Name: low density lipoprotein receptor-related protein 6
Synonyms: Cd, skam26Jus, skax26, ska26
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16974
HGNC: HGNC:6698
Homologene: 1747
Ptprc
Name: protein tyrosine phosphatase receptor type C
Synonyms: Lyt-4, Ly-5, T200, CD45, B220
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19264
HGNC: HGNC:9666
Homologene: 2126
Dhx32
Name: DEAH-box helicase 32 (putative)
Synonyms: DEAH (Asp-Glu-Ala-His) box polypeptide 32, Ddx32
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101437
Homologene: 56798
Coq5
Name: coenzyme Q5 methyltransferase
Synonyms: D5Ertd33e, 1810014G04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52064
Homologene: 6559
Grik4
Name: glutamate receptor, ionotropic, kainate 4
Synonyms: KA-1, 6330551K01Rik, GluRgamma1, KA1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110637
HGNC: HGNC:4582
Homologene: 81829
Stk32b
Name: serine/threonine kinase 32B
Synonyms: YANK2, STKG6, Stk32, 2510009F08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 64293
Homologene: 48654
Txnip
Name: thioredoxin interacting protein
Synonyms: mVDUP1, THIF, VDUP1, Hyplip1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56338
Homologene: 38186
Or52h9
Name: olfactory receptor family 52 subfamily H member 9
Synonyms: GA_x6K02T2PBJ9-7179540-7180481, Olfr651, MOR31-11
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258809
Homologene: 64922
Gm872
Name: predicted gene 872
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Stab2
Name: stabilin 2
Synonyms: FEEL-2, STAB-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 192188
Homologene: 23022
Gm5114
Name: predicted gene 5114
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330513
Homologene: 45597
Fbxo44
Name: F-box protein 44
Synonyms: Fbxo6a, Fbx6a, FBX30, FBG3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230903
Homologene: 13232
Slco1a1
Name: solute carrier organic anion transporter family, member 1a1
Synonyms: Oatp1a1, Slc21a1, Oatp1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28248
Homologene: 137261
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC5, 2300002I04Rik, MUC9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Scd3
Name: stearoyl-coenzyme A desaturase 3
Synonyms: 4930513N16Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 30049
VEGA: 19
Homologene: 137370
Iqcm
Name: IQ motif containing M
Synonyms: 1700007B14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71831
Homologene: 53050
Slc15a2
Name: solute carrier family 15 (H+/peptide transporter), member 2
Synonyms: 8430408C16Rik, Pept2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 57738
Homologene: 56912
Ptprt
Name: protein tyrosine phosphatase receptor type T
Synonyms: RPTPrho
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19281
HGNC: HGNC:9682
Homologene: 56924
Tmem145
Name: transmembrane protein 145
Synonyms: B930076A02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330485
Homologene: 18333
Vmn2r104
Name: vomeronasal 2, receptor 104
Synonyms: V2r7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22313
Homologene: 129751
Map1a
Name: microtubule-associated protein 1 A
Synonyms: Mtap-1, Mtap1a, Mtap1, 6330416M19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17754
HGNC: HGNC:6835
Homologene: 1778
4930402F06Rik
Name: RIKEN cDNA 4930402F06 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74854
Homologene: 78017
Mug2
Name: murinoglobulin 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17837
HGNC: HGNC:9750
Homologene: 136663
Or5p69
Name: olfactory receptor family 5 subfamily P member 69
Synonyms: Olfr494, MOR204-10, GA_x6K02T2PBJ9-10697517-10698461
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258732
Homologene: 133602
Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Synonyms: SXR, Pregnane X receptor, PXR.1, PXR.2, mPXR, PXR
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 18171
HGNC: HGNC:7968
Homologene: 40757
Tmc4
Name: transmembrane channel-like gene family 4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 353499
Homologene: 16971
Or51f5
Name: olfactory receptor family 51 subfamily F member 5
Synonyms: GA_x6K02T2PBJ9-5491151-5492095, Olfr561, MOR14-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259096
Homologene: 133029
Pramel14
Name: PRAME like 14
Synonyms: Gm13107, Pramef17
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 626943
Homologene: 129642
Ngly1
Name: N-glycanase 1
Synonyms: Png1, PNGase, 1110002C09Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 59007
Homologene: 10117
Lrfn5
Name: leucine rich repeat and fibronectin type III domain containing 5
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238205
Homologene: 17582
Vmn1r32
Name: vomeronasal 1 receptor 32
Synonyms: V1rc15
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171188
Homologene: 115644
Cyp2j13
Name: cytochrome P450, family 2, subfamily j, polypeptide 13
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230459
HGNC: HGNC:2634
Homologene: 138297
Cimip3
Name: ciliary microtubule inner protein 3
Synonyms: 1700001C19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 75462
Homologene: 129540
Cyp2d34
Name: cytochrome P450, family 2, subfamily d, polypeptide 34
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223706
VEGA: 15
Homologene: 86099
Adh6a
Name: alcohol dehydrogenase 6A (class V)
Synonyms: 1810009C16Rik, Adh5a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69117
Homologene: 66291
Sertad2
Name: SERTA domain containing 2
Synonyms: Trip-Br2, SEI-2, Sei2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 58172
Homologene: 8843
Fam114a1
Name: family with sequence similarity 114, member A1
Synonyms: 1190001N04Rik, 9130005N14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68303
Homologene: 12259
Oxct2a
Name: 3-oxoacid CoA transferase 2A
Synonyms: Scot-t1, Oxct2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 64059
Homologene: 137359
AC129217.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Rps20
Name: ribosomal protein S20
Synonyms: Dsk4, 4632426K06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67427
Homologene: 37417
Tmem238
Name: transmembrane protein 238
Synonyms: 2210411K11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 664968
Homologene: 47692
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 138,083,567 bp
  • A to G, chromosome 2 at 35,385,683 bp
  • G to A, chromosome 2 at 121,307,322 bp
  • A to G, chromosome 2 at 161,547,387 bp
  • C to G, chromosome 3 at 96,559,447 bp
  • G to A, chromosome 3 at 138,327,514 bp
  • A to T, chromosome 4 at 3,834,610 bp
  • C to T, chromosome 4 at 96,056,557 bp
  • A to T, chromosome 4 at 116,098,475 bp
  • C to T, chromosome 4 at 123,322,473 bp
  • T to A, chromosome 4 at 143,994,226 bp
  • A to G, chromosome 4 at 148,156,250 bp
  • T to C, chromosome 5 at 37,455,011 bp
  • C to T, chromosome 5 at 65,006,073 bp
  • G to T, chromosome 5 at 115,284,576 bp
  • C to A, chromosome 6 at 66,553,663 bp
  • T to C, chromosome 6 at 113,257,009 bp
  • T to C, chromosome 6 at 122,049,787 bp
  • G to A, chromosome 6 at 134,462,670 bp
  • G to T, chromosome 6 at 141,943,437 bp
  • C to T, chromosome 7 at 3,672,007 bp
  • C to A, chromosome 7 at 4,789,079 bp
  • T to C, chromosome 7 at 25,311,361 bp
  • T to A, chromosome 7 at 39,408,737 bp
  • T to A, chromosome 7 at 49,545,858 bp
  • A to G, chromosome 7 at 102,775,286 bp
  • T to A, chromosome 7 at 104,553,345 bp
  • A to T, chromosome 7 at 108,368,072 bp
  • T to A, chromosome 7 at 133,721,400 bp
  • A to T, chromosome 7 at 141,859,181 bp
  • T to C, chromosome 8 at 75,577,752 bp
  • T to C, chromosome 9 at 42,629,123 bp
  • A to T, chromosome 10 at 86,949,912 bp
  • A to G, chromosome 10 at 92,801,123 bp
  • T to C, chromosome 11 at 20,648,482 bp
  • T to C, chromosome 11 at 107,073,857 bp
  • T to A, chromosome 12 at 61,840,030 bp
  • T to C, chromosome 14 at 16,290,766 bp
  • A to G, chromosome 15 at 82,616,746 bp
  • A to G, chromosome 16 at 15,791,946 bp
  • A to T, chromosome 16 at 36,772,128 bp
  • T to C, chromosome 16 at 38,253,929 bp
  • C to T, chromosome 17 at 20,029,921 bp
  • AC to A, chromosome 17 at 47,433,423 bp
  • G to A, chromosome 19 at 8,884,057 bp
  • A to G, chromosome 19 at 34,935,028 bp
  • A to G, chromosome 19 at 44,241,717 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3834 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040889-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.